LeishMANIAdb
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DUF3849 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF3849 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9ARG2_LEIMU
TriTrypDb:
LmxM.18.0250
Length:
144

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ARG2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARG2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 131 133 PF00675 0.477
CLV_NRD_NRD_1 15 17 PF00675 0.557
CLV_NRD_NRD_1 51 53 PF00675 0.630
CLV_PCSK_KEX2_1 131 133 PF00082 0.468
CLV_PCSK_KEX2_1 15 17 PF00082 0.557
CLV_PCSK_KEX2_1 51 53 PF00082 0.627
CLV_PCSK_SKI1_1 103 107 PF00082 0.672
DOC_PP4_FxxP_1 110 113 PF00568 0.531
DOC_WW_Pin1_4 104 109 PF00397 0.534
DOC_WW_Pin1_4 65 70 PF00397 0.514
DOC_WW_Pin1_4 81 86 PF00397 0.430
LIG_14-3-3_CanoR_1 28 38 PF00244 0.505
LIG_Actin_WH2_2 35 53 PF00022 0.445
LIG_BRCT_BRCA1_1 106 110 PF00533 0.495
LIG_FHA_2 118 124 PF00498 0.564
LIG_LIR_Apic_2 107 113 PF02991 0.530
LIG_SH2_STAP1 126 130 PF00017 0.485
LIG_SH3_3 82 88 PF00018 0.518
LIG_TRAF2_1 113 116 PF00917 0.531
MOD_CK1_1 104 110 PF00069 0.497
MOD_CK1_1 83 89 PF00069 0.393
MOD_GlcNHglycan 102 106 PF01048 0.494
MOD_GlcNHglycan 42 45 PF01048 0.438
MOD_GSK3_1 40 47 PF00069 0.487
MOD_PIKK_1 29 35 PF00454 0.518
MOD_ProDKin_1 104 110 PF00069 0.531
MOD_ProDKin_1 65 71 PF00069 0.507
MOD_ProDKin_1 81 87 PF00069 0.428
MOD_SUMO_for_1 91 94 PF00179 0.407
TRG_DiLeu_BaEn_1 13 18 PF01217 0.423
TRG_DiLeu_BaLyEn_6 133 138 PF01217 0.390
TRG_ER_diArg_1 130 132 PF00400 0.462
TRG_ER_diArg_1 134 137 PF00400 0.486
TRG_ER_diArg_1 15 17 PF00400 0.508
TRG_ER_diArg_1 50 52 PF00400 0.511
TRG_Pf-PMV_PEXEL_1 136 140 PF00026 0.417

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0P7L2 Trypanosomatidae 48% 68%
A0A3Q8I9W5 Leishmania donovani 92% 100%
A0A3S5IS43 Trypanosoma rangeli 48% 99%
A4H9C9 Leishmania braziliensis 77% 100%
A4HXQ1 Leishmania infantum 92% 100%
D0A029 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 66%
Q4QE17 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS