Protein-serine/threonine phosphatase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine protein phosphatase type 5, putative

Species:

Leishmania mexicana

UniProt:

E9ARF2_LEIMU

TriTrypDb:

LmxM.18.0150

Length:

469

Annotations

LeishMANIAdb annotations

A large collection of various protein phosphatases. Very highly expanded in kinetoplastids.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9ARF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARF2

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016311	dephosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004721	phosphoprotein phosphatase activity	3	12
GO:0004722	protein serine/threonine phosphatase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016791	phosphatase activity	5	12
GO:0017018	myosin phosphatase activity	5	12
GO:0042578	phosphoric ester hydrolase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.561
CLV_NRD_NRD_1	178	180	PF00675	0.406
CLV_NRD_NRD_1	75	77	PF00675	0.368
CLV_PCSK_KEX2_1	119	121	PF00082	0.352
CLV_PCSK_KEX2_1	178	180	PF00082	0.393
CLV_PCSK_KEX2_1	371	373	PF00082	0.352
CLV_PCSK_KEX2_1	457	459	PF00082	0.502
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.438
CLV_PCSK_PC1ET2_1	371	373	PF00082	0.352
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.502
CLV_PCSK_PC7_1	367	373	PF00082	0.352
CLV_PCSK_SKI1_1	116	120	PF00082	0.473
CLV_PCSK_SKI1_1	190	194	PF00082	0.368
CLV_PCSK_SKI1_1	237	241	PF00082	0.348
CLV_PCSK_SKI1_1	414	418	PF00082	0.388
CLV_PCSK_SKI1_1	431	435	PF00082	0.343
DEG_Nend_UBRbox_2	1	3	PF02207	0.660
DOC_CYCLIN_RxL_1	231	243	PF00134	0.380
DOC_MAPK_gen_1	174	183	PF00069	0.399
DOC_MAPK_gen_1	76	84	PF00069	0.368
DOC_MAPK_HePTP_8	176	188	PF00069	0.387
DOC_MAPK_HePTP_8	40	52	PF00069	0.475
DOC_MAPK_MEF2A_6	179	188	PF00069	0.356
DOC_MAPK_MEF2A_6	389	397	PF00069	0.369
DOC_MAPK_MEF2A_6	43	52	PF00069	0.478
DOC_PP1_RVXF_1	117	124	PF00149	0.419
DOC_PP1_RVXF_1	177	184	PF00149	0.464
DOC_PP2B_LxvP_1	50	53	PF13499	0.543
DOC_PP4_FxxP_1	419	422	PF00568	0.383
DOC_USP7_MATH_1	126	130	PF00917	0.449
DOC_USP7_MATH_1	23	27	PF00917	0.447
DOC_USP7_UBL2_3	227	231	PF12436	0.437
DOC_USP7_UBL2_3	88	92	PF12436	0.350
DOC_WW_Pin1_4	230	235	PF00397	0.407
DOC_WW_Pin1_4	33	38	PF00397	0.431
DOC_WW_Pin1_4	365	370	PF00397	0.410
LIG_14-3-3_CanoR_1	247	253	PF00244	0.341
LIG_14-3-3_CanoR_1	292	302	PF00244	0.453
LIG_14-3-3_CanoR_1	76	84	PF00244	0.387
LIG_APCC_ABBA_1	300	305	PF00400	0.352
LIG_BRCT_BRCA1_1	303	307	PF00533	0.352
LIG_FHA_1	136	142	PF00498	0.352
LIG_FHA_1	155	161	PF00498	0.352
LIG_FHA_1	198	204	PF00498	0.518
LIG_FHA_1	310	316	PF00498	0.387
LIG_FHA_1	34	40	PF00498	0.476
LIG_FHA_2	101	107	PF00498	0.557
LIG_FHA_2	200	206	PF00498	0.501
LIG_FHA_2	332	338	PF00498	0.373
LIG_GBD_Chelix_1	181	189	PF00786	0.387
LIG_LIR_Apic_2	147	151	PF02991	0.357
LIG_LIR_Apic_2	355	361	PF02991	0.352
LIG_LIR_Apic_2	417	422	PF02991	0.369
LIG_LIR_Gen_1	180	191	PF02991	0.368
LIG_LIR_Gen_1	298	307	PF02991	0.357
LIG_LIR_Gen_1	447	455	PF02991	0.468
LIG_LIR_Gen_1	93	102	PF02991	0.473
LIG_LIR_Nem_3	180	186	PF02991	0.368
LIG_LIR_Nem_3	194	198	PF02991	0.368
LIG_LIR_Nem_3	298	303	PF02991	0.353
LIG_LIR_Nem_3	304	310	PF02991	0.354
LIG_LIR_Nem_3	447	452	PF02991	0.459
LIG_LIR_Nem_3	93	97	PF02991	0.369
LIG_Pex14_2	240	244	PF04695	0.352
LIG_Pex14_2	303	307	PF04695	0.352
LIG_PTB_Apo_2	238	245	PF02174	0.352
LIG_PTB_Apo_2	39	46	PF02174	0.440
LIG_RPA_C_Fungi	38	50	PF08784	0.447
LIG_SH2_CRK	148	152	PF00017	0.368
LIG_SH2_CRK	220	224	PF00017	0.352
LIG_SH2_CRK	261	265	PF00017	0.368
LIG_SH2_STAP1	27	31	PF00017	0.352
LIG_SH2_STAP1	295	299	PF00017	0.387
LIG_SH2_STAT3	424	427	PF00017	0.432
LIG_SH2_STAT5	14	17	PF00017	0.509
LIG_SH2_STAT5	238	241	PF00017	0.352
LIG_SH2_STAT5	424	427	PF00017	0.430
LIG_SH2_STAT5	446	449	PF00017	0.536
LIG_SH3_3	198	204	PF00018	0.492
LIG_SH3_3	371	377	PF00018	0.383
LIG_SH3_3	449	455	PF00018	0.473
LIG_SUMO_SIM_par_1	156	161	PF11976	0.229
LIG_SUMO_SIM_par_1	199	208	PF11976	0.515
LIG_TRAF2_1	165	168	PF00917	0.473
LIG_UBA3_1	185	193	PF00899	0.358
LIG_UBA3_1	222	227	PF00899	0.387
LIG_WRC_WIRS_1	446	451	PF05994	0.479
MOD_CDK_SPxK_1	365	371	PF00069	0.410
MOD_CDK_SPxxK_3	230	237	PF00069	0.410
MOD_CDK_SPxxK_3	365	372	PF00069	0.410
MOD_Cter_Amidation	455	458	PF01082	0.509
MOD_GlcNHglycan	135	138	PF01048	0.226
MOD_GlcNHglycan	295	298	PF01048	0.464
MOD_GlcNHglycan	419	422	PF01048	0.383
MOD_GlcNHglycan	78	81	PF01048	0.368
MOD_N-GLC_1	154	159	PF02516	0.438
MOD_N-GLC_2	423	425	PF02516	0.397
MOD_NEK2_1	191	196	PF00069	0.357
MOD_PKA_1	76	82	PF00069	0.368
MOD_PKA_2	246	252	PF00069	0.352
MOD_PKA_2	435	441	PF00069	0.428
MOD_Plk_1	154	160	PF00069	0.423
MOD_Plk_1	207	213	PF00069	0.371
MOD_Plk_1	331	337	PF00069	0.410
MOD_Plk_2-3	156	162	PF00069	0.219
MOD_Plk_2-3	331	337	PF00069	0.387
MOD_Plk_4	254	260	PF00069	0.343
MOD_Plk_4	35	41	PF00069	0.481
MOD_Plk_4	353	359	PF00069	0.352
MOD_ProDKin_1	230	236	PF00069	0.407
MOD_ProDKin_1	33	39	PF00069	0.423
MOD_ProDKin_1	365	371	PF00069	0.410
MOD_SUMO_for_1	48	51	PF00179	0.414
MOD_SUMO_for_1	7	10	PF00179	0.533
MOD_SUMO_rev_2	112	121	PF00179	0.463
MOD_SUMO_rev_2	168	176	PF00179	0.473
TRG_DiLeu_BaEn_4	2	8	PF01217	0.485
TRG_ENDOCYTIC_2	195	198	PF00928	0.400
TRG_ENDOCYTIC_2	220	223	PF00928	0.342
TRG_ENDOCYTIC_2	261	264	PF00928	0.368
TRG_ENDOCYTIC_2	446	449	PF00928	0.541
TRG_ENDOCYTIC_2	47	50	PF00928	0.516
TRG_ER_diArg_1	120	123	PF00400	0.358
TRG_NLS_MonoExtC_3	118	124	PF00514	0.473
TRG_NLS_MonoExtN_4	116	123	PF00514	0.438
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSR2	Leptomonas seymouri	35%	100%
A0A0N1ILH2	Leptomonas seymouri	29%	100%
A0A0N1PBN9	Leptomonas seymouri	84%	100%
A0A0S4IIW0	Bodo saltans	35%	100%
A0A0S4J323	Bodo saltans	33%	81%
A0A0S4JDD1	Bodo saltans	34%	100%
A0A0S4JEU6	Bodo saltans	68%	99%
A0A0S4JKZ6	Bodo saltans	34%	95%
A0A1X0NUA6	Trypanosomatidae	32%	100%
A0A1X0P6J3	Trypanosomatidae	33%	100%
A0A1X0P6Y9	Trypanosomatidae	78%	99%
A0A1X0P7H9	Trypanosomatidae	36%	100%
A0A1X0P7Q5	Trypanosomatidae	34%	100%
A0A1X0P9R6	Trypanosomatidae	30%	100%
A0A3R7MM48	Trypanosoma rangeli	31%	100%
A0A3S5H6T9	Leishmania donovani	35%	100%
A0A3S5H7Q6	Leishmania donovani	42%	100%
A0A3S7WUR2	Leishmania donovani	98%	100%
A0A3S7WZ39	Leishmania donovani	41%	100%
A0A3S7XAY3	Leishmania donovani	30%	100%
A0A422N1U7	Trypanosoma rangeli	28%	78%
A0A422N9D5	Trypanosoma rangeli	34%	100%
A0A422NWG6	Trypanosoma rangeli	76%	99%
A4H7D2	Leishmania braziliensis	34%	86%
A4H7Z3	Leishmania braziliensis	35%	100%
A4H9C0	Leishmania braziliensis	92%	100%
A4HJQ1	Leishmania braziliensis	42%	100%
A4HP65	Leishmania braziliensis	29%	100%
A4HWC1	Leishmania infantum	35%	100%
A4HXP1	Leishmania infantum	97%	100%
A4I1H6	Leishmania infantum	41%	100%
A4I768	Leishmania infantum	42%	100%
A4IDH0	Leishmania infantum	30%	100%
C9ZM48	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZX13	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
D0A019	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	99%
D0A358	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
D0A366	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	74%
E9AQ21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9ASX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AXL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9B262	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
O14829	Homo sapiens	34%	72%
O35655	Mus musculus	35%	72%
O43049	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	49%	99%
O74789	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
P14747	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	78%
P20654	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	36%	100%
P23287	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	85%
P48456	Drosophila melanogaster	35%	75%
P53041	Homo sapiens	49%	94%
P53042	Rattus norvegicus	48%	94%
P53043	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	91%
P62136	Homo sapiens	36%	100%
P62137	Mus musculus	36%	100%
P62138	Rattus norvegicus	36%	100%
P62139	Oryctolagus cuniculus	36%	100%
Q05681	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	33%	84%
Q28IV3	Xenopus tropicalis	26%	71%
Q3SWT6	Rattus norvegicus	36%	73%
Q3T0E7	Bos taurus	36%	100%
Q4Q1M5	Leishmania major	29%	100%
Q4Q5Z8	Leishmania major	43%	100%
Q4Q9W1	Leishmania major	41%	100%
Q4QE27	Leishmania major	97%	100%
Q4QFG0	Leishmania major	34%	100%
Q60676	Mus musculus	48%	94%
Q84K11	Solanum lycopersicum	46%	84%
Q84XU2	Arabidopsis thaliana	47%	87%
Q8WMS6	Canis lupus familiaris	36%	100%
Q9NES8	Caenorhabditis elegans	52%	95%
Q9XW79	Caenorhabditis elegans	35%	100%
V5B3V2	Trypanosoma cruzi	34%	100%
V5BBR3	Trypanosoma cruzi	34%	100%
V5BBS3	Trypanosoma cruzi	28%	78%
V5BGM0	Trypanosoma cruzi	30%	100%
V5D5S2	Trypanosoma cruzi	78%	99%