Putative L-gulonolactone oxidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

L-galactonolactone oxidase, putative

Species:

Leishmania mexicana

UniProt:

E9ARA9_LEIMU

TriTrypDb:

LmxM.17.1360

Length:

502

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0020022	acidocalcisome	5	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9ARA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARA9

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	1
GO:0005996	monosaccharide metabolic process	3	1
GO:0006082	organic acid metabolic process	3	1
GO:0006766	vitamin metabolic process	3	1
GO:0006767	water-soluble vitamin metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009110	vitamin biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0016051	carbohydrate biosynthetic process	4	1
GO:0016053	organic acid biosynthetic process	4	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0019852	L-ascorbic acid metabolic process	4	1
GO:0019853	L-ascorbic acid biosynthetic process	5	1
GO:0042364	water-soluble vitamin biosynthetic process	5	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046364	monosaccharide biosynthetic process	4	1
GO:0046394	carboxylic acid biosynthetic process	5	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901334	lactone metabolic process	4	1
GO:1901336	lactone biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0003885	D-arabinono-1,4-lactone oxidase activity	5	12
GO:0005488	binding	1	12
GO:0016491	oxidoreductase activity	2	12
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	12
GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0050105	L-gulonolactone oxidase activity	5	5
GO:0050660	flavin adenine dinucleotide binding	4	12
GO:0071949	FAD binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0010181	FMN binding	4	1
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	2
GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	4	2
GO:0032553	ribonucleotide binding	3	1
GO:0050024	L-galactonolactone oxidase activity	5	2
GO:0097367	carbohydrate derivative binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	144	148	PF00656	0.234
CLV_NRD_NRD_1	427	429	PF00675	0.387
CLV_NRD_NRD_1	473	475	PF00675	0.330
CLV_PCSK_KEX2_1	427	429	PF00082	0.387
CLV_PCSK_KEX2_1	472	474	PF00082	0.379
CLV_PCSK_SKI1_1	141	145	PF00082	0.373
CLV_PCSK_SKI1_1	290	294	PF00082	0.496
CLV_PCSK_SKI1_1	329	333	PF00082	0.300
CLV_PCSK_SKI1_1	455	459	PF00082	0.333
CLV_Separin_Metazoa	38	42	PF03568	0.299
DEG_MDM2_SWIB_1	481	489	PF02201	0.262
DOC_CDC14_PxL_1	242	250	PF14671	0.542
DOC_CKS1_1	249	254	PF01111	0.430
DOC_CYCLIN_yCln2_LP_2	384	390	PF00134	0.403
DOC_MAPK_MEF2A_6	379	386	PF00069	0.356
DOC_MAPK_MEF2A_6	406	415	PF00069	0.262
DOC_MAPK_NFAT4_5	379	387	PF00069	0.403
DOC_PP1_RVXF_1	185	191	PF00149	0.478
DOC_PP1_RVXF_1	327	333	PF00149	0.232
DOC_PP4_FxxP_1	392	395	PF00568	0.447
DOC_USP7_MATH_1	125	129	PF00917	0.322
DOC_USP7_MATH_1	264	268	PF00917	0.469
DOC_USP7_MATH_1	280	284	PF00917	0.593
DOC_USP7_MATH_1	395	399	PF00917	0.387
DOC_USP7_UBL2_3	290	294	PF12436	0.607
DOC_WW_Pin1_4	248	253	PF00397	0.627
DOC_WW_Pin1_4	260	265	PF00397	0.582
DOC_WW_Pin1_4	398	403	PF00397	0.262
DOC_WW_Pin1_4	488	493	PF00397	0.406
DOC_WW_Pin1_4	52	57	PF00397	0.262
LIG_14-3-3_CanoR_1	115	119	PF00244	0.363
LIG_14-3-3_CanoR_1	329	337	PF00244	0.415
LIG_14-3-3_CanoR_1	391	395	PF00244	0.373
LIG_14-3-3_CanoR_1	494	502	PF00244	0.394
LIG_Actin_WH2_2	149	167	PF00022	0.452
LIG_APCC_Cbox_1	466	472	PF00515	0.299
LIG_BIR_II_1	1	5	PF00653	0.689
LIG_CSL_BTD_1	221	224	PF09270	0.287
