Putative alpha glucosidase II subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

alpha glucosidase II subunit, putative

Species:

Leishmania mexicana

UniProt:

E9ARE6_LEIMU

TriTrypDb:

LmxM.18.0090

Length:

812

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 11, no: 0
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ARE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARE6

Function

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Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	5
GO:0006491	N-glycan processing	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	6
GO:0009100	glycoprotein metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	6

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	12
GO:0004558	alpha-1,4-glucosidase activity	7	7
GO:0005488	binding	1	12
GO:0015926	glucosidase activity	5	8
GO:0016787	hydrolase activity	2	12
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	12
GO:0030246	carbohydrate binding	2	12
GO:0032450	maltose alpha-glucosidase activity	8	7
GO:0033919	glucan 1,3-alpha-glucosidase activity	8	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.678
CLV_NRD_NRD_1	317	319	PF00675	0.291
CLV_NRD_NRD_1	372	374	PF00675	0.143
CLV_NRD_NRD_1	547	549	PF00675	0.242
CLV_NRD_NRD_1	678	680	PF00675	0.299
CLV_NRD_NRD_1	794	796	PF00675	0.369
CLV_PCSK_FUR_1	676	680	PF00082	0.305
CLV_PCSK_KEX2_1	2	4	PF00082	0.509
CLV_PCSK_KEX2_1	329	331	PF00082	0.289
CLV_PCSK_KEX2_1	372	374	PF00082	0.160

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5F9	Leptomonas seymouri	69%	99%
A0A0S4ITP0	Bodo saltans	39%	94%
A0A0S4JEB6	Bodo saltans	47%	97%
A0A0S4JFD6	Bodo saltans	29%	85%
A0A0S4JJL0	Bodo saltans	27%	100%
A0A1X0P3Y3	Trypanosomatidae	30%	67%
A0A1X0P7R2	Trypanosomatidae	52%	99%
A0A3R7MQZ9	Trypanosoma rangeli	51%	99%
A0A3S5H722	Leishmania donovani	93%	100%
A0A422NT82	Trypanosoma rangeli	31%	77%

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