Rhodanese domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ARE7_LEIMU

TriTrypDb:

LmxM.18.0100

Length:

452

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ARE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARE7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.592
CLV_NRD_NRD_1	177	179	PF00675	0.571
CLV_NRD_NRD_1	237	239	PF00675	0.409
CLV_NRD_NRD_1	276	278	PF00675	0.421
CLV_NRD_NRD_1	357	359	PF00675	0.324
CLV_NRD_NRD_1	379	381	PF00675	0.420
CLV_NRD_NRD_1	449	451	PF00675	0.520
CLV_PCSK_KEX2_1	138	140	PF00082	0.629
CLV_PCSK_KEX2_1	177	179	PF00082	0.551
CLV_PCSK_KEX2_1	237	239	PF00082	0.421
CLV_PCSK_KEX2_1	276	278	PF00082	0.403
CLV_PCSK_KEX2_1	449	451	PF00082	0.520
CLV_PCSK_KEX2_1	66	68	PF00082	0.409
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.629
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.426
CLV_PCSK_SKI1_1	237	241	PF00082	0.454
CLV_PCSK_SKI1_1	31	35	PF00082	0.399
CLV_PCSK_SKI1_1	328	332	PF00082	0.294
DEG_APCC_DBOX_1	236	244	PF00400	0.479
DOC_CDC14_PxL_1	332	340	PF14671	0.344
DOC_CKS1_1	48	53	PF01111	0.594
DOC_CYCLIN_yCln2_LP_2	26	32	PF00134	0.456
DOC_MAPK_gen_1	109	118	PF00069	0.376
DOC_MAPK_gen_1	358	366	PF00069	0.305
DOC_MAPK_gen_1	380	388	PF00069	0.388
DOC_MAPK_gen_1	66	73	PF00069	0.489
DOC_MAPK_HePTP_8	356	368	PF00069	0.294
DOC_MAPK_HePTP_8	63	75	PF00069	0.419
DOC_MAPK_MEF2A_6	208	216	PF00069	0.553
DOC_MAPK_MEF2A_6	358	366	PF00069	0.555
DOC_MAPK_MEF2A_6	380	388	PF00069	0.558
DOC_MAPK_MEF2A_6	66	75	PF00069	0.493
DOC_MAPK_NFAT4_5	381	389	PF00069	0.544
DOC_PP1_RVXF_1	261	268	PF00149	0.467
DOC_PP1_RVXF_1	326	332	PF00149	0.439
DOC_PP2B_LxvP_1	26	29	PF13499	0.440
DOC_PP2B_LxvP_1	388	391	PF13499	0.410
DOC_PP4_FxxP_1	216	219	PF00568	0.614
DOC_USP7_MATH_1	185	189	PF00917	0.415
DOC_USP7_MATH_1	285	289	PF00917	0.453
DOC_WW_Pin1_4	188	193	PF00397	0.620
DOC_WW_Pin1_4	19	24	PF00397	0.401
DOC_WW_Pin1_4	299	304	PF00397	0.697
DOC_WW_Pin1_4	405	410	PF00397	0.324
DOC_WW_Pin1_4	47	52	PF00397	0.515
LIG_14-3-3_CanoR_1	112	117	PF00244	0.519
LIG_14-3-3_CanoR_1	164	168	PF00244	0.553
LIG_14-3-3_CanoR_1	206	212	PF00244	0.649
LIG_14-3-3_CanoR_1	343	347	PF00244	0.528
LIG_APCC_ABBA_1	116	121	PF00400	0.386
LIG_BIR_II_1	1	5	PF00653	0.407
LIG_BIR_III_4	184	188	PF00653	0.377
LIG_BIR_III_4	221	225	PF00653	0.347
LIG_BRCT_BRCA1_1	240	244	PF00533	0.480
LIG_CSL_BTD_1	26	29	PF09270	0.323
LIG_EVH1_2	212	216	PF00568	0.579
LIG_FHA_1	113	119	PF00498	0.587
LIG_FHA_1	170	176	PF00498	0.577
LIG_FHA_1	193	199	PF00498	0.632
LIG_FHA_1	23	29	PF00498	0.480
LIG_FHA_1	363	369	PF00498	0.321
LIG_FHA_1	395	401	PF00498	0.474
LIG_FHA_1	41	47	PF00498	0.437
LIG_FHA_1	411	417	PF00498	0.491
LIG_FHA_1	57	63	PF00498	0.435
LIG_FHA_1	82	88	PF00498	0.502
LIG_FHA_2	221	227	PF00498	0.472
LIG_FHA_2	245	251	PF00498	0.579
LIG_FHA_2	300	306	PF00498	0.544
LIG_FHA_2	319	325	PF00498	0.220
LIG_FHA_2	439	445	PF00498	0.506
LIG_FHA_2	55	61	PF00498	0.461
LIG_FHA_2	93	99	PF00498	0.277
LIG_LIR_Nem_3	25	30	PF02991	0.348
LIG_LIR_Nem_3	324	330	PF02991	0.344
LIG_LIR_Nem_3	333	338	PF02991	0.397
LIG_LYPXL_yS_3	335	338	PF13949	0.360
LIG_MAD2	328	336	PF02301	0.311
LIG_NRP_CendR_1	449	452	PF00754	0.441
LIG_PCNA_PIPBox_1	392	401	PF02747	0.470
LIG_Pex14_2	327	331	PF04695	0.307
LIG_Rb_LxCxE_1	1	22	PF01857	0.427
LIG_SH2_STAT5	268	271	PF00017	0.406
LIG_SH2_STAT5	344	347	PF00017	0.448
LIG_SH2_STAT5	442	445	PF00017	0.421
LIG_SH3_3	45	51	PF00018	0.488
LIG_SH3_3	84	90	PF00018	0.439
LIG_SUMO_SIM_anti_2	163	169	PF11976	0.569
LIG_SUMO_SIM_anti_2	305	311	PF11976	0.364
LIG_SUMO_SIM_anti_2	365	371	PF11976	0.306
LIG_SUMO_SIM_anti_2	385	390	PF11976	0.435
LIG_SUMO_SIM_anti_2	50	57	PF11976	0.397
LIG_SUMO_SIM_par_1	365	371	PF11976	0.306
LIG_SUMO_SIM_par_1	42	47	PF11976	0.471
LIG_SUMO_SIM_par_1	50	57	PF11976	0.429
LIG_SUMO_SIM_par_1	59	65	PF11976	0.443
LIG_SUMO_SIM_par_1	82	89	PF11976	0.421
LIG_TRAF2_1	248	251	PF00917	0.586
LIG_TRAF2_1	303	306	PF00917	0.518
LIG_WRC_WIRS_1	319	324	PF05994	0.357
LIG_WRC_WIRS_1	395	400	PF05994	0.346
MOD_CDK_SPK_2	188	193	PF00069	0.608
MOD_CDK_SPxxK_3	405	412	PF00069	0.336
MOD_CK1_1	163	169	PF00069	0.727
MOD_CK1_1	188	194	PF00069	0.572
MOD_CK1_1	22	28	PF00069	0.549
MOD_CK1_1	220	226	PF00069	0.444
MOD_CK1_1	246	252	PF00069	0.551
MOD_CK1_1	253	259	PF00069	0.416
MOD_CK1_1	342	348	PF00069	0.529
MOD_CK1_1	374	380	PF00069	0.435
MOD_CK1_1	42	48	PF00069	0.368
MOD_CK2_1	220	226	PF00069	0.444
MOD_CK2_1	244	250	PF00069	0.541
MOD_CK2_1	299	305	PF00069	0.733
MOD_CK2_1	318	324	PF00069	0.212
MOD_CK2_1	8	14	PF00069	0.426
MOD_CK2_1	92	98	PF00069	0.299
MOD_Cter_Amidation	107	110	PF01082	0.482
MOD_GlcNHglycan	126	129	PF01048	0.560
MOD_GSK3_1	145	152	PF00069	0.635
MOD_GSK3_1	188	195	PF00069	0.582
MOD_GSK3_1	197	204	PF00069	0.567
MOD_GSK3_1	228	235	PF00069	0.564
MOD_GSK3_1	246	253	PF00069	0.432
MOD_GSK3_1	275	282	PF00069	0.507
MOD_GSK3_1	285	292	PF00069	0.608
MOD_GSK3_1	342	349	PF00069	0.547
MOD_GSK3_1	364	371	PF00069	0.324
MOD_GSK3_1	394	401	PF00069	0.399
MOD_GSK3_1	4	11	PF00069	0.500
MOD_GSK3_1	417	424	PF00069	0.391
MOD_GSK3_1	54	61	PF00069	0.491
MOD_N-GLC_1	144	149	PF02516	0.620
