LeishMANIAdb
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MFS domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MFS domain-containing protein
Gene product:
major facilitator superfamily, putative
Species:
Leishmania mexicana
UniProt:
E9ARB7_LEIMU
TriTrypDb:
LmxM.17.1430
Length:
483

Annotations

LeishMANIAdb annotations

An MFS-superfamily protein homologous to human FLVCR2 hem transporter. Only duplicated extensively in Strigomonas

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

E9ARB7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARB7

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 8
GO:0022857 transmembrane transporter activity 2 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 27 31 PF00656 0.729
CLV_NRD_NRD_1 225 227 PF00675 0.585
CLV_NRD_NRD_1 474 476 PF00675 0.463
CLV_PCSK_KEX2_1 474 476 PF00082 0.419
CLV_PCSK_SKI1_1 273 277 PF00082 0.302
DEG_Nend_Nbox_1 1 3 PF02207 0.780
DOC_CDC14_PxL_1 108 116 PF14671 0.190
DOC_CDC14_PxL_1 175 183 PF14671 0.354
DOC_CDC14_PxL_1 383 391 PF14671 0.479
DOC_CYCLIN_yCln2_LP_2 109 115 PF00134 0.408
DOC_CYCLIN_yCln2_LP_2 308 314 PF00134 0.283
DOC_CYCLIN_yCln2_LP_2 392 398 PF00134 0.438
DOC_PP2B_LxvP_1 109 112 PF13499 0.408
DOC_PP2B_LxvP_1 176 179 PF13499 0.354
DOC_PP2B_LxvP_1 392 395 PF13499 0.438
DOC_PP4_FxxP_1 212 215 PF00568 0.356
DOC_SPAK_OSR1_1 65 69 PF12202 0.585
DOC_USP7_MATH_1 143 147 PF00917 0.479
DOC_USP7_UBL2_3 476 480 PF12436 0.655
DOC_WW_Pin1_4 211 216 PF00397 0.408
DOC_WW_Pin1_4 369 374 PF00397 0.293
DOC_WW_Pin1_4 59 64 PF00397 0.661
LIG_14-3-3_CanoR_1 192 202 PF00244 0.496
LIG_14-3-3_CanoR_1 258 267 PF00244 0.595
LIG_Actin_WH2_2 134 151 PF00022 0.389
LIG_BRCT_BRCA1_1 422 426 PF00533 0.408
LIG_CSL_BTD_1 185 188 PF09270 0.534
LIG_EH1_1 238 246 PF00400 0.190
LIG_eIF4E_1 383 389 PF01652 0.313
LIG_FHA_1 357 363 PF00498 0.389
LIG_FHA_1 370 376 PF00498 0.253
LIG_FHA_1 379 385 PF00498 0.335
LIG_FHA_1 416 422 PF00498 0.499
LIG_FHA_1 453 459 PF00498 0.395
LIG_FHA_2 223 229 PF00498 0.324
LIG_FHA_2 260 266 PF00498 0.506
LIG_FHA_2 337 343 PF00498 0.417
LIG_GBD_Chelix_1 242 250 PF00786 0.479
LIG_GBD_Chelix_1 301 309 PF00786 0.408
LIG_GBD_Chelix_1 399 407 PF00786 0.408
LIG_LIR_Apic_2 264 270 PF02991 0.534
LIG_LIR_Apic_2 406 412 PF02991 0.496
LIG_LIR_Gen_1 214 221 PF02991 0.275
LIG_LIR_Gen_1 24 31 PF02991 0.571
LIG_LIR_Gen_1 277 287 PF02991 0.543
LIG_LIR_Gen_1 295 305 PF02991 0.244
LIG_LIR_Gen_1 381 391 PF02991 0.346
LIG_LIR_Gen_1 423 434 PF02991 0.413
LIG_LIR_Gen_1 447 458 PF02991 0.395
LIG_LIR_Nem_3 214 219 PF02991 0.217
LIG_LIR_Nem_3 24 28 PF02991 0.689
LIG_LIR_Nem_3 277 282 PF02991 0.543
LIG_LIR_Nem_3 288 294 PF02991 0.348
LIG_LIR_Nem_3 295 301 PF02991 0.244
LIG_LIR_Nem_3 344 349 PF02991 0.574
LIG_LIR_Nem_3 381 386 PF02991 0.429
LIG_LIR_Nem_3 423 429 PF02991 0.408
LIG_LIR_Nem_3 446 452 PF02991 0.336
LIG_LIR_Nem_3 462 466 PF02991 0.398
LIG_LIR_Nem_3 61 67 PF02991 0.529
LIG_LIR_Nem_3 73 78 PF02991 0.321
LIG_LIR_Nem_3 93 99 PF02991 0.318
LIG_LYPXL_yS_3 158 161 PF13949 0.324
LIG_NRBOX 105 111 PF00104 0.479
LIG_NRBOX 241 247 PF00104 0.476
LIG_NRBOX 304 310 PF00104 0.283
LIG_PDZ_Class_1 478 483 PF00595 0.528
LIG_Pex14_1 154 158 PF04695 0.296
LIG_Pex14_2 150 154 PF04695 0.252
LIG_Pex14_2 463 467 PF04695 0.241
LIG_REV1ctd_RIR_1 465 474 PF16727 0.556
LIG_SH2_CRK 126 130 PF00017 0.539
LIG_SH2_CRK 133 137 PF00017 0.376
LIG_SH2_CRK 267 271 PF00017 0.515
LIG_SH2_CRK 349 353 PF00017 0.355
