Elongation factor 1-alpha

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

elongation factor 1-alpha

Species:

Leishmania mexicana

UniProt:

E9ARD3_LEIMU

TriTrypDb:

LmxM.17.0083

Length:

208

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ARD3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARD3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003676	nucleic acid binding	3	6
GO:0003746	translation elongation factor activity	4	6
GO:0003824	catalytic activity	1	6
GO:0003924	GTPase activity	7	6
GO:0005488	binding	1	6
GO:0005525	GTP binding	5	6
GO:0008135	translation factor activity, RNA binding	3	6
GO:0016462	pyrophosphatase activity	5	6
GO:0016787	hydrolase activity	2	6
GO:0016817	hydrolase activity, acting on acid anhydrides	3	6
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	6
GO:0019001	guanyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032561	guanyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0045182	translation regulator activity	1	6
GO:0090079	translation regulator activity, nucleic acid binding	2	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.457
CLV_C14_Caspase3-7	203	207	PF00656	0.525
CLV_C14_Caspase3-7	88	92	PF00656	0.457
CLV_PCSK_KEX2_1	179	181	PF00082	0.380
CLV_PCSK_KEX2_1	36	38	PF00082	0.257
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.382
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.257
CLV_PCSK_SKI1_1	69	73	PF00082	0.257
CLV_PCSK_SKI1_1	84	88	PF00082	0.257
DOC_MAPK_gen_1	3	12	PF00069	0.277
DOC_MAPK_gen_1	64	73	PF00069	0.457
DOC_MAPK_MEF2A_6	3	12	PF00069	0.272
DOC_MAPK_MEF2A_6	67	75	PF00069	0.457
DOC_MAPK_NFAT4_5	5	13	PF00069	0.272
DOC_PP1_RVXF_1	185	191	PF00149	0.524
DOC_PP4_FxxP_1	80	83	PF00568	0.457
DOC_USP7_MATH_1	18	22	PF00917	0.457
DOC_USP7_UBL2_3	154	158	PF12436	0.511
DOC_USP7_UBL2_3	51	55	PF12436	0.457
DOC_WW_Pin1_4	79	84	PF00397	0.457
LIG_BIR_III_4	91	95	PF00653	0.457
LIG_FHA_1	140	146	PF00498	0.483
LIG_FHA_1	22	28	PF00498	0.457
LIG_FHA_1	70	76	PF00498	0.457
LIG_FHA_2	86	92	PF00498	0.457
LIG_LIR_Gen_1	165	174	PF02991	0.540
LIG_LIR_Gen_1	53	63	PF02991	0.457
LIG_LIR_Gen_1	85	93	PF02991	0.457
LIG_LIR_Nem_3	165	170	PF02991	0.540
LIG_LIR_Nem_3	53	59	PF02991	0.457
LIG_LIR_Nem_3	85	90	PF02991	0.457
LIG_Pex14_2	54	58	PF04695	0.457
LIG_SH2_NCK_1	167	171	PF00017	0.582
LIG_SH2_SRC	167	170	PF00017	0.511
LIG_SH2_STAP1	56	60	PF00017	0.457
LIG_SH2_STAT5	177	180	PF00017	0.540
LIG_SUMO_SIM_par_1	112	119	PF11976	0.457
MOD_CDK_SPK_2	79	84	PF00069	0.457
MOD_CK1_1	21	27	PF00069	0.457
MOD_CK1_1	82	88	PF00069	0.457
MOD_GlcNHglycan	173	177	PF01048	0.288
MOD_GlcNHglycan	193	196	PF01048	0.340
MOD_GSK3_1	168	175	PF00069	0.496
MOD_NEK2_1	115	120	PF00069	0.582
MOD_NEK2_1	139	144	PF00069	0.477
MOD_NEK2_2	50	55	PF00069	0.457
MOD_PIKK_1	104	110	PF00454	0.457
MOD_PKB_1	67	75	PF00069	0.457
MOD_Plk_1	156	162	PF00069	0.540
MOD_Plk_1	172	178	PF00069	0.540
MOD_Plk_2-3	35	41	PF00069	0.457
MOD_Plk_4	156	162	PF00069	0.499
MOD_Plk_4	82	88	PF00069	0.457
MOD_ProDKin_1	79	85	PF00069	0.457
MOD_SUMO_for_1	63	66	PF00179	0.457
TRG_DiLeu_BaEn_2	185	191	PF01217	0.524
TRG_ENDOCYTIC_2	167	170	PF00928	0.511
TRG_ENDOCYTIC_2	56	59	PF00928	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IXQ3	Bodo saltans	93%	100%
A0A0S4J1P6	Bodo saltans	88%	100%
A0A3R7NEG4	Trypanosoma rangeli	87%	100%
D0A1M8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	87%	100%
Q5FCW3	Ehrlichia ruminantium (strain Welgevonden)	37%	91%