Protein SDA1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein SDA1

Gene product:

NUC130/3NT domain/SDA1, putative

Species:

Leishmania mexicana

UniProt:

E9ARB0_LEIMU

TriTrypDb:

LmxM.17.1370

Length:

866

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	10
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9ARB0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARB0

Function

Biological processes
Term	Name	Level	Count
GO:0000054	ribosomal subunit export from nucleus	3	10
GO:0000055	ribosomal large subunit export from nucleus	4	10
GO:0006810	transport	3	10
GO:0006913	nucleocytoplasmic transport	5	10
GO:0006996	organelle organization	4	10
GO:0007010	cytoskeleton organization	5	10
GO:0008104	protein localization	4	10
GO:0009987	cellular process	1	10
GO:0015031	protein transport	4	10
GO:0016043	cellular component organization	3	10
GO:0022613	ribonucleoprotein complex biogenesis	4	10
GO:0030029	actin filament-based process	2	10
GO:0030036	actin cytoskeleton organization	3	10
GO:0031503	protein-containing complex localization	2	10
GO:0033036	macromolecule localization	2	10
GO:0033750	ribosome localization	3	10
GO:0042273	ribosomal large subunit biogenesis	5	10
GO:0044085	cellular component biogenesis	3	10
GO:0045184	establishment of protein localization	3	10
GO:0046907	intracellular transport	3	10
GO:0051168	nuclear export	6	10
GO:0051169	nuclear transport	4	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0051640	organelle localization	2	10
GO:0051641	cellular localization	2	10
GO:0051649	establishment of localization in cell	3	10
GO:0051656	establishment of organelle localization	3	10
GO:0070727	cellular macromolecule localization	3	10
GO:0071702	organic substance transport	4	10
GO:0071705	nitrogen compound transport	4	10
GO:0071840	cellular component organization or biogenesis	2	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	395	399	PF00656	0.303
CLV_C14_Caspase3-7	512	516	PF00656	0.251
CLV_C14_Caspase3-7	523	527	PF00656	0.198
CLV_C14_Caspase3-7	568	572	PF00656	0.210
CLV_C14_Caspase3-7	593	597	PF00656	0.290
CLV_C14_Caspase3-7	609	613	PF00656	0.243
CLV_C14_Caspase3-7	684	688	PF00656	0.214
CLV_NRD_NRD_1	130	132	PF00675	0.253
CLV_NRD_NRD_1	142	144	PF00675	0.295
CLV_NRD_NRD_1	18	20	PF00675	0.414
CLV_NRD_NRD_1	189	191	PF00675	0.291
CLV_NRD_NRD_1	275	277	PF00675	0.370
CLV_NRD_NRD_1	744	746	PF00675	0.259
CLV_NRD_NRD_1	793	795	PF00675	0.236
CLV_NRD_NRD_1	803	805	PF00675	0.175
CLV_PCSK_FUR_1	16	20	PF00082	0.312
CLV_PCSK_FUR_1	742	746	PF00082	0.403
CLV_PCSK_FUR_1	859	863	PF00082	0.195
CLV_PCSK_KEX2_1	18	20	PF00082	0.354
CLV_PCSK_KEX2_1	188	190	PF00082	0.289
CLV_PCSK_KEX2_1	262	264	PF00082	0.353
CLV_PCSK_KEX2_1	268	270	PF00082	0.340
CLV_PCSK_KEX2_1	275	277	PF00082	0.354
CLV_PCSK_KEX2_1	412	414	PF00082	0.283
CLV_PCSK_KEX2_1	579	581	PF00082	0.242
CLV_PCSK_KEX2_1	744	746	PF00082	0.250
CLV_PCSK_KEX2_1	754	756	PF00082	0.198
CLV_PCSK_KEX2_1	778	780	PF00082	0.195
CLV_PCSK_KEX2_1	803	805	PF00082	0.205
CLV_PCSK_KEX2_1	819	821	PF00082	0.174
CLV_PCSK_KEX2_1	828	830	PF00082	0.195
CLV_PCSK_KEX2_1	861	863	PF00082	0.195
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.365
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.363
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.383
CLV_PCSK_PC1ET2_1	412	414	PF00082	0.283
CLV_PCSK_PC1ET2_1	579	581	PF00082	0.242
CLV_PCSK_PC1ET2_1	744	746	PF00082	0.258
CLV_PCSK_PC1ET2_1	754	756	PF00082	0.235
CLV_PCSK_PC1ET2_1	778	780	PF00082	0.195
CLV_PCSK_PC1ET2_1	819	821	PF00082	0.195
CLV_PCSK_PC1ET2_1	828	830	PF00082	0.195
CLV_PCSK_PC1ET2_1	861	863	PF00082	0.242
CLV_PCSK_PC7_1	408	414	PF00082	0.312
CLV_PCSK_SKI1_1	132	136	PF00082	0.263
CLV_PCSK_SKI1_1	214	218	PF00082	0.250
CLV_PCSK_SKI1_1	255	259	PF00082	0.382
CLV_PCSK_SKI1_1	265	269	PF00082	0.326
CLV_PCSK_SKI1_1	272	276	PF00082	0.322
CLV_PCSK_SKI1_1	718	722	PF00082	0.213
CLV_PCSK_SKI1_1	783	787	PF00082	0.228
CLV_PCSK_SKI1_1	82	86	PF00082	0.209
CLV_PCSK_SKI1_1	854	858	PF00082	0.203
CLV_PCSK_SKI1_1	94	98	PF00082	0.208
CLV_Separin_Metazoa	79	83	PF03568	0.213
DEG_APCC_DBOX_1	217	225	PF00400	0.272
DEG_APCC_DBOX_1	6	14	PF00400	0.320
DEG_APCC_DBOX_1	819	827	PF00400	0.195
DEG_Kelch_Keap1_1	515	520	PF01344	0.277
DEG_SPOP_SBC_1	514	518	PF00917	0.192
DOC_ANK_TNKS_1	568	575	PF00023	0.192
DOC_CDC14_PxL_1	483	491	PF14671	0.192
DOC_CYCLIN_RxL_1	126	136	PF00134	0.356
DOC_MAPK_DCC_7	290	298	PF00069	0.318
DOC_MAPK_gen_1	126	135	PF00069	0.271
DOC_MAPK_gen_1	249	256	PF00069	0.309
DOC_MAPK_gen_1	579	589	PF00069	0.135
DOC_MAPK_HePTP_8	174	186	PF00069	0.247
DOC_MAPK_MEF2A_6	177	186	PF00069	0.240
DOC_MAPK_MEF2A_6	582	591	PF00069	0.135
DOC_MAPK_MEF2A_6	68	76	PF00069	0.248
DOC_PP1_RVXF_1	852	859	PF00149	0.195
DOC_PP2B_LxvP_1	222	225	PF13499	0.348
DOC_PP2B_LxvP_1	340	343	PF13499	0.301
DOC_PP4_MxPP_1	373	376	PF00568	0.282
DOC_SPAK_OSR1_1	319	323	PF12202	0.281
DOC_USP7_MATH_1	522	526	PF00917	0.384
DOC_USP7_MATH_1	539	543	PF00917	0.208
DOC_USP7_MATH_1	592	596	PF00917	0.227
DOC_USP7_MATH_1	654	658	PF00917	0.136
DOC_USP7_MATH_1	703	707	PF00917	0.311
DOC_USP7_UBL2_3	128	132	PF12436	0.315
DOC_USP7_UBL2_3	249	253	PF12436	0.350
DOC_USP7_UBL2_3	255	259	PF12436	0.373
DOC_USP7_UBL2_3	795	799	PF12436	0.212
DOC_USP7_UBL2_3	805	809	PF12436	0.182
DOC_USP7_UBL2_3	849	853	PF12436	0.197
DOC_USP7_UBL2_3	857	861	PF12436	0.198
DOC_WW_Pin1_4	207	212	PF00397	0.294
DOC_WW_Pin1_4	694	699	PF00397	0.161
LIG_14-3-3_CanoR_1	226	231	PF00244	0.527
LIG_14-3-3_CanoR_1	315	322	PF00244	0.266
LIG_14-3-3_CanoR_1	332	340	PF00244	0.475
LIG_14-3-3_CanoR_1	36	43	PF00244	0.400
LIG_14-3-3_CanoR_1	394	402	PF00244	0.433
LIG_14-3-3_CanoR_1	692	698	PF00244	0.171
LIG_14-3-3_CanoR_1	718	725	PF00244	0.182
LIG_14-3-3_CanoR_1	794	802	PF00244	0.301
LIG_Actin_WH2_2	69	84	PF00022	0.301
LIG_APCC_ABBA_1	116	121	PF00400	0.255
LIG_APCC_ABBA_1	446	451	PF00400	0.213
LIG_BIR_II_1	1	5	PF00653	0.532
LIG_BIR_III_1	1	5	PF00653	0.445
LIG_BIR_III_2	551	555	PF00653	0.166
LIG_BIR_III_3	1	5	PF00653	0.445
LIG_BIR_III_4	571	575	PF00653	0.192
LIG_BRCT_BRCA1_1	316	320	PF00533	0.310
LIG_BRCT_BRCA1_1	796	800	PF00533	0.301
LIG_FHA_1	113	119	PF00498	0.310
LIG_FHA_1	134	140	PF00498	0.359
LIG_FHA_1	195	201	PF00498	0.257
LIG_FHA_1	208	214	PF00498	0.270
LIG_FHA_1	304	310	PF00498	0.240
LIG_FHA_1	358	364	PF00498	0.324
LIG_FHA_1	399	405	PF00498	0.263
LIG_FHA_1	684	690	PF00498	0.135
LIG_FHA_1	7	13	PF00498	0.310
LIG_FHA_2	15	21	PF00498	0.312
LIG_FHA_2	226	232	PF00498	0.435
LIG_FHA_2	331	337	PF00498	0.278
LIG_FHA_2	404	410	PF00498	0.251
LIG_FHA_2	498	504	PF00498	0.198
LIG_FHA_2	521	527	PF00498	0.401
LIG_FHA_2	568	574	PF00498	0.418
LIG_FHA_2	602	608	PF00498	0.235
LIG_FHA_2	651	657	PF00498	0.337
LIG_FHA_2	719	725	PF00498	0.213
LIG_FHA_2	811	817	PF00498	0.195
LIG_Integrin_RGD_1	433	435	PF01839	0.195
LIG_LIR_Apic_2	349	354	PF02991	0.284
LIG_LIR_Gen_1	532	543	PF02991	0.242
LIG_LIR_Gen_1	680	689	PF02991	0.243
LIG_LIR_Gen_1	722	731	PF02991	0.195
LIG_LIR_Nem_3	113	119	PF02991	0.280
LIG_LIR_Nem_3	451	456	PF02991	0.242
LIG_LIR_Nem_3	532	538	PF02991	0.242
LIG_LIR_Nem_3	680	685	PF02991	0.243
LIG_LIR_Nem_3	722	728	PF02991	0.195
LIG_LRP6_Inhibitor_1	402	408	PF00058	0.252
LIG_LYPXL_S_1	452	456	PF13949	0.213
LIG_LYPXL_yS_3	453	456	PF13949	0.213
LIG_MYND_1	454	458	PF01753	0.195
LIG_MYND_1	554	558	PF01753	0.242
LIG_PALB2_WD40_1	677	685	PF16756	0.213
LIG_Pex14_2	116	120	PF04695	0.264
LIG_PTB_Apo_2	46	53	PF02174	0.298
LIG_SH2_GRB2like	326	329	PF00017	0.284
LIG_SH2_NCK_1	483	487	PF00017	0.192
LIG_SH2_SRC	326	329	PF00017	0.284
LIG_SH2_STAT3	278	281	PF00017	0.369
LIG_SH2_STAT3	429	432	PF00017	0.177
LIG_SH2_STAT5	326	329	PF00017	0.284
LIG_SH2_STAT5	483	486	PF00017	0.209
LIG_SH2_STAT5	58	61	PF00017	0.211
LIG_SH3_3	533	539	PF00018	0.187
LIG_SUMO_SIM_anti_2	100	105	PF11976	0.242
LIG_SUMO_SIM_anti_2	197	202	PF11976	0.263
LIG_SUMO_SIM_anti_2	9	14	PF11976	0.296
LIG_SUMO_SIM_par_1	180	185	PF11976	0.237
LIG_SUMO_SIM_par_1	194	202	PF11976	0.261
LIG_SUMO_SIM_par_1	360	366	PF11976	0.287
LIG_SUMO_SIM_par_1	587	593	PF11976	0.287
LIG_TRAF2_1	542	545	PF00917	0.417
LIG_TRAF2_1	604	607	PF00917	0.157
LIG_TRAF2_1	653	656	PF00917	0.181
