NTF2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ARG7_LEIMU

TriTrypDb:

LmxM.18.0300

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0005930	axoneme	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	3
GO:1990904	ribonucleoprotein complex	2	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	2
GO:0043229	intracellular organelle	3	2

Expansion

Sequence features

E9ARG7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARG7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.649
CLV_NRD_NRD_1	315	317	PF00675	0.662
CLV_NRD_NRD_1	371	373	PF00675	0.765
CLV_NRD_NRD_1	381	383	PF00675	0.694
CLV_PCSK_FUR_1	313	317	PF00082	0.486
CLV_PCSK_KEX2_1	313	315	PF00082	0.650
CLV_PCSK_SKI1_1	244	248	PF00082	0.726
CLV_PCSK_SKI1_1	384	388	PF00082	0.683
DEG_Nend_UBRbox_1	1	4	PF02207	0.502
DEG_SPOP_SBC_1	267	271	PF00917	0.605
DEG_SPOP_SBC_1	285	289	PF00917	0.374
DEG_SPOP_SBC_1	76	80	PF00917	0.408
DOC_CKS1_1	24	29	PF01111	0.418
DOC_CKS1_1	296	301	PF01111	0.518
DOC_CYCLIN_yCln2_LP_2	332	338	PF00134	0.577
DOC_MAPK_MEF2A_6	139	148	PF00069	0.439
DOC_PP2B_LxvP_1	33	36	PF13499	0.272
DOC_USP7_MATH_1	167	171	PF00917	0.665
DOC_USP7_MATH_1	252	256	PF00917	0.767
DOC_USP7_MATH_1	261	265	PF00917	0.636
DOC_USP7_MATH_1	378	382	PF00917	0.665
DOC_USP7_MATH_1	77	81	PF00917	0.426
DOC_USP7_UBL2_3	240	244	PF12436	0.795
DOC_USP7_UBL2_3	262	266	PF12436	0.785
DOC_USP7_UBL2_3	383	387	PF12436	0.765
DOC_USP7_UBL2_3	84	88	PF12436	0.485
DOC_WW_Pin1_4	156	161	PF00397	0.654
DOC_WW_Pin1_4	195	200	PF00397	0.625
DOC_WW_Pin1_4	23	28	PF00397	0.418
DOC_WW_Pin1_4	250	255	PF00397	0.709
DOC_WW_Pin1_4	295	300	PF00397	0.551
LIG_14-3-3_CanoR_1	2	8	PF00244	0.494
LIG_Actin_WH2_2	97	112	PF00022	0.194
LIG_BRCT_BRCA1_1	323	327	PF00533	0.317
LIG_FHA_1	111	117	PF00498	0.275
LIG_FHA_1	19	25	PF00498	0.391
LIG_FHA_1	229	235	PF00498	0.600
LIG_FHA_1	99	105	PF00498	0.378
LIG_FHA_2	286	292	PF00498	0.462
LIG_FHA_2	59	65	PF00498	0.331
LIG_LIR_Gen_1	122	131	PF02991	0.621
LIG_LIR_Gen_1	324	335	PF02991	0.480
LIG_LIR_Nem_3	122	126	PF02991	0.493
LIG_LIR_Nem_3	273	279	PF02991	0.499
LIG_LIR_Nem_3	324	330	PF02991	0.477
LIG_NRBOX	52	58	PF00104	0.485
LIG_PDZ_Class_2	383	388	PF00595	0.685
LIG_SH2_CRK	123	127	PF00017	0.592
LIG_SH2_CRK	20	24	PF00017	0.366
LIG_SH2_CRK	277	281	PF00017	0.424
LIG_SH2_NCK_1	123	127	PF00017	0.606
LIG_SH2_SRC	277	280	PF00017	0.484
LIG_SH2_SRC	34	37	PF00017	0.374
LIG_SH2_STAP1	20	24	PF00017	0.331
LIG_SH2_STAP1	277	281	PF00017	0.424
LIG_SH2_STAT5	20	23	PF00017	0.315
LIG_SH3_2	164	169	PF14604	0.587
LIG_SH3_3	161	167	PF00018	0.748
LIG_SH3_3	21	27	PF00018	0.358
LIG_SH3_3	71	77	PF00018	0.396
LIG_SH3_4	262	269	PF00018	0.700
LIG_SUMO_SIM_par_1	71	80	PF11976	0.288
LIG_TRAF2_1	155	158	PF00917	0.719
LIG_TRAF2_1	288	291	PF00917	0.480
LIG_TYR_ITIM	121	126	PF00017	0.552
LIG_TYR_ITIM	274	279	PF00017	0.460
MOD_CK1_1	255	261	PF00069	0.752
MOD_CK1_1	55	61	PF00069	0.498
MOD_CK2_1	204	210	PF00069	0.608
MOD_CK2_1	284	290	PF00069	0.468
MOD_CK2_1	342	348	PF00069	0.325
MOD_GlcNHglycan	123	126	PF01048	0.633
MOD_GlcNHglycan	169	172	PF01048	0.690
MOD_GlcNHglycan	254	257	PF01048	0.740
MOD_GlcNHglycan	36	39	PF01048	0.439
MOD_GlcNHglycan	367	370	PF01048	0.693
MOD_GlcNHglycan	79	82	PF01048	0.432
MOD_GlcNHglycan	92	95	PF01048	0.445
MOD_GSK3_1	110	117	PF00069	0.383
MOD_GSK3_1	19	26	PF00069	0.355
MOD_GSK3_1	266	273	PF00069	0.746
MOD_GSK3_1	338	345	PF00069	0.414
MOD_GSK3_1	51	58	PF00069	0.444
MOD_GSK3_1	90	97	PF00069	0.409
MOD_N-GLC_1	183	188	PF02516	0.509
MOD_NEK2_1	109	114	PF00069	0.344
MOD_NEK2_1	121	126	PF00069	0.539
MOD_NEK2_1	223	228	PF00069	0.693
MOD_NEK2_1	56	61	PF00069	0.485
MOD_PIKK_1	94	100	PF00454	0.425
MOD_PKA_1	110	116	PF00069	0.194
MOD_PKA_2	1	7	PF00069	0.564
MOD_PKA_2	173	179	PF00069	0.494
MOD_PKA_2	228	234	PF00069	0.686
MOD_PKA_2	371	377	PF00069	0.701
MOD_Plk_1	51	57	PF00069	0.449
MOD_Plk_4	19	25	PF00069	0.325
MOD_Plk_4	270	276	PF00069	0.637
MOD_Plk_4	3	9	PF00069	0.487
MOD_Plk_4	52	58	PF00069	0.487
MOD_ProDKin_1	156	162	PF00069	0.658
MOD_ProDKin_1	195	201	PF00069	0.620
MOD_ProDKin_1	23	29	PF00069	0.418
MOD_ProDKin_1	250	256	PF00069	0.711
MOD_ProDKin_1	295	301	PF00069	0.545
MOD_SUMO_for_1	309	312	PF00179	0.594
MOD_SUMO_rev_2	103	112	PF00179	0.280
MOD_SUMO_rev_2	287	293	PF00179	0.601
MOD_SUMO_rev_2	381	388	PF00179	0.636
TRG_DiLeu_BaEn_1	52	57	PF01217	0.444
TRG_ENDOCYTIC_2	123	126	PF00928	0.577
TRG_ENDOCYTIC_2	20	23	PF00928	0.309
TRG_ENDOCYTIC_2	276	279	PF00928	0.441
TRG_ER_diArg_1	313	316	PF00400	0.664
TRG_NES_CRM1_1	348	361	PF08389	0.347

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAH4	Leptomonas seymouri	52%	97%
A0A1X0P6X4	Trypanosomatidae	31%	77%
A0A3S7WUR4	Leishmania donovani	87%	100%
A4H9D4	Leishmania braziliensis	62%	93%
A4HXQ6	Leishmania infantum	86%	100%
B6DTE9	Bodo saltans	25%	86%
D0A036	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	90%
Q4QE12	Leishmania major	82%	94%