CNNM transmembrane domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function DUF21, putative

Species:

Leishmania mexicana

UniProt:

E9ARF1_LEIMU

TriTrypDb:

LmxM.18.0140

Length:

744

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 27

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 14, no: 11
NetGPI	no	yes: 0, no: 25

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	26
GO:0110165	cellular anatomical entity	1	26
GO:0005886	plasma membrane	3	9
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3

Expansion

Sequence features

E9ARF1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARF1

Function

Biological processes
Term	Name	Level	Count
GO:0010960	magnesium ion homeostasis	8	26
GO:0042592	homeostatic process	3	26
GO:0048878	chemical homeostasis	4	26
GO:0050801	monoatomic ion homeostasis	5	26
GO:0055065	obsolete metal ion homeostasis	7	26
GO:0055080	monoatomic cation homeostasis	6	26
GO:0065007	biological regulation	1	26
GO:0065008	regulation of biological quality	2	26
GO:0072507	obsolete divalent inorganic cation homeostasis	7	26
GO:0098771	inorganic ion homeostasis	6	26

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	716	720	PF00656	0.541
CLV_NRD_NRD_1	116	118	PF00675	0.235
CLV_NRD_NRD_1	243	245	PF00675	0.446
CLV_NRD_NRD_1	277	279	PF00675	0.525
CLV_NRD_NRD_1	53	55	PF00675	0.605
CLV_PCSK_KEX2_1	58	60	PF00082	0.608
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.635
CLV_PCSK_PC7_1	54	60	PF00082	0.516
CLV_PCSK_SKI1_1	267	271	PF00082	0.600
CLV_PCSK_SKI1_1	372	376	PF00082	0.540
CLV_PCSK_SKI1_1	527	531	PF00082	0.499
CLV_PCSK_SKI1_1	613	617	PF00082	0.509
CLV_PCSK_SKI1_1	670	674	PF00082	0.590
DEG_COP1_1	647	655	PF00400	0.371
DEG_Nend_UBRbox_3	1	3	PF02207	0.593
DOC_CKS1_1	283	288	PF01111	0.306
DOC_CKS1_1	298	303	PF01111	0.284
DOC_CKS1_1	478	483	PF01111	0.334
DOC_CKS1_1	554	559	PF01111	0.508
DOC_CKS1_1	646	651	PF01111	0.279
DOC_CYCLIN_RxL_1	524	532	PF00134	0.265
DOC_CYCLIN_RxL_1	664	674	PF00134	0.383
DOC_CYCLIN_yCln2_LP_2	213	219	PF00134	0.285
DOC_CYCLIN_yCln2_LP_2	646	652	PF00134	0.405
DOC_MAPK_gen_1	12	20	PF00069	0.555
DOC_MAPK_gen_1	192	199	PF00069	0.418
DOC_MAPK_gen_1	240	249	PF00069	0.340
DOC_MAPK_gen_1	309	317	PF00069	0.352
DOC_MAPK_gen_1	453	462	PF00069	0.529
DOC_MAPK_gen_1	610	618	PF00069	0.348
DOC_MAPK_gen_1	684	692	PF00069	0.482
DOC_MAPK_MEF2A_6	12	20	PF00069	0.559
DOC_MAPK_MEF2A_6	263	270	PF00069	0.369
DOC_MAPK_MEF2A_6	610	618	PF00069	0.376
DOC_MAPK_NFAT4_5	263	271	PF00069	0.277
DOC_PP1_RVXF_1	481	487	PF00149	0.416
DOC_PP2B_LxvP_1	472	475	PF13499	0.446
DOC_PP4_FxxP_1	490	493	PF00568	0.470
DOC_PP4_FxxP_1	650	653	PF00568	0.383
DOC_USP7_MATH_1	201	205	PF00917	0.308
DOC_USP7_MATH_1	316	320	PF00917	0.391
DOC_USP7_MATH_1	363	367	PF00917	0.310
DOC_USP7_MATH_1	493	497	PF00917	0.355
DOC_USP7_UBL2_3	118	122	PF12436	0.520
DOC_USP7_UBL2_3	241	245	PF12436	0.351
DOC_USP7_UBL2_3	263	267	PF12436	0.405
DOC_WW_Pin1_4	101	106	PF00397	0.401
DOC_WW_Pin1_4	282	287	PF00397	0.327
DOC_WW_Pin1_4	297	302	PF00397	0.317
DOC_WW_Pin1_4	340	345	PF00397	0.396
DOC_WW_Pin1_4	477	482	PF00397	0.474
DOC_WW_Pin1_4	553	558	PF00397	0.522
DOC_WW_Pin1_4	645	650	PF00397	0.407
DOC_WW_Pin1_4	691	696	PF00397	0.521
LIG_14-3-3_CanoR_1	155	162	PF00244	0.178
LIG_14-3-3_CanoR_1	192	198	PF00244	0.527
LIG_14-3-3_CanoR_1	467	473	PF00244	0.506
LIG_14-3-3_CanoR_1	59	64	PF00244	0.353
LIG_14-3-3_CanoR_1	684	693	PF00244	0.468
LIG_14-3-3_CanoR_1	7	12	PF00244	0.577
LIG_Actin_WH2_2	183	200	PF00022	0.285
LIG_APCC_ABBA_1	179	184	PF00400	0.294
LIG_APCC_ABBA_1	247	252	PF00400	0.253
LIG_BRCT_BRCA1_1	338	342	PF00533	0.408
LIG_BRCT_BRCA1_1	581	585	PF00533	0.538
LIG_BRCT_BRCA1_1	76	80	PF00533	0.259
LIG_BRCT_BRCA1_2	581	587	PF00533	0.381
LIG_FHA_1	124	130	PF00498	0.301
LIG_FHA_1	156	162	PF00498	0.293
LIG_FHA_1	174	180	PF00498	0.243
LIG_FHA_1	212	218	PF00498	0.416
LIG_FHA_1	232	238	PF00498	0.180
LIG_FHA_1	294	300	PF00498	0.314
LIG_FHA_1	469	475	PF00498	0.509
LIG_FHA_1	492	498	PF00498	0.415
LIG_FHA_1	55	61	PF00498	0.438
LIG_FHA_1	82	88	PF00498	0.290
LIG_FHA_1	90	96	PF00498	0.439
LIG_FHA_2	283	289	PF00498	0.364
LIG_FHA_2	336	342	PF00498	0.413
LIG_FHA_2	399	405	PF00498	0.431
LIG_FHA_2	426	432	PF00498	0.294
LIG_FHA_2	554	560	PF00498	0.534
LIG_FHA_2	60	66	PF00498	0.339
LIG_GBD_Chelix_1	173	181	PF00786	0.440
LIG_IRF3_LxIS_1	124	130	PF10401	0.334
LIG_LIR_Apic_2	409	413	PF02991	0.321
LIG_LIR_Apic_2	488	493	PF02991	0.434
LIG_LIR_Apic_2	520	524	PF02991	0.362
LIG_LIR_Apic_2	647	653	PF02991	0.355
LIG_LIR_Gen_1	141	149	PF02991	0.316
LIG_LIR_Gen_1	204	213	PF02991	0.440
LIG_LIR_Gen_1	300	307	PF02991	0.423
LIG_LIR_Gen_1	355	364	PF02991	0.301
LIG_LIR_Gen_1	454	463	PF02991	0.521
LIG_LIR_Gen_1	637	646	PF02991	0.309
LIG_LIR_LC3C_4	325	330	PF02991	0.388
LIG_LIR_Nem_3	141	145	PF02991	0.303
LIG_LIR_Nem_3	167	173	PF02991	0.246
LIG_LIR_Nem_3	204	209	PF02991	0.417
