Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Lipase (class 3), putative

Species:

Leishmania mexicana

UniProt:

E9ARF3_LEIMU

TriTrypDb:

LmxM.18.0160

Length:

705

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9ARF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARF3

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0009056	catabolic process	2	1
GO:0016042	lipid catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016298	lipase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0005488	binding	1	1
GO:0008901	ferredoxin hydrogenase activity	5	1
GO:0016151	nickel cation binding	6	1
GO:0016491	oxidoreductase activity	2	1
GO:0016695	oxidoreductase activity, acting on hydrogen as donor	3	1
GO:0016699	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor	4	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	167	169	PF00675	0.335
CLV_NRD_NRD_1	237	239	PF00675	0.261
CLV_NRD_NRD_1	562	564	PF00675	0.651
CLV_NRD_NRD_1	585	587	PF00675	0.460
CLV_NRD_NRD_1	93	95	PF00675	0.289
CLV_PCSK_FUR_1	235	239	PF00082	0.312
CLV_PCSK_KEX2_1	167	169	PF00082	0.398
CLV_PCSK_KEX2_1	237	239	PF00082	0.252
CLV_PCSK_KEX2_1	562	564	PF00082	0.651
CLV_PCSK_KEX2_1	93	95	PF00082	0.260
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.260
CLV_PCSK_SKI1_1	137	141	PF00082	0.435
CLV_PCSK_SKI1_1	237	241	PF00082	0.304
CLV_PCSK_SKI1_1	353	357	PF00082	0.280
CLV_PCSK_SKI1_1	546	550	PF00082	0.444
CLV_PCSK_SKI1_1	571	575	PF00082	0.553
CLV_PCSK_SKI1_1	638	642	PF00082	0.586
DEG_APCC_DBOX_1	236	244	PF00400	0.569
DEG_APCC_DBOX_1	470	478	PF00400	0.235
DEG_SPOP_SBC_1	690	694	PF00917	0.435
DOC_CDC14_PxL_1	505	513	PF14671	0.313
DOC_CYCLIN_RxL_1	234	241	PF00134	0.517
DOC_MAPK_DCC_7	397	405	PF00069	0.435
DOC_MAPK_gen_1	93	103	PF00069	0.446
DOC_MAPK_HePTP_8	91	103	PF00069	0.464
DOC_MAPK_MEF2A_6	365	374	PF00069	0.480
DOC_MAPK_MEF2A_6	397	405	PF00069	0.435
DOC_MAPK_MEF2A_6	60	67	PF00069	0.282
DOC_MAPK_MEF2A_6	93	101	PF00069	0.460
DOC_MAPK_NFAT4_5	60	68	PF00069	0.303
DOC_PP1_RVXF_1	354	361	PF00149	0.386
DOC_SPAK_OSR1_1	183	187	PF12202	0.497
DOC_SPAK_OSR1_1	283	287	PF12202	0.477
DOC_USP7_MATH_1	19	23	PF00917	0.346
DOC_USP7_MATH_1	484	488	PF00917	0.227
DOC_USP7_MATH_1	553	557	PF00917	0.406
DOC_WW_Pin1_4	265	270	PF00397	0.568
DOC_WW_Pin1_4	396	401	PF00397	0.483
DOC_WW_Pin1_4	633	638	PF00397	0.303
LIG_14-3-3_CanoR_1	133	140	PF00244	0.325
