Aha1_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Activator of Hsp90 ATPase, N-terminal/Activator of Hsp90 ATPase homolog 1-like protein, putative

Species:

Leishmania mexicana

UniProt:

E9ARF8_LEIMU

TriTrypDb:

LmxM.18.0210

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ARF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARF8

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1
GO:0032781	positive regulation of ATP-dependent activity	4	1
GO:0043462	regulation of ATP-dependent activity	3	1
GO:0044093	positive regulation of molecular function	3	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1

Molecular functions
Term	Name	Level	Count
GO:0001671	ATPase activator activity	3	12
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0031072	heat shock protein binding	3	12
GO:0051087	protein-folding chaperone binding	3	12
GO:0051879	Hsp90 protein binding	4	12
GO:0098772	molecular function regulator activity	1	12
GO:0140677	molecular function activator activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.449
CLV_C14_Caspase3-7	15	19	PF00656	0.548
CLV_NRD_NRD_1	78	80	PF00675	0.252
CLV_PCSK_SKI1_1	171	175	PF00082	0.502
CLV_PCSK_SKI1_1	342	346	PF00082	0.252
CLV_PCSK_SKI1_1	41	45	PF00082	0.278
DOC_PP2B_LxvP_1	179	182	PF13499	0.572
DOC_USP7_MATH_1	188	192	PF00917	0.747
DOC_USP7_UBL2_3	90	94	PF12436	0.447
DOC_WW_Pin1_4	190	195	PF00397	0.676
DOC_WW_Pin1_4	248	253	PF00397	0.538
LIG_14-3-3_CanoR_1	149	153	PF00244	0.538
LIG_14-3-3_CanoR_1	250	256	PF00244	0.475
LIG_14-3-3_CanoR_1	262	266	PF00244	0.504
LIG_BIR_II_1	1	5	PF00653	0.545
LIG_deltaCOP1_diTrp_1	331	338	PF00928	0.452
LIG_EVH1_1	179	183	PF00568	0.618
LIG_FHA_1	252	258	PF00498	0.557
LIG_FHA_2	127	133	PF00498	0.467
LIG_FHA_2	156	162	PF00498	0.488
LIG_FHA_2	310	316	PF00498	0.482
LIG_LIR_Gen_1	158	167	PF02991	0.450
LIG_LIR_Gen_1	234	242	PF02991	0.446
LIG_LIR_Gen_1	271	282	PF02991	0.462
LIG_LIR_Gen_1	58	67	PF02991	0.541
LIG_LIR_LC3C_4	298	301	PF02991	0.474
LIG_LIR_Nem_3	158	163	PF02991	0.458
LIG_LIR_Nem_3	234	239	PF02991	0.435
LIG_LIR_Nem_3	271	277	PF02991	0.462
LIG_LIR_Nem_3	58	64	PF02991	0.541
LIG_Pex14_1	333	337	PF04695	0.452
LIG_Pex14_2	160	164	PF04695	0.452
LIG_SH2_CRK	124	128	PF00017	0.425
LIG_SH2_CRK	236	240	PF00017	0.517
LIG_SH2_PTP2	274	277	PF00017	0.513
LIG_SH2_SRC	124	127	PF00017	0.513
LIG_SH2_SRC	167	170	PF00017	0.425
LIG_SH2_SRC	274	277	PF00017	0.513
LIG_SH2_STAP1	124	128	PF00017	0.463
LIG_SH2_STAP1	347	351	PF00017	0.374
LIG_SH2_STAT5	248	251	PF00017	0.452
LIG_SH2_STAT5	265	268	PF00017	0.452
LIG_SH2_STAT5	274	277	PF00017	0.491
LIG_SH2_STAT5	61	64	PF00017	0.529
LIG_SH2_STAT5	86	89	PF00017	0.452
LIG_SH3_3	177	183	PF00018	0.602
LIG_SUMO_SIM_anti_2	298	303	PF11976	0.524
LIG_TRAF2_1	328	331	PF00917	0.513
LIG_TYR_ITIM	59	64	PF00017	0.538
LIG_WRC_WIRS_1	156	161	PF05994	0.488
MOD_CK1_1	14	20	PF00069	0.661
MOD_CK1_1	175	181	PF00069	0.400
MOD_CK1_1	186	192	PF00069	0.759
MOD_CK1_1	193	199	PF00069	0.714
MOD_CK1_1	211	217	PF00069	0.628
MOD_CK1_1	243	249	PF00069	0.473
MOD_CK1_1	251	257	PF00069	0.450
MOD_CK1_1	33	39	PF00069	0.538
MOD_CK1_1	68	74	PF00069	0.457
MOD_CK2_1	202	208	PF00069	0.741
MOD_CK2_1	212	218	PF00069	0.725
MOD_CK2_1	309	315	PF00069	0.468
MOD_CK2_1	325	331	PF00069	0.463
MOD_GlcNHglycan	174	177	PF01048	0.671
MOD_GlcNHglycan	186	189	PF01048	0.689
MOD_GlcNHglycan	210	213	PF01048	0.591
MOD_GlcNHglycan	270	273	PF01048	0.300
MOD_GlcNHglycan	318	321	PF01048	0.326
MOD_GlcNHglycan	69	73	PF01048	0.252
MOD_GSK3_1	184	191	PF00069	0.724
MOD_GSK3_1	208	215	PF00069	0.632
MOD_GSK3_1	310	317	PF00069	0.553
MOD_GSK3_1	35	42	PF00069	0.539
MOD_GSK3_1	68	75	PF00069	0.456
MOD_LATS_1	37	43	PF00433	0.549
MOD_N-GLC_1	218	223	PF02516	0.526
MOD_NEK2_1	314	319	PF00069	0.541
MOD_NEK2_1	89	94	PF00069	0.466
MOD_NEK2_2	148	153	PF00069	0.538
MOD_PIKK_1	134	140	PF00454	0.461
MOD_PIKK_1	30	36	PF00454	0.538
MOD_PIKK_1	314	320	PF00454	0.557
MOD_PK_1	39	45	PF00069	0.557
MOD_PKA_1	203	209	PF00069	0.754
MOD_PKA_2	148	154	PF00069	0.535
MOD_PKA_2	261	267	PF00069	0.484
MOD_Plk_1	217	223	PF00069	0.519
MOD_Plk_1	55	61	PF00069	0.418
MOD_Plk_1	72	78	PF00069	0.444
MOD_Plk_2-3	155	161	PF00069	0.528
MOD_Plk_2-3	325	331	PF00069	0.530
MOD_Plk_4	139	145	PF00069	0.538
MOD_Plk_4	155	161	PF00069	0.538
MOD_Plk_4	243	249	PF00069	0.469
MOD_Plk_4	278	284	PF00069	0.504
MOD_Plk_4	295	301	PF00069	0.370
MOD_Plk_4	39	45	PF00069	0.547
MOD_ProDKin_1	190	196	PF00069	0.674
MOD_ProDKin_1	248	254	PF00069	0.538
MOD_SUMO_for_1	305	308	PF00179	0.479
MOD_SUMO_for_1	62	65	PF00179	0.538
MOD_SUMO_rev_2	114	123	PF00179	0.473
MOD_SUMO_rev_2	196	206	PF00179	0.761
MOD_SUMO_rev_2	251	259	PF00179	0.538
TRG_ENDOCYTIC_2	124	127	PF00928	0.425
TRG_ENDOCYTIC_2	236	239	PF00928	0.527
TRG_ENDOCYTIC_2	274	277	PF00928	0.513
TRG_ENDOCYTIC_2	61	64	PF00928	0.538
TRG_ENDOCYTIC_2	86	89	PF00928	0.452
TRG_NES_CRM1_1	54	66	PF08389	0.517
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.263

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2A4	Leptomonas seymouri	70%	99%
A0A0S4JAT2	Bodo saltans	49%	100%
A0A1X0P6W4	Trypanosomatidae	57%	100%
A0A3R7MY48	Trypanosoma rangeli	53%	100%
A0A3S7WUS5	Leishmania donovani	92%	100%
A4H9C6	Leishmania braziliensis	84%	100%
A4HXP7	Leishmania infantum	92%	100%
A6QQC0	Bos taurus	27%	100%
D0A023	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
O95433	Homo sapiens	30%	100%
Q12449	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q4QE21	Leishmania major	93%	100%
Q55DB6	Dictyostelium discoideum	28%	92%
Q8BK64	Mus musculus	29%	100%
Q8N9S3	Mus musculus	28%	100%
Q9P782	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
V5B6E4	Trypanosoma cruzi	55%	100%