Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ARA5_LEIMU

TriTrypDb:

LmxM.17.1320

Length:

586

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ARA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARA5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.647
CLV_NRD_NRD_1	123	125	PF00675	0.615
CLV_NRD_NRD_1	427	429	PF00675	0.500
CLV_PCSK_FUR_1	120	124	PF00082	0.621
CLV_PCSK_KEX2_1	122	124	PF00082	0.620
CLV_PCSK_KEX2_1	521	523	PF00082	0.408
CLV_PCSK_PC1ET2_1	521	523	PF00082	0.390
CLV_PCSK_SKI1_1	450	454	PF00082	0.529
DEG_Nend_UBRbox_3	1	3	PF02207	0.616
DEG_SCF_FBW7_1	144	150	PF00400	0.690
DEG_SCF_TRCP1_1	136	141	PF00400	0.696
DOC_CKS1_1	144	149	PF01111	0.687
DOC_CKS1_1	92	97	PF01111	0.655
DOC_PP4_FxxP_1	269	272	PF00568	0.588
DOC_PP4_FxxP_1	89	92	PF00568	0.527
DOC_USP7_MATH_1	147	151	PF00917	0.514
DOC_USP7_MATH_1	259	263	PF00917	0.637
DOC_USP7_MATH_1	306	310	PF00917	0.595
DOC_USP7_MATH_1	359	363	PF00917	0.640
DOC_USP7_MATH_1	478	482	PF00917	0.566
DOC_USP7_MATH_1	573	577	PF00917	0.594
DOC_USP7_MATH_1	64	68	PF00917	0.715
DOC_USP7_UBL2_3	429	433	PF12436	0.463
DOC_WW_Pin1_4	124	129	PF00397	0.619
DOC_WW_Pin1_4	143	148	PF00397	0.791
DOC_WW_Pin1_4	152	157	PF00397	0.580
DOC_WW_Pin1_4	189	194	PF00397	0.678
DOC_WW_Pin1_4	213	218	PF00397	0.669
DOC_WW_Pin1_4	22	27	PF00397	0.578
DOC_WW_Pin1_4	223	228	PF00397	0.677
DOC_WW_Pin1_4	243	248	PF00397	0.797
DOC_WW_Pin1_4	249	254	PF00397	0.774
DOC_WW_Pin1_4	295	300	PF00397	0.724
DOC_WW_Pin1_4	351	356	PF00397	0.613
DOC_WW_Pin1_4	36	41	PF00397	0.608
DOC_WW_Pin1_4	485	490	PF00397	0.555
DOC_WW_Pin1_4	55	60	PF00397	0.577
DOC_WW_Pin1_4	91	96	PF00397	0.600
LIG_14-3-3_CanoR_1	305	311	PF00244	0.562
LIG_14-3-3_CanoR_1	456	464	PF00244	0.425
LIG_14-3-3_CanoR_1	496	506	PF00244	0.450
LIG_14-3-3_CanoR_1	578	584	PF00244	0.615
LIG_14-3-3_CanoR_1	60	69	PF00244	0.583
LIG_14-3-3_CanoR_1	98	105	PF00244	0.541
LIG_BRCT_BRCA1_1	306	310	PF00533	0.584
LIG_BRCT_BRCA1_1	332	336	PF00533	0.626
LIG_BRCT_BRCA1_1	480	484	PF00533	0.528
LIG_EVH1_2	319	323	PF00568	0.579
LIG_FHA_1	435	441	PF00498	0.466
LIG_FHA_1	474	480	PF00498	0.572
LIG_FHA_1	540	546	PF00498	0.415
LIG_FHA_2	206	212	PF00498	0.539
LIG_FHA_2	29	35	PF00498	0.613
LIG_FHA_2	78	84	PF00498	0.681
LIG_LIR_Apic_2	104	108	PF02991	0.601
LIG_LIR_Apic_2	267	272	PF02991	0.580
LIG_LIR_Apic_2	67	72	PF02991	0.494
LIG_LIR_Gen_1	298	306	PF02991	0.510
LIG_LIR_Gen_1	481	492	PF02991	0.516
LIG_LIR_Gen_1	505	513	PF02991	0.420
LIG_LIR_Nem_3	298	304	PF02991	0.511
LIG_LIR_Nem_3	35	41	PF02991	0.700
LIG_LIR_Nem_3	481	487	PF02991	0.518
LIG_LIR_Nem_3	505	509	PF02991	0.466
LIG_LIR_Nem_3	511	515	PF02991	0.438
LIG_LIR_Nem_3	519	523	PF02991	0.406
LIG_PDZ_Class_3	581	586	PF00595	0.532
LIG_PROFILIN_1	227	233	PF00235	0.631
LIG_PTB_Apo_2	215	222	PF02174	0.713
LIG_PTB_Phospho_1	215	221	PF10480	0.711
LIG_SH2_CRK	105	109	PF00017	0.599
LIG_SH2_NCK_1	69	73	PF00017	0.507
LIG_SH2_PTP2	301	304	PF00017	0.553
LIG_SH2_SRC	22	25	PF00017	0.578
LIG_SH2_SRC	301	304	PF00017	0.553
LIG_SH2_STAT3	195	198	PF00017	0.656
LIG_SH2_STAT3	523	526	PF00017	0.395
LIG_SH2_STAT5	221	224	PF00017	0.850
LIG_SH2_STAT5	301	304	PF00017	0.553
LIG_SH2_STAT5	350	353	PF00017	0.648
LIG_SH2_STAT5	498	501	PF00017	0.386
LIG_SH2_STAT5	523	526	PF00017	0.420
LIG_SH2_STAT5	56	59	PF00017	0.627
LIG_SH3_3	141	147	PF00018	0.648
LIG_SH3_3	150	156	PF00018	0.680
LIG_SH3_3	224	230	PF00018	0.691
LIG_SH3_3	411	417	PF00018	0.507
LIG_SH3_3	459	465	PF00018	0.617
LIG_SH3_3	486	492	PF00018	0.505
LIG_SH3_3	89	95	PF00018	0.620
LIG_UBA3_1	395	401	PF00899	0.495
LIG_WRC_WIRS_1	517	522	PF05994	0.361
LIG_WW_2	231	234	PF00397	0.655
LIG_WW_3	151	155	PF00397	0.614
MOD_CDK_SPK_2	189	194	PF00069	0.586
MOD_CDK_SPK_2	55	60	PF00069	0.577
MOD_CDK_SPxxK_3	189	196	PF00069	0.661
MOD_CDK_SPxxK_3	91	98	PF00069	0.580
MOD_CK1_1	127	133	PF00069	0.632
MOD_CK1_1	134	140	PF00069	0.641
MOD_CK1_1	163	169	PF00069	0.651
MOD_CK1_1	200	206	PF00069	0.625
MOD_CK1_1	248	254	PF00069	0.632
MOD_CK1_1	309	315	PF00069	0.591
MOD_CK1_1	362	368	PF00069	0.813
MOD_CK1_1	39	45	PF00069	0.597
MOD_CK1_1	397	403	PF00069	0.520
MOD_CK1_1	405	411	PF00069	0.559
MOD_CK1_1	485	491	PF00069	0.549
MOD_CK1_1	58	64	PF00069	0.751
MOD_CK1_1	7	13	PF00069	0.604
MOD_CK1_1	90	96	PF00069	0.667
MOD_CK1_1	97	103	PF00069	0.604
MOD_CK2_1	205	211	PF00069	0.535
MOD_CK2_1	460	466	PF00069	0.525
MOD_CK2_1	565	571	PF00069	0.434
MOD_CK2_1	64	70	PF00069	0.756
MOD_CK2_1	77	83	PF00069	0.598
MOD_DYRK1A_RPxSP_1	213	217	PF00069	0.714
MOD_GlcNHglycan	112	115	PF01048	0.538
MOD_GlcNHglycan	136	139	PF01048	0.721
MOD_GlcNHglycan	140	143	PF01048	0.769
MOD_GlcNHglycan	161	165	PF01048	0.666
MOD_GlcNHglycan	171	174	PF01048	0.595
MOD_GlcNHglycan	199	202	PF01048	0.716
MOD_GlcNHglycan	282	285	PF01048	0.628
MOD_GlcNHglycan	314	317	PF01048	0.754
MOD_GlcNHglycan	332	335	PF01048	0.569
MOD_GlcNHglycan	346	349	PF01048	0.630
MOD_GlcNHglycan	361	364	PF01048	0.801
MOD_GlcNHglycan	404	407	PF01048	0.705
MOD_GlcNHglycan	458	461	PF01048	0.527
MOD_GlcNHglycan	468	471	PF01048	0.617
MOD_GlcNHglycan	49	52	PF01048	0.707
MOD_GlcNHglycan	532	535	PF01048	0.421
MOD_GlcNHglycan	575	578	PF01048	0.611
MOD_GlcNHglycan	62	65	PF01048	0.651
MOD_GlcNHglycan	83	87	PF01048	0.673
MOD_GlcNHglycan	89	92	PF01048	0.773
MOD_GSK3_1	12	19	PF00069	0.569
MOD_GSK3_1	127	134	PF00069	0.677
MOD_GSK3_1	143	150	PF00069	0.619
MOD_GSK3_1	205	212	PF00069	0.671
MOD_GSK3_1	219	226	PF00069	0.688
MOD_GSK3_1	245	252	PF00069	0.649
MOD_GSK3_1	260	267	PF00069	0.689
MOD_GSK3_1	282	289	PF00069	0.687
MOD_GSK3_1	293	300	PF00069	0.582
MOD_GSK3_1	346	353	PF00069	0.685
MOD_GSK3_1	362	369	PF00069	0.604
MOD_GSK3_1	396	403	PