Elongation factor 1-alpha

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania mexicana

UniProt:

E9ARD4_LEIMU

TriTrypDb:

Length:

216

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ARD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARD4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	4
GO:0003676	nucleic acid binding	3	4
GO:0003746	translation elongation factor activity	4	4
GO:0005488	binding	1	4
GO:0005525	GTP binding	5	4
GO:0008135	translation factor activity, RNA binding	3	4
GO:0017076	purine nucleotide binding	4	4
GO:0019001	guanyl nucleotide binding	5	4
GO:0032553	ribonucleotide binding	3	4
GO:0032555	purine ribonucleotide binding	4	4
GO:0032561	guanyl ribonucleotide binding	5	4
GO:0035639	purine ribonucleoside triphosphate binding	4	4
GO:0036094	small molecule binding	2	4
GO:0043167	ion binding	2	4
GO:0043168	anion binding	3	4
GO:0045182	translation regulator activity	1	4
GO:0090079	translation regulator activity, nucleic acid binding	2	4
GO:0097159	organic cyclic compound binding	2	4
GO:0097367	carbohydrate derivative binding	2	4
GO:1901265	nucleoside phosphate binding	3	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	136	138	PF00675	0.333
CLV_NRD_NRD_1	76	78	PF00675	0.333
CLV_PCSK_KEX2_1	136	138	PF00082	0.333
CLV_PCSK_KEX2_1	76	78	PF00082	0.333
CLV_PCSK_SKI1_1	147	151	PF00082	0.318
CLV_PCSK_SKI1_1	208	212	PF00082	0.509
DEG_APCC_DBOX_1	1	9	PF00400	0.421
DEG_Nend_UBRbox_1	1	4	PF02207	0.303
DOC_MAPK_gen_1	182	192	PF00069	0.533
DOC_MAPK_MEF2A_6	185	192	PF00069	0.533
DOC_SPAK_OSR1_1	178	182	PF12202	0.533
DOC_USP7_MATH_1	148	152	PF00917	0.570
DOC_USP7_UBL2_3	140	144	PF12436	0.533
DOC_USP7_UBL2_3	194	198	PF12436	0.533
DOC_USP7_UBL2_3	208	212	PF12436	0.544
LIG_14-3-3_CanoR_1	185	189	PF00244	0.533
LIG_APCC_ABBA_1	167	172	PF00400	0.633
LIG_APCC_ABBA_1	47	52	PF00400	0.533
LIG_FHA_1	118	124	PF00498	0.533
LIG_FHA_1	14	20	PF00498	0.352
LIG_FHA_1	185	191	PF00498	0.533
LIG_FHA_1	39	45	PF00498	0.610
LIG_FHA_1	94	100	PF00498	0.533
LIG_LIR_Nem_3	109	115	PF02991	0.570
LIG_LIR_Nem_3	168	173	PF02991	0.510
LIG_SH2_CRK	112	116	PF00017	0.533
LIG_SH2_CRK	173	177	PF00017	0.633
LIG_SH2_SRC	112	115	PF00017	0.570
LIG_SH3_1	158	164	PF00018	0.533
LIG_SH3_3	158	164	PF00018	0.533
LIG_WRC_WIRS_1	32	37	PF05994	0.533
MOD_CK2_1	135	141	PF00069	0.533
MOD_GlcNHglycan	137	140	PF01048	0.333
MOD_GlcNHglycan	150	153	PF01048	0.333
MOD_GlcNHglycan	200	204	PF01048	0.597
MOD_GSK3_1	204	211	PF00069	0.544
MOD_GSK3_1	39	46	PF00069	0.533
MOD_N-GLC_1	38	43	PF02516	0.333
MOD_N-GLC_1	68	73	PF02516	0.333
MOD_N-GLC_2	79	81	PF02516	0.433
MOD_NEK2_1	184	189	PF00069	0.533
MOD_PK_1	68	74	PF00069	0.533
MOD_PKA_1	198	204	PF00069	0.526
MOD_PKA_2	135	141	PF00069	0.563
MOD_PKA_2	184	190	PF00069	0.533
MOD_Plk_1	68	74	PF00069	0.533
MOD_Plk_2-3	43	49	PF00069	0.533
MOD_SUMO_rev_2	129	134	PF00179	0.553
TRG_ENDOCYTIC_2	112	115	PF00928	0.508
TRG_ENDOCYTIC_2	173	176	PF00928	0.533
TRG_ER_diArg_1	75	77	PF00400	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J1F6	Bodo saltans	84%	90%
A0A0S4J6H7	Bodo saltans	81%	67%