Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein 29, putative

Species:

Leishmania mexicana

UniProt:

E9ARF9_LEIMU

TriTrypDb:

LmxM.18.0220

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	4	1
GO:0005849	mRNA cleavage factor complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9ARF9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARF9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006379	mRNA cleavage	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0098787	mRNA cleavage involved in mRNA processing	8	1
GO:0098789	pre-mRNA cleavage required for polyadenylation	9	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	357	359	PF00675	0.459
CLV_NRD_NRD_1	365	367	PF00675	0.508
CLV_NRD_NRD_1	75	77	PF00675	0.297
CLV_PCSK_KEX2_1	400	402	PF00082	0.674
CLV_PCSK_PC1ET2_1	400	402	PF00082	0.674
CLV_PCSK_SKI1_1	134	138	PF00082	0.468
CLV_PCSK_SKI1_1	19	23	PF00082	0.292
CLV_PCSK_SKI1_1	27	31	PF00082	0.320
CLV_PCSK_SKI1_1	397	401	PF00082	0.593
CLV_PCSK_SKI1_1	64	68	PF00082	0.269
CLV_PCSK_SKI1_1	76	80	PF00082	0.269
CLV_Separin_Metazoa	355	359	PF03568	0.470
DEG_APCC_DBOX_1	133	141	PF00400	0.468
DEG_SCF_FBW7_1	1	8	PF00400	0.575
DOC_MAPK_gen_1	76	82	PF00069	0.469
DOC_PP2B_LxvP_1	203	206	PF13499	0.791
DOC_PP4_FxxP_1	333	336	PF00568	0.654
DOC_PP4_MxPP_1	264	267	PF00568	0.662
DOC_PP4_MxPP_1	285	288	PF00568	0.662
DOC_USP7_MATH_1	381	385	PF00917	0.637
DOC_USP7_MATH_1	399	403	PF00917	0.615
DOC_USP7_UBL2_3	344	348	PF12436	0.610
DOC_USP7_UBL2_3	359	363	PF12436	0.409
DOC_USP7_UBL2_3	367	371	PF12436	0.512
DOC_USP7_UBL2_3	396	400	PF12436	0.613
DOC_USP7_UBL2_3	404	408	PF12436	0.602
DOC_WW_Pin1_4	1	6	PF00397	0.596
DOC_WW_Pin1_4	123	128	PF00397	0.559
DOC_WW_Pin1_4	148	153	PF00397	0.507
DOC_WW_Pin1_4	179	184	PF00397	0.699
DOC_WW_Pin1_4	198	203	PF00397	0.636
LIG_Actin_WH2_2	14	29	PF00022	0.469
LIG_BIR_II_1	1	5	PF00653	0.560
LIG_eIF4E_1	68	74	PF01652	0.469
LIG_FHA_1	340	346	PF00498	0.513
LIG_FHA_2	33	39	PF00498	0.469
LIG_FHA_2	56	62	PF00498	0.476
LIG_Integrin_isoDGR_2	42	44	PF01839	0.269
LIG_LIR_Apic_2	331	336	PF02991	0.540
LIG_LIR_Gen_1	351	361	PF02991	0.474
LIG_LIR_Nem_3	351	357	PF02991	0.478
LIG_LIR_Nem_3	8	13	PF02991	0.385
LIG_SH2_STAP1	364	368	PF00017	0.541
LIG_SH2_STAT5	13	16	PF00017	0.469
LIG_SH3_3	203	209	PF00018	0.647
LIG_SH3_3	264	270	PF00018	0.627
LIG_SH3_3	84	90	PF00018	0.502
LIG_TRAF2_2	272	277	PF00917	0.653
LIG_UBA3_1	136	144	PF00899	0.486
LIG_WW_3	265	269	PF00397	0.623
MOD_CK1_1	175	181	PF00069	0.713
MOD_CK1_1	384	390	PF00069	0.613
MOD_CK2_1	399	405	PF00069	0.595
MOD_Cter_Amidation	74	77	PF01082	0.269
MOD_GlcNHglycan	1	4	PF01048	0.567
MOD_GlcNHglycan	174	177	PF01048	0.645
MOD_GlcNHglycan	184	187	PF01048	0.661
MOD_GlcNHglycan	196	199	PF01048	0.820
MOD_GlcNHglycan	210	213	PF01048	0.578
MOD_GlcNHglycan	320	323	PF01048	0.655
MOD_GlcNHglycan	330	333	PF01048	0.672
MOD_GlcNHglycan	374	377	PF01048	0.559
MOD_GlcNHglycan	382	386	PF01048	0.610
MOD_GlcNHglycan	387	390	PF01048	0.605
MOD_GSK3_1	1	8	PF00069	0.575
MOD_GSK3_1	175	182	PF00069	0.801
MOD_GSK3_1	194	201	PF00069	0.738
MOD_GSK3_1	204	211	PF00069	0.697
MOD_GSK3_1	381	388	PF00069	0.679
MOD_GSK3_1	399	406	PF00069	0.510
MOD_N-GLC_1	227	232	PF02516	0.508
MOD_N-GLC_1	328	333	PF02516	0.558
MOD_NEK2_1	118	123	PF00069	0.581
MOD_NEK2_1	157	162	PF00069	0.475
MOD_NEK2_1	194	199	PF00069	0.762
MOD_NEK2_2	339	344	PF00069	0.560
MOD_Plk_1	17	23	PF00069	0.469
MOD_Plk_1	37	43	PF00069	0.383
MOD_Plk_2-3	55	61	PF00069	0.469
MOD_Plk_4	250	256	PF00069	0.675
MOD_Plk_4	32	38	PF00069	0.493
MOD_ProDKin_1	1	7	PF00069	0.585
MOD_ProDKin_1	123	129	PF00069	0.553
MOD_ProDKin_1	148	154	PF00069	0.502
MOD_ProDKin_1	179	185	PF00069	0.699
MOD_ProDKin_1	198	204	PF00069	0.632
MOD_SUMO_rev_2	360	368	PF00179	0.480
MOD_SUMO_rev_2	388	398	PF00179	0.608
TRG_DiLeu_BaEn_1	132	137	PF01217	0.458
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.459
TRG_ENDOCYTIC_2	262	265	PF00928	0.672
TRG_ENDOCYTIC_2	68	71	PF00928	0.504
TRG_NLS_MonoExtC_3	399	404	PF00514	0.614
TRG_NLS_MonoExtN_4	397	404	PF00514	0.612
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	366	370	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P353	Leptomonas seymouri	53%	100%
A0A3Q8IE55	Leishmania donovani	95%	100%
A4HXP8	Leishmania infantum	94%	100%
E9AI57	Leishmania braziliensis	85%	100%
Q4QE20	Leishmania major	95%	100%