Ion_trans domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ion transport protein, putative

Species:

Leishmania mexicana

UniProt:

E9ARB8_LEIMU

TriTrypDb:

LmxM.17.1440

Length:

1414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	1
GO:0005891	voltage-gated calcium channel complex	4	1
GO:0016020	membrane	2	6
GO:0032991	protein-containing complex	1	1
GO:0034702	monoatomic ion channel complex	4	1
GO:0034703	cation channel complex	5	1
GO:0034704	calcium channel complex	6	1
GO:0098796	membrane protein complex	2	1
GO:0098797	plasma membrane protein complex	3	1
GO:0110165	cellular anatomical entity	1	6

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Expansion

Sequence features

E9ARB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006816	calcium ion transport	7	1
GO:0009987	cellular process	1	1
GO:0030001	metal ion transport	6	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	7
GO:0005216	monoatomic ion channel activity	4	7
GO:0005244	voltage-gated monoatomic ion channel activity	4	1
GO:0005245	voltage-gated calcium channel activity	6	1
GO:0005261	monoatomic cation channel activity	5	2
GO:0005262	calcium channel activity	6	1
GO:0008324	monoatomic cation transmembrane transporter activity	4	2
GO:0008331	high voltage-gated calcium channel activity	7	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	7
GO:0015085	calcium ion transmembrane transporter activity	6	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1256	1260	PF00656	0.516
CLV_C14_Caspase3-7	320	324	PF00656	0.433
CLV_C14_Caspase3-7	575	579	PF00656	0.397
CLV_NRD_NRD_1	1135	1137	PF00675	0.366
CLV_NRD_NRD_1	114	116	PF00675	0.416
CLV_NRD_NRD_1	1227	1229	PF00675	0.291
CLV_NRD_NRD_1	1299	1301	PF00675	0.275
CLV_NRD_NRD_1	1318	1320	PF00675	0.269
CLV_NRD_NRD_1	203	205	PF00675	0.310
CLV_NRD_NRD_1	247	249	PF00675	0.442

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7S1	Leptomonas seymouri	51%	91%
A0A1X0NSN2	Trypanosomatidae	29%	89%
A0A3Q8IAU1	Leishmania donovani	85%	99%
A4HXM2	Leishmania infantum	86%	99%
C9D7C2	Apis mellifera	24%	74%
D0E0C2	Periplaneta americana	21%	91%
O57483	Lithobates catesbeianus	22%	84%
P07293	Oryctolagus cuniculus	21%	75%
Q01815	Mus musculus	21%	66%
Q02485	Rattus norvegicus	22%	76%

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