DZANK-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger of a C2HC-type/Double zinc ribbon, putative

Species:

Leishmania mexicana

UniProt:

E9ARE4_LEIMU

TriTrypDb:

LmxM.18.0070

Length:

724

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0036064	ciliary basal body	3	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ARE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARE4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	426	430	PF00656	0.335
CLV_C14_Caspase3-7	504	508	PF00656	0.528
CLV_C14_Caspase3-7	570	574	PF00656	0.484
CLV_NRD_NRD_1	145	147	PF00675	0.630
CLV_NRD_NRD_1	150	152	PF00675	0.650
CLV_NRD_NRD_1	241	243	PF00675	0.275
CLV_NRD_NRD_1	267	269	PF00675	0.706
CLV_NRD_NRD_1	594	596	PF00675	0.287
CLV_NRD_NRD_1	614	616	PF00675	0.460
CLV_NRD_NRD_1	655	657	PF00675	0.461
CLV_NRD_NRD_1	696	698	PF00675	0.292
CLV_PCSK_KEX2_1	145	147	PF00082	0.708
CLV_PCSK_KEX2_1	150	152	PF00082	0.641
CLV_PCSK_KEX2_1	241	243	PF00082	0.333
CLV_PCSK_KEX2_1	267	269	PF00082	0.598
CLV_PCSK_KEX2_1	325	327	PF00082	0.614
CLV_PCSK_KEX2_1	594	596	PF00082	0.368
CLV_PCSK_KEX2_1	613	615	PF00082	0.494
CLV_PCSK_KEX2_1	644	646	PF00082	0.566
CLV_PCSK_KEX2_1	655	657	PF00082	0.429
CLV_PCSK_KEX2_1	696	698	PF00082	0.404
CLV_PCSK_KEX2_1	722	724	PF00082	0.612
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.696
CLV_PCSK_PC1ET2_1	613	615	PF00082	0.589
CLV_PCSK_PC1ET2_1	644	646	PF00082	0.628
CLV_PCSK_PC7_1	146	152	PF00082	0.560
CLV_PCSK_PC7_1	718	724	PF00082	0.455
CLV_PCSK_SKI1_1	241	245	PF00082	0.307
CLV_PCSK_SKI1_1	267	271	PF00082	0.621
CLV_PCSK_SKI1_1	367	371	PF00082	0.426
CLV_PCSK_SKI1_1	470	474	PF00082	0.467
CLV_PCSK_SKI1_1	527	531	PF00082	0.500
CLV_PCSK_SKI1_1	544	548	PF00082	0.704
CLV_PCSK_SKI1_1	558	562	PF00082	0.543
CLV_PCSK_SKI1_1	614	618	PF00082	0.522
CLV_PCSK_SKI1_1	655	659	PF00082	0.464
CLV_PCSK_SKI1_1	98	102	PF00082	0.283
DEG_SPOP_SBC_1	278	282	PF00917	0.547
DEG_SPOP_SBC_1	312	316	PF00917	0.603
DOC_CKS1_1	546	551	PF01111	0.700
DOC_PP2B_LxvP_1	500	503	PF13499	0.545
DOC_PP2B_LxvP_1	677	680	PF13499	0.516
DOC_USP7_MATH_1	119	123	PF00917	0.593
DOC_USP7_MATH_1	237	241	PF00917	0.292
DOC_USP7_MATH_1	294	298	PF00917	0.689
DOC_USP7_MATH_1	313	317	PF00917	0.684
DOC_USP7_MATH_1	330	334	PF00917	0.581
DOC_USP7_MATH_1	336	340	PF00917	0.573
DOC_USP7_MATH_1	381	385	PF00917	0.271
DOC_USP7_MATH_1	463	467	PF00917	0.716
DOC_USP7_MATH_1	529	533	PF00917	0.798
DOC_USP7_MATH_1	537	541	PF00917	0.597
DOC_USP7_MATH_1	597	601	PF00917	0.292
DOC_USP7_MATH_1	632	636	PF00917	0.615
DOC_USP7_UBL2_3	113	117	PF12436	0.542
DOC_USP7_UBL2_3	305	309	PF12436	0.815
DOC_USP7_UBL2_3	367	371	PF12436	0.439
DOC_USP7_UBL2_3	644	648	PF12436	0.611
DOC_WW_Pin1_4	131	136	PF00397	0.766
DOC_WW_Pin1_4	151	156	PF00397	0.615
DOC_WW_Pin1_4	214	219	PF00397	0.681
DOC_WW_Pin1_4	262	267	PF00397	0.645
DOC_WW_Pin1_4	282	287	PF00397	0.764
DOC_WW_Pin1_4	297	302	PF00397	0.508
DOC_WW_Pin1_4	400	405	PF00397	0.404
DOC_WW_Pin1_4	455	460	PF00397	0.663
DOC_WW_Pin1_4	530	535	PF00397	0.587
DOC_WW_Pin1_4	545	550	PF00397	0.584
DOC_WW_Pin1_4	573	578	PF00397	0.687
LIG_14-3-3_CanoR_1	150	154	PF00244	0.644
LIG_14-3-3_CanoR_1	276	286	PF00244	0.676
LIG_14-3-3_CanoR_1	331	336	PF00244	0.601
LIG_14-3-3_CanoR_1	453	459	PF00244	0.503
LIG_14-3-3_CanoR_1	586	596	PF00244	0.292
LIG_14-3-3_CanoR_1	709	715	PF00244	0.495
LIG_BIR_III_4	427	431	PF00653	0.289
LIG_BRCT_BRCA1_1	239	243	PF00533	0.292
LIG_BRCT_BRCA1_1	650	654	PF00533	0.459
LIG_deltaCOP1_diTrp_1	646	654	PF00928	0.504
LIG_FHA_1	160	166	PF00498	0.376
LIG_FHA_1	170	176	PF00498	0.307
LIG_FHA_1	483	489	PF00498	0.571
LIG_FHA_1	545	551	PF00498	0.750
LIG_FHA_1	559	565	PF00498	0.504
LIG_FHA_2	283	289	PF00498	0.734
LIG_FHA_2	502	508	PF00498	0.683
LIG_FHA_2	536	542	PF00498	0.564
LIG_FHA_2	570	576	PF00498	0.715
LIG_FHA_2	671	677	PF00498	0.536
LIG_FHA_2	682	688	PF00498	0.456
LIG_LIR_Apic_2	319	324	PF02991	0.606
LIG_LIR_Gen_1	223	233	PF02991	0.428
LIG_LIR_Gen_1	81	91	PF02991	0.402
LIG_LIR_LC3C_4	246	250	PF02991	0.289
LIG_LIR_Nem_3	223	229	PF02991	0.440
LIG_LIR_Nem_3	81	86	PF02991	0.388
LIG_MYND_1	157	161	PF01753	0.564
LIG_NBox_RRM_1	654	664	PF00076	0.573
LIG_NRP_CendR_1	722	724	PF00754	0.637
LIG_PTAP_UEV_1	639	644	PF05743	0.521
LIG_PTB_Apo_2	682	689	PF02174	0.603
LIG_PTB_Phospho_1	682	688	PF10480	0.611
LIG_SH2_STAP1	183	187	PF00017	0.427
LIG_SH2_STAP1	350	354	PF00017	0.382
LIG_SH2_STAT5	164	167	PF00017	0.274
LIG_SH2_STAT5	21	24	PF00017	0.271
LIG_SH2_STAT5	474	477	PF00017	0.450
LIG_SH2_STAT5	688	691	PF00017	0.289
LIG_SH3_2	257	262	PF14604	0.549
LIG_SH3_2	263	268	PF14604	0.566
LIG_SH3_2	404	409	PF14604	0.292
LIG_SH3_2	640	645	PF14604	0.677
LIG_SH3_2	717	722	PF14604	0.547
LIG_SH3_3	152	158	PF00018	0.591
LIG_SH3_3	199	205	PF00018	0.482
LIG_SH3_3	254	260	PF00018	0.606
LIG_SH3_3	362	368	PF00018	0.388
LIG_SH3_3	401	407	PF00018	0.317
LIG_SH3_3	414	420	PF00018	0.213
LIG_SH3_3	51	57	PF00018	0.479
LIG_SH3_3	531	537	PF00018	0.642
LIG_SH3_3	543	549	PF00018	0.672
LIG_SH3_3	553	559	PF00018	0.621
LIG_SH3_3	637	643	PF00018	0.642
LIG_SH3_3	686	692	PF00018	0.335
LIG_SH3_3	711	717	PF00018	0.511
LIG_SH3_3	88	94	PF00018	0.404
LIG_SH3_4	367	374	PF00018	0.435
LIG_SH3_CIN85_PxpxPR_1	717	722	PF14604	0.547
LIG_UBA3_1	4	9	PF00899	0.478
LIG_WW_1	679	682	PF00397	0.533
LIG_WW_3	259	263	PF00397	0.520
LIG_WW_3	719	723	PF00397	0.562
MOD_CDC14_SPxK_1	265	268	PF00782	0.659
MOD_CDK_SPK_2	131	136	PF00069	0.507
MOD_CDK_SPK_2	214	219	PF00069	0.513
MOD_CDK_SPK_2	262	267	PF00069	0.601
MOD_CDK_SPxK_1	262	268	PF00069	0.649
MOD_CDK_SPxxK_3	297	304	PF00069	0.504
MOD_CDK_SPxxK_3	455	462	PF00069	0.494
MOD_CK1_1	214	220	PF00069	0.595
MOD_CK1_1	297	303	PF00069	0.649
MOD_CK1_1	363	369	PF00069	0.481
MOD_CK1_1	458	464	PF00069	0.716
MOD_CK1_1	635	641	PF00069	0.700
MOD_CK2_1	214	220	PF00069	0.560
MOD_CK2_1	282	288	PF00069	0.554
MOD_CK2_1	313	319	PF00069	0.739
MOD_CK2_1	42	48	PF00069	0.465
MOD_CK2_1	535	541	PF00069	0.757
MOD_CK2_1	569	575	PF00069	0.661
MOD_Cter_Amidation	148	151	PF01082	0.608
MOD_Cter_Amidation	592	595	PF01082	0.284
MOD_DYRK1A_RPxSP_1	151	155	PF00069	0.619
MOD_DYRK1A_RPxSP_1	262	266	PF00069	0.552
MOD_GlcNHglycan	213	216	PF01048	0.451
MOD_GlcNHglycan	28	31	PF01048	0.289
MOD_GlcNHglycan	315	318	PF01048	0.710
MOD_GlcNHglycan	448	451	PF01048	0.528
MOD_GlcNHglycan	552	555	PF01048	0.640
MOD_GlcNHglycan	634	637	PF01048	0.692
MOD_GlcNHglycan	73	76	PF01048	0.369
MOD_GSK3_1	277	284	PF00069	0.664
MOD_GSK3_1	363	370	PF00069	0.502
MOD_GSK3_1	409	416	PF00069	0.362
MOD_GSK3_1	451	458	PF00069	0.577
MOD_GSK3_1	514	521	PF00069	0.668
MOD_GSK3_1	569	576	PF00069	0.609
MOD_GSK3_1	631	638	PF00069	0.528
MOD_N-GLC_1	237	242	PF02516	0.292
MOD_N-GLC_1	617	622	PF02516	0.565
MOD_N-GLC_2	431	433	PF02516	0.289
MOD_N-GLC_2	563	565	PF02516	0.544
MOD_NEK2_1	386	391	PF00069	0.249
MOD_NEK2_1	617	622	PF00069	0.603
MOD_PIKK_1	42	48	PF00454	0.465
MOD_PIKK_1	607	613	PF00454	0.572
MOD_PIKK_1	635	641	PF00454	0.600
MOD_PIKK_1	85	91	PF00454	0.390
MOD_PKA_1	42	48	PF00069	0.465
MOD_PKA_2	149	155	PF00069	0.616
MOD_PKA_2	261	267	PF00069	0.472
MOD_PKA_2	330	336	PF00069	0.592
MOD_Plk_1	483	489	PF00069	0.416
MOD_Plk_2-3	423	429	PF00069	0.335
MOD_Plk_2-3	569	575	PF00069	0.609
MOD_Plk_4	360	366	PF00069	0.602
MOD_ProDKin_1	131	137	PF00069	0.768
MOD_ProDKin_1	151	157	PF00069	0.609
MOD_ProDKin_1	214	220	PF00069	0.677
MOD_ProDKin_1	262	268	PF00069	0.648
MOD_ProDKin_1	282	288	PF00069	0.766
MOD_ProDKin_1	297	303	PF00069	0.552
MOD_ProDKin_1	400	406	PF00069	0.404
MOD_ProDKin_1	455	461	PF00069	0.664
MOD_ProDKin_1	530	536	PF00069	0.587
MOD_ProDKin_1	545	551	PF00069	0.585
MOD_ProDKin_1	573	579	PF00069	0.689
MOD_SUMO_for_1	602	605	PF00179	0.292
MOD_SUMO_rev_2	349	356	PF00179	0.510
MOD_SUMO_rev_2	466	472	PF00179	0.575
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.534
TRG_ENDOCYTIC_2	83	86	PF00928	0.516
TRG_ER_diArg_1	144	146	PF00400	0.770
TRG_ER_diArg_1	195	198	PF00400	0.686
TRG_ER_diArg_1	210	213	PF00400	0.549
TRG_ER_diArg_1	241	243	PF00400	0.333
TRG_ER_diArg_1	266	268	PF00400	0.644
TRG_ER_diArg_1	326	329	PF00400	0.616
TRG_ER_diArg_1	594	596	PF00400	0.374
TRG_ER_diArg_1	614	616	PF00400	0.543
TRG_ER_diArg_1	654	656	PF00400	0.467
TRG_ER_diArg_1	696	698	PF00400	0.404
TRG_ER_diArg_1	716	719	PF00400	0.385
TRG_ER_diArg_1	721	724	PF00400	0.597
TRG_NLS_Bipartite_1	594	616	PF00514	0.378
TRG_NLS_MonoCore_2	611	616	PF00514	0.578
TRG_NLS_MonoExtN_4	324	329	PF00514	0.586
TRG_NLS_MonoExtN_4	612	617	PF00514	0.639
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.371
TRG_Pf-PMV_PEXEL_1	656	660	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P519	Leptomonas seymouri	56%	97%
A0A1X0P6N6	Trypanosomatidae	47%	97%
A0A3Q8I9V6	Leishmania donovani	91%	100%
A0A3S5IS42	Trypanosoma rangeli	44%	96%
A4H9B2	Leishmania braziliensis	72%	100%
A4HXN3	Leishmania infantum	90%	100%
D0A010	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	99%
Q4QE35	Leishmania major	89%	100%
V5BEH8	Trypanosoma cruzi	50%	100%