RNA recognition motif family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania mexicana

UniProt:

E9ARF4_LEIMU

TriTrypDb:

LmxM.18.0170

Length:

347

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9ARF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARF4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003727	single-stranded RNA binding	5	1
GO:0003729	mRNA binding	5	1
GO:0003730	mRNA 3'-UTR binding	6	1
GO:0008143	poly(A) binding	7	1
GO:0008187	poly-pyrimidine tract binding	6	1
GO:0008266	poly(U) RNA binding	7	1
GO:0070717	poly-purine tract binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	314	318	PF00656	0.573
CLV_NRD_NRD_1	145	147	PF00675	0.273
CLV_NRD_NRD_1	164	166	PF00675	0.328
CLV_NRD_NRD_1	255	257	PF00675	0.568
CLV_PCSK_KEX2_1	163	165	PF00082	0.327
CLV_PCSK_KEX2_1	210	212	PF00082	0.572
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.561
CLV_PCSK_SKI1_1	120	124	PF00082	0.439
CLV_PCSK_SKI1_1	146	150	PF00082	0.338
CLV_PCSK_SKI1_1	165	169	PF00082	0.365
CLV_PCSK_SKI1_1	43	47	PF00082	0.327
DEG_Nend_UBRbox_3	1	3	PF02207	0.588
DEG_SCF_FBW7_1	279	286	PF00400	0.606
DEG_SPOP_SBC_1	321	325	PF00917	0.579
DOC_CKS1_1	20	25	PF01111	0.534
DOC_MAPK_gen_1	115	123	PF00069	0.476
DOC_MAPK_gen_1	163	171	PF00069	0.535
DOC_MAPK_gen_1	82	92	PF00069	0.521
DOC_MAPK_MEF2A_6	163	171	PF00069	0.538
DOC_PP1_RVXF_1	162	169	PF00149	0.527
DOC_PP4_FxxP_1	20	23	PF00568	0.565
DOC_USP7_MATH_1	141	145	PF00917	0.540
DOC_USP7_MATH_1	206	210	PF00917	0.601
DOC_USP7_MATH_1	232	236	PF00917	0.652
DOC_USP7_MATH_1	283	287	PF00917	0.615
DOC_USP7_MATH_1	308	312	PF00917	0.571
DOC_USP7_MATH_1	321	325	PF00917	0.754
DOC_WW_Pin1_4	1	6	PF00397	0.764
DOC_WW_Pin1_4	106	111	PF00397	0.554
DOC_WW_Pin1_4	137	142	PF00397	0.530
DOC_WW_Pin1_4	19	24	PF00397	0.489
DOC_WW_Pin1_4	227	232	PF00397	0.674
DOC_WW_Pin1_4	261	266	PF00397	0.626
DOC_WW_Pin1_4	279	284	PF00397	0.690
DOC_WW_Pin1_4	300	305	PF00397	0.692
LIG_14-3-3_CanoR_1	146	151	PF00244	0.448
LIG_14-3-3_CanoR_1	256	261	PF00244	0.563
LIG_14-3-3_CanoR_1	322	329	PF00244	0.659
LIG_Actin_WH2_2	30	45	PF00022	0.538
LIG_APCC_ABBA_1	148	153	PF00400	0.495
LIG_APCC_ABBAyCdc20_2	147	153	PF00400	0.538
LIG_BIR_III_4	86	90	PF00653	0.521
LIG_BRCT_BRCA1_1	329	333	PF00533	0.648
LIG_FHA_1	152	158	PF00498	0.527
LIG_FHA_1	231	237	PF00498	0.510
LIG_FHA_1	67	73	PF00498	0.538
LIG_FHA_1	94	100	PF00498	0.588
LIG_FHA_2	129	135	PF00498	0.495
LIG_FHA_2	168	174	PF00498	0.538
LIG_IBAR_NPY_1	336	338	PF08397	0.671
LIG_LIR_Gen_1	217	227	PF02991	0.482
LIG_LIR_Gen_1	44	52	PF02991	0.497
LIG_LIR_Nem_3	140	145	PF02991	0.538
LIG_LIR_Nem_3	217	222	PF02991	0.477
LIG_LIR_Nem_3	26	32	PF02991	0.417
LIG_LIR_Nem_3	44	49	PF02991	0.608
LIG_LIR_Nem_3	69	74	PF02991	0.538
LIG_PCNA_yPIPBox_3	285	298	PF02747	0.550
LIG_PDZ_Class_1	342	347	PF00595	0.540
LIG_SH2_CRK	142	146	PF00017	0.533
LIG_SH2_CRK	219	223	PF00017	0.486
LIG_SH2_CRK	338	342	PF00017	0.557
LIG_SH2_GRB2like	219	222	PF00017	0.486
LIG_SH2_SRC	74	77	PF00017	0.497
LIG_SH2_STAP1	329	333	PF00017	0.644
LIG_SH2_STAT3	62	65	PF00017	0.521
LIG_SH2_STAT5	21	24	PF00017	0.508
LIG_SH2_STAT5	32	35	PF00017	0.486
LIG_SH3_3	304	310	PF00018	0.556
LIG_SH3_CIN85_PxpxPR_1	304	309	PF14604	0.556
LIG_SUMO_SIM_anti_2	4	12	PF11976	0.500
LIG_SUMO_SIM_par_1	126	134	PF11976	0.537
LIG_TRAF2_1	111	114	PF00917	0.673
LIG_TRAF2_1	274	277	PF00917	0.562
LIG_TYR_ITSM	215	222	PF00017	0.471
LIG_WRC_WIRS_1	168	173	PF05994	0.509
LIG_WRC_WIRS_1	260	265	PF05994	0.629
MOD_CDK_SPxK_1	279	285	PF00069	0.588
MOD_CK1_1	230	236	PF00069	0.631
MOD_CK1_1	259	265	PF00069	0.630
MOD_CK1_1	275	281	PF00069	0.622
MOD_CK1_1	300	306	PF00069	0.613
MOD_CK1_1	315	321	PF00069	0.546
MOD_CK1_1	325	331	PF00069	0.613
MOD_CK1_1	63	69	PF00069	0.517
MOD_CK2_1	167	173	PF00069	0.509
MOD_CK2_1	270	276	PF00069	0.574
MOD_GlcNHglycan	310	313	PF01048	0.620
MOD_GlcNHglycan	46	49	PF01048	0.424
MOD_GlcNHglycan	62	65	PF01048	0.201
MOD_GSK3_1	137	144	PF00069	0.527
MOD_GSK3_1	19	26	PF00069	0.580
MOD_GSK3_1	221	228	PF00069	0.679
MOD_GSK3_1	232	239	PF00069	0.596
MOD_GSK3_1	252	259	PF00069	0.648
MOD_GSK3_1	271	278	PF00069	0.613
MOD_GSK3_1	279	286	PF00069	0.666
MOD_GSK3_1	308	315	PF00069	0.658
MOD_GSK3_1	316	323	PF00069	0.619
MOD_GSK3_1	9	16	PF00069	0.714
MOD_N-GLC_1	151	156	PF02516	0.338
MOD_N-GLC_1	214	219	PF02516	0.663
MOD_N-GLC_1	252	257	PF02516	0.501
MOD_N-GLC_1	50	55	PF02516	0.230
MOD_N-GLC_2	186	188	PF02516	0.327
MOD_NEK2_1	214	219	PF00069	0.695
MOD_NEK2_1	252	257	PF00069	0.554
MOD_NEK2_1	9	14	PF00069	0.642
MOD_NEK2_1	93	98	PF00069	0.551
MOD_NEK2_2	141	146	PF00069	0.554
MOD_NEK2_2	232	237	PF00069	0.528
MOD_PIKK_1	13	19	PF00454	0.675
MOD_PIKK_1	263	269	PF00454	0.615
MOD_PK_1	95	101	PF00069	0.605
MOD_PKA_1	146	152	PF00069	0.538
MOD_PKA_1	256	262	PF00069	0.552
MOD_PKA_2	236	242	PF00069	0.648
MOD_PKA_2	308	314	PF00069	0.793
MOD_PKA_2	321	327	PF00069	0.691
MOD_Plk_1	214	220	PF00069	0.461
MOD_Plk_1	275	281	PF00069	0.589
MOD_Plk_1	316	322	PF00069	0.741
MOD_Plk_1	325	331	PF00069	0.515
MOD_Plk_4	336	342	PF00069	0.742
MOD_Plk_4	52	58	PF00069	0.527
MOD_ProDKin_1	1	7	PF00069	0.766
MOD_ProDKin_1	106	112	PF00069	0.554
MOD_ProDKin_1	137	143	PF00069	0.530
MOD_ProDKin_1	19	25	PF00069	0.481
MOD_ProDKin_1	227	233	PF00069	0.676
MOD_ProDKin_1	261	267	PF00069	0.628
MOD_ProDKin_1	279	285	PF00069	0.694
MOD_ProDKin_1	300	306	PF00069	0.693
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.497
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.521
TRG_ENDOCYTIC_2	142	145	PF00928	0.565
TRG_ENDOCYTIC_2	219	222	PF00928	0.486
TRG_ENDOCYTIC_2	338	341	PF00928	0.556
TRG_ER_diArg_1	115	118	PF00400	0.402
TRG_ER_diArg_1	163	165	PF00400	0.567
TRG_ER_diArg_1	211	214	PF00400	0.772
TRG_NES_CRM1_1	250	261	PF08389	0.470
TRG_NLS_MonoExtN_4	208	214	PF00514	0.613
TRG_Pf-PMV_PEXEL_1	31	36	PF00026	0.338

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P516	Leptomonas seymouri	59%	93%
A0A0N1HUA1	Leptomonas seymouri	48%	99%
A0A3Q8IAV4	Leishmania donovani	46%	100%
A0A3Q8IAX1	Leishmania donovani	92%	100%
A4H9C2	Leishmania braziliensis	80%	100%
A4H9C4	Leishmania braziliensis	48%	100%
A4HXP3	Leishmania infantum	92%	100%
A4HXP5	Leishmania infantum	46%	100%
E9ARF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4QE25	Leishmania major	91%	100%