J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ARH0_LEIMU

TriTrypDb:

LmxM.18.0330

Length:

244

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 16
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16
GO:0031207	Sec62/Sec63 complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1

Expansion

Sequence features

E9ARH0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARH0

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006613	cotranslational protein targeting to membrane	6	1
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	1
GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	6	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0045047	protein targeting to ER	6	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070972	protein localization to endoplasmic reticulum	6	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0008320	protein transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0022884	macromolecule transmembrane transporter activity	3	1
GO:0140318	protein transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.557
CLV_NRD_NRD_1	104	106	PF00675	0.716
CLV_NRD_NRD_1	172	174	PF00675	0.632
CLV_NRD_NRD_1	216	218	PF00675	0.441
CLV_NRD_NRD_1	226	228	PF00675	0.433
CLV_NRD_NRD_1	73	75	PF00675	0.462
CLV_PCSK_KEX2_1	172	174	PF00082	0.631
CLV_PCSK_SKI1_1	12	16	PF00082	0.697
CLV_PCSK_SKI1_1	201	205	PF00082	0.335
DEG_APCC_DBOX_1	200	208	PF00400	0.377
DEG_MDM2_SWIB_1	189	196	PF02201	0.336
DEG_Nend_UBRbox_1	1	4	PF02207	0.560
DEG_SPOP_SBC_1	31	35	PF00917	0.351
DOC_CYCLIN_RxL_1	227	240	PF00134	0.573
DOC_MAPK_DCC_7	227	237	PF00069	0.609
DOC_MAPK_MEF2A_6	201	208	PF00069	0.326
DOC_MAPK_NFAT4_5	201	209	PF00069	0.328
DOC_PP1_RVXF_1	199	206	PF00149	0.378
DOC_PP4_MxPP_1	207	210	PF00568	0.417
DOC_SPAK_OSR1_1	188	192	PF12202	0.353
DOC_USP7_MATH_1	22	26	PF00917	0.415
DOC_USP7_MATH_1	81	85	PF00917	0.267
DOC_USP7_UBL2_3	214	218	PF12436	0.701
DOC_USP7_UBL2_3	62	66	PF12436	0.285
DOC_WW_Pin1_4	33	38	PF00397	0.493
LIG_14-3-3_CanoR_1	12	19	PF00244	0.436
LIG_14-3-3_CanoR_1	236	243	PF00244	0.682
LIG_14-3-3_CanoR_1	43	51	PF00244	0.425
LIG_Actin_WH2_1	188	203	PF00022	0.435
LIG_Actin_WH2_2	185	203	PF00022	0.248
LIG_AP2alpha_2	155	157	PF02296	0.498
LIG_BIR_III_4	79	83	PF00653	0.266
LIG_EH_1	173	177	PF12763	0.428
LIG_FHA_1	13	19	PF00498	0.559
LIG_FHA_1	147	153	PF00498	0.446
LIG_FHA_1	26	32	PF00498	0.505
LIG_FHA_1	33	39	PF00498	0.467
LIG_IBAR_NPY_1	49	51	PF08397	0.255
LIG_LIR_Gen_1	139	147	PF02991	0.425
LIG_LIR_Gen_1	93	102	PF02991	0.308
LIG_LIR_Nem_3	139	143	PF02991	0.431
LIG_LIR_Nem_3	85	91	PF02991	0.280
LIG_LIR_Nem_3	93	98	PF02991	0.299
LIG_MAD2	70	78	PF02301	0.266
LIG_PDZ_Class_2	239	244	PF00595	0.628
LIG_Pex14_1	193	197	PF04695	0.270
LIG_Pex14_2	189	193	PF04695	0.367
LIG_Pex14_2	208	212	PF04695	0.596
LIG_SH2_CRK	51	55	PF00017	0.288
LIG_SH2_CRK	69	73	PF00017	0.288
LIG_SH2_STAP1	140	144	PF00017	0.415
LIG_SH2_STAT5	128	131	PF00017	0.510
LIG_SH3_1	228	234	PF00018	0.644
LIG_SH3_1	75	81	PF00018	0.280
LIG_SH3_2	231	236	PF14604	0.660
LIG_SH3_3	160	166	PF00018	0.368
LIG_SH3_3	226	232	PF00018	0.677
LIG_SH3_3	75	81	PF00018	0.280
LIG_SH3_4	214	221	PF00018	0.715
LIG_UBA3_1	204	211	PF00899	0.574
LIG_WW_3	219	223	PF00397	0.760
MOD_CDK_SPxK_1	33	39	PF00069	0.348
MOD_CK1_1	113	119	PF00069	0.461
MOD_CK1_1	136	142	PF00069	0.438
MOD_CK1_1	25	31	PF00069	0.409
MOD_Cter_Amidation	225	228	PF01082	0.462
MOD_GlcNHglycan	109	113	PF01048	0.710
MOD_GlcNHglycan	114	118	PF01048	0.747
MOD_GlcNHglycan	123	126	PF01048	0.713
MOD_GlcNHglycan	24	27	PF01048	0.651
MOD_GlcNHglycan	99	102	PF01048	0.619
MOD_GSK3_1	129	136	PF00069	0.535
MOD_GSK3_1	33	40	PF00069	0.385
MOD_NEK2_1	1	6	PF00069	0.452
MOD_NEK2_1	126	131	PF00069	0.451
MOD_PIKK_1	37	43	PF00454	0.532
MOD_PKA_2	1	7	PF00069	0.513
MOD_PKA_2	121	127	PF00069	0.444
MOD_PKA_2	235	241	PF00069	0.606
MOD_ProDKin_1	33	39	PF00069	0.495
MOD_SUMO_for_1	210	213	PF00179	0.629
TRG_ENDOCYTIC_2	123	126	PF00928	0.440
TRG_ENDOCYTIC_2	140	143	PF00928	0.419
TRG_ENDOCYTIC_2	144	147	PF00928	0.404
TRG_ENDOCYTIC_2	51	54	PF00928	0.288
TRG_ENDOCYTIC_2	69	72	PF00928	0.288
TRG_ENDOCYTIC_2	95	98	PF00928	0.280
TRG_ER_diArg_1	171	173	PF00400	0.456
TRG_ER_diArg_1	224	227	PF00400	0.730

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA62	Leptomonas seymouri	73%	100%
A0A1X0NIB0	Trypanosomatidae	28%	100%
A0A1X0P719	Trypanosomatidae	61%	100%
A0A3Q8IAY4	Leishmania donovani	94%	100%
A0A3R7M6A3	Trypanosoma rangeli	62%	100%
A0A3S7X515	Leishmania donovani	28%	100%
A0A422NEY3	Trypanosoma rangeli	29%	100%
A4H9D7	Leishmania braziliensis	84%	100%
A4HJV4	Leishmania braziliensis	27%	100%
A4HXQ8	Leishmania infantum	94%	100%
A4I7B6	Leishmania infantum	28%	100%
B6DTF2	Bodo saltans	62%	100%
D0A039	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9B2A9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
Q4Q5U7	Leishmania major	29%	100%
Q4QE09	Leishmania major	93%	100%