RRM_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ARC7_LEIMU

TriTrypDb:

LmxM.17.0050

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ARC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARC7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.670
CLV_NRD_NRD_1	16	18	PF00675	0.686
CLV_NRD_NRD_1	222	224	PF00675	0.552
CLV_NRD_NRD_1	84	86	PF00675	0.482
CLV_NRD_NRD_1	93	95	PF00675	0.467
CLV_PCSK_KEX2_1	16	18	PF00082	0.601
CLV_PCSK_KEX2_1	222	224	PF00082	0.552
CLV_PCSK_KEX2_1	79	81	PF00082	0.438
CLV_PCSK_KEX2_1	83	85	PF00082	0.464
CLV_PCSK_KEX2_1	93	95	PF00082	0.424
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.499
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.404
CLV_PCSK_PC7_1	218	224	PF00082	0.579
CLV_PCSK_PC7_1	80	86	PF00082	0.567
CLV_PCSK_SKI1_1	206	210	PF00082	0.494
CLV_PCSK_SKI1_1	222	226	PF00082	0.369
CLV_PCSK_SKI1_1	54	58	PF00082	0.433
CLV_PCSK_SKI1_1	95	99	PF00082	0.476
DOC_CYCLIN_RxL_1	13	24	PF00134	0.559
DOC_CYCLIN_RxL_1	92	101	PF00134	0.503
DOC_CYCLIN_yCln2_LP_2	25	31	PF00134	0.509
DOC_MAPK_MEF2A_6	194	201	PF00069	0.546
DOC_PP1_RVXF_1	14	21	PF00149	0.545
DOC_PP2B_LxvP_1	25	28	PF13499	0.467
DOC_USP7_MATH_1	164	168	PF00917	0.589
DOC_USP7_MATH_1	174	178	PF00917	0.714
DOC_USP7_MATH_1	46	50	PF00917	0.462
DOC_USP7_UBL2_3	200	204	PF12436	0.490
DOC_WW_Pin1_4	103	108	PF00397	0.461
LIG_14-3-3_CanoR_1	17	23	PF00244	0.552
LIG_14-3-3_CanoR_1	227	232	PF00244	0.566
LIG_BIR_III_4	186	190	PF00653	0.644
LIG_BRCT_BRCA1_1	48	52	PF00533	0.533
LIG_deltaCOP1_diTrp_1	41	51	PF00928	0.431
LIG_FHA_1	133	139	PF00498	0.573
LIG_FHA_2	115	121	PF00498	0.477
LIG_FHA_2	124	130	PF00498	0.429
LIG_FHA_2	174	180	PF00498	0.769
LIG_LIR_Gen_1	108	118	PF02991	0.351
LIG_LIR_Gen_1	41	52	PF02991	0.435
LIG_LIR_LC3C_4	7	10	PF02991	0.592
LIG_LIR_Nem_3	108	113	PF02991	0.354
LIG_LIR_Nem_3	150	155	PF02991	0.521
LIG_LIR_Nem_3	41	47	PF02991	0.457
LIG_LIR_Nem_3	49	55	PF02991	0.473
LIG_PTB_Apo_2	31	38	PF02174	0.492
LIG_SH2_STAP1	40	44	PF00017	0.506
LIG_SH2_STAT3	40	43	PF00017	0.518
LIG_SUMO_SIM_anti_2	192	199	PF11976	0.419
LIG_WRC_WIRS_1	47	52	PF05994	0.527
MOD_CK2_1	114	120	PF00069	0.429
MOD_CK2_1	123	129	PF00069	0.431
MOD_CK2_1	173	179	PF00069	0.724
MOD_CK2_1	199	205	PF00069	0.509
MOD_Cter_Amidation	14	17	PF01082	0.606
MOD_GlcNHglycan	100	103	PF01048	0.607
MOD_GlcNHglycan	107	110	PF01048	0.511
MOD_GlcNHglycan	166	169	PF01048	0.660
MOD_GlcNHglycan	176	179	PF01048	0.744
MOD_GlcNHglycan	180	183	PF01048	0.573
MOD_GlcNHglycan	58	61	PF01048	0.510
MOD_GSK3_1	170	177	PF00069	0.770
MOD_N-GLC_1	114	119	PF02516	0.543
MOD_NEK2_1	18	23	PF00069	0.492
MOD_NEK2_1	199	204	PF00069	0.466
MOD_NEK2_1	214	219	PF00069	0.366
MOD_NEK2_1	56	61	PF00069	0.551
MOD_NEK2_1	98	103	PF00069	0.625
MOD_Plk_1	114	120	PF00069	0.480
MOD_Plk_1	86	92	PF00069	0.524
MOD_Plk_4	4	10	PF00069	0.592
MOD_Plk_4	46	52	PF00069	0.534
MOD_Plk_4	86	92	PF00069	0.544
MOD_ProDKin_1	103	109	PF00069	0.457
MOD_SUMO_rev_2	21	28	PF00179	0.539
TRG_DiLeu_BaEn_1	129	134	PF01217	0.542
TRG_DiLeu_BaLyEn_6	93	98	PF01217	0.468
TRG_ER_diArg_1	16	18	PF00400	0.686
TRG_ER_diArg_1	222	224	PF00400	0.552
TRG_ER_diArg_1	83	85	PF00400	0.491
TRG_ER_diArg_1	94	97	PF00400	0.440
TRG_NLS_Bipartite_1	79	98	PF00514	0.466
TRG_NLS_MonoCore_2	91	96	PF00514	0.502
TRG_NLS_MonoExtC_3	91	96	PF00514	0.462
TRG_NLS_MonoExtN_4	92	98	PF00514	0.494
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.621
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I083	Leptomonas seymouri	59%	95%
A0A1X0NT13	Trypanosomatidae	44%	94%
A0A3R7KLV2	Trypanosoma rangeli	44%	90%
A0A3S5H6Z6	Leishmania donovani	90%	98%
A4H8V1	Leishmania braziliensis	73%	100%
A4HX70	Leishmania infantum	90%	98%
C9ZTU2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
Q4QEJ3	Leishmania major	89%	100%