RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RNA-binding protein

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania mexicana

UniProt:

E9ARF5_LEIMU

TriTrypDb:

LmxM.18.0180

Length:

347

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005829	cytosol	2	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

E9ARF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARF5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003727	single-stranded RNA binding	5	2
GO:0003729	mRNA binding	5	2
GO:0003730	mRNA 3'-UTR binding	6	2
GO:0008143	poly(A) binding	7	2
GO:0008187	poly-pyrimidine tract binding	6	2
GO:0008266	poly(U) RNA binding	7	2
GO:0070717	poly-purine tract binding	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	137	139	PF00675	0.424
CLV_NRD_NRD_1	156	158	PF00675	0.288
CLV_NRD_NRD_1	268	270	PF00675	0.554
CLV_PCSK_KEX2_1	155	157	PF00082	0.322
CLV_PCSK_KEX2_1	268	270	PF00082	0.554
CLV_PCSK_SKI1_1	112	116	PF00082	0.368
CLV_PCSK_SKI1_1	138	142	PF00082	0.431
CLV_PCSK_SKI1_1	157	161	PF00082	0.266
CLV_PCSK_SKI1_1	229	233	PF00082	0.609
CLV_PCSK_SKI1_1	341	345	PF00082	0.557
CLV_PCSK_SKI1_1	35	39	PF00082	0.320
DEG_SCF_TRCP1_1	327	333	PF00400	0.575
DOC_CKS1_1	202	207	PF01111	0.523
DOC_CKS1_1	258	263	PF01111	0.525
DOC_CKS1_1	264	269	PF01111	0.684
DOC_MAPK_gen_1	107	115	PF00069	0.461
DOC_MAPK_gen_1	155	163	PF00069	0.522
DOC_MAPK_gen_1	74	84	PF00069	0.548
DOC_MAPK_MEF2A_6	155	163	PF00069	0.548
DOC_PP1_RVXF_1	154	161	PF00149	0.520
DOC_PP4_FxxP_1	317	320	PF00568	0.540
DOC_USP7_MATH_1	133	137	PF00917	0.496
DOC_USP7_MATH_1	223	227	PF00917	0.553
DOC_USP7_MATH_1	273	277	PF00917	0.689
DOC_USP7_MATH_1	278	282	PF00917	0.622
DOC_USP7_MATH_1	325	329	PF00917	0.663
DOC_WW_Pin1_4	11	16	PF00397	0.598
DOC_WW_Pin1_4	129	134	PF00397	0.525
DOC_WW_Pin1_4	2	7	PF00397	0.609
DOC_WW_Pin1_4	201	206	PF00397	0.578
DOC_WW_Pin1_4	219	224	PF00397	0.644
DOC_WW_Pin1_4	257	262	PF00397	0.597
DOC_WW_Pin1_4	263	268	PF00397	0.649
DOC_WW_Pin1_4	98	103	PF00397	0.552
LIG_14-3-3_CanoR_1	138	143	PF00244	0.477
LIG_14-3-3_CanoR_1	203	211	PF00244	0.526
LIG_14-3-3_CanoR_1	221	231	PF00244	0.552
LIG_14-3-3_CanoR_1	311	318	PF00244	0.677
LIG_Actin_WH2_2	22	37	PF00022	0.548
LIG_APCC_ABBA_1	140	145	PF00400	0.493
LIG_APCC_ABBAyCdc20_2	139	145	PF00400	0.548
LIG_BIR_II_1	1	5	PF00653	0.627
LIG_BIR_III_4	78	82	PF00653	0.548
LIG_BRCT_BRCA1_1	339	343	PF00533	0.599
LIG_FHA_1	144	150	PF00498	0.525
LIG_FHA_1	205	211	PF00498	0.570
LIG_FHA_1	284	290	PF00498	0.579
LIG_FHA_1	294	300	PF00498	0.585
LIG_FHA_1	302	308	PF00498	0.683
LIG_FHA_1	329	335	PF00498	0.576
LIG_FHA_1	59	65	PF00498	0.555
LIG_FHA_1	86	92	PF00498	0.553
LIG_FHA_2	121	127	PF00498	0.485
LIG_FHA_2	160	166	PF00498	0.548
LIG_FHA_2	254	260	PF00498	0.503
LIG_LIR_Apic_2	315	320	PF02991	0.541
LIG_LIR_Gen_1	36	44	PF02991	0.525
LIG_LIR_Nem_3	132	137	PF02991	0.547
LIG_LIR_Nem_3	18	24	PF02991	0.448
LIG_LIR_Nem_3	340	346	PF02991	0.488
LIG_LIR_Nem_3	36	41	PF02991	0.477
LIG_LIR_Nem_3	61	66	PF02991	0.527
LIG_SH2_CRK	134	138	PF00017	0.632
LIG_SH2_SRC	66	69	PF00017	0.525
LIG_SH2_STAP1	198	202	PF00017	0.529
LIG_SH2_STAT3	54	57	PF00017	0.548
LIG_SH2_STAT5	198	201	PF00017	0.565
LIG_SH2_STAT5	227	230	PF00017	0.502
LIG_SH2_STAT5	24	27	PF00017	0.477
LIG_SH3_3	235	241	PF00018	0.574
LIG_SH3_3	304	310	PF00018	0.648
LIG_SUMO_SIM_par_1	118	126	PF11976	0.535
LIG_TRAF2_1	103	106	PF00917	0.698
LIG_WRC_WIRS_1	160	165	PF05994	0.548
MOD_CDC14_SPxK_1	5	8	PF00782	0.512
MOD_CDK_SPK_2	201	206	PF00069	0.536
MOD_CDK_SPK_2	257	262	PF00069	0.548
MOD_CDK_SPK_2	263	268	PF00069	0.574
MOD_CDK_SPxK_1	2	8	PF00069	0.520
MOD_CDK_SPxK_1	263	269	PF00069	0.558
MOD_CK1_1	11	17	PF00069	0.523
MOD_CK1_1	2	8	PF00069	0.624
MOD_CK1_1	219	225	PF00069	0.658
MOD_CK1_1	276	282	PF00069	0.659
MOD_CK1_1	328	334	PF00069	0.598
MOD_CK1_1	339	345	PF00069	0.599
MOD_CK1_1	55	61	PF00069	0.541
MOD_CK2_1	159	165	PF00069	0.548
MOD_GlcNHglycan	247	250	PF01048	0.516
MOD_GlcNHglycan	327	330	PF01048	0.548
MOD_GlcNHglycan	38	41	PF01048	0.348
MOD_GlcNHglycan	54	57	PF01048	0.249
MOD_GSK3_1	129	136	PF00069	0.527
MOD_GSK3_1	192	199	PF00069	0.549
MOD_GSK3_1	219	226	PF00069	0.624
MOD_GSK3_1	253	260	PF00069	0.661
MOD_GSK3_1	269	276	PF00069	0.716
MOD_GSK3_1	9	16	PF00069	0.688
MOD_N-GLC_1	143	148	PF02516	0.348
MOD_N-GLC_1	42	47	PF02516	0.247
MOD_N-GLC_2	178	180	PF02516	0.320
MOD_NEK2_1	293	298	PF00069	0.617
MOD_NEK2_1	85	90	PF00069	0.548
MOD_NEK2_2	133	138	PF00069	0.508
MOD_PIKK_1	196	202	PF00454	0.513
MOD_PIKK_1	278	284	PF00454	0.658
MOD_PIKK_1	293	299	PF00454	0.545
MOD_PK_1	87	93	PF00069	0.617
MOD_PKA_1	138	144	PF00069	0.548
MOD_PKA_2	310	316	PF00069	0.609
MOD_PKA_2	336	342	PF00069	0.583
MOD_PKB_1	335	343	PF00069	0.554
MOD_Plk_4	223	229	PF00069	0.514
MOD_Plk_4	313	319	PF00069	0.507
MOD_Plk_4	44	50	PF00069	0.520
MOD_ProDKin_1	11	17	PF00069	0.590
MOD_ProDKin_1	129	135	PF00069	0.525
MOD_ProDKin_1	2	8	PF00069	0.610
MOD_ProDKin_1	201	207	PF00069	0.577
MOD_ProDKin_1	219	225	PF00069	0.643
MOD_ProDKin_1	257	263	PF00069	0.599
MOD_ProDKin_1	98	104	PF00069	0.551
TRG_DiLeu_BaEn_2	301	307	PF01217	0.499
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.525
TRG_DiLeu_BaLyEn_6	80	85	PF01217	0.548
TRG_ENDOCYTIC_2	134	137	PF00928	0.632
TRG_ER_diArg_1	107	110	PF00400	0.413
TRG_ER_diArg_1	155	157	PF00400	0.522
TRG_ER_diArg_1	267	269	PF00400	0.541
TRG_ER_diArg_1	334	337	PF00400	0.596
TRG_Pf-PMV_PEXEL_1	23	28	PF00026	0.348

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IAX1	Leishmania donovani	79%	100%
A0A3S7WUT6	Leishmania donovani	87%	100%
A4H9C3	Leishmania braziliensis	68%	100%
A4HXP3	Leishmania infantum	73%	100%
A4HXP4	Leishmania infantum	86%	100%
E9ARF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
E9ARF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
Q4QE23	Leishmania major	48%	100%
Q4QE24	Leishmania major	86%	100%