CNNM transmembrane domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function DUF21, putative

Species:

Leishmania mexicana

UniProt:

E9ARF0_LEIMU

TriTrypDb:

LmxM.18.0130

Length:

706

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 10, no: 9
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	7
GO:0016020	membrane	2	20
GO:0110165	cellular anatomical entity	1	20
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

E9ARF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARF0

Function

Biological processes
Term	Name	Level	Count
GO:0010960	magnesium ion homeostasis	8	20
GO:0042592	homeostatic process	3	20
GO:0048878	chemical homeostasis	4	20
GO:0050801	monoatomic ion homeostasis	5	20
GO:0055065	obsolete metal ion homeostasis	7	20
GO:0055080	monoatomic cation homeostasis	6	20
GO:0065007	biological regulation	1	20
GO:0065008	regulation of biological quality	2	20
GO:0072507	obsolete divalent inorganic cation homeostasis	7	20
GO:0098771	inorganic ion homeostasis	6	20

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	302	306	PF00656	0.405
CLV_C14_Caspase3-7	569	573	PF00656	0.386
CLV_NRD_NRD_1	274	276	PF00675	0.563
CLV_NRD_NRD_1	365	367	PF00675	0.747
CLV_NRD_NRD_1	98	100	PF00675	0.269
CLV_PCSK_KEX2_1	274	276	PF00082	0.594
CLV_PCSK_KEX2_1	364	366	PF00082	0.598
CLV_PCSK_KEX2_1	462	464	PF00082	0.519
CLV_PCSK_KEX2_1	701	703	PF00082	0.682
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.558
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.519
CLV_PCSK_PC1ET2_1	701	703	PF00082	0.701
CLV_PCSK_SKI1_1	236	240	PF00082	0.599
CLV_PCSK_SKI1_1	326	330	PF00082	0.586
CLV_PCSK_SKI1_1	41	45	PF00082	0.651
CLV_PCSK_SKI1_1	462	466	PF00082	0.719
CLV_PCSK_SKI1_1	51	55	PF00082	0.468
CLV_PCSK_SKI1_1	530	534	PF00082	0.508
CLV_PCSK_SKI1_1	701	705	PF00082	0.666
CLV_PCSK_SKI1_1	99	103	PF00082	0.335
DEG_APCC_DBOX_1	209	217	PF00400	0.230
DEG_APCC_DBOX_1	235	243	PF00400	0.391
DEG_SPOP_SBC_1	369	373	PF00917	0.567
DEG_SPOP_SBC_1	9	13	PF00917	0.544
DOC_ANK_TNKS_1	290	297	PF00023	0.264
DOC_CKS1_1	413	418	PF01111	0.450
DOC_CYCLIN_RxL_1	658	671	PF00134	0.495
DOC_CYCLIN_yCln2_LP_2	662	668	PF00134	0.508
DOC_MAPK_gen_1	289	297	PF00069	0.425
DOC_MAPK_gen_1	414	424	PF00069	0.476
DOC_MAPK_gen_1	641	650	PF00069	0.329
DOC_MAPK_MEF2A_6	173	182	PF00069	0.318
DOC_MAPK_MEF2A_6	99	106	PF00069	0.447
DOC_PP1_RVXF_1	483	489	PF00149	0.442
DOC_PP2B_LxvP_1	666	669	PF13499	0.329
DOC_PP4_FxxP_1	353	356	PF00568	0.272
DOC_USP7_MATH_1	252	256	PF00917	0.362
DOC_USP7_MATH_1	36	40	PF00917	0.426
DOC_USP7_MATH_1	369	373	PF00917	0.406
DOC_USP7_MATH_1	631	635	PF00917	0.359
DOC_USP7_MATH_1	8	12	PF00917	0.708
DOC_USP7_UBL2_3	223	227	PF12436	0.407
DOC_WW_Pin1_4	10	15	PF00397	0.639
DOC_WW_Pin1_4	263	268	PF00397	0.347
DOC_WW_Pin1_4	365	370	PF00397	0.579
DOC_WW_Pin1_4	392	397	PF00397	0.509
DOC_WW_Pin1_4	412	417	PF00397	0.455
DOC_WW_Pin1_4	553	558	PF00397	0.476
DOC_WW_Pin1_4	562	567	PF00397	0.461
LIG_14-3-3_CanoR_1	236	242	PF00244	0.418
LIG_14-3-3_CanoR_1	609	618	PF00244	0.286
LIG_APCC_ABBA_1	149	154	PF00400	0.318
LIG_APCC_ABBA_1	217	222	PF00400	0.264
LIG_BRCT_BRCA1_1	554	558	PF00533	0.430
LIG_BRCT_BRCA1_1	583	587	PF00533	0.294
LIG_Clathr_ClatBox_1	351	355	PF01394	0.314
LIG_Clathr_ClatBox_1	437	441	PF01394	0.291
LIG_Clathr_ClatBox_1	75	79	PF01394	0.505
LIG_FHA_1	112	118	PF00498	0.308
LIG_FHA_1	120	126	PF00498	0.308
LIG_FHA_1	144	150	PF00498	0.268
LIG_FHA_1	170	176	PF00498	0.409
LIG_FHA_1	347	353	PF00498	0.378
LIG_FHA_1	521	527	PF00498	0.313
LIG_FHA_1	58	64	PF00498	0.341
LIG_FHA_1	584	590	PF00498	0.263
LIG_FHA_1	628	634	PF00498	0.311
LIG_FHA_1	677	683	PF00498	0.391
LIG_FHA_1	70	76	PF00498	0.299
LIG_FHA_1	78	84	PF00498	0.427
LIG_FHA_2	252	258	PF00498	0.347
LIG_FHA_2	264	270	PF00498	0.377
LIG_FHA_2	314	320	PF00498	0.304
LIG_FHA_2	437	443	PF00498	0.291
LIG_FHA_2	468	474	PF00498	0.373
LIG_FHA_2	641	647	PF00498	0.347
LIG_GBD_Chelix_1	112	120	PF00786	0.303
LIG_GBD_Chelix_1	139	147	PF00786	0.341
LIG_KLC1_Yacidic_2	79	84	PF13176	0.535
LIG_LIR_Gen_1	515	526	PF02991	0.331
LIG_LIR_Gen_1	584	595	PF02991	0.253
LIG_LIR_Gen_1	610	619	PF02991	0.312
LIG_LIR_Gen_1	628	633	PF02991	0.181
LIG_LIR_Gen_1	79	89	PF02991	0.505
LIG_LIR_LC3C_4	146	149	PF02991	0.403
LIG_LIR_LC3C_4	327	331	PF02991	0.395
LIG_LIR_Nem_3	432	437	PF02991	0.415
LIG_LIR_Nem_3	490	494	PF02991	0.327
LIG_LIR_Nem_3	515	521	PF02991	0.312
LIG_LIR_Nem_3	555	561	PF02991	0.481
LIG_LIR_Nem_3	584	590	PF02991	0.265
LIG_LIR_Nem_3	610	614	PF02991	0.313
LIG_LIR_Nem_3	628	632	PF02991	0.184
LIG_LIR_Nem_3	65	71	PF02991	0.357
LIG_LIR_Nem_3	79	85	PF02991	0.480
LIG_MAD2	575	583	PF02301	0.409
LIG_NRBOX	111	117	PF00104	0.318
LIG_Pex14_1	508	512	PF04695	0.324
LIG_SH2_CRK	491	495	PF00017	0.407
LIG_SH2_CRK	629	633	PF00017	0.332
LIG_SH2_CRK	68	72	PF00017	0.439
LIG_SH2_SRC	82	85	PF00017	0.535
LIG_SH2_STAP1	629	633	PF00017	0.338
LIG_SH2_STAP1	97	101	PF00017	0.464
LIG_SH2_STAT3	208	211	PF00017	0.219
LIG_SH2_STAT5	299	302	PF00017	0.294
LIG_SH2_STAT5	308	311	PF00017	0.390
LIG_SH2_STAT5	342	345	PF00017	0.389
LIG_SH2_STAT5	458	461	PF00017	0.483
LIG_SH2_STAT5	513	516	PF00017	0.320
LIG_SH2_STAT5	518	521	PF00017	0.319
LIG_SH2_STAT5	629	632	PF00017	0.300
LIG_SH2_STAT5	68	71	PF00017	0.370
LIG_SH2_STAT5	82	85	PF00017	0.535
LIG_SH3_2	480	485	PF14604	0.438
LIG_SH3_2	685	690	PF14604	0.343
LIG_SH3_3	181	187	PF00018	0.295
LIG_SH3_3	353	359	PF00018	0.237
LIG_SH3_3	477	483	PF00018	0.442
LIG_SH3_3	621	627	PF00018	0.371
LIG_SH3_3	677	683	PF00018	0.520
LIG_Sin3_3	113	120	PF02671	0.295
LIG_SUMO_SIM_anti_2	146	152	PF11976	0.359
LIG_SUMO_SIM_par_1	121	127	PF11976	0.324
LIG_SUMO_SIM_par_1	237	243	PF11976	0.406
LIG_SUMO_SIM_par_1	436	442	PF11976	0.262
LIG_SUMO_SIM_par_1	538	545	PF11976	0.304
LIG_SUMO_SIM_par_1	584	592	PF11976	0.292
LIG_SUMO_SIM_par_1	60	65	PF11976	0.395
LIG_SUMO_SIM_par_1	646	651	PF11976	0.321
LIG_TRAF2_1	89	92	PF00917	0.535
LIG_TRFH_1	183	187	PF08558	0.318
LIG_TYR_ITSM	78	85	PF00017	0.535
LIG_UBA3_1	155	163	PF00899	0.295
LIG_UBA3_1	182	190	PF00899	0.318
LIG_UBA3_1	216	223	PF00899	0.335
LIG_WRC_WIRS_1	608	613	PF05994	0.373
LIG_WW_3	482	486	PF00397	0.432
MOD_CDK_SPK_2	365	370	PF00069	0.556
MOD_CDK_SPK_2	412	417	PF00069	0.397
MOD_CK1_1	225	231	PF00069	0.417
MOD_CK1_1	368	374	PF00069	0.552
MOD_CK1_1	426	432	PF00069	0.459
MOD_CK1_1	553	559	PF00069	0.521
MOD_CK1_1	585	591	PF00069	0.406
MOD_CK1_1	634	640	PF00069	0.315
MOD_CK2_1	251	257	PF00069	0.378
MOD_CK2_1	267	273	PF00069	0.384
MOD_CK2_1	467	473	PF00069	0.339
MOD_CK2_1	492	498	PF00069	0.461
MOD_CK2_1	545	551	PF00069	0.519
MOD_CMANNOS	49	52	PF00535	0.595
MOD_GlcNHglycan	226	230	PF01048	0.526
MOD_GlcNHglycan	591	594	PF01048	0.487
MOD_GlcNHglycan	620	623	PF01048	0.621
MOD_GlcNHglycan	64	67	PF01048	0.319
MOD_GSK3_1	119	126	PF00069	0.342
MOD_GSK3_1	263	270	PF00069	0.387
MOD_GSK3_1	309	316	PF00069	0.380
MOD_GSK3_1	365	372	PF00069	0.494
MOD_GSK3_1	384	391	PF00069	0.530
MOD_GSK3_1	4	11	PF00069	0.706
MOD_GSK3_1	426	433	PF00069	0.368
MOD_GSK3_1	562	569	PF00069	0.445
MOD_GSK3_1	58	65	PF00069	0.398
MOD_GSK3_1	581	588	PF00069	0.265
MOD_GSK3_1	603	610	PF00069	0.352
MOD_GSK3_1	627	634	PF00069	0.314
MOD_NEK2_1	111	116	PF00069	0.306
MOD_NEK2_1	123	128	PF00069	0.301
MOD_NEK2_1	178	183	PF00069	0.428
MOD_NEK2_1	237	242	PF00069	0.404
MOD_NEK2_1	262	267	PF00069	0.398
MOD_NEK2_1	57	62	PF00069	0.341
MOD_NEK2_1	589	594	PF00069	0.289
MOD_NEK2_2	77	82	PF00069	0.535
MOD_PIKK_1	124	130	PF00454	0.318
MOD_PIKK_1	346	352	PF00454	0.321
MOD_PIKK_1	370	376	PF00454	0.588
MOD_PKA_2	634	640	PF00069	0.307
MOD_Plk_1	304	310	PF00069	0.458
MOD_Plk_1	313	319	PF00069	0.405
MOD_Plk_1	627	633	PF00069	0.295
MOD_Plk_1	93	99	PF00069	0.430
MOD_Plk_2-3	545	551	PF00069	0.524
MOD_Plk_2-3	607	613	PF00069	0.372
MOD_Plk_4	111	117	PF00069	0.278
MOD_Plk_4	119	125	PF00069	0.308
MOD_Plk_4	143	149	PF00069	0.339
MOD_Plk_4	178	184	PF00069	0.349
MOD_Plk_4	237	243	PF00069	0.356
MOD_Plk_4	304	310	PF00069	0.458
MOD_Plk_4	332	338	PF00069	0.332
MOD_Plk_4	430	436	PF00069	0.421
MOD_Plk_4	58	64	PF00069	0.355
MOD_Plk_4	676	682	PF00069	0.531
MOD_Plk_4	77	83	PF00069	0.478
MOD_ProDKin_1	10	16	PF00069	0.637
MOD_ProDKin_1	263	269	PF00069	0.350
MOD_ProDKin_1	365	371	PF00069	0.581
MOD_ProDKin_1	392	398	PF00069	0.509
MOD_ProDKin_1	412	418	PF00069	0.451
MOD_ProDKin_1	553	559	PF00069	0.477
MOD_ProDKin_1	562	568	PF00069	0.455
MOD_SUMO_rev_2	209	216	PF00179	0.273
MOD_SUMO_rev_2	646	654	PF00179	0.417
MOD_SUMO_rev_2	694	703	PF00179	0.544
TRG_DiLeu_BaEn_1	212	217	PF01217	0.264
TRG_DiLeu_BaEn_2	137	143	PF01217	0.282
TRG_DiLeu_BaEn_2	429	435	PF01217	0.356
TRG_DiLeu_BaLyEn_6	460	465	PF01217	0.313
TRG_DiLeu_BaLyEn_6	635	640	PF01217	0.373
TRG_ENDOCYTIC_2	491	494	PF00928	0.408
TRG_ENDOCYTIC_2	518	521	PF00928	0.297
TRG_ENDOCYTIC_2	629	632	PF00928	0.310
TRG_ENDOCYTIC_2	68	71	PF00928	0.394
TRG_ENDOCYTIC_2	82	85	PF00928	0.535
TRG_ER_diArg_1	274	276	PF00400	0.367
TRG_NES_CRM1_1	231	243	PF08389	0.331
TRG_Pf-PMV_PEXEL_1	105	110	PF00026	0.335
TRG_Pf-PMV_PEXEL_1	274	278	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	463	467	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	652	656	PF00026	0.621

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5K6	Leptomonas seymouri	61%	96%
A0A0N1IK76	Leptomonas seymouri	29%	93%
A0A0S4JDJ1	Bodo saltans	31%	75%
A0A1X0P6Q5	Trypanosomatidae	33%	95%
A0A1X0P7K4	Trypanosomatidae	37%	100%
A0A3R7M693	Trypanosoma rangeli	37%	100%
A0A3S7WUR9	Leishmania donovani	31%	95%
A0A3S7WUS2	Leishmania donovani	88%	100%
A0A422NWG4	Trypanosoma rangeli	32%	96%
A4H9B8	Leishmania braziliensis	75%	100%
A4H9B9	Leishmania braziliensis	30%	100%
A4HXN9	Leishmania infantum	88%	100%
A4HXP0	Leishmania infantum	31%	95%
E9ARF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	95%
Q4QE28	Leishmania major	31%	100%
Q4QE29	Leishmania major	86%	97%
Q5U2P1	Rattus norvegicus	25%	81%
Q9GYL2	Caenorhabditis elegans	23%	93%
Q9H8M5	Homo sapiens	25%	81%
V5B9W6	Trypanosoma cruzi	32%	96%
V5BEH2	Trypanosoma cruzi	38%	100%