RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RNA-binding protein

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania mexicana

UniProt:

E9ARF6_LEIMU

TriTrypDb:

LmxM.18.0190

Length:

342

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005829	cytosol	2	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

E9ARF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARF6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003727	single-stranded RNA binding	5	2
GO:0003729	mRNA binding	5	2
GO:0003730	mRNA 3'-UTR binding	6	2
GO:0008143	poly(A) binding	7	2
GO:0008187	poly-pyrimidine tract binding	6	2
GO:0008266	poly(U) RNA binding	7	2
GO:0070717	poly-purine tract binding	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.489
CLV_C14_Caspase3-7	290	294	PF00656	0.623
CLV_NRD_NRD_1	162	164	PF00675	0.288
CLV_PCSK_KEX2_1	162	164	PF00082	0.308
CLV_PCSK_KEX2_1	88	90	PF00082	0.273
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.273
CLV_PCSK_SKI1_1	118	122	PF00082	0.358
CLV_PCSK_SKI1_1	163	167	PF00082	0.268
CLV_PCSK_SKI1_1	41	45	PF00082	0.309
CLV_PCSK_SKI1_1	57	61	PF00082	0.309
CLV_Separin_Metazoa	135	139	PF03568	0.428
DEG_SCF_FBW7_1	262	267	PF00400	0.616
DOC_MAPK_gen_1	113	121	PF00069	0.440
DOC_MAPK_gen_1	162	169	PF00069	0.508
DOC_MAPK_MEF2A_6	23	30	PF00069	0.342
DOC_MAPK_MEF2A_6	304	311	PF00069	0.610
DOC_PP1_RVXF_1	160	167	PF00149	0.510
DOC_PP2B_LxvP_1	314	317	PF13499	0.551
DOC_PP2B_LxvP_1	334	337	PF13499	0.573
DOC_PP4_FxxP_1	223	226	PF00568	0.587
DOC_PP4_FxxP_1	43	46	PF00568	0.498
DOC_USP7_MATH_1	19	23	PF00917	0.460
DOC_USP7_MATH_1	264	268	PF00917	0.621
DOC_USP7_MATH_1	287	291	PF00917	0.661
DOC_WW_Pin1_4	104	109	PF00397	0.525
DOC_WW_Pin1_4	226	231	PF00397	0.599
DOC_WW_Pin1_4	249	254	PF00397	0.522
DOC_WW_Pin1_4	258	263	PF00397	0.557
DOC_WW_Pin1_4	278	283	PF00397	0.770
DOC_WW_Pin1_4	303	308	PF00397	0.668
LIG_14-3-3_CanoR_1	11	17	PF00244	0.462
LIG_14-3-3_CanoR_1	310	315	PF00244	0.725
LIG_14-3-3_CterR_2	338	342	PF00244	0.652
LIG_APCC_ABBA_1	166	171	PF00400	0.498
LIG_APCC_ABBA_1	44	49	PF00400	0.479
LIG_BIR_II_1	1	5	PF00653	0.560
LIG_BRCT_BRCA1_1	63	67	PF00533	0.465
LIG_FHA_1	227	233	PF00498	0.514
LIG_FHA_2	127	133	PF00498	0.474
LIG_FHA_2	140	146	PF00498	0.474
LIG_FHA_2	16	22	PF00498	0.516
LIG_IBAR_NPY_1	328	330	PF08397	0.667
LIG_LIR_Nem_3	245	251	PF02991	0.602
LIG_LIR_Nem_3	37	43	PF02991	0.541
LIG_LIR_Nem_3	45	50	PF02991	0.622
LIG_LIR_Nem_3	64	70	PF02991	0.465
LIG_NRBOX	132	138	PF00104	0.473
LIG_Pex14_2	40	44	PF04695	0.474
LIG_SH2_CRK	140	144	PF00017	0.620
LIG_SH2_STAP1	330	334	PF00017	0.644
LIG_SH3_3	316	322	PF00018	0.601
LIG_SUMO_SIM_anti_2	132	138	PF11976	0.465
LIG_TRAF2_1	109	112	PF00917	0.669
LIG_TRAF2_1	297	300	PF00917	0.594
LIG_UBA3_1	196	205	PF00899	0.430
LIG_WRC_WIRS_1	248	253	PF05994	0.557
MOD_CDK_SPK_2	249	254	PF00069	0.501
MOD_CDK_SPxxK_3	303	310	PF00069	0.608
MOD_CK1_1	147	153	PF00069	0.498
MOD_CK1_1	15	21	PF00069	0.527
MOD_CK1_1	211	217	PF00069	0.686
MOD_CK1_1	224	230	PF00069	0.618
MOD_CK2_1	126	132	PF00069	0.495
MOD_CK2_1	139	145	PF00069	0.424
MOD_CK2_1	270	276	PF00069	0.665
MOD_Cter_Amidation	86	89	PF01082	0.265
MOD_GlcNHglycan	210	213	PF01048	0.597
MOD_GlcNHglycan	223	226	PF01048	0.601
MOD_GlcNHglycan	272	275	PF01048	0.564
MOD_GlcNHglycan	282	285	PF01048	0.573
MOD_GlcNHglycan	74	77	PF01048	0.294
MOD_GSK3_1	15	22	PF00069	0.649
MOD_GSK3_1	208	215	PF00069	0.737
MOD_GSK3_1	260	267	PF00069	0.582
MOD_N-GLC_1	216	221	PF02516	0.672
MOD_N-GLC_2	184	186	PF02516	0.309
MOD_NEK2_1	244	249	PF00069	0.491
MOD_NEK2_1	270	275	PF00069	0.631
MOD_NEK2_1	309	314	PF00069	0.585
MOD_NEK2_2	264	269	PF00069	0.621
MOD_OFUCOSY	186	191	PF10250	0.388
MOD_PIKK_1	287	293	PF00454	0.606
MOD_PIKK_1	35	41	PF00454	0.473
MOD_PKA_2	12	18	PF00069	0.660
MOD_PKA_2	309	315	PF00069	0.636
MOD_Plk_1	144	150	PF00069	0.465
MOD_Plk_1	235	241	PF00069	0.497
MOD_Plk_1	244	250	PF00069	0.454
MOD_Plk_1	35	41	PF00069	0.493
MOD_Plk_4	244	250	PF00069	0.494
MOD_Plk_4	330	336	PF00069	0.672
MOD_Plk_4	50	56	PF00069	0.510
MOD_ProDKin_1	104	110	PF00069	0.524
MOD_ProDKin_1	226	232	PF00069	0.600
MOD_ProDKin_1	249	255	PF00069	0.522
MOD_ProDKin_1	258	264	PF00069	0.556
MOD_ProDKin_1	278	284	PF00069	0.770
MOD_ProDKin_1	303	309	PF00069	0.670
MOD_SUMO_rev_2	15	24	PF00179	0.470
MOD_SUMO_rev_2	201	206	PF00179	0.503
MOD_SUMO_rev_2	84	90	PF00179	0.498
TRG_DiLeu_BaEn_1	132	137	PF01217	0.498
TRG_ENDOCYTIC_2	140	143	PF00928	0.620
TRG_ER_diArg_1	162	164	PF00400	0.508
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.298

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUA1	Leptomonas seymouri	52%	97%
A0A3Q8IAV4	Leishmania donovani	96%	100%
A0A3Q8IAX1	Leishmania donovani	48%	99%
A4H9C4	Leishmania braziliensis	82%	100%
A4HXP3	Leishmania infantum	48%	99%
A4HXP5	Leishmania infantum	96%	100%
E9ARF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
Q4QE23	Leishmania major	96%	100%
Q4QE25	Leishmania major	48%	99%