RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein 27, putative

Species:

Leishmania mexicana

UniProt:

E9ARE0_LEIMU

TriTrypDb:

LmxM.18.0030

Length:

344

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ARE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARE0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.749
CLV_NRD_NRD_1	216	218	PF00675	0.659
CLV_PCSK_KEX2_1	113	115	PF00082	0.588
CLV_PCSK_KEX2_1	296	298	PF00082	0.595
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.588
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.621
CLV_PCSK_SKI1_1	146	150	PF00082	0.451
CLV_PCSK_SKI1_1	218	222	PF00082	0.685
CLV_PCSK_SKI1_1	271	275	PF00082	0.530
DOC_CYCLIN_yCln2_LP_2	126	129	PF00134	0.623
DOC_MAPK_gen_1	112	123	PF00069	0.626
DOC_MAPK_gen_1	71	79	PF00069	0.476
DOC_PP1_RVXF_1	229	236	PF00149	0.503
DOC_PP1_RVXF_1	36	42	PF00149	0.581
DOC_PP2B_LxvP_1	126	129	PF13499	0.623
DOC_PP4_MxPP_1	133	136	PF00568	0.473
DOC_USP7_MATH_1	285	289	PF00917	0.568
DOC_USP7_MATH_1	316	320	PF00917	0.510
DOC_WD40_RPTOR_TOS_1	327	332	PF00400	0.581
DOC_WW_Pin1_4	207	212	PF00397	0.744
DOC_WW_Pin1_4	236	241	PF00397	0.552
DOC_WW_Pin1_4	259	264	PF00397	0.353
DOC_WW_Pin1_4	97	102	PF00397	0.717
LIG_14-3-3_CanoR_1	315	321	PF00244	0.516
LIG_APCC_ABBA_1	169	174	PF00400	0.592
LIG_APCC_ABBA_1	8	13	PF00400	0.344
LIG_Clathr_ClatBox_1	326	330	PF01394	0.659
LIG_FHA_1	116	122	PF00498	0.602
LIG_FHA_1	188	194	PF00498	0.577
LIG_LIR_Apic_2	196	200	PF02991	0.617
LIG_LIR_Gen_1	120	131	PF02991	0.648
LIG_LIR_Gen_1	170	180	PF02991	0.524
LIG_LIR_Gen_1	26	35	PF02991	0.468
LIG_LIR_Nem_3	120	126	PF02991	0.529
LIG_LIR_Nem_3	170	175	PF02991	0.522
LIG_LIR_Nem_3	248	254	PF02991	0.518
LIG_LIR_Nem_3	26	30	PF02991	0.476
LIG_LIR_Nem_3	304	308	PF02991	0.585
LIG_MYND_3	141	145	PF01753	0.543
LIG_NRBOX	188	194	PF00104	0.524
LIG_PCNA_yPIPBox_3	159	172	PF02747	0.456
LIG_PCNA_yPIPBox_3	334	343	PF02747	0.610
LIG_SH2_GRB2like	66	69	PF00017	0.553
LIG_SH2_PTP2	9	12	PF00017	0.449
LIG_SH2_SRC	66	69	PF00017	0.484
LIG_SH2_STAT5	140	143	PF00017	0.610
LIG_SH2_STAT5	51	54	PF00017	0.562
LIG_SH2_STAT5	66	69	PF00017	0.418
LIG_SH2_STAT5	9	12	PF00017	0.417
LIG_SUMO_SIM_par_1	241	249	PF11976	0.542
LIG_SUMO_SIM_par_1	252	259	PF11976	0.574
LIG_SUMO_SIM_par_1	75	81	PF11976	0.615
LIG_TYR_ITIM	7	12	PF00017	0.515
MOD_CDK_SPxK_1	236	242	PF00069	0.581
MOD_CK1_1	210	216	PF00069	0.642
MOD_CK1_1	255	261	PF00069	0.506
MOD_CK1_1	94	100	PF00069	0.654
MOD_CK2_1	92	98	PF00069	0.729
MOD_Cter_Amidation	215	218	PF01082	0.660
MOD_GlcNHglycan	101	104	PF01048	0.753
MOD_GlcNHglycan	145	149	PF01048	0.434
MOD_GlcNHglycan	212	215	PF01048	0.727
MOD_GlcNHglycan	287	290	PF01048	0.567
MOD_GlcNHglycan	55	58	PF01048	0.244
MOD_GSK3_1	144	151	PF00069	0.641
MOD_GSK3_1	205	212	PF00069	0.601
MOD_GSK3_1	255	262	PF00069	0.463
MOD_GSK3_1	283	290	PF00069	0.580
MOD_GSK3_1	87	94	PF00069	0.661
MOD_NEK2_1	144	149	PF00069	0.523
MOD_NEK2_1	175	180	PF00069	0.475
MOD_NEK2_1	193	198	PF00069	0.632
MOD_PIKK_1	187	193	PF00454	0.574
MOD_PIKK_1	297	303	PF00454	0.523
MOD_PIKK_1	87	93	PF00454	0.694
MOD_PKA_2	115	121	PF00069	0.612
MOD_PKA_2	216	222	PF00069	0.627
MOD_PKB_1	114	122	PF00069	0.579
MOD_Plk_1	144	150	PF00069	0.446
MOD_Plk_4	304	310	PF00069	0.526
MOD_ProDKin_1	207	213	PF00069	0.745
MOD_ProDKin_1	236	242	PF00069	0.551
MOD_ProDKin_1	259	265	PF00069	0.341
MOD_ProDKin_1	97	103	PF00069	0.716
MOD_SUMO_rev_2	298	308	PF00179	0.361
MOD_SUMO_rev_2	33	39	PF00179	0.477
TRG_ENDOCYTIC_2	51	54	PF00928	0.569
TRG_ENDOCYTIC_2	9	12	PF00928	0.449
TRG_NES_CRM1_1	167	181	PF08389	0.589
TRG_NES_CRM1_1	26	40	PF08389	0.562
TRG_NLS_MonoExtC_3	111	116	PF00514	0.514
TRG_NLS_MonoExtN_4	109	116	PF00514	0.527
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJR6	Leptomonas seymouri	42%	99%
A0A1X0P7J4	Trypanosomatidae	28%	96%
A0A3S7WUR3	Leishmania donovani	88%	100%
A0A422NWM0	Trypanosoma rangeli	30%	96%
A4H9A9	Leishmania braziliensis	67%	100%
A4HXM9	Leishmania infantum	87%	100%
C9ZZY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
D0A069	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4QE39	Leishmania major	87%	100%
V5B9X5	Trypanosoma cruzi	31%	99%