MOD_N-GLC_1	403	408	PF02516	0.502
MOD_N-GLC_1	436	441	PF02516	0.500
MOD_NEK2_1	137	142	PF00069	0.631
MOD_NEK2_1	154	159	PF00069	0.607
MOD_NEK2_1	198	203	PF00069	0.538
MOD_NEK2_1	244	249	PF00069	0.461
MOD_NEK2_1	364	369	PF00069	0.384
MOD_NEK2_1	384	389	PF00069	0.472
MOD_NEK2_1	403	408	PF00069	0.248
MOD_NEK2_1	54	59	PF00069	0.476
MOD_NEK2_2	394	399	PF00069	0.343
MOD_PIKK_1	13	19	PF00454	0.393
MOD_PIKK_1	185	191	PF00454	0.478
MOD_PIKK_1	192	198	PF00454	0.526
MOD_PIKK_1	207	213	PF00454	0.581
MOD_PKA_2	101	107	PF00069	0.486
MOD_PKA_2	163	169	PF00069	0.635
MOD_PKA_2	192	198	PF00069	0.554
MOD_PKA_2	207	213	PF00069	0.589
MOD_PKA_2	244	250	PF00069	0.469
MOD_PKA_2	275	281	PF00069	0.539
MOD_PKA_2	342	348	PF00069	0.556
MOD_PKA_2	421	427	PF00069	0.591
MOD_PKB_1	277	285	PF00069	0.447
MOD_Plk_1	144	150	PF00069	0.641
MOD_Plk_1	346	352	PF00069	0.484
MOD_Plk_1	384	390	PF00069	0.550
MOD_Plk_1	403	409	PF00069	0.243
MOD_Plk_1	436	442	PF00069	0.496
MOD_Plk_1	8	14	PF00069	0.440
MOD_Plk_1	81	87	PF00069	0.498
MOD_Plk_2-3	318	324	PF00069	0.354
MOD_Plk_2-3	8	14	PF00069	0.383
MOD_Plk_4	112	118	PF00069	0.499
MOD_Plk_4	163	169	PF00069	0.525
MOD_Plk_4	198	204	PF00069	0.412
MOD_Plk_4	22	28	PF00069	0.578
MOD_Plk_4	364	370	PF00069	0.340
MOD_Plk_4	384	390	PF00069	0.519
MOD_Plk_4	394	400	PF00069	0.423
MOD_Plk_4	438	444	PF00069	0.367
MOD_Plk_4	58	64	PF00069	0.535
MOD_Plk_4	82	88	PF00069	0.507
MOD_ProDKin_1	188	194	PF00069	0.618
MOD_ProDKin_1	19	25	PF00069	0.394
MOD_ProDKin_1	299	305	PF00069	0.690
MOD_ProDKin_1	405	411	PF00069	0.329
MOD_ProDKin_1	47	53	PF00069	0.507
MOD_SUMO_for_1	311	314	PF00179	0.459
MOD_SUMO_rev_2	292	298	PF00179	0.768
MOD_SUMO_rev_2	406	414	PF00179	0.500
TRG_DiLeu_BaEn_1	305	310	PF01217	0.432
TRG_ENDOCYTIC_2	335	338	PF00928	0.441
TRG_ER_diArg_1	139	142	PF00400	0.694
TRG_ER_diArg_1	177	180	PF00400	0.589
TRG_ER_diArg_1	205	208	PF00400	0.479
TRG_ER_diArg_1	237	239	PF00400	0.404
TRG_ER_diArg_1	275	277	PF00400	0.369
TRG_ER_diArg_1	448	450	PF00400	0.481
TRG_NLS_MonoExtC_3	137	143	PF00514	0.612
TRG_NLS_MonoExtN_4	106	113	PF00514	0.526
TRG_Pf-PMV_PEXEL_1	446	451	PF00026	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P518	Leptomonas seymouri	60%	99%
A0A1X0P854	Trypanosomatidae	28%	100%
A0A3Q8IJL1	Leishmania donovani	91%	100%
A0A3R7KLI0	Trypanosoma rangeli	29%	100%
A4H9B5	Leishmania braziliensis	79%	100%
A4HXN6	Leishmania infantum	91%	100%
D0A013	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	99%
Q4QE32	Leishmania major	90%	100%
V5APZ6	Trypanosoma cruzi	27%	100%