LeishMANIAdb
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DNA helicase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DNA helicase
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9ARG8_LEIMU
TriTrypDb:
LmxM.18.0310
Length:
102

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9ARG8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARG8

PDB structure(s): 7aih_BD , 7ane_BD

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 49 51 PF00675 0.496
CLV_PCSK_KEX2_1 49 51 PF00082 0.483
DOC_WW_Pin1_4 86 91 PF00397 0.489
LIG_14-3-3_CanoR_1 68 74 PF00244 0.276
LIG_BIR_II_1 1 5 PF00653 0.418
LIG_BRCT_BRCA1_1 1 5 PF00533 0.418
LIG_FHA_1 92 98 PF00498 0.435
LIG_FHA_2 87 93 PF00498 0.534
LIG_LIR_Nem_3 71 76 PF02991 0.406
LIG_Pex14_2 5 9 PF04695 0.423
LIG_REV1ctd_RIR_1 3 12 PF16727 0.408
LIG_SH2_CRK 26 30 PF00017 0.441
LIG_SH2_STAT5 10 13 PF00017 0.365
LIG_TRAF2_1 89 92 PF00917 0.505
MOD_CDK_SPxxK_3 86 93 PF00069 0.489
MOD_CK2_1 86 92 PF00069 0.472
MOD_GlcNHglycan 16 19 PF01048 0.481
MOD_GlcNHglycan 21 24 PF01048 0.498
MOD_GlcNHglycan 54 57 PF01048 0.472
MOD_N-GLC_1 14 19 PF02516 0.436
MOD_NEK2_1 57 62 PF00069 0.411
MOD_NEK2_1 97 102 PF00069 0.580
MOD_PIKK_1 91 97 PF00454 0.424
MOD_Plk_1 14 20 PF00069 0.457
MOD_ProDKin_1 86 92 PF00069 0.486
MOD_SUMO_rev_2 77 86 PF00179 0.448
TRG_ENDOCYTIC_2 26 29 PF00928 0.450
TRG_ENDOCYTIC_2 54 57 PF00928 0.496

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HU10 Leptomonas seymouri 86% 100%
A0A1X0P7S7 Trypanosomatidae 66% 88%
A0A3R7KLJ1 Trypanosoma rangeli 63% 92%
A0A3S5H726 Leishmania donovani 92% 100%
A4H9D5 Leishmania braziliensis 88% 100%
A4HXQ7 Leishmania infantum 94% 100%
B6DTF0 Bodo saltans 53% 84%
D0A037 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 67% 90%
Q4QE11 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS