Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ARB2_LEIMU

TriTrypDb:

LmxM.17.1380

Length:

847

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ARB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARB2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.476
CLV_C14_Caspase3-7	454	458	PF00656	0.685
CLV_C14_Caspase3-7	599	603	PF00656	0.690
CLV_NRD_NRD_1	191	193	PF00675	0.754
CLV_NRD_NRD_1	339	341	PF00675	0.745
CLV_NRD_NRD_1	567	569	PF00675	0.515
CLV_NRD_NRD_1	578	580	PF00675	0.522
CLV_NRD_NRD_1	624	626	PF00675	0.505
CLV_NRD_NRD_1	637	639	PF00675	0.495
CLV_NRD_NRD_1	668	670	PF00675	0.510
CLV_NRD_NRD_1	686	688	PF00675	0.432
CLV_NRD_NRD_1	714	716	PF00675	0.477
CLV_NRD_NRD_1	720	722	PF00675	0.456
CLV_NRD_NRD_1	775	777	PF00675	0.287
CLV_NRD_NRD_1	799	801	PF00675	0.539
CLV_NRD_NRD_1	810	812	PF00675	0.483
CLV_NRD_NRD_1	840	842	PF00675	0.534
CLV_NRD_NRD_1	97	99	PF00675	0.464
CLV_PCSK_FUR_1	797	801	PF00082	0.448
CLV_PCSK_KEX2_1	191	193	PF00082	0.732
CLV_PCSK_KEX2_1	567	569	PF00082	0.517
CLV_PCSK_KEX2_1	637	639	PF00082	0.536
CLV_PCSK_KEX2_1	686	688	PF00082	0.536
CLV_PCSK_KEX2_1	71	73	PF00082	0.591
CLV_PCSK_KEX2_1	714	716	PF00082	0.500
CLV_PCSK_KEX2_1	720	722	PF00082	0.471
CLV_PCSK_KEX2_1	775	777	PF00082	0.300
CLV_PCSK_KEX2_1	782	784	PF00082	0.523
CLV_PCSK_KEX2_1	797	799	PF00082	0.549
CLV_PCSK_KEX2_1	810	812	PF00082	0.471
CLV_PCSK_KEX2_1	821	823	PF00082	0.511
CLV_PCSK_KEX2_1	839	841	PF00082	0.216
CLV_PCSK_KEX2_1	97	99	PF00082	0.464
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.591
CLV_PCSK_PC1ET2_1	782	784	PF00082	0.543
CLV_PCSK_PC1ET2_1	821	823	PF00082	0.616
CLV_PCSK_PC7_1	836	842	PF00082	0.243
CLV_PCSK_SKI1_1	246	250	PF00082	0.590
CLV_PCSK_SKI1_1	341	345	PF00082	0.762
CLV_PCSK_SKI1_1	391	395	PF00082	0.621
CLV_PCSK_SKI1_1	443	447	PF00082	0.507
CLV_PCSK_SKI1_1	714	718	PF00082	0.488
CLV_PCSK_SKI1_1	74	78	PF00082	0.459
CLV_PCSK_SKI1_1	811	815	PF00082	0.562
CLV_PCSK_SKI1_1	841	845	PF00082	0.566
DEG_APCC_DBOX_1	286	294	PF00400	0.568
DOC_ANK_TNKS_1	306	313	PF00023	0.379
DOC_CKS1_1	134	139	PF01111	0.484
DOC_CYCLIN_yCln2_LP_2	168	174	PF00134	0.493
DOC_CYCLIN_yCln2_LP_2	252	258	PF00134	0.705
DOC_CYCLIN_yCln2_LP_2	6	12	PF00134	0.428
DOC_MAPK_gen_1	44	52	PF00069	0.464
DOC_MAPK_gen_1	579	589	PF00069	0.592
DOC_MAPK_gen_1	649	657	PF00069	0.466
DOC_MAPK_gen_1	71	79	PF00069	0.459
DOC_MAPK_gen_1	797	804	PF00069	0.640
DOC_MAPK_gen_1	836	846	PF00069	0.653
DOC_MAPK_MEF2A_6	44	52	PF00069	0.464
DOC_MAPK_MEF2A_6	582	591	PF00069	0.601
DOC_MAPK_MEF2A_6	71	79	PF00069	0.459
DOC_PP1_RVXF_1	604	611	PF00149	0.501
DOC_PP2B_LxvP_1	252	255	PF13499	0.682
DOC_PP2B_LxvP_1	324	327	PF13499	0.699
DOC_PP2B_LxvP_1	366	369	PF13499	0.504
DOC_PP2B_LxvP_1	510	513	PF13499	0.729
DOC_PP4_FxxP_1	251	254	PF00568	0.587
DOC_USP7_MATH_1	227	231	PF00917	0.597
DOC_USP7_MATH_1	499	503	PF00917	0.692
DOC_USP7_MATH_1	505	509	PF00917	0.665
DOC_WW_Pin1_4	102	107	PF00397	0.491
DOC_WW_Pin1_4	133	138	PF00397	0.608
DOC_WW_Pin1_4	144	149	PF00397	0.609
DOC_WW_Pin1_4	19	24	PF00397	0.582
DOC_WW_Pin1_4	250	255	PF00397	0.618
DOC_WW_Pin1_4	273	278	PF00397	0.680
DOC_WW_Pin1_4	341	346	PF00397	0.704
DOC_WW_Pin1_4	35	40	PF00397	0.627
DOC_WW_Pin1_4	357	362	PF00397	0.582
DOC_WW_Pin1_4	448	453	PF00397	0.753
DOC_WW_Pin1_4	465	470	PF00397	0.592
LIG_14-3-3_CanoR_1	13	17	PF00244	0.437
LIG_14-3-3_CanoR_1	177	181	PF00244	0.720
LIG_14-3-3_CanoR_1	222	229	PF00244	0.628
LIG_14-3-3_CanoR_1	241	246	PF00244	0.621
LIG_14-3-3_CanoR_1	267	273	PF00244	0.725
LIG_14-3-3_CanoR_1	35	39	PF00244	0.634
LIG_14-3-3_CanoR_1	418	427	PF00244	0.570
LIG_14-3-3_CanoR_1	483	488	PF00244	0.366
LIG_14-3-3_CanoR_1	567	572	PF00244	0.486
LIG_14-3-3_CanoR_1	654	663	PF00244	0.586
LIG_14-3-3_CanoR_1	66	75	PF00244	0.698
LIG_14-3-3_CanoR_1	742	748	PF00244	0.460
LIG_14-3-3_CanoR_1	783	788	PF00244	0.535
LIG_14-3-3_CanoR_1	80	89	PF00244	0.424
LIG_14-3-3_CanoR_1	822	827	PF00244	0.647
LIG_14-3-3_CanoR_1	97	102	PF00244	0.442
LIG_Actin_WH2_2	48	65	PF00022	0.628
LIG_BRCT_BRCA1_1	125	129	PF00533	0.495
LIG_BRCT_BRCA1_1	421	425	PF00533	0.534
LIG_CaM_IQ_9	544	559	PF13499	0.482
LIG_CaM_IQ_9	641	656	PF13499	0.482
LIG_CaM_IQ_9	678	694	PF13499	0.430
LIG_CaM_IQ_9	701	717	PF13499	0.443
LIG_CaM_IQ_9	762	778	PF13499	0.378
LIG_deltaCOP1_diTrp_1	527	533	PF00928	0.592
LIG_deltaCOP1_diTrp_1	741	747	PF00928	0.566
LIG_DLG_GKlike_1	783	791	PF00625	0.337
LIG_EVH1_1	110	114	PF00568	0.486
LIG_FHA_1	113	119	PF00498	0.505
LIG_FHA_1	280	286	PF00498	0.726
LIG_FHA_1	29	35	PF00498	0.593
LIG_FHA_1	319	325	PF00498	0.618
LIG_FHA_1	342	348	PF00498	0.765
LIG_FHA_1	350	356	PF00498	0.645
LIG_FHA_1	499	505	PF00498	0.622
LIG_FHA_2	134	140	PF00498	0.486
LIG_FHA_2	159	165	PF00498	0.684
LIG_FHA_2	333	339	PF00498	0.679
LIG_FHA_2	358	364	PF00498	0.572
LIG_FHA_2	468	474	PF00498	0.431
LIG_FHA_2	488	494	PF00498	0.475
LIG_Integrin_RGD_1	455	457	PF01839	0.768
LIG_LIR_Gen_1	266	277	PF02991	0.669
LIG_LIR_Gen_1	486	496	PF02991	0.501
LIG_LIR_Gen_1	741	750	PF02991	0.557
LIG_LIR_Nem_3	144	149	PF02991	0.601
LIG_LIR_Nem_3	244	248	PF02991	0.517
LIG_LIR_Nem_3	266	272	PF02991	0.773
LIG_LIR_Nem_3	486	491	PF02991	0.489
LIG_LIR_Nem_3	683	688	PF02991	0.509
LIG_LIR_Nem_3	741	747	PF02991	0.573
LIG_MYND_1	250	254	PF01753	0.588
LIG_PAM2_1	383	395	PF00658	0.335
LIG_PCNA_yPIPBox_3	232	246	PF02747	0.589
LIG_Pex14_1	743	747	PF04695	0.564
LIG_REV1ctd_RIR_1	608	618	PF16727	0.537
LIG_RPA_C_Fungi	633	645	PF08784	0.408
LIG_SH2_NCK_1	223	227	PF00017	0.518
LIG_SH2_SRC	519	522	PF00017	0.622
LIG_SH2_STAP1	223	227	PF00017	0.518
LIG_SH2_STAP1	744	748	PF00017	0.552
LIG_SH2_STAT3	688	691	PF00017	0.555
LIG_SH2_STAT5	223	226	PF00017	0.466
LIG_SH2_STAT5	426	429	PF00017	0.545
LIG_SH2_STAT5	462	465	PF00017	0.676
LIG_SH2_STAT5	519	522	PF00017	0.622
LIG_SH2_STAT5	81	84	PF00017	0.452
LIG_SH3_1	72	78	PF00018	0.460
LIG_SH3_2	254	259	PF14604	0.643
LIG_SH3_2	75	80	PF14604	0.459
LIG_SH3_3	100	106	PF00018	0.479
LIG_SH3_3	108	114	PF00018	0.476
LIG_SH3_3	168	174	PF00018	0.574
LIG_SH3_3	20	26	PF00018	0.434
LIG_SH3_3	251	257	PF00018	0.608
LIG_SH3_3	362	368	PF00018	0.706
LIG_SH3_3	40	46	PF00018	0.424
LIG_SH3_3	466	472	PF00018	0.662
LIG_SH3_3	72	78	PF00018	0.460
LIG_SUMO_SIM_anti_2	432	438	PF11976	0.624
LIG_SUMO_SIM_anti_2	761	766	PF11976	0.393
LIG_TRAF2_1	429	432	PF00917	0.610
LIG_TRAF2_1	479	482	PF00917	0.614
LIG_TRAF2_1	778	781	PF00917	0.324
LIG_WRC_WIRS_1	180	185	PF05994	0.680
LIG_WRC_WIRS_1	245	250	PF05994	0.551
LIG_WRC_WIRS_1	269	274	PF05994	0.560
LIG_WRC_WIRS_1	744	749	PF05994	0.503
LIG_WRPW_2	248	251	PF00400	0.585
MOD_CDC14_SPxK_1	276	279	PF00782	0.472
MOD_CDK_SPK_2	39	44	PF00069	0.687
MOD_CDK_SPxK_1	273	279	PF00069	0.475
MOD_CDK_SPxxK_3	448	455	PF00069	0.686
MOD_CK1_1	105	111	PF00069	0.476
MOD_CK1_1	158	164	PF00069	0.599
MOD_CK1_1	175	181	PF00069	0.641
MOD_CK1_1	221	227	PF00069	0.599
MOD_CK1_1	281	287	PF00069	0.631
MOD_CK1_1	37	43	PF00069	0.693
MOD_CK1_1	451	457	PF00069	0.653
MOD_CK1_1	786	792	PF00069	0.341
MOD_CK1_1	83	89	PF00069	0.447
MOD_CK2_1	133	139	PF00069	0.491
MOD_CK2_1	332	338	PF00069	0.732
MOD_CK2_1	467	473	PF00069	0.735
MOD_GlcNHglycan	124	128	PF01048	0.669
MOD_GlcNHglycan	332	335	PF01048	0.661
MOD_GlcNHglycan	355	358	PF01048	0.581
MOD_GlcNHglycan	385	388	PF01048	0.620
MOD_GlcNHglycan	397	400	PF01048	0.529
MOD_GlcNHglycan	507	510	PF01048	0.683
MOD_GlcNHglycan	516	519	PF01048	0.560
MOD_GlcNHglycan	541	544	PF01048	0.477
MOD_GlcNHglycan	575	578	PF01048	0.606
MOD_GlcNHglycan	598	601	PF01048	0.674
MOD_GlcNHglycan	675	679	PF01048	0.397
MOD_GlcNHglycan	727	731	PF01048	0.580
MOD_GlcNHglycan	788	791	PF01048	0.536
MOD_GlcNHglycan	814	817	PF01048	0.455
MOD_GlcNHglycan	82	85	PF01048	0.461
MOD_GSK3_1	172	179	PF00069	0.701
MOD_GSK3_1	204	211	PF00069	0.706
MOD_GSK3_1	217	224	PF00069	0.638
MOD_GSK3_1	237	244	PF00069	0.559
MOD_GSK3_1	279	286	PF00069	0.666
MOD_GSK3_1	314	321	PF00069	0.537
MOD_GSK3_1	326	333	PF00069	0.697
MOD_GSK3_1	34	41	PF00069	0.657
MOD_GSK3_1	349	356	PF00069	0.728
MOD_GSK3_1	446	453	PF00069	0.564
MOD_GSK3_1	483	490	PF00069	0.545
MOD_GSK3_1	567	574	PF00069	0.360
MOD_GSK3_1	592	599	PF00069	0.596
MOD_GSK3_1	726	733	PF00069	0.558
MOD_GSK3_1	782	789	PF00069	0.485
MOD_GSK3_1	80	87	PF00069	0.474
MOD_LATS_1	265	271	PF00433	0.553
MOD_N-GLC_1	144	149	PF02516	0.674
MOD_NEK2_1	12	17	PF00069	0.593
MOD_NEK2_1	157	162	PF00069	0.646
MOD_NEK2_1	298	303	PF00069	0.599
MOD_NEK2_1	318	323	PF00069	0.315
MOD_NEK2_1	34	39	PF00069	0.682
MOD_NEK2_1	487	492	PF00069	0.627
MOD_NEK2_1	51	56	PF00069	0.464
MOD_NEK2_1	529	534	PF00069	0.643
MOD_NEK2_1	571	576	PF00069	0.588
MOD_NEK2_1	680	685	PF00069	0.584
MOD_NEK2_1	814	819	PF00069	0.621
MOD_NEK2_1	82	87	PF00069	0.461
MOD_PIKK_1	112	118	PF00454	0.503
MOD_PIKK_1	155	161	PF00454	0.642
MOD_PIKK_1	221	227	PF00454	0.621
MOD_PIKK_1	228	234	PF00454	0.613
MOD_PK_1	204	210	PF00069	0.699
MOD_PKA_1	191	197	PF00069	0.726
MOD_PKA_1	567	573	PF00069	0.403
MOD_PKA_1	782	788	PF00069	0.594
MOD_PKA_1	97	103	PF00069	0.459
MOD_PKA_2	12	18	PF00069	0.437
MOD_PKA_2	176	182	PF00069	0.719
MOD_PKA_2	191	197	PF00069	0.578
MOD_PKA_2	221	227	PF00069	0.583
MOD_PKA_2	278	284	PF00069	0.719
MOD_PKA_2	34	40	PF00069	0.636
MOD_PKA_2	419	425	PF00069	0.571
MOD_PKA_2	567	573	PF00069	0.454
MOD_PKA_2	782	788	PF00069	0.599
MOD_PKA_2	97	103	PF00069	0.481
MOD_PKB_1	202	210	PF00069	0.584
MOD_Plk_1	218	224	PF00069	0.532
MOD_Plk_1	259	265	PF00069	0.547
MOD_Plk_1	298	304	PF00069	0.642
MOD_Plk_1	318	324	PF00069	0.314
MOD_Plk_1	601	607	PF00069	0.561
MOD_Plk_4	114	120	PF00069	0.789
MOD_Plk_4	332	338	PF00069	0.764
MOD_Plk_4	483	489	PF00069	0.574
MOD_Plk_4	567	573	PF00069	0.450
MOD_Plk_4	703	709	PF00069	0.479
MOD_Plk_4	743	749	PF00069	0.529
MOD_Plk_4	84	90	PF00069	0.463
MOD_ProDKin_1	102	108	PF00069	0.493
MOD_ProDKin_1	133	139	PF00069	0.609
MOD_ProDKin_1	144	150	PF00069	0.611
MOD_ProDKin_1	19	25	PF00069	0.578
MOD_ProDKin_1	250	256	PF00069	0.623
MOD_ProDKin_1	273	279	PF00069	0.682
MOD_ProDKin_1	341	347	PF00069	0.705
MOD_ProDKin_1	35	41	PF00069	0.627
MOD_ProDKin_1	357	363	PF00069	0.585
MOD_ProDKin_1	448	454	PF00069	0.753
MOD_ProDKin_1	465	471	PF00069	0.588
MOD_SUMO_for_1	477	480	PF00179	0.617
MOD_SUMO_rev_2	574	581	PF00179	0.505
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.463
TRG_ENDOCYTIC_2	245	248	PF00928	0.518
TRG_ENDOCYTIC_2	744	747	PF00928	0.540
TRG_ER_diArg_1	202	205	PF00400	0.754
TRG_ER_diArg_1	554	557	PF00400	0.358
TRG_ER_diArg_1	636	638	PF00400	0.542
TRG_ER_diArg_1	652	655	PF00400	0.212
TRG_ER_diArg_1	685	687	PF00400	0.549
TRG_ER_diArg_1	695	698	PF00400	0.410
TRG_ER_diArg_1	708	711	PF00400	0.454
TRG_ER_diArg_1	714	716	PF00400	0.405
TRG_ER_diArg_1	72	75	PF00400	0.461
TRG_ER_diArg_1	720	722	PF00400	0.480
TRG_ER_diArg_1	797	800	PF00400	0.547
TRG_ER_diArg_1	838	841	PF00400	0.406
TRG_ER_diArg_1	89	92	PF00400	0.419
TRG_ER_diArg_1	96	98	PF00400	0.448
TRG_Pf-PMV_PEXEL_1	715	719	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	792	796	PF00026	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8D9	Leptomonas seymouri	46%	100%
A0A0S4J9A9	Bodo saltans	28%	95%
A0A1X0NSM4	Trypanosomatidae	28%	100%
A0A3R7K6T1	Trypanosoma rangeli	28%	100%
A0A3S7WUM7	Leishmania donovani	84%	100%
A4H995	Leishmania braziliensis	67%	100%
A4HXL6	Leishmania infantum	84%	100%
C9ZPB0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
Q4QE51	Leishmania major	85%	100%