LIG_deltaCOP1_diTrp_1	307	311	PF00928	0.381
LIG_deltaCOP1_diTrp_1	463	468	PF00928	0.353
LIG_FHA_1	179	185	PF00498	0.402
LIG_FHA_1	28	34	PF00498	0.377
LIG_FHA_1	296	302	PF00498	0.368
LIG_FHA_1	406	412	PF00498	0.285
LIG_FHA_2	142	148	PF00498	0.224
LIG_FHA_2	391	397	PF00498	0.297
LIG_LIR_Apic_2	389	395	PF02991	0.353
LIG_LIR_Gen_1	347	356	PF02991	0.280
LIG_LIR_Gen_1	368	377	PF02991	0.335
LIG_LIR_Gen_1	431	440	PF02991	0.387
LIG_LIR_Gen_1	463	471	PF02991	0.269
LIG_LIR_Gen_1	7	16	PF02991	0.450
LIG_LIR_Nem_3	227	233	PF02991	0.375
LIG_LIR_Nem_3	347	351	PF02991	0.280
LIG_LIR_Nem_3	368	373	PF02991	0.335
LIG_LIR_Nem_3	408	413	PF02991	0.261
LIG_LIR_Nem_3	431	436	PF02991	0.387
LIG_LIR_Nem_3	463	468	PF02991	0.292
LIG_LIR_Nem_3	7	13	PF02991	0.453
LIG_LYPXL_S_1	315	319	PF13949	0.327
LIG_LYPXL_yS_3	316	319	PF13949	0.327
LIG_PALB2_WD40_1	481	489	PF16756	0.403
LIG_Pex14_1	446	450	PF04695	0.262
LIG_Pex14_2	348	352	PF04695	0.262
LIG_Pex14_2	386	390	PF04695	0.265
LIG_Pex14_2	481	485	PF04695	0.262
LIG_PTB_Apo_2	321	328	PF02174	0.278
LIG_PTB_Apo_2	480	487	PF02174	0.403
LIG_PTB_Phospho_1	321	327	PF10480	0.278
LIG_SH2_CRK	327	331	PF00017	0.238
LIG_SH2_GRB2like	322	325	PF00017	0.297
LIG_SH2_STAT5	113	116	PF00017	0.322
LIG_SH2_STAT5	139	142	PF00017	0.297
LIG_SH2_STAT5	295	298	PF00017	0.423
LIG_SH2_STAT5	322	325	PF00017	0.302
LIG_SH3_3	190	196	PF00018	0.419
LIG_SH3_3	243	249	PF00018	0.638
LIG_SH3_3	401	407	PF00018	0.299
LIG_SUMO_SIM_par_1	74	80	PF11976	0.321
LIG_TRAF2_1	266	269	PF00917	0.557
LIG_TRAF2_1	29	32	PF00917	0.257
LIG_WRPW_2	416	419	PF00400	0.274
MOD_CDC14_SPxK_1	491	494	PF00782	0.484
MOD_CDK_SPxK_1	488	494	PF00069	0.461
MOD_CK1_1	283	289	PF00069	0.482
MOD_CK1_1	398	404	PF00069	0.403
MOD_CK1_1	55	61	PF00069	0.322
MOD_CK1_1	77	83	PF00069	0.403
MOD_CK1_1	8	14	PF00069	0.469
MOD_CK2_1	26	32	PF00069	0.277
MOD_CK2_1	338	344	PF00069	0.330
MOD_CMANNOS	308	311	PF00535	0.381
MOD_GlcNHglycan	1	4	PF01048	0.635
MOD_GlcNHglycan	128	131	PF01048	0.262
MOD_GlcNHglycan	241	245	PF01048	0.640
MOD_GlcNHglycan	275	278	PF01048	0.704
MOD_GlcNHglycan	282	286	PF01048	0.596
MOD_GlcNHglycan	332	335	PF01048	0.317
MOD_GlcNHglycan	340	343	PF01048	0.272
MOD_GSK3_1	109	116	PF00069	0.271
MOD_GSK3_1	121	128	PF00069	0.244
MOD_GSK3_1	15	22	PF00069	0.550
MOD_GSK3_1	260	267	PF00069	0.629
MOD_GSK3_1	55	62	PF00069	0.314
MOD_GSK3_1	77	84	PF00069	0.379
MOD_N-GLC_1	495	500	PF02516	0.379
MOD_NEK2_1	39	44	PF00069	0.353
MOD_NEK2_1	390	395	PF00069	0.356
MOD_NEK2_2	15	20	PF00069	0.550
MOD_PIKK_1	191	197	PF00454	0.417
MOD_PIKK_1	264	270	PF00454	0.499
MOD_PIKK_1	27	33	PF00454	0.232
MOD_PIKK_1	39	45	PF00454	0.337
MOD_PK_1	74	80	PF00069	0.278
MOD_PKA_2	114	120	PF00069	0.374
MOD_PKA_2	271	277	PF00069	0.406
MOD_PKA_2	338	344	PF00069	0.390
MOD_PKA_2	390	396	PF00069	0.274
MOD_PKA_2	405	411	PF00069	0.230
MOD_PKA_2	423	429	PF00069	0.262
MOD_PKA_2	8	14	PF00069	0.531
MOD_Plk_1	178	184	PF00069	0.446
MOD_Plk_1	240	246	PF00069	0.629
MOD_Plk_1	306	312	PF00069	0.395
MOD_Plk_2-3	344	350	PF00069	0.278
MOD_Plk_4	109	115	PF00069	0.262
MOD_Plk_4	141	147	PF00069	0.192
MOD_Plk_4	283	289	PF00069	0.553
MOD_ProDKin_1	248	254	PF00069	0.630
MOD_ProDKin_1	260	266	PF00069	0.580
MOD_ProDKin_1	398	404	PF00069	0.262
MOD_ProDKin_1	488	494	PF00069	0.409
MOD_ProDKin_1	52	58	PF00069	0.262
TRG_DiLeu_BaLyEn_6	243	248	PF01217	0.394
TRG_ENDOCYTIC_2	233	236	PF00928	0.479
TRG_ENDOCYTIC_2	316	319	PF00928	0.272
TRG_ENDOCYTIC_2	327	330	PF00928	0.195
TRG_ENDOCYTIC_2	430	433	PF00928	0.270
TRG_ER_diArg_1	471	474	PF00400	0.400
TRG_NES_CRM1_1	237	250	PF08389	0.367
TRG_Pf-PMV_PEXEL_1	74	79	PF00026	0.322

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA41	Leptomonas seymouri	61%	94%
A0A0S4J5V1	Bodo saltans	42%	92%
A0A1X0NU47	Trypanosomatidae	42%	91%
A0A3S5H719	Leishmania donovani	89%	100%
A0A422NB30	Trypanosoma rangeli	44%	99%
A4H992	Leishmania braziliensis	82%	100%
A4HXL3	Leishmania infantum	89%	100%
C9ZPA7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	97%
O47881	Brassica oleracea	22%	84%
O81030	Arabidopsis thaliana	23%	85%
O93852	Candida albicans (strain SC5314 / ATCC MYA-2876)	21%	90%
P10867	Rattus norvegicus	26%	100%
P54783	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	95%
P58710	Mus musculus	26%	100%
P9WIT2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	25%	100%
P9WIT3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	25%	100%
Q2QXY1	Oryza sativa subsp. japonica	23%	86%
Q2RAP0	Oryza sativa subsp. japonica	24%	86%
Q3ZC33	Bos taurus	27%	100%
Q4QE54	Leishmania major	90%	100%
Q6CG88	Yarrowia lipolytica (strain CLIB 122 / E 150)	21%	95%
Q6CSY3	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	22%	96%
Q6NQ66	Arabidopsis thaliana	23%	85%
Q752Y3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	22%	94%
Q7SGY1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	27%	90%
Q8HXW0	Sus scrofa	26%	100%
Q90YK3	Scyliorhinus torazame	27%	100%
Q9LYD8	Arabidopsis thaliana	21%	86%
Q9SU56	Arabidopsis thaliana	23%	82%
V5BEU1	Trypanosoma cruzi	46%	91%