Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ARC1_LEIMU

TriTrypDb:

LmxM.17.1470

Length:

292

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9ARC1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARC1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.539
CLV_C14_Caspase3-7	265	269	PF00656	0.677
CLV_NRD_NRD_1	36	38	PF00675	0.383
CLV_PCSK_SKI1_1	10	14	PF00082	0.357
CLV_PCSK_SKI1_1	117	121	PF00082	0.577
CLV_PCSK_SKI1_1	122	126	PF00082	0.606
CLV_PCSK_SKI1_1	228	232	PF00082	0.495
DEG_SPOP_SBC_1	47	51	PF00917	0.204
DOC_MAPK_gen_1	37	45	PF00069	0.426
DOC_MAPK_MEF2A_6	10	17	PF00069	0.531
DOC_USP7_MATH_1	136	140	PF00917	0.737
DOC_USP7_MATH_1	154	158	PF00917	0.712
DOC_USP7_MATH_1	46	50	PF00917	0.204
DOC_USP7_UBL2_3	149	153	PF12436	0.750
DOC_WW_Pin1_4	122	127	PF00397	0.747
DOC_WW_Pin1_4	144	149	PF00397	0.706
DOC_WW_Pin1_4	198	203	PF00397	0.779
DOC_WW_Pin1_4	22	27	PF00397	0.562
DOC_WW_Pin1_4	242	247	PF00397	0.704
DOC_WW_Pin1_4	48	53	PF00397	0.246
LIG_14-3-3_CanoR_1	10	16	PF00244	0.529
LIG_14-3-3_CanoR_1	106	116	PF00244	0.708
LIG_14-3-3_CanoR_1	135	144	PF00244	0.718
LIG_14-3-3_CanoR_1	241	246	PF00244	0.635
LIG_14-3-3_CanoR_1	37	45	PF00244	0.396
LIG_14-3-3_CanoR_1	48	52	PF00244	0.189
LIG_Clathr_ClatBox_1	57	61	PF01394	0.324
LIG_FHA_1	153	159	PF00498	0.586
LIG_FHA_1	38	44	PF00498	0.552
LIG_FHA_2	165	171	PF00498	0.653
LIG_FHA_2	178	184	PF00498	0.633
LIG_LIR_Gen_1	61	71	PF02991	0.492
LIG_LIR_Gen_1	75	84	PF02991	0.361
LIG_LIR_Nem_3	61	66	PF02991	0.495
LIG_LIR_Nem_3	7	12	PF02991	0.529
LIG_LIR_Nem_3	75	79	PF02991	0.452
LIG_SH2_NCK_1	76	80	PF00017	0.390
LIG_SH2_SRC	76	79	PF00017	0.452
LIG_SH2_STAP1	76	80	PF00017	0.449
LIG_SH3_3	124	130	PF00018	0.707
LIG_SH3_3	199	205	PF00018	0.779
LIG_SH3_3	207	213	PF00018	0.806
LIG_SH3_3	23	29	PF00018	0.568
LIG_SH3_3	62	68	PF00018	0.541
LIG_SUMO_SIM_par_1	154	160	PF11976	0.569
LIG_SUMO_SIM_par_1	67	72	PF11976	0.349
LIG_TRAF2_1	196	199	PF00917	0.776
MOD_CDK_SPK_2	144	149	PF00069	0.595
MOD_CDK_SPxxK_3	122	129	PF00069	0.749
MOD_CK1_1	128	134	PF00069	0.758
MOD_CK1_1	157	163	PF00069	0.555
MOD_CK2_1	281	287	PF00069	0.624
MOD_DYRK1A_RPxSP_1	48	52	PF00069	0.204
MOD_GlcNHglycan	138	141	PF01048	0.596
MOD_GlcNHglycan	283	286	PF01048	0.483
MOD_GSK3_1	11	18	PF00069	0.531
MOD_GSK3_1	215	222	PF00069	0.809
MOD_NEK2_1	11	16	PF00069	0.529
MOD_NEK2_1	17	22	PF00069	0.537
MOD_NEK2_1	187	192	PF00069	0.745
MOD_NEK2_1	281	286	PF00069	0.663
MOD_PKA_1	37	43	PF00069	0.614
MOD_PKA_2	105	111	PF00069	0.674
MOD_PKA_2	134	140	PF00069	0.604
MOD_PKA_2	47	53	PF00069	0.204
MOD_Plk_1	164	170	PF00069	0.650
MOD_Plk_2-3	177	183	PF00069	0.593
MOD_Plk_2-3	67	73	PF00069	0.325
MOD_Plk_4	177	183	PF00069	0.640
MOD_Plk_4	190	196	PF00069	0.668
MOD_ProDKin_1	122	128	PF00069	0.748
MOD_ProDKin_1	144	150	PF00069	0.705
MOD_ProDKin_1	198	204	PF00069	0.780
MOD_ProDKin_1	22	28	PF00069	0.563
MOD_ProDKin_1	242	248	PF00069	0.706
MOD_ProDKin_1	48	54	PF00069	0.246
MOD_SUMO_rev_2	250	258	PF00179	0.631
TRG_DiLeu_BaEn_1	177	182	PF01217	0.641
TRG_DiLeu_BaEn_1	272	277	PF01217	0.718
TRG_DiLeu_BaEn_4	272	278	PF01217	0.718
TRG_ENDOCYTIC_2	76	79	PF00928	0.507
TRG_NES_CRM1_1	224	236	PF08389	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HR49	Leptomonas seymouri	41%	100%
A0A3Q8IE41	Leishmania donovani	78%	100%
A4H9A5	Leishmania braziliensis	63%	100%
A4HTR3	Leishmania infantum	79%	100%
A4HXM5	Leishmania infantum	78%	100%
C9ZUK7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
Q4QBZ4	Leishmania major	78%	100%
Q4QE42	Leishmania major	79%	100%