Dephospho-CoA kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dephospho-CoA kinase, putative

Species:

Leishmania mexicana

UniProt:

E9ARG6_LEIMU

TriTrypDb:

LmxM.18.0290

Length:

337

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ARG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARG6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006163	purine nucleotide metabolic process	5	11
GO:0006164	purine nucleotide biosynthetic process	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006753	nucleoside phosphate metabolic process	4	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009117	nucleotide metabolic process	5	11
GO:0009150	purine ribonucleotide metabolic process	6	11
GO:0009152	purine ribonucleotide biosynthetic process	7	11
GO:0009165	nucleotide biosynthetic process	6	11
GO:0009259	ribonucleotide metabolic process	5	11
GO:0009260	ribonucleotide biosynthetic process	6	11
GO:0009987	cellular process	1	11
GO:0015936	coenzyme A metabolic process	6	11
GO:0015937	coenzyme A biosynthetic process	7	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0019637	organophosphate metabolic process	3	11
GO:0019693	ribose phosphate metabolic process	4	11
GO:0033865	nucleoside bisphosphate metabolic process	5	11
GO:0033866	nucleoside bisphosphate biosynthetic process	6	11
GO:0033875	ribonucleoside bisphosphate metabolic process	6	11
GO:0034030	ribonucleoside bisphosphate biosynthetic process	7	11
GO:0034032	purine nucleoside bisphosphate metabolic process	5	11
GO:0034033	purine nucleoside bisphosphate biosynthetic process	6	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034654	nucleobase-containing compound biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0044281	small molecule metabolic process	2	11
GO:0046390	ribose phosphate biosynthetic process	5	11
GO:0046483	heterocycle metabolic process	3	11
GO:0055086	nucleobase-containing small molecule metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0072521	purine-containing compound metabolic process	4	11
GO:0072522	purine-containing compound biosynthetic process	5	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:1901135	carbohydrate derivative metabolic process	3	11
GO:1901137	carbohydrate derivative biosynthetic process	4	11
GO:1901293	nucleoside phosphate biosynthetic process	5	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0016310	phosphorylation	5	4

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004140	dephospho-CoA kinase activity	5	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.584
CLV_NRD_NRD_1	128	130	PF00675	0.687
CLV_NRD_NRD_1	145	147	PF00675	0.437
CLV_NRD_NRD_1	156	158	PF00675	0.406
CLV_NRD_NRD_1	280	282	PF00675	0.356
CLV_NRD_NRD_1	289	291	PF00675	0.353
CLV_NRD_NRD_1	329	331	PF00675	0.466
CLV_PCSK_KEX2_1	128	130	PF00082	0.734
CLV_PCSK_KEX2_1	145	147	PF00082	0.474
CLV_PCSK_KEX2_1	280	282	PF00082	0.347
CLV_PCSK_SKI1_1	145	149	PF00082	0.532
CLV_PCSK_SKI1_1	280	284	PF00082	0.356
CLV_PCSK_SKI1_1	290	294	PF00082	0.321
DEG_APCC_DBOX_1	144	152	PF00400	0.469
DEG_MDM2_SWIB_1	325	333	PF02201	0.389
DEG_Nend_UBRbox_1	1	4	PF02207	0.559
DEG_SPOP_SBC_1	211	215	PF00917	0.521
DOC_ANK_TNKS_1	128	135	PF00023	0.492
DOC_CYCLIN_yCln2_LP_2	103	109	PF00134	0.446
DOC_MAPK_gen_1	145	153	PF00069	0.474
DOC_MAPK_gen_1	17	27	PF00069	0.386
DOC_MAPK_gen_1	280	288	PF00069	0.576
DOC_MAPK_gen_1	327	337	PF00069	0.468
DOC_MAPK_MEF2A_6	330	337	PF00069	0.514
DOC_PP1_RVXF_1	3	10	PF00149	0.529
DOC_PP2B_LxvP_1	103	106	PF13499	0.576
DOC_PP2B_LxvP_1	225	228	PF13499	0.556
DOC_USP7_MATH_1	37	41	PF00917	0.627
DOC_USP7_MATH_1	46	50	PF00917	0.712
DOC_USP7_MATH_1	51	55	PF00917	0.774
DOC_USP7_UBL2_3	22	26	PF12436	0.496
DOC_WW_Pin1_4	202	207	PF00397	0.742
DOC_WW_Pin1_4	212	217	PF00397	0.728
DOC_WW_Pin1_4	256	261	PF00397	0.546
DOC_WW_Pin1_4	44	49	PF00397	0.724
LIG_14-3-3_CanoR_1	280	288	PF00244	0.551
LIG_CaM_NSCaTE_8	31	38	PF13499	0.382
LIG_Clathr_ClatBox_1	232	236	PF01394	0.482
LIG_eIF4E_1	73	79	PF01652	0.511
LIG_FHA_1	169	175	PF00498	0.526
LIG_FHA_1	203	209	PF00498	0.673
LIG_FHA_1	242	248	PF00498	0.543
LIG_FHA_1	281	287	PF00498	0.456
LIG_FHA_1	307	313	PF00498	0.481
LIG_FHA_1	8	14	PF00498	0.403
LIG_FHA_1	98	104	PF00498	0.475
LIG_FHA_2	216	222	PF00498	0.684
LIG_FHA_2	260	266	PF00498	0.538
LIG_LIR_Gen_1	176	185	PF02991	0.439
LIG_LIR_Nem_3	164	170	PF02991	0.502
LIG_LIR_Nem_3	176	181	PF02991	0.526
LIG_LIR_Nem_3	322	328	PF02991	0.369
LIG_LYPXL_yS_3	189	192	PF13949	0.548
LIG_PDZ_Class_2	332	337	PF00595	0.536
LIG_Pex14_2	325	329	PF04695	0.381
LIG_SH2_CRK	178	182	PF00017	0.513
LIG_SH2_GRB2like	73	76	PF00017	0.494
LIG_SH2_SRC	73	76	PF00017	0.473
LIG_SH2_SRC	84	87	PF00017	0.419
LIG_SH2_STAT5	169	172	PF00017	0.457
LIG_SH2_STAT5	73	76	PF00017	0.441
LIG_SH3_2	133	138	PF14604	0.464
LIG_SH3_3	130	136	PF00018	0.570
LIG_SH3_3	184	190	PF00018	0.585
LIG_SH3_3	205	211	PF00018	0.745
LIG_SH3_3	83	89	PF00018	0.410
LIG_SUMO_SIM_par_1	231	236	PF11976	0.340
LIG_SUMO_SIM_par_1	244	252	PF11976	0.492
LIG_TRAF2_1	313	316	PF00917	0.453
LIG_TYR_ITIM	187	192	PF00017	0.324
MOD_CK1_1	15	21	PF00069	0.404
MOD_CK1_1	195	201	PF00069	0.741
MOD_CK1_1	210	216	PF00069	0.686
MOD_CK1_1	40	46	PF00069	0.666
MOD_CK2_1	310	316	PF00069	0.459
MOD_GlcNHglycan	103	106	PF01048	0.568
MOD_GlcNHglycan	14	17	PF01048	0.401
MOD_GlcNHglycan	194	197	PF01048	0.696
MOD_GlcNHglycan	200	203	PF01048	0.715
MOD_GlcNHglycan	40	43	PF01048	0.681
MOD_GlcNHglycan	44	47	PF01048	0.653
MOD_GlcNHglycan	48	51	PF01048	0.639
MOD_GlcNHglycan	65	68	PF01048	0.482
MOD_GSK3_1	12	19	PF00069	0.405
MOD_GSK3_1	198	205	PF00069	0.717
MOD_GSK3_1	207	214	PF00069	0.722
MOD_GSK3_1	3	10	PF00069	0.428
MOD_GSK3_1	306	313	PF00069	0.429
MOD_GSK3_1	38	45	PF00069	0.612
MOD_GSK3_1	97	104	PF00069	0.482
MOD_NEK2_1	192	197	PF00069	0.460
MOD_NEK2_1	200	205	PF00069	0.533
MOD_NEK2_1	253	258	PF00069	0.519
MOD_NEK2_1	307	312	PF00069	0.483
MOD_NEK2_1	9	14	PF00069	0.425
MOD_PIKK_1	110	116	PF00454	0.762
MOD_PIKK_1	117	123	PF00454	0.664
MOD_PIKK_1	281	287	PF00454	0.508
MOD_PIKK_1	307	313	PF00454	0.534
MOD_PKA_1	280	286	PF00069	0.449
MOD_PKA_2	280	286	PF00069	0.449
MOD_Plk_1	307	313	PF00069	0.523
MOD_Plk_4	195	201	PF00069	0.644
MOD_ProDKin_1	202	208	PF00069	0.743
MOD_ProDKin_1	212	218	PF00069	0.727
MOD_ProDKin_1	256	262	PF00069	0.546
MOD_ProDKin_1	44	50	PF00069	0.731
MOD_SUMO_for_1	174	177	PF00179	0.538
MOD_SUMO_rev_2	155	159	PF00179	0.507
MOD_SUMO_rev_2	284	293	PF00179	0.499
TRG_DiLeu_BaLyEn_6	138	143	PF01217	0.337
TRG_ENDOCYTIC_2	178	181	PF00928	0.517
TRG_ENDOCYTIC_2	189	192	PF00928	0.467
TRG_ENDOCYTIC_2	91	94	PF00928	0.405
TRG_ER_diArg_1	145	147	PF00400	0.566
TRG_ER_diArg_1	280	282	PF00400	0.553
TRG_NLS_MonoExtN_4	327	334	PF00514	0.458
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I144	Leptomonas seymouri	53%	100%
A0A0S4JER7	Bodo saltans	30%	100%
A0A1X0P6Q6	Trypanosomatidae	32%	100%
A0A3R7MR11	Trypanosoma rangeli	32%	100%
A0A3S7WUR7	Leishmania donovani	88%	100%
A4H9D3	Leishmania braziliensis	74%	100%
A4HXQ5	Leishmania infantum	87%	100%
Q4QE13	Leishmania major	88%	100%
V5BRM4	Trypanosoma cruzi	31%	100%