ATP synthase mitochondrial F1 complex assembly factor 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP12 chaperone protein, putative

Species:

Leishmania mexicana

UniProt:

E9ARH2_LEIMU

TriTrypDb:

LmxM.18.0350

Length:

304

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9ARH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARH2

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0043461	proton-transporting ATP synthase complex assembly	7	12
GO:0043933	protein-containing complex organization	4	12
GO:0065003	protein-containing complex assembly	5	12
GO:0070071	proton-transporting two-sector ATPase complex assembly	6	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0033615	mitochondrial proton-transporting ATP synthase complex assembly	8	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	73	75	PF00675	0.274
CLV_PCSK_SKI1_1	195	199	PF00082	0.364
CLV_PCSK_SKI1_1	278	282	PF00082	0.486
CLV_PCSK_SKI1_1	74	78	PF00082	0.273
CLV_Separin_Metazoa	174	178	PF03568	0.266
CLV_Separin_Metazoa	290	294	PF03568	0.422
DEG_APCC_DBOX_1	194	202	PF00400	0.345
DEG_SCF_FBW7_1	184	191	PF00400	0.474
DOC_ANK_TNKS_1	176	183	PF00023	0.372
DOC_CKS1_1	128	133	PF01111	0.394
DOC_CYCLIN_yCln2_LP_2	221	227	PF00134	0.300
DOC_MAPK_gen_1	40	49	PF00069	0.465
DOC_MAPK_gen_1	77	87	PF00069	0.391
DOC_PP1_RVXF_1	46	52	PF00149	0.273
DOC_PP2B_LxvP_1	110	113	PF13499	0.273
DOC_PP2B_LxvP_1	221	224	PF13499	0.297
DOC_PP2B_LxvP_1	289	292	PF13499	0.512
DOC_PP2B_LxvP_1	85	88	PF13499	0.273
DOC_PP4_FxxP_1	147	150	PF00568	0.244
DOC_USP7_MATH_1	41	45	PF00917	0.619
DOC_USP7_MATH_1	78	82	PF00917	0.273
DOC_USP7_MATH_1	86	90	PF00917	0.273
DOC_WW_Pin1_4	127	132	PF00397	0.375
DOC_WW_Pin1_4	184	189	PF00397	0.472
DOC_WW_Pin1_4	2	7	PF00397	0.435
LIG_14-3-3_CanoR_1	25	33	PF00244	0.572
LIG_BIR_II_1	1	5	PF00653	0.469
LIG_eIF4E_1	106	112	PF01652	0.259
LIG_FHA_1	102	108	PF00498	0.391
LIG_FHA_1	128	134	PF00498	0.394
LIG_FHA_1	216	222	PF00498	0.302
LIG_FHA_1	274	280	PF00498	0.319
LIG_FHA_2	5	11	PF00498	0.419
LIG_IBAR_NPY_1	204	206	PF08397	0.289
LIG_PDZ_Class_3	299	304	PF00595	0.572
LIG_SH2_CRK	206	210	PF00017	0.292
LIG_SH2_GRB2like	106	109	PF00017	0.259
LIG_SH2_STAP1	171	175	PF00017	0.471
LIG_SH2_STAT3	100	103	PF00017	0.289
LIG_SH2_STAT3	106	109	PF00017	0.289
LIG_SH2_STAT5	106	109	PF00017	0.283
LIG_SH2_STAT5	135	138	PF00017	0.273
LIG_SH2_STAT5	146	149	PF00017	0.273
LIG_SH3_3	229	235	PF00018	0.339
LIG_SH3_5	131	135	PF00018	0.273
LIG_SUMO_SIM_anti_2	53	58	PF11976	0.367
LIG_SUMO_SIM_par_1	223	229	PF11976	0.348
LIG_SUMO_SIM_par_1	230	236	PF11976	0.318
LIG_SUMO_SIM_par_1	55	61	PF11976	0.409
LIG_SUMO_SIM_par_1	81	90	PF11976	0.360
LIG_TRAF2_1	297	300	PF00917	0.642
LIG_WRC_WIRS_1	136	141	PF05994	0.273
MOD_CDK_SPK_2	127	132	PF00069	0.394
MOD_CK1_1	2	8	PF00069	0.525
MOD_CK1_1	28	34	PF00069	0.584
MOD_CK2_1	245	251	PF00069	0.432
MOD_CK2_1	293	299	PF00069	0.578
MOD_CK2_1	4	10	PF00069	0.463
MOD_Cter_Amidation	72	75	PF01082	0.273
MOD_GlcNHglycan	118	121	PF01048	0.304
MOD_GlcNHglycan	228	231	PF01048	0.470
MOD_GlcNHglycan	295	298	PF01048	0.607
MOD_GlcNHglycan	43	46	PF01048	0.495
MOD_GSK3_1	112	119	PF00069	0.273
MOD_GSK3_1	135	142	PF00069	0.235
MOD_GSK3_1	184	191	PF00069	0.474
MOD_GSK3_1	21	28	PF00069	0.576
MOD_GSK3_1	211	218	PF00069	0.441
MOD_NEK2_1	211	216	PF00069	0.342
MOD_NEK2_1	217	222	PF00069	0.355
MOD_NEK2_1	35	40	PF00069	0.509
MOD_NEK2_1	79	84	PF00069	0.333
MOD_NEK2_2	135	140	PF00069	0.273
MOD_PIKK_1	152	158	PF00454	0.153
MOD_PIKK_1	4	10	PF00454	0.369
MOD_PIKK_1	79	85	PF00454	0.367
MOD_PKA_2	41	47	PF00069	0.525
MOD_Plk_1	21	27	PF00069	0.492
MOD_Plk_1	28	34	PF00069	0.482
MOD_Plk_1	35	41	PF00069	0.509
MOD_Plk_2-3	245	251	PF00069	0.483
MOD_Plk_4	135	141	PF00069	0.273
MOD_Plk_4	217	223	PF00069	0.297
MOD_Plk_4	28	34	PF00069	0.478
MOD_ProDKin_1	127	133	PF00069	0.375
MOD_ProDKin_1	184	190	PF00069	0.465
MOD_ProDKin_1	2	8	PF00069	0.431
TRG_ENDOCYTIC_2	206	209	PF00928	0.293
TRG_ENDOCYTIC_2	258	261	PF00928	0.381
TRG_Pf-PMV_PEXEL_1	25	29	PF00026	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E1	Leptomonas seymouri	87%	78%
A0A1X0P7M1	Trypanosomatidae	67%	78%
A0A3R7KUB6	Trypanosoma rangeli	66%	78%
A0A3S7WUT0	Leishmania donovani	95%	100%
A4H9D9	Leishmania braziliensis	92%	100%
A4HXR0	Leishmania infantum	95%	100%
B6DTF4	Bodo saltans	62%	80%
D0A042	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	80%
Q1LZ96	Bos taurus	24%	100%
Q4QE07	Leishmania major	94%	100%
Q8N5M1	Homo sapiens	25%	100%
Q91YY4	Mus musculus	26%	100%
V5BRM9	Trypanosoma cruzi	66%	78%