LeishMANIAdb
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RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
RING-type domain-containing protein
Gene product:
Ring finger domain containing protein, putative
Species:
Leishmania mexicana
UniProt:
E9ARC5_LEIMU
TriTrypDb:
LmxM.17.0030
Length:
188

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ARC5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARC5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 117 119 PF00675 0.520
CLV_NRD_NRD_1 170 172 PF00675 0.572
CLV_PCSK_FUR_1 115 119 PF00082 0.558
CLV_PCSK_KEX2_1 115 117 PF00082 0.517
CLV_PCSK_SKI1_1 134 138 PF00082 0.651
DEG_Nend_UBRbox_3 1 3 PF02207 0.550
DOC_CYCLIN_yCln2_LP_2 66 72 PF00134 0.376
DOC_MAPK_gen_1 115 122 PF00069 0.600
DOC_PP2B_LxvP_1 122 125 PF13499 0.650
DOC_USP7_MATH_1 12 16 PF00917 0.638
DOC_USP7_MATH_1 125 129 PF00917 0.533
DOC_USP7_MATH_1 20 24 PF00917 0.543
DOC_USP7_MATH_1 26 30 PF00917 0.609
LIG_14-3-3_CanoR_1 107 114 PF00244 0.596
LIG_14-3-3_CanoR_1 88 94 PF00244 0.430
LIG_FHA_1 137 143 PF00498 0.642
LIG_FHA_1 44 50 PF00498 0.539
LIG_FHA_1 54 60 PF00498 0.376
LIG_Rb_LxCxE_1 76 92 PF01857 0.430
LIG_SH2_GRB2like 34 37 PF00017 0.710
LIG_SH2_STAT5 34 37 PF00017 0.710
LIG_SUMO_SIM_anti_2 160 167 PF11976 0.760
LIG_SUMO_SIM_par_1 164 170 PF11976 0.662
MOD_CK1_1 15 21 PF00069 0.653
MOD_CK1_1 29 35 PF00069 0.687
MOD_CK2_1 125 131 PF00069 0.460
MOD_GlcNHglycan 125 128 PF01048 0.734
MOD_GSK3_1 125 132 PF00069 0.749
MOD_GSK3_1 20 27 PF00069 0.648
MOD_N-GLC_1 29 34 PF02516 0.674
MOD_NEK2_1 137 142 PF00069 0.501
MOD_PKA_2 89 95 PF00069 0.376
MOD_Plk_1 36 42 PF00069 0.616
MOD_Plk_2-3 154 160 PF00069 0.761
MOD_Plk_2-3 43 49 PF00069 0.676
MOD_Plk_2-3 62 68 PF00069 0.187
MOD_Plk_4 36 42 PF00069 0.678
MOD_SUMO_for_1 73 76 PF00179 0.430
TRG_DiLeu_BaEn_1 133 138 PF01217 0.681
TRG_ER_diArg_1 114 117 PF00400 0.514
TRG_ER_diArg_1 87 90 PF00400 0.376

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2S1 Leptomonas seymouri 57% 99%
A0A3S7WU93 Leishmania donovani 92% 89%
A4H8U9 Leishmania braziliensis 76% 100%
A4HX68 Leishmania infantum 92% 89%
Q4QEJ5 Leishmania major 85% 100%
V5ASR6 Trypanosoma cruzi 41% 95%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS