Rab-GAP TBC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rab-GTPase-TBC domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ARB9_LEIMU

TriTrypDb:

LmxM.17.1450

Length:

486

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ARB9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARB9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0003924	GTPase activity	7	2
GO:0003925	G protein activity	2	2
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2
GO:0098772	molecular function regulator activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.716
CLV_C14_Caspase3-7	122	126	PF00656	0.670
CLV_C14_Caspase3-7	252	256	PF00656	0.291
CLV_NRD_NRD_1	248	250	PF00675	0.393
CLV_NRD_NRD_1	78	80	PF00675	0.493
CLV_NRD_NRD_1	88	90	PF00675	0.550
CLV_PCSK_KEX2_1	248	250	PF00082	0.393
CLV_PCSK_KEX2_1	78	80	PF00082	0.493
CLV_PCSK_SKI1_1	14	18	PF00082	0.504
CLV_PCSK_SKI1_1	284	288	PF00082	0.322
CLV_PCSK_SKI1_1	315	319	PF00082	0.300
CLV_PCSK_SKI1_1	368	372	PF00082	0.377
CLV_PCSK_SKI1_1	409	413	PF00082	0.416
CLV_PCSK_SKI1_1	477	481	PF00082	0.389
CLV_PCSK_SKI1_1	93	97	PF00082	0.693
DEG_MDM2_SWIB_1	38	46	PF02201	0.348
DEG_Nend_UBRbox_3	1	3	PF02207	0.499
DEG_ODPH_VHL_1	132	144	PF01847	0.451
DEG_SPOP_SBC_1	119	123	PF00917	0.688
DOC_CDC14_PxL_1	419	427	PF14671	0.344
DOC_CKS1_1	345	350	PF01111	0.387
DOC_CYCLIN_yClb1_LxF_4	1	7	PF00134	0.481
DOC_MAPK_gen_1	281	290	PF00069	0.373
DOC_MAPK_gen_1	409	419	PF00069	0.459
DOC_MAPK_gen_1	474	481	PF00069	0.398
DOC_MAPK_gen_1	89	97	PF00069	0.716
DOC_MAPK_MEF2A_6	281	290	PF00069	0.174
DOC_PP1_RVXF_1	157	163	PF00149	0.300
DOC_PP1_RVXF_1	313	319	PF00149	0.300
DOC_PP1_RVXF_1	91	98	PF00149	0.659
DOC_PP2B_LxvP_1	49	52	PF13499	0.389
DOC_PP4_FxxP_1	27	30	PF00568	0.448
DOC_PP4_FxxP_1	449	452	PF00568	0.356
DOC_USP7_MATH_1	109	113	PF00917	0.714
DOC_USP7_MATH_1	135	139	PF00917	0.581
DOC_USP7_MATH_1	222	226	PF00917	0.421
DOC_WW_Pin1_4	107	112	PF00397	0.668
DOC_WW_Pin1_4	344	349	PF00397	0.386
DOC_WW_Pin1_4	402	407	PF00397	0.510
DOC_WW_Pin1_4	84	89	PF00397	0.647
LIG_14-3-3_CanoR_1	14	21	PF00244	0.509
LIG_14-3-3_CanoR_1	150	154	PF00244	0.306
LIG_14-3-3_CanoR_1	159	163	PF00244	0.280
LIG_14-3-3_CanoR_1	248	258	PF00244	0.369
LIG_14-3-3_CanoR_1	329	335	PF00244	0.291
LIG_Actin_WH2_2	458	476	PF00022	0.554
LIG_Actin_WH2_2	6	24	PF00022	0.248
LIG_APCC_ABBA_1	164	169	PF00400	0.342
LIG_BIR_III_2	106	110	PF00653	0.578
LIG_BIR_III_4	374	378	PF00653	0.389
LIG_BRCT_BRCA1_1	224	228	PF00533	0.427
LIG_Clathr_ClatBox_1	287	291	PF01394	0.257
LIG_deltaCOP1_diTrp_1	67	73	PF00928	0.508
LIG_FHA_1	15	21	PF00498	0.508
LIG_FHA_1	386	392	PF00498	0.412
LIG_FHA_1	46	52	PF00498	0.427
LIG_FHA_1	89	95	PF00498	0.556
LIG_FHA_2	120	126	PF00498	0.586
LIG_FHA_2	173	179	PF00498	0.428
LIG_LIR_Apic_2	161	165	PF02991	0.291
LIG_LIR_Apic_2	24	30	PF02991	0.425
LIG_LIR_Gen_1	230	240	PF02991	0.322
LIG_LIR_Gen_1	337	344	PF02991	0.367
LIG_LIR_Gen_1	39	50	PF02991	0.402
LIG_LIR_Nem_3	225	231	PF02991	0.326
LIG_LIR_Nem_3	3	9	PF02991	0.431
LIG_LIR_Nem_3	337	342	PF02991	0.354
LIG_LIR_Nem_3	39	45	PF02991	0.319
LIG_NRBOX	293	299	PF00104	0.427
LIG_PCNA_yPIPBox_3	289	302	PF02747	0.334
LIG_Pex14_1	331	335	PF04695	0.443
LIG_Pex14_1	40	44	PF04695	0.441
LIG_Pex14_2	228	232	PF04695	0.427
LIG_Pex14_2	318	322	PF04695	0.352
LIG_Pex14_2	38	42	PF04695	0.349
LIG_PTB_Apo_2	185	192	PF02174	0.443
LIG_PTB_Phospho_1	185	191	PF10480	0.334
LIG_SH2_NCK_1	183	187	PF00017	0.238
LIG_SH2_PTP2	339	342	PF00017	0.360
LIG_SH2_STAP1	140	144	PF00017	0.300
LIG_SH2_STAP1	396	400	PF00017	0.489
LIG_SH2_STAP1	466	470	PF00017	0.388
LIG_SH2_STAT3	140	143	PF00017	0.492
LIG_SH2_STAT5	309	312	PF00017	0.312
LIG_SH2_STAT5	339	342	PF00017	0.453
LIG_SH2_STAT5	358	361	PF00017	0.435
LIG_SH3_1	420	426	PF00018	0.498
LIG_SH3_3	128	134	PF00018	0.529
LIG_SH3_3	420	426	PF00018	0.512
LIG_TRAF2_1	455	458	PF00917	0.475
LIG_TRAF2_2	387	392	PF00917	0.254
LIG_TYR_ITIM	181	186	PF00017	0.450
LIG_TYR_ITIM	234	239	PF00017	0.446
LIG_UBA3_1	246	254	PF00899	0.174
MOD_CDC14_SPxK_1	87	90	PF00782	0.531
MOD_CDK_SPK_2	84	89	PF00069	0.554
MOD_CDK_SPxK_1	84	90	PF00069	0.558
MOD_CDK_SPxxK_3	402	409	PF00069	0.552
MOD_CK1_1	101	107	PF00069	0.621
MOD_CK1_1	118	124	PF00069	0.530
MOD_CK1_1	136	142	PF00069	0.546
MOD_CK1_1	158	164	PF00069	0.312
MOD_CK1_1	405	411	PF00069	0.567
MOD_CK2_1	181	187	PF00069	0.403
MOD_CK2_1	398	404	PF00069	0.343
MOD_CK2_1	80	86	PF00069	0.608
MOD_CK2_1	99	105	PF00069	0.653
MOD_Cter_Amidation	76	79	PF01082	0.539
MOD_GlcNHglycan	111	114	PF01048	0.733
MOD_GlcNHglycan	117	120	PF01048	0.747
MOD_GlcNHglycan	122	125	PF01048	0.587
MOD_GlcNHglycan	224	227	PF01048	0.485
MOD_GlcNHglycan	271	275	PF01048	0.429
MOD_GlcNHglycan	276	279	PF01048	0.410
MOD_GSK3_1	115	122	PF00069	0.486
MOD_GSK3_1	270	277	PF00069	0.306
MOD_GSK3_1	398	405	PF00069	0.550
MOD_GSK3_1	80	87	PF00069	0.655
MOD_GSK3_1	97	104	PF00069	0.641
MOD_N-GLC_1	351	356	PF02516	0.358
MOD_NEK2_1	181	186	PF00069	0.488
MOD_NEK2_1	351	356	PF00069	0.344
MOD_NEK2_1	45	50	PF00069	0.423
MOD_NEK2_1	80	85	PF00069	0.580
MOD_NEK2_1	97	102	PF00069	0.681
MOD_NEK2_2	427	432	PF00069	0.606
MOD_PIKK_1	385	391	PF00454	0.435
MOD_PKA_2	149	155	PF00069	0.321
MOD_PKA_2	158	164	PF00069	0.321
MOD_PKA_2	21	27	PF00069	0.435
MOD_PKA_2	88	94	PF00069	0.600
MOD_Plk_1	136	142	PF00069	0.561
MOD_Plk_1	155	161	PF00069	0.453
MOD_Plk_1	2	8	PF00069	0.450
MOD_Plk_1	351	357	PF00069	0.335
MOD_Plk_1	427	433	PF00069	0.566
MOD_Plk_1	80	86	PF00069	0.577
MOD_Plk_2-3	369	375	PF00069	0.364
MOD_Plk_2-3	99	105	PF00069	0.719
MOD_Plk_4	181	187	PF00069	0.408
MOD_Plk_4	2	8	PF00069	0.419
MOD_Plk_4	303	309	PF00069	0.298
MOD_Plk_4	330	336	PF00069	0.407
MOD_ProDKin_1	107	113	PF00069	0.666
MOD_ProDKin_1	344	350	PF00069	0.387
MOD_ProDKin_1	402	408	PF00069	0.506
MOD_ProDKin_1	84	90	PF00069	0.652
MOD_SUMO_rev_2	343	348	PF00179	0.305
MOD_SUMO_rev_2	54	59	PF00179	0.464
TRG_DiLeu_BaEn_1	230	235	PF01217	0.291
TRG_DiLeu_BaEn_2	196	202	PF01217	0.300
TRG_DiLeu_BaLyEn_6	312	317	PF01217	0.285
TRG_ENDOCYTIC_2	183	186	PF00928	0.476
TRG_ENDOCYTIC_2	236	239	PF00928	0.365
TRG_ENDOCYTIC_2	244	247	PF00928	0.315
TRG_ENDOCYTIC_2	339	342	PF00928	0.360
TRG_ER_diArg_1	247	249	PF00400	0.427
TRG_ER_diArg_1	78	80	PF00400	0.505
TRG_NES_CRM1_1	362	374	PF08389	0.386
TRG_Pf-PMV_PEXEL_1	14	19	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	78	82	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P848	Leptomonas seymouri	57%	100%
A0A0S4IV10	Bodo saltans	27%	84%
A0A1X0NSL3	Trypanosomatidae	32%	92%
A0A3S7WUR8	Leishmania donovani	91%	100%
A0A3S7X3S6	Leishmania donovani	25%	100%
A0A422NB36	Trypanosoma rangeli	34%	99%
A4H9A3	Leishmania braziliensis	79%	100%
A4HXM3	Leishmania infantum	91%	100%
A4I5W2	Leishmania infantum	25%	100%
C9ZPB8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	90%
Q4QE44	Leishmania major	88%	100%
V5BEU9	Trypanosoma cruzi	32%	97%