LIG_LIR_Nem_3	339	345	PF02991	0.398
LIG_LIR_Nem_3	355	361	PF02991	0.285
LIG_LIR_Nem_3	439	445	PF02991	0.355
LIG_LIR_Nem_3	446	451	PF02991	0.408
LIG_LIR_Nem_3	454	460	PF02991	0.455
LIG_LIR_Nem_3	637	641	PF02991	0.315
LIG_LIR_Nem_3	674	679	PF02991	0.364
LIG_LIR_Nem_3	77	83	PF02991	0.323
LIG_MLH1_MIPbox_1	581	585	PF16413	0.394
LIG_NRBOX	265	271	PF00104	0.356
LIG_Pex14_1	406	410	PF04695	0.316
LIG_Pex14_1	505	509	PF04695	0.308
LIG_Pex14_1	521	525	PF04695	0.313
LIG_Pex14_2	142	146	PF04695	0.340
LIG_Pex14_2	486	490	PF04695	0.312
LIG_REV1ctd_RIR_1	582	591	PF16727	0.344
LIG_RPA_C_Fungi	720	732	PF08784	0.514
LIG_SH2_CRK	410	414	PF00017	0.396
LIG_SH2_CRK	666	670	PF00017	0.357
LIG_SH2_CRK	73	77	PF00017	0.300
LIG_SH2_GRB2like	510	513	PF00017	0.298
LIG_SH2_NCK_1	448	452	PF00017	0.600
LIG_SH2_NCK_1	457	461	PF00017	0.664
LIG_SH2_PTP2	525	528	PF00017	0.452
LIG_SH2_SRC	448	451	PF00017	0.632
LIG_SH2_STAP1	109	113	PF00017	0.336
LIG_SH2_STAP1	195	199	PF00017	0.249
LIG_SH2_STAP1	655	659	PF00017	0.367
LIG_SH2_STAT3	519	522	PF00017	0.496
LIG_SH2_STAT5	292	295	PF00017	0.348
LIG_SH2_STAT5	489	492	PF00017	0.342
LIG_SH2_STAT5	510	513	PF00017	0.361
LIG_SH2_STAT5	525	528	PF00017	0.343
LIG_SH2_STAT5	61	64	PF00017	0.392
LIG_SH2_STAT5	640	643	PF00017	0.479
LIG_SH3_2	478	483	PF14604	0.541
LIG_SH3_3	256	262	PF00018	0.331
LIG_SH3_3	457	463	PF00018	0.698
LIG_SH3_3	472	478	PF00018	0.520
LIG_SH3_3	692	698	PF00018	0.714
LIG_SUMO_SIM_anti_2	175	182	PF11976	0.328
LIG_SUMO_SIM_anti_2	325	332	PF11976	0.373
LIG_SUMO_SIM_anti_2	611	618	PF11976	0.537
LIG_SUMO_SIM_anti_2	94	101	PF11976	0.259
LIG_SUMO_SIM_par_1	125	130	PF11976	0.292
LIG_SUMO_SIM_par_1	135	141	PF11976	0.317
LIG_SUMO_SIM_par_1	325	332	PF11976	0.337
LIG_UBA3_1	113	118	PF00899	0.413
LIG_UBA3_1	283	289	PF00899	0.431
LIG_WRC_WIRS_1	635	640	PF05994	0.477
LIG_WW_3	480	484	PF00397	0.571
MOD_CDK_SPxK_1	477	483	PF00069	0.626
MOD_CDK_SPxxK_3	101	108	PF00069	0.220
MOD_CDK_SPxxK_3	282	289	PF00069	0.494
MOD_CK1_1	101	107	PF00069	0.237
MOD_CK1_1	193	199	PF00069	0.299
MOD_CK1_1	231	237	PF00069	0.416
MOD_CK1_1	310	316	PF00069	0.383
MOD_CK1_1	343	349	PF00069	0.521
MOD_CK1_1	366	372	PF00069	0.366
MOD_CK1_1	43	49	PF00069	0.566
MOD_CK1_1	488	494	PF00069	0.522
MOD_CK1_1	564	570	PF00069	0.652
MOD_CK1_1	598	604	PF00069	0.502
MOD_CK1_1	703	709	PF00069	0.549
MOD_CK2_1	282	288	PF00069	0.510
MOD_CK2_1	335	341	PF00069	0.482
MOD_CK2_1	398	404	PF00069	0.545
MOD_CK2_1	473	479	PF00069	0.642
MOD_GlcNHglycan	100	103	PF01048	0.281
MOD_GlcNHglycan	166	169	PF01048	0.308
MOD_GlcNHglycan	217	220	PF01048	0.416
MOD_GlcNHglycan	309	312	PF01048	0.407
MOD_GlcNHglycan	318	321	PF01048	0.385
MOD_GlcNHglycan	409	413	PF01048	0.496
MOD_GlcNHglycan	654	658	PF01048	0.467
MOD_GlcNHglycan	703	706	PF01048	0.619
MOD_GlcNHglycan	727	730	PF01048	0.667
MOD_GlcNHglycan	76	79	PF01048	0.299
MOD_GSK3_1	123	130	PF00069	0.315
MOD_GSK3_1	151	158	PF00069	0.417
MOD_GSK3_1	186	193	PF00069	0.352
MOD_GSK3_1	211	218	PF00069	0.416
MOD_GSK3_1	293	300	PF00069	0.428
MOD_GSK3_1	332	339	PF00069	0.407
MOD_GSK3_1	36	43	PF00069	0.468
MOD_GSK3_1	362	369	PF00069	0.385
MOD_GSK3_1	398	405	PF00069	0.583
MOD_GSK3_1	473	480	PF00069	0.625
MOD_GSK3_1	493	500	PF00069	0.535
MOD_GSK3_1	561	568	PF00069	0.623
MOD_GSK3_1	6	13	PF00069	0.633
MOD_GSK3_1	630	637	PF00069	0.441
MOD_GSK3_1	680	687	PF00069	0.490
MOD_GSK3_1	696	703	PF00069	0.618
MOD_GSK3_1	709	716	PF00069	0.680
MOD_GSK3_1	736	743	PF00069	0.652
MOD_LATS_1	5	11	PF00433	0.350
MOD_N-GLC_1	336	341	PF02516	0.526
MOD_N-GLC_1	511	516	PF02516	0.430
MOD_N-GLC_1	546	551	PF02516	0.490
MOD_NEK2_1	127	132	PF00069	0.302
MOD_NEK2_1	172	177	PF00069	0.277
MOD_NEK2_1	211	216	PF00069	0.450
MOD_NEK2_1	217	222	PF00069	0.450
MOD_NEK2_1	27	32	PF00069	0.543
MOD_NEK2_1	307	312	PF00069	0.412
MOD_NEK2_1	408	413	PF00069	0.512
MOD_NEK2_1	416	421	PF00069	0.665
MOD_NEK2_1	499	504	PF00069	0.427
MOD_NEK2_1	511	516	PF00069	0.387
MOD_NEK2_1	552	557	PF00069	0.678
MOD_NEK2_1	561	566	PF00069	0.621
MOD_NEK2_1	579	584	PF00069	0.561
MOD_NEK2_1	6	11	PF00069	0.459
MOD_NEK2_1	64	69	PF00069	0.461
MOD_NEK2_1	700	705	PF00069	0.640
MOD_NEK2_2	201	206	PF00069	0.366
MOD_PIKK_1	40	46	PF00454	0.706
MOD_PIKK_1	499	505	PF00454	0.440
MOD_PIKK_1	567	573	PF00454	0.773
MOD_PIKK_1	577	583	PF00454	0.638
MOD_PK_1	664	670	PF00069	0.455
MOD_PKA_1	54	60	PF00069	0.559
MOD_PKA_2	154	160	PF00069	0.416
MOD_PKA_2	164	170	PF00069	0.416
MOD_PKA_2	293	299	PF00069	0.464
MOD_PKA_2	6	12	PF00069	0.571
MOD_PKA_2	685	691	PF00069	0.571
MOD_PKA_2	701	707	PF00069	0.683
MOD_PKA_2	717	723	PF00069	0.709
MOD_PKB_1	153	161	PF00069	0.189
MOD_Plk_1	336	342	PF00069	0.646
MOD_Plk_1	511	517	PF00069	0.460
MOD_Plk_1	598	604	PF00069	0.504
MOD_Plk_1	64	70	PF00069	0.457
MOD_Plk_2-3	444	450	PF00069	0.601
MOD_Plk_4	109	115	PF00069	0.320
MOD_Plk_4	123	129	PF00069	0.282
MOD_Plk_4	173	179	PF00069	0.324
MOD_Plk_4	201	207	PF00069	0.320
MOD_Plk_4	288	294	PF00069	0.343
MOD_Plk_4	323	329	PF00069	0.492
MOD_Plk_4	366	372	PF00069	0.376
MOD_Plk_4	485	491	PF00069	0.388
MOD_Plk_4	59	65	PF00069	0.429
MOD_Plk_4	696	702	PF00069	0.659
MOD_Plk_4	717	723	PF00069	0.758
MOD_ProDKin_1	101	107	PF00069	0.220
MOD_ProDKin_1	282	288	PF00069	0.406
MOD_ProDKin_1	297	303	PF00069	0.379
MOD_ProDKin_1	340	346	PF00069	0.481
MOD_ProDKin_1	477	483	PF00069	0.602
MOD_ProDKin_1	553	559	PF00069	0.669
MOD_ProDKin_1	645	651	PF00069	0.503
MOD_ProDKin_1	691	697	PF00069	0.671
MOD_SUMO_for_1	262	265	PF00179	0.521
MOD_SUMO_rev_2	100	110	PF00179	0.241
MOD_SUMO_rev_2	233	243	PF00179	0.357
MOD_SUMO_rev_2	264	269	PF00179	0.372
MOD_SUMO_rev_2	274	280	PF00179	0.340
MOD_SUMO_rev_2	41	50	PF00179	0.720
MOD_SUMO_rev_2	531	536	PF00179	0.531
TRG_DiLeu_BaEn_1	242	247	PF01217	0.308
TRG_DiLeu_BaEn_1	265	270	PF01217	0.338
TRG_DiLeu_BaEn_1	717	722	PF01217	0.679
TRG_DiLeu_BaEn_3	386	392	PF01217	0.394
TRG_DiLeu_BaEn_4	232	238	PF01217	0.416
TRG_DiLeu_BaLyEn_6	610	615	PF01217	0.512
TRG_ENDOCYTIC_2	23	26	PF00928	0.495
TRG_ENDOCYTIC_2	448	451	PF00928	0.584
TRG_ENDOCYTIC_2	457	460	PF00928	0.612
TRG_ENDOCYTIC_2	487	490	PF00928	0.500
TRG_ENDOCYTIC_2	525	528	PF00928	0.343
TRG_ENDOCYTIC_2	61	64	PF00928	0.408
TRG_ENDOCYTIC_2	678	681	PF00928	0.392
TRG_ENDOCYTIC_2	73	76	PF00928	0.352
TRG_ER_diArg_1	152	155	PF00400	0.416
TRG_ER_diArg_1	312	315	PF00400	0.399
TRG_ER_diLys_1	741	744	PF00400	0.485
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK76	Leptomonas seymouri	66%	98%
A0A0S4JDJ1	Bodo saltans	39%	79%
A0A0S4JGZ5	Bodo saltans	31%	89%
A0A0S4JSF9	Bodo saltans	28%	100%
A0A1X0P6Q5	Trypanosomatidae	41%	100%
A0A1X0P7K4	Trypanosomatidae	28%	100%
A0A3Q8IL77	Leishmania donovani	30%	100%
A0A3R7M693	Trypanosoma rangeli	27%	100%
A0A3S7WUR9	Leishmania donovani	93%	100%
A0A3S7WUS2	Leishmania donovani	32%	100%
A0A422NWG4	Trypanosoma rangeli	40%	100%
A4H9B8	Leishmania braziliensis	31%	92%
A4H9B9	Leishmania braziliensis	78%	100%
A4HXN9	Leishmania infantum	32%	100%
A4HXP0	Leishmania infantum	93%	100%
A4IA41	Leishmania infantum	30%	100%
C9ZM59	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A017	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ARF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
Q4Q2T0	Leishmania major	31%	100%
Q4QE28	Leishmania major	91%	100%
Q4QE29	Leishmania major	32%	100%
V5B9W6	Trypanosoma cruzi	43%	100%
V5BEH2	Trypanosoma cruzi	28%	100%