LIG_TRAF2_1	657	660	PF00917	0.180
LIG_TRAF2_1	661	664	PF00917	0.403
LIG_TYR_ITIM	324	329	PF00017	0.287
LIG_UBA3_1	101	107	PF00899	0.238
LIG_UBA3_1	422	430	PF00899	0.213
LIG_UBA3_1	823	828	PF00899	0.195
MOD_CDK_SPK_2	694	699	PF00069	0.161
MOD_CDK_SPxxK_3	207	214	PF00069	0.287
MOD_CK1_1	207	213	PF00069	0.271
MOD_CK1_1	38	44	PF00069	0.400
MOD_CK1_1	392	398	PF00069	0.382
MOD_CK1_1	507	513	PF00069	0.214
MOD_CK1_1	590	596	PF00069	0.255
MOD_CK1_1	600	606	PF00069	0.184
MOD_CK1_1	702	708	PF00069	0.255
MOD_CK1_1	710	716	PF00069	0.287
MOD_CK1_1	737	743	PF00069	0.213
MOD_CK2_1	258	264	PF00069	0.467
MOD_CK2_1	330	336	PF00069	0.254
MOD_CK2_1	403	409	PF00069	0.252
MOD_CK2_1	502	508	PF00069	0.252
MOD_CK2_1	514	520	PF00069	0.184
MOD_CK2_1	522	528	PF00069	0.214
MOD_CK2_1	538	544	PF00069	0.135
MOD_CK2_1	600	606	PF00069	0.271
MOD_CK2_1	621	627	PF00069	0.263
MOD_CK2_1	638	644	PF00069	0.218
MOD_CK2_1	649	655	PF00069	0.202
MOD_CK2_1	658	664	PF00069	0.200
MOD_CK2_1	795	801	PF00069	0.207
MOD_CK2_1	810	816	PF00069	0.169
MOD_Cter_Amidation	742	745	PF01082	0.192
MOD_GlcNHglycan	365	368	PF01048	0.358
MOD_GlcNHglycan	38	41	PF01048	0.398
MOD_GlcNHglycan	395	398	PF01048	0.310
MOD_GlcNHglycan	503	507	PF01048	0.224
MOD_GlcNHglycan	517	520	PF01048	0.192
MOD_GlcNHglycan	541	544	PF01048	0.210
MOD_GlcNHglycan	564	567	PF01048	0.230
MOD_GlcNHglycan	655	659	PF01048	0.155
MOD_GlcNHglycan	668	671	PF01048	0.185
MOD_GlcNHglycan	676	679	PF01048	0.277
MOD_GlcNHglycan	689	692	PF01048	0.163
MOD_GlcNHglycan	701	704	PF01048	0.134
MOD_GSK3_1	108	115	PF00069	0.303
MOD_GSK3_1	133	140	PF00069	0.274
MOD_GSK3_1	389	396	PF00069	0.295
MOD_GSK3_1	493	500	PF00069	0.189
MOD_GSK3_1	502	509	PF00069	0.201
MOD_GSK3_1	520	527	PF00069	0.310
MOD_GSK3_1	597	604	PF00069	0.268
MOD_GSK3_1	650	657	PF00069	0.205
MOD_GSK3_1	683	690	PF00069	0.190
MOD_GSK3_1	699	706	PF00069	0.213
MOD_GSK3_1	710	717	PF00069	0.197
MOD_GSK3_1	730	737	PF00069	0.182
MOD_GSK3_1	805	812	PF00069	0.195
MOD_LATS_1	34	40	PF00433	0.299
MOD_N-GLC_1	14	19	PF02516	0.306
MOD_N-GLC_1	497	502	PF02516	0.155
MOD_N-GLC_1	539	544	PF02516	0.156
MOD_N-GLC_1	692	697	PF02516	0.243
MOD_N-GLC_1	810	815	PF02516	0.213
MOD_NEK2_1	133	138	PF00069	0.273
MOD_NEK2_1	163	168	PF00069	0.313
MOD_NEK2_1	267	272	PF00069	0.352
MOD_NEK2_1	35	40	PF00069	0.298
MOD_NEK2_1	357	362	PF00069	0.356
MOD_NEK2_1	363	368	PF00069	0.363
MOD_NEK2_1	382	387	PF00069	0.459
MOD_NEK2_1	461	466	PF00069	0.265
MOD_NEK2_1	599	604	PF00069	0.213
MOD_NEK2_1	6	11	PF00069	0.362
MOD_NEK2_1	714	719	PF00069	0.268
MOD_NEK2_1	810	815	PF00069	0.210
MOD_NEK2_1	824	829	PF00069	0.195
MOD_NEK2_1	837	842	PF00069	0.176
MOD_NEK2_1	97	102	PF00069	0.184
MOD_NEK2_2	403	408	PF00069	0.249
MOD_PIKK_1	352	358	PF00454	0.298
MOD_PIKK_1	41	47	PF00454	0.411
MOD_PIKK_1	590	596	PF00454	0.305
MOD_PIKK_1	730	736	PF00454	0.192
MOD_PIKK_1	827	833	PF00454	0.187
MOD_PK_1	226	232	PF00069	0.427
MOD_PKA_1	258	264	PF00069	0.381
MOD_PKA_1	778	784	PF00069	0.202
MOD_PKA_1	794	800	PF00069	0.227
MOD_PKA_1	803	809	PF00069	0.176
MOD_PKA_2	225	231	PF00069	0.476
MOD_PKA_2	314	320	PF00069	0.333
MOD_PKA_2	35	41	PF00069	0.365
MOD_PKA_2	393	399	PF00069	0.410
MOD_PKA_2	461	467	PF00069	0.277
MOD_PKA_2	6	12	PF00069	0.339
MOD_PKA_2	691	697	PF00069	0.140
MOD_PKA_2	778	784	PF00069	0.259
MOD_PKA_2	803	809	PF00069	0.192
MOD_PKA_2	843	849	PF00069	0.301
MOD_Plk_1	112	118	PF00069	0.267
MOD_Plk_1	126	132	PF00069	0.281
MOD_Plk_1	194	200	PF00069	0.265
MOD_Plk_2-3	194	200	PF00069	0.312
MOD_Plk_2-3	20	26	PF00069	0.371
MOD_Plk_2-3	520	526	PF00069	0.257
MOD_Plk_2-3	546	552	PF00069	0.315
MOD_Plk_2-3	601	607	PF00069	0.280
MOD_Plk_2-3	621	627	PF00069	0.158
MOD_Plk_2-3	638	644	PF00069	0.314
MOD_Plk_4	38	44	PF00069	0.350
MOD_Plk_4	6	12	PF00069	0.310
MOD_Plk_4	97	103	PF00069	0.301
MOD_ProDKin_1	207	213	PF00069	0.287
MOD_ProDKin_1	694	700	PF00069	0.161
MOD_SUMO_for_1	785	788	PF00179	0.277
MOD_SUMO_rev_2	850	858	PF00179	0.195
TRG_DiLeu_BaEn_4	663	669	PF01217	0.187
TRG_DiLeu_BaLyEn_6	294	299	PF01217	0.279
TRG_DiLeu_BaLyEn_6	305	310	PF01217	0.269
TRG_DiLeu_BaLyEn_6	320	325	PF01217	0.281
TRG_DiLeu_BaLyEn_6	378	383	PF01217	0.361
TRG_DiLeu_BaLyEn_6	715	720	PF01217	0.301
TRG_ENDOCYTIC_2	326	329	PF00928	0.280
TRG_ENDOCYTIC_2	345	348	PF00928	0.193
TRG_ENDOCYTIC_2	449	452	PF00928	0.201
TRG_ENDOCYTIC_2	453	456	PF00928	0.189
TRG_ENDOCYTIC_2	483	486	PF00928	0.211
TRG_ER_diArg_1	16	19	PF00400	0.332
TRG_ER_diArg_1	187	190	PF00400	0.274
TRG_ER_diArg_1	580	583	PF00400	0.296
TRG_ER_diArg_1	802	804	PF00400	0.206
TRG_NLS_Bipartite_1	258	279	PF00514	0.291
TRG_NLS_Bipartite_1	794	808	PF00514	0.211
TRG_NLS_MonoExtC_3	578	584	PF00514	0.228
TRG_NLS_MonoExtN_4	272	279	PF00514	0.304
TRG_NLS_MonoExtN_4	577	583	PF00514	0.278
TRG_NLS_MonoExtN_4	803	808	PF00514	0.194
TRG_Pf-PMV_PEXEL_1	297	301	PF00026	0.321
TRG_Pf-PMV_PEXEL_1	424	428	PF00026	0.212
TRG_Pf-PMV_PEXEL_1	443	447	PF00026	0.139
TRG_Pf-PMV_PEXEL_1	46	51	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	718	722	PF00026	0.195

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7R9	Leptomonas seymouri	73%	100%
A0A0S4J2U0	Bodo saltans	59%	97%
A0A1X0NT40	Trypanosomatidae	71%	100%
A0A3S5H720	Leishmania donovani	91%	99%
A4H993	Leishmania braziliensis	82%	99%
A4HXL4	Leishmania infantum	92%	99%
C9ZPA8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
P53313	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
Q4QE53	Leishmania major	92%	100%
Q6NV26	Danio rerio	35%	100%