Protein-serine/threonine phosphatase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine protein phosphatase type 5, putative

Species:

Leishmania mexicana

UniProt:

E9ARF2_LEIMU

TriTrypDb:

LmxM.18.0150

Length:

469

Annotations

LeishMANIAdb annotations

A large collection of various protein phosphatases. Very highly expanded in kinetoplastids.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	12
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

E9ARF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARF2

Function

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Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016311	dephosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004721	phosphoprotein phosphatase activity	3	12
GO:0004722	protein serine/threonine phosphatase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016791	phosphatase activity	5	12
GO:0017018	myosin phosphatase activity	5	12
GO:0042578	phosphoric ester hydrolase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.561
CLV_NRD_NRD_1	178	180	PF00675	0.406
CLV_NRD_NRD_1	75	77	PF00675	0.368
CLV_PCSK_KEX2_1	119	121	PF00082	0.352
CLV_PCSK_KEX2_1	178	180	PF00082	0.393
CLV_PCSK_KEX2_1	371	373	PF00082	0.352
CLV_PCSK_KEX2_1	457	459	PF00082	0.502
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.438
CLV_PCSK_PC1ET2_1	371	373	PF00082	0.352
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.502

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSR2	Leptomonas seymouri	35%	100%
A0A0N1ILH2	Leptomonas seymouri	29%	100%
A0A0N1PBN9	Leptomonas seymouri	84%	100%
A0A0S4IIW0	Bodo saltans	35%	100%
A0A0S4J323	Bodo saltans	33%	81%
A0A0S4JDD1	Bodo saltans	34%	100%
A0A0S4JEU6	Bodo saltans	68%	99%
A0A0S4JKZ6	Bodo saltans	34%	95%
A0A1X0NUA6	Trypanosomatidae	32%	100%
A0A1X0P6J3	Trypanosomatidae	33%	100%

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