J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ARC6_LEIMU

TriTrypDb:

LmxM.17.0040

Length:

262

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9ARC6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARC6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	164	166	PF00675	0.426
CLV_NRD_NRD_1	219	221	PF00675	0.624
CLV_NRD_NRD_1	241	243	PF00675	0.633
CLV_NRD_NRD_1	56	58	PF00675	0.397
CLV_PCSK_KEX2_1	164	166	PF00082	0.413
CLV_PCSK_KEX2_1	221	223	PF00082	0.625
CLV_PCSK_KEX2_1	233	235	PF00082	0.606
CLV_PCSK_KEX2_1	241	243	PF00082	0.575
CLV_PCSK_KEX2_1	55	57	PF00082	0.389
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.629
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.550
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.425
CLV_PCSK_SKI1_1	153	157	PF00082	0.432
CLV_PCSK_SKI1_1	23	27	PF00082	0.480
CLV_PCSK_SKI1_1	241	245	PF00082	0.603
CLV_PCSK_SKI1_1	43	47	PF00082	0.236
DEG_Nend_UBRbox_3	1	3	PF02207	0.557
DOC_AGCK_PIF_1	172	177	PF00069	0.322
DOC_CYCLIN_RxL_1	101	111	PF00134	0.536
DOC_CYCLIN_RxL_1	150	159	PF00134	0.628
DOC_CYCLIN_RxL_1	40	50	PF00134	0.629
DOC_MAPK_gen_1	101	109	PF00069	0.442
DOC_MAPK_gen_1	160	171	PF00069	0.662
DOC_MAPK_MEF2A_6	55	62	PF00069	0.659
DOC_PP1_RVXF_1	239	246	PF00149	0.387
DOC_PP1_RVXF_1	72	79	PF00149	0.579
DOC_PP4_FxxP_1	202	205	PF00568	0.373
DOC_USP7_MATH_1	41	45	PF00917	0.561
DOC_WW_Pin1_4	145	150	PF00397	0.621
DOC_WW_Pin1_4	47	52	PF00397	0.560
DOC_WW_Pin1_4	81	86	PF00397	0.526
LIG_14-3-3_CanoR_1	103	108	PF00244	0.536
LIG_14-3-3_CanoR_1	170	176	PF00244	0.326
LIG_FHA_1	187	193	PF00498	0.386
LIG_FHA_1	67	73	PF00498	0.632
LIG_FHA_2	109	115	PF00498	0.455
LIG_FHA_2	117	123	PF00498	0.455
LIG_FHA_2	62	68	PF00498	0.600
LIG_LIR_Gen_1	122	132	PF02991	0.457
LIG_LIR_Gen_1	174	185	PF02991	0.293
LIG_LIR_Gen_1	206	212	PF02991	0.356
LIG_LIR_Gen_1	44	54	PF02991	0.568
LIG_LIR_Nem_3	122	128	PF02991	0.457
LIG_LIR_Nem_3	204	210	PF02991	0.340
LIG_LIR_Nem_3	44	49	PF02991	0.570
LIG_Pex14_2	203	207	PF04695	0.359
LIG_Pex14_2	245	249	PF04695	0.385
LIG_SH2_CRK	104	108	PF00017	0.536
LIG_SH2_CRK	125	129	PF00017	0.455
LIG_SH2_STAP1	177	181	PF00017	0.391
LIG_SUMO_SIM_par_1	188	193	PF11976	0.410
LIG_WRC_WIRS_1	172	177	PF05994	0.306
MOD_CK2_1	116	122	PF00069	0.496
MOD_CK2_1	61	67	PF00069	0.603
MOD_GSK3_1	108	115	PF00069	0.467
MOD_GSK3_1	116	123	PF00069	0.476
MOD_GSK3_1	186	193	PF00069	0.355
MOD_GSK3_1	41	48	PF00069	0.612
MOD_N-GLC_1	117	122	PF02516	0.262
MOD_NEK2_1	155	160	PF00069	0.566
MOD_NEK2_1	186	191	PF00069	0.414
MOD_NEK2_1	45	50	PF00069	0.561
MOD_NEK2_2	41	46	PF00069	0.623
MOD_PIKK_1	12	18	PF00454	0.518
MOD_PIKK_1	26	32	PF00454	0.497
MOD_PKB_1	101	109	PF00069	0.536
MOD_Plk_4	137	143	PF00069	0.505
MOD_Plk_4	186	192	PF00069	0.355
MOD_ProDKin_1	145	151	PF00069	0.616
MOD_ProDKin_1	47	53	PF00069	0.561
MOD_ProDKin_1	81	87	PF00069	0.532
MOD_SUMO_rev_2	215	223	PF00179	0.454
MOD_SUMO_rev_2	229	235	PF00179	0.317
TRG_DiLeu_BaEn_2	205	211	PF01217	0.357
TRG_DiLeu_BaLyEn_6	239	244	PF01217	0.387
TRG_ENDOCYTIC_2	104	107	PF00928	0.442
TRG_ENDOCYTIC_2	125	128	PF00928	0.442
TRG_ENDOCYTIC_2	177	180	PF00928	0.279
TRG_ENDOCYTIC_2	208	211	PF00928	0.340
TRG_ER_diArg_1	100	103	PF00400	0.442
TRG_ER_diArg_1	163	165	PF00400	0.638
TRG_ER_diArg_1	168	171	PF00400	0.614
TRG_ER_diArg_1	240	242	PF00400	0.462
TRG_ER_diArg_1	56	58	PF00400	0.577
TRG_NLS_MonoExtC_3	159	164	PF00514	0.537
TRG_NLS_MonoExtN_4	160	165	PF00514	0.539
TRG_Pf-PMV_PEXEL_1	105	110	PF00026	0.255

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P361	Leptomonas seymouri	73%	100%
A0A0S4J092	Bodo saltans	47%	80%
A0A1X0NT05	Trypanosomatidae	62%	96%
A0A3Q8IJ96	Leishmania donovani	93%	100%
A0A3R7LVM9	Trypanosoma rangeli	58%	98%
A4H8V0	Leishmania braziliensis	84%	100%
A4HX69	Leishmania infantum	93%	100%
C9ZTU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	92%
Q4QEJ4	Leishmania major	92%	100%