CTP_transf_like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytidylyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9ARA7_LEIMU

TriTrypDb:

LmxM.17.1340

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ARA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARA7

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009165	nucleotide biosynthetic process	6	1
GO:0009435	NAD biosynthetic process	8	1
GO:0009987	cellular process	1	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019359	nicotinamide nucleotide biosynthetic process	7	1
GO:0019362	pyridine nucleotide metabolic process	5	1
GO:0019363	pyridine nucleotide biosynthetic process	6	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046496	nicotinamide nucleotide metabolic process	6	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072524	pyridine-containing compound metabolic process	4	1
GO:0072525	pyridine-containing compound biosynthetic process	5	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901293	nucleoside phosphate biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0000309	nicotinamide-nucleotide adenylyltransferase activity	6	2
GO:0004515	nicotinate-nucleotide adenylyltransferase activity	6	2
GO:0016740	transferase activity	2	4
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	4
GO:0016779	nucleotidyltransferase activity	4	4
GO:0070566	adenylyltransferase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	71	75	PF00656	0.537
CLV_NRD_NRD_1	105	107	PF00675	0.322
CLV_NRD_NRD_1	189	191	PF00675	0.203
CLV_NRD_NRD_1	90	92	PF00675	0.376
CLV_PCSK_KEX2_1	189	191	PF00082	0.226
CLV_PCSK_SKI1_1	106	110	PF00082	0.298
CLV_PCSK_SKI1_1	129	133	PF00082	0.391
CLV_PCSK_SKI1_1	164	168	PF00082	0.321
CLV_PCSK_SKI1_1	189	193	PF00082	0.293
CLV_PCSK_SKI1_1	278	282	PF00082	0.517
CLV_PCSK_SKI1_1	286	290	PF00082	0.474
DOC_CYCLIN_RxL_1	186	194	PF00134	0.508
DOC_MAPK_gen_1	159	168	PF00069	0.551
DOC_MAPK_MEF2A_6	159	167	PF00069	0.414
DOC_PP1_RVXF_1	162	168	PF00149	0.514
DOC_PP2B_LxvP_1	249	252	PF13499	0.552
DOC_PP4_FxxP_1	177	180	PF00568	0.490
DOC_PP4_FxxP_1	82	85	PF00568	0.508
DOC_USP7_MATH_1	24	28	PF00917	0.652
DOC_USP7_MATH_1	280	284	PF00917	0.559
DOC_USP7_MATH_1	293	297	PF00917	0.372
DOC_USP7_MATH_1	66	70	PF00917	0.569
DOC_WW_Pin1_4	267	272	PF00397	0.502
DOC_WW_Pin1_4	81	86	PF00397	0.490
LIG_14-3-3_CanoR_1	241	247	PF00244	0.526
LIG_14-3-3_CanoR_1	261	267	PF00244	0.440
LIG_APCC_ABBA_1	198	203	PF00400	0.551
LIG_APCC_ABBA_1	298	303	PF00400	0.465
LIG_CSL_BTD_1	177	180	PF09270	0.536
LIG_FHA_1	11	17	PF00498	0.563
LIG_FHA_1	128	134	PF00498	0.508
LIG_FHA_1	219	225	PF00498	0.595
LIG_LIR_Apic_2	175	180	PF02991	0.490
LIG_LIR_Apic_2	88	93	PF02991	0.563
LIG_LIR_Gen_1	172	180	PF02991	0.475
LIG_LIR_Gen_1	213	223	PF02991	0.436
LIG_LIR_Gen_1	243	252	PF02991	0.561
LIG_LIR_Nem_3	128	134	PF02991	0.529
LIG_LIR_Nem_3	172	177	PF02991	0.492
LIG_LIR_Nem_3	193	198	PF02991	0.561
LIG_LIR_Nem_3	213	218	PF02991	0.355
LIG_LIR_Nem_3	243	249	PF02991	0.561
LIG_LIR_Nem_3	299	304	PF02991	0.503
LIG_LIR_Nem_3	51	55	PF02991	0.494
LIG_NRBOX	187	193	PF00104	0.508
LIG_PCNA_yPIPBox_3	278	289	PF02747	0.561
LIG_Pex14_2	174	178	PF04695	0.561
LIG_SH2_CRK	90	94	PF00017	0.561
LIG_SH2_STAP1	127	131	PF00017	0.539
LIG_SH2_STAP1	242	246	PF00017	0.531
LIG_SH2_STAT3	9	12	PF00017	0.301
LIG_SH2_STAT5	127	130	PF00017	0.469
LIG_SH2_STAT5	242	245	PF00017	0.542
LIG_TRAF2_1	136	139	PF00917	0.592
LIG_WRC_WIRS_1	174	179	PF05994	0.344
LIG_WRC_WIRS_1	192	197	PF05994	0.344
MOD_CK1_1	240	246	PF00069	0.441
MOD_CK1_1	27	33	PF00069	0.644
MOD_CK2_1	26	32	PF00069	0.705
MOD_CK2_1	260	266	PF00069	0.276
MOD_CK2_1	293	299	PF00069	0.485
MOD_GlcNHglycan	249	252	PF01048	0.459
MOD_GlcNHglycan	26	29	PF01048	0.497
MOD_GlcNHglycan	262	265	PF01048	0.361
MOD_GlcNHglycan	96	99	PF01048	0.429
MOD_GSK3_1	32	39	PF00069	0.697
MOD_NEK2_1	173	178	PF00069	0.344
MOD_NEK2_1	191	196	PF00069	0.344
MOD_NEK2_2	127	132	PF00069	0.401
MOD_PIKK_1	32	38	PF00454	0.717
MOD_PKA_2	240	246	PF00069	0.388
MOD_PKA_2	260	266	PF00069	0.276
MOD_Plk_1	237	243	PF00069	0.400
MOD_Plk_4	173	179	PF00069	0.327
MOD_Plk_4	293	299	PF00069	0.401
MOD_ProDKin_1	267	273	PF00069	0.506
MOD_ProDKin_1	81	87	PF00069	0.344
TRG_DiLeu_BaLyEn_6	183	188	PF01217	0.418
TRG_DiLeu_BaLyEn_6	220	225	PF01217	0.491
TRG_ENDOCYTIC_2	301	304	PF00928	0.532
TRG_ER_diArg_1	161	164	PF00400	0.429
TRG_ER_diArg_1	188	190	PF00400	0.254
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDK8	Leptomonas seymouri	56%	100%
A0A0S4J2V8	Bodo saltans	36%	100%
A0A3Q8ICX3	Leishmania donovani	91%	100%
A0A3R7KAJ0	Trypanosoma rangeli	41%	100%
A4H990	Leishmania braziliensis	77%	100%
A4HXL1	Leishmania infantum	90%	100%
Q4QE56	Leishmania major	89%	100%
V5BNX9	Trypanosoma cruzi	41%	100%