LIG_14-3-3_CanoR_1	256	263	PF00244	0.480
LIG_14-3-3_CanoR_1	365	372	PF00244	0.475
LIG_14-3-3_CanoR_1	39	48	PF00244	0.329
LIG_14-3-3_CanoR_1	562	568	PF00244	0.395
LIG_14-3-3_CanoR_1	638	645	PF00244	0.369
LIG_Actin_WH2_2	383	399	PF00022	0.462
LIG_Actin_WH2_2	529	545	PF00022	0.367
LIG_BRCT_BRCA1_1	14	18	PF00533	0.443
LIG_BRCT_BRCA1_1	281	285	PF00533	0.476
LIG_BRCT_BRCA1_1	555	559	PF00533	0.438
LIG_FHA_1	103	109	PF00498	0.335
LIG_FHA_1	391	397	PF00498	0.478
LIG_FHA_1	40	46	PF00498	0.332
LIG_FHA_1	542	548	PF00498	0.376
LIG_FHA_1	583	589	PF00498	0.355
LIG_FHA_1	605	611	PF00498	0.449
LIG_FHA_1	694	700	PF00498	0.451
LIG_FHA_2	346	352	PF00498	0.506
LIG_FHA_2	397	403	PF00498	0.489
LIG_FHA_2	690	696	PF00498	0.416
LIG_GBD_Chelix_1	331	339	PF00786	0.258
LIG_GBD_Chelix_1	370	378	PF00786	0.222
LIG_GBD_Chelix_1	455	463	PF00786	0.281
LIG_LIR_Apic_2	605	611	PF02991	0.376
LIG_LIR_Gen_1	17	28	PF02991	0.444
LIG_LIR_Gen_1	198	209	PF02991	0.523
LIG_LIR_Gen_1	288	299	PF02991	0.481
LIG_LIR_Gen_1	385	394	PF02991	0.413
LIG_LIR_Gen_1	515	524	PF02991	0.300
LIG_LIR_Gen_1	626	635	PF02991	0.399
LIG_LIR_Nem_3	17	23	PF02991	0.400
LIG_LIR_Nem_3	198	204	PF02991	0.517
LIG_LIR_Nem_3	288	294	PF02991	0.475
LIG_LIR_Nem_3	295	299	PF02991	0.534
LIG_LIR_Nem_3	385	390	PF02991	0.413
LIG_LIR_Nem_3	417	422	PF02991	0.337
LIG_LIR_Nem_3	515	519	PF02991	0.333
LIG_LIR_Nem_3	521	527	PF02991	0.320
LIG_LIR_Nem_3	617	623	PF02991	0.288
LIG_LIR_Nem_3	626	630	PF02991	0.326
LIG_MLH1_MIPbox_1	281	285	PF16413	0.476
LIG_Pex14_1	180	184	PF04695	0.560
LIG_Pex14_2	208	212	PF04695	0.509
LIG_Pex14_2	7	11	PF04695	0.477
LIG_PTB_Apo_2	101	108	PF02174	0.144
LIG_SH2_CRK	215	219	PF00017	0.453
LIG_SH2_CRK	479	483	PF00017	0.203
LIG_SH2_CRK	505	509	PF00017	0.331
LIG_SH2_GRB2like	102	105	PF00017	0.282
LIG_SH2_GRB2like	176	179	PF00017	0.481
LIG_SH2_NCK_1	215	219	PF00017	0.453
LIG_SH2_NCK_1	479	483	PF00017	0.210
LIG_SH2_NCK_1	505	509	PF00017	0.313
LIG_SH2_NCK_1	616	620	PF00017	0.221
LIG_SH2_PTP2	154	157	PF00017	0.430
LIG_SH2_PTP2	201	204	PF00017	0.506
LIG_SH2_PTP2	597	600	PF00017	0.273
LIG_SH2_PTP2	620	623	PF00017	0.277
LIG_SH2_SRC	215	218	PF00017	0.514
LIG_SH2_SRC	409	412	PF00017	0.435
LIG_SH2_SRC	479	482	PF00017	0.235
LIG_SH2_SRC	616	619	PF00017	0.288
LIG_SH2_SRC	620	623	PF00017	0.261
LIG_SH2_SRC	686	689	PF00017	0.498
LIG_SH2_STAP1	176	180	PF00017	0.464
LIG_SH2_STAP1	281	285	PF00017	0.435
LIG_SH2_STAP1	616	620	PF00017	0.308
LIG_SH2_STAT5	102	105	PF00017	0.236
LIG_SH2_STAT5	130	133	PF00017	0.368
LIG_SH2_STAT5	154	157	PF00017	0.327
LIG_SH2_STAT5	176	179	PF00017	0.523
LIG_SH2_STAT5	201	204	PF00017	0.600
LIG_SH2_STAT5	420	423	PF00017	0.457
LIG_SH2_STAT5	47	50	PF00017	0.323
LIG_SH2_STAT5	597	600	PF00017	0.259
LIG_SH2_STAT5	620	623	PF00017	0.321
LIG_SH2_STAT5	686	689	PF00017	0.381
LIG_SH3_3	398	404	PF00018	0.503
LIG_SH3_3	616	622	PF00018	0.255
LIG_SUMO_SIM_par_1	390	395	PF11976	0.457
LIG_SUMO_SIM_par_1	599	605	PF11976	0.287
LIG_TYR_ITIM	152	157	PF00017	0.282
LIG_TYR_ITIM	503	508	PF00017	0.224
LIG_TYR_ITIM	595	600	PF00017	0.335
LIG_UBA3_1	113	120	PF00899	0.282
LIG_UBA3_1	648	654	PF00899	0.323
LIG_WRC_WIRS_1	516	521	PF05994	0.446
MOD_CDK_SPK_2	633	638	PF00069	0.483
MOD_CK1_1	129	135	PF00069	0.486
MOD_CK1_1	174	180	PF00069	0.409
MOD_CK1_1	465	471	PF00069	0.364
MOD_CK1_1	564	570	PF00069	0.392
MOD_CK1_1	689	695	PF00069	0.588
MOD_CK1_1	698	704	PF00069	0.648
MOD_CK2_1	345	351	PF00069	0.320
MOD_CK2_1	515	521	PF00069	0.428
MOD_CK2_1	566	572	PF00069	0.480
MOD_CK2_1	689	695	PF00069	0.591
MOD_Cter_Amidation	165	168	PF01082	0.396
MOD_Cter_Amidation	440	443	PF01082	0.282
MOD_GlcNHglycan	163	167	PF01048	0.464
MOD_GlcNHglycan	300	303	PF01048	0.410
MOD_GlcNHglycan	31	34	PF01048	0.270
MOD_GlcNHglycan	416	419	PF01048	0.153
MOD_GlcNHglycan	459	462	PF01048	0.390
MOD_GlcNHglycan	529	532	PF01048	0.476
MOD_GlcNHglycan	555	558	PF01048	0.486
MOD_GlcNHglycan	563	566	PF01048	0.529
MOD_GlcNHglycan	71	74	PF01048	0.277
MOD_GSK3_1	129	136	PF00069	0.451
MOD_GSK3_1	392	399	PF00069	0.426
MOD_GSK3_1	547	554	PF00069	0.426
MOD_GSK3_1	575	582	PF00069	0.456
MOD_GSK3_1	686	693	PF00069	0.545
MOD_GSK3_1	76	83	PF00069	0.276
MOD_LATS_1	254	260	PF00433	0.537
MOD_N-GLC_1	194	199	PF02516	0.338
MOD_N-GLC_1	575	580	PF02516	0.469
MOD_N-GLC_1	589	594	PF02516	0.453
MOD_NEK2_1	112	117	PF00069	0.332
MOD_NEK2_1	18	23	PF00069	0.248
MOD_NEK2_1	285	290	PF00069	0.207
MOD_NEK2_1	29	34	PF00069	0.301
MOD_NEK2_1	335	340	PF00069	0.284
MOD_NEK2_1	414	419	PF00069	0.206
MOD_NEK2_1	435	440	PF00069	0.293
MOD_NEK2_1	447	452	PF00069	0.203
MOD_NEK2_1	457	462	PF00069	0.258
MOD_NEK2_1	527	532	PF00069	0.310
MOD_NEK2_1	542	547	PF00069	0.361
MOD_NEK2_1	7	12	PF00069	0.335
MOD_NEK2_1	76	81	PF00069	0.287
MOD_NEK2_1	89	94	PF00069	0.297
MOD_NEK2_2	80	85	PF00069	0.426
MOD_OFUCOSY	110	116	PF10250	0.144
MOD_PIKK_1	256	262	PF00454	0.401
MOD_PKA_2	132	138	PF00069	0.384
MOD_PKA_2	255	261	PF00069	0.357
MOD_PKA_2	364	370	PF00069	0.327
MOD_PKA_2	374	380	PF00069	0.209
MOD_PKA_2	542	548	PF00069	0.472
MOD_PKA_2	561	567	PF00069	0.540
MOD_Plk_1	126	132	PF00069	0.442
MOD_Plk_1	465	471	PF00069	0.380
MOD_Plk_1	575	581	PF00069	0.511
MOD_Plk_1	589	595	PF00069	0.424
MOD_Plk_4	19	25	PF00069	0.288
MOD_Plk_4	31	37	PF00069	0.316
MOD_Plk_4	335	341	PF00069	0.348
MOD_Plk_4	465	471	PF00069	0.289
MOD_Plk_4	52	58	PF00069	0.327
MOD_Plk_4	575	581	PF00069	0.465
MOD_Plk_4	589	595	PF00069	0.291
MOD_Plk_4	695	701	PF00069	0.550
MOD_ProDKin_1	265	271	PF00069	0.463
MOD_ProDKin_1	396	402	PF00069	0.349
MOD_ProDKin_1	633	639	PF00069	0.375
TRG_DiLeu_BaEn_1	342	347	PF01217	0.359
TRG_DiLeu_BaEn_1	695	700	PF01217	0.487
TRG_DiLeu_BaLyEn_6	235	240	PF01217	0.429
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.361
TRG_ENDOCYTIC_2	154	157	PF00928	0.338
TRG_ENDOCYTIC_2	201	204	PF00928	0.421
TRG_ENDOCYTIC_2	215	218	PF00928	0.228
TRG_ENDOCYTIC_2	281	284	PF00928	0.274
TRG_ENDOCYTIC_2	289	292	PF00928	0.288
TRG_ENDOCYTIC_2	419	422	PF00928	0.319
TRG_ENDOCYTIC_2	505	508	PF00928	0.397
TRG_ENDOCYTIC_2	597	600	PF00928	0.385
TRG_ENDOCYTIC_2	616	619	PF00928	0.355
TRG_ENDOCYTIC_2	620	623	PF00928	0.318
TRG_ER_diArg_1	167	169	PF00400	0.510
TRG_ER_diArg_1	235	238	PF00400	0.341
TRG_ER_diArg_1	470	473	PF00400	0.283
TRG_NES_CRM1_1	147	163	PF08389	0.319
TRG_NES_CRM1_1	646	660	PF08389	0.335
TRG_NLS_MonoCore_2	92	97	PF00514	0.289
TRG_NLS_MonoExtC_3	93	98	PF00514	0.204
TRG_NLS_MonoExtN_4	93	98	PF00514	0.204
TRG_Pf-PMV_PEXEL_1	321	325	PF00026	0.351
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.319
TRG_Pf-PMV_PEXEL_1	638	642	PF00026	0.355

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJR2	Leptomonas seymouri	57%	100%
A0A0S4JEE8	Bodo saltans	37%	90%
A0A1X0P6P4	Trypanosomatidae	43%	100%
A0A3R7KUA8	Trypanosoma rangeli	43%	100%
A0A3S7WUY2	Leishmania donovani	90%	100%
A4H9C1	Leishmania braziliensis	73%	100%
A4HXP2	Leishmania infantum	90%	100%
D0A020	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
P0C1S9	Rattus norvegicus	25%	100%
Q4QE26	Leishmania major	88%	100%
Q5YLM1	Rattus norvegicus	26%	68%
Q6WQJ1	Mus musculus	26%	68%
Q8NCG7	Homo sapiens	27%	100%
Q91WC9	Mus musculus	27%	100%
Q9Y4D2	Homo sapiens	26%	68%
V5APZ1	Trypanosoma cruzi	42%	100%