LIG_SH2_NCK_1 126 130 PF00017 0.523
LIG_SH2_PTP2 383 386 PF00017 0.408
LIG_SH2_PTP2 450 453 PF00017 0.417
LIG_SH2_STAT5 115 118 PF00017 0.354
LIG_SH2_STAT5 216 219 PF00017 0.179
LIG_SH2_STAT5 349 352 PF00017 0.354
LIG_SH2_STAT5 383 386 PF00017 0.408
LIG_SH2_STAT5 450 453 PF00017 0.393
LIG_SH2_STAT5 83 86 PF00017 0.389
LIG_SH2_STAT5 96 99 PF00017 0.255
LIG_SH3_3 14 20 PF00018 0.727
LIG_SH3_3 150 156 PF00018 0.356
LIG_SH3_3 392 398 PF00018 0.393
LIG_SUMO_SIM_anti_2 240 246 PF11976 0.408
LIG_SUMO_SIM_anti_2 358 365 PF11976 0.434
LIG_SUMO_SIM_par_1 244 249 PF11976 0.361
LIG_SUMO_SIM_par_1 416 423 PF11976 0.537
LIG_SUMO_SIM_par_1 450 455 PF11976 0.417
LIG_SUMO_SIM_par_1 67 73 PF11976 0.190
LIG_TRFH_1 383 387 PF08558 0.393
LIG_TYR_ITIM 131 136 PF00017 0.523
LIG_TYR_ITSM 379 386 PF00017 0.179
LIG_UBA3_1 246 254 PF00899 0.479
LIG_UBA3_1 271 276 PF00899 0.585
LIG_UBA3_1 434 442 PF00899 0.253
LIG_WRC_WIRS_1 22 27 PF05994 0.576
LIG_WRC_WIRS_1 337 342 PF05994 0.417
LIG_WRC_WIRS_1 379 384 PF05994 0.179
LIG_WRC_WIRS_1 426 431 PF05994 0.408
LIG_WRC_WIRS_1 453 458 PF05994 0.456
MOD_CDK_SPxK_1 59 65 PF00069 0.602
MOD_CK1_1 232 238 PF00069 0.417
MOD_CK1_1 24 30 PF00069 0.765
MOD_CK1_1 260 266 PF00069 0.502
MOD_CK1_1 459 465 PF00069 0.406
MOD_CK2_1 222 228 PF00069 0.324
MOD_CK2_1 259 265 PF00069 0.534
MOD_CK2_1 41 47 PF00069 0.665
MOD_CK2_1 97 103 PF00069 0.341
MOD_GlcNHglycan 318 321 PF01048 0.499
MOD_GlcNHglycan 4 7 PF01048 0.485
MOD_GlcNHglycan 458 461 PF01048 0.406
MOD_GlcNHglycan 72 75 PF01048 0.267
MOD_GlcNHglycan 99 102 PF01048 0.541
MOD_GSK3_1 193 200 PF00069 0.370
MOD_GSK3_1 257 264 PF00069 0.496
MOD_GSK3_1 292 299 PF00069 0.426
MOD_GSK3_1 312 319 PF00069 0.150
MOD_GSK3_1 411 418 PF00069 0.556
MOD_GSK3_1 441 448 PF00069 0.378
MOD_GSK3_1 452 459 PF00069 0.398
MOD_NEK2_1 174 179 PF00069 0.386
MOD_NEK2_1 2 7 PF00069 0.691
MOD_NEK2_1 237 242 PF00069 0.426
MOD_NEK2_1 246 251 PF00069 0.443
MOD_NEK2_1 274 279 PF00069 0.561
MOD_NEK2_1 336 341 PF00069 0.363
MOD_NEK2_1 34 39 PF00069 0.722
MOD_NEK2_1 445 450 PF00069 0.366
MOD_NEK2_1 452 457 PF00069 0.390
MOD_NEK2_1 97 102 PF00069 0.351
MOD_PIKK_1 232 238 PF00454 0.437
MOD_PIKK_1 274 280 PF00454 0.583
MOD_PIKK_1 90 96 PF00454 0.394
MOD_PKA_2 257 263 PF00069 0.585
MOD_PKA_2 90 96 PF00069 0.385
MOD_Plk_1 190 196 PF00069 0.534
MOD_Plk_1 341 347 PF00069 0.585
MOD_Plk_1 405 411 PF00069 0.514
MOD_Plk_1 445 451 PF00069 0.334
MOD_Plk_2-3 41 47 PF00069 0.707
MOD_Plk_2-3 441 447 PF00069 0.437
MOD_Plk_4 143 149 PF00069 0.479
MOD_Plk_4 197 203 PF00069 0.476
MOD_Plk_4 336 342 PF00069 0.376
MOD_Plk_4 347 353 PF00069 0.466
MOD_Plk_4 415 421 PF00069 0.524
MOD_Plk_4 445 451 PF00069 0.380
MOD_ProDKin_1 211 217 PF00069 0.408
MOD_ProDKin_1 369 375 PF00069 0.293
MOD_ProDKin_1 59 65 PF00069 0.654
MOD_SUMO_rev_2 24 34 PF00179 0.657
MOD_SUMO_rev_2 310 319 PF00179 0.385
TRG_DiLeu_BaEn_1 103 108 PF01217 0.389
TRG_DiLeu_BaLyEn_6 156 161 PF01217 0.324
TRG_DiLeu_BaLyEn_6 177 182 PF01217 0.408
TRG_DiLeu_BaLyEn_6 267 272 PF01217 0.585
TRG_DiLeu_BaLyEn_6 384 389 PF01217 0.252
TRG_ENDOCYTIC_2 126 129 PF00928 0.523
TRG_ENDOCYTIC_2 133 136 PF00928 0.398
TRG_ENDOCYTIC_2 158 161 PF00928 0.337
TRG_ENDOCYTIC_2 216 219 PF00928 0.179
TRG_ENDOCYTIC_2 349 352 PF00928 0.355
TRG_ENDOCYTIC_2 383 386 PF00928 0.408
TRG_ENDOCYTIC_2 450 453 PF00928 0.393
TRG_ENDOCYTIC_2 83 86 PF00928 0.389
TRG_ENDOCYTIC_2 96 99 PF00928 0.284
TRG_ER_diArg_1 473 475 PF00400 0.610
TRG_Pf-PMV_PEXEL_1 13 18 PF00026 0.436

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1ILZ7 Leptomonas seymouri 61% 90%
A0A0S4J692 Bodo saltans 32% 80%
A0A0S4J989 Bodo saltans 24% 97%
A0A0S4JN91 Bodo saltans 26% 100%
A0A1X0NWR8 Trypanosomatidae 27% 100%
A0A1X0PA49 Trypanosomatidae 26% 84%
A0A3R7LY82 Trypanosoma rangeli 27% 88%
A0A3S7WUW1 Leishmania donovani 89% 94%
A0A3S7WW86 Leishmania donovani 23% 100%
A0A422NQJ7 Trypanosoma rangeli 25% 84%
A4H9A1 Leishmania braziliensis 74% 100%
A4HBK5 Leishmania braziliensis 24% 100%
A4HXM1 Leishmania infantum 89% 94%
B2RXV4 Mus musculus 26% 86%
D0A244 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 89%
E9AGU5 Leishmania infantum 23% 100%
O01735 Caenorhabditis elegans 25% 82%
P60815 Rattus norvegicus 28% 88%
Q11073 Caenorhabditis elegans 24% 95%
Q28FF3 Xenopus tropicalis 25% 100%
Q4H425 Epichloe festucae (strain Fl1) 21% 100%
Q4QCK8 Leishmania major 23% 88%
Q4QE46 Leishmania major 86% 100%
Q501I9 Xenopus tropicalis 24% 100%
Q503P5 Danio rerio 23% 100%
Q66H95 Rattus norvegicus 23% 100%
Q6GNV7 Xenopus laevis 24% 100%
Q6UXD7 Homo sapiens 26% 86%
Q8BFQ6 Mus musculus 23% 100%
Q8CE47 Mus musculus 27% 94%
Q91X85 Mus musculus 28% 88%
Q96SL1 Homo sapiens 23% 100%
Q9ES43 Mus terricolor 26% 86%
Q9N1F2 Felis catus 28% 86%
Q9UPI3 Homo sapiens 29% 92%
Q9Y5Y0 Homo sapiens 28% 87%
V5BQV3 Trypanosoma cruzi 28% 88%
V5DGX2 Trypanosoma cruzi 23% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS