Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ARB6_LEIMU

TriTrypDb:

LmxM.17.1420

Length:

257

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ARB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARB6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	171	173	PF00675	0.484
CLV_NRD_NRD_1	176	178	PF00675	0.483
CLV_NRD_NRD_1	186	188	PF00675	0.488
CLV_NRD_NRD_1	38	40	PF00675	0.577
CLV_NRD_NRD_1	56	58	PF00675	0.456
CLV_NRD_NRD_1	73	75	PF00675	0.273
CLV_NRD_NRD_1	84	86	PF00675	0.607
CLV_PCSK_KEX2_1	107	109	PF00082	0.553
CLV_PCSK_KEX2_1	171	173	PF00082	0.500
CLV_PCSK_KEX2_1	40	42	PF00082	0.583
CLV_PCSK_KEX2_1	56	58	PF00082	0.456
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.592
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.583
CLV_PCSK_SKI1_1	173	177	PF00082	0.584
CLV_PCSK_SKI1_1	194	198	PF00082	0.585
DEG_APCC_DBOX_1	203	211	PF00400	0.528
DOC_CYCLIN_RxL_1	170	180	PF00134	0.432
DOC_CYCLIN_RxL_1	188	201	PF00134	0.512
DOC_USP7_MATH_1	229	233	PF00917	0.609
LIG_14-3-3_CanoR_1	171	176	PF00244	0.516
LIG_BRCT_BRCA1_1	5	9	PF00533	0.579
LIG_FHA_2	179	185	PF00498	0.548
LIG_FHA_2	233	239	PF00498	0.648
LIG_LIR_Gen_1	6	17	PF02991	0.568
LIG_LIR_Nem_3	6	12	PF02991	0.561
LIG_PCNA_PIPBox_1	24	33	PF02747	0.547
LIG_PCNA_yPIPBox_3	24	33	PF02747	0.551
LIG_SH2_CRK	13	17	PF00017	0.507
LIG_SH2_STAT3	31	34	PF00017	0.541
LIG_SH2_STAT5	31	34	PF00017	0.456
LIG_SH2_STAT5	37	40	PF00017	0.433
LIG_TRAF2_1	128	131	PF00917	0.555
LIG_TRAF2_1	249	252	PF00917	0.700
LIG_TRAF2_1	99	102	PF00917	0.590
MOD_CK1_1	232	238	PF00069	0.618
MOD_CK2_1	178	184	PF00069	0.556
MOD_CK2_1	245	251	PF00069	0.707
MOD_GlcNHglycan	247	250	PF01048	0.726
MOD_GlcNHglycan	70	73	PF01048	0.398
MOD_PIKK_1	229	235	PF00454	0.582
MOD_PIKK_1	85	91	PF00454	0.489
MOD_PKA_1	171	177	PF00069	0.514
MOD_PKA_1	85	91	PF00069	0.598
MOD_PKA_2	171	177	PF00069	0.564
MOD_Plk_1	240	246	PF00069	0.570
MOD_Plk_4	122	128	PF00069	0.459
MOD_Plk_4	171	177	PF00069	0.561
MOD_SUMO_rev_2	180	189	PF00179	0.542
MOD_SUMO_rev_2	82	88	PF00179	0.477
TRG_DiLeu_BaEn_1	119	124	PF01217	0.575
TRG_DiLeu_BaEn_1	193	198	PF01217	0.613
TRG_DiLeu_BaEn_2	143	149	PF01217	0.605
TRG_ENDOCYTIC_2	13	16	PF00928	0.490
TRG_ER_diArg_1	145	148	PF00400	0.528
TRG_ER_diArg_1	38	41	PF00400	0.554
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	162	167	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	57	62	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEK9	Leptomonas seymouri	74%	94%
A0A0S4J6Y0	Bodo saltans	32%	94%
A0A1X0NU37	Trypanosomatidae	48%	96%
A0A3S7WUP8	Leishmania donovani	97%	100%
A0A422NB62	Trypanosoma rangeli	46%	96%
A4H9A0	Leishmania braziliensis	91%	100%
A4HXM0	Leishmania infantum	97%	100%
C9ZPB7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	75%
Q4QE47	Leishmania major	95%	100%
V5BNY4	Trypanosoma cruzi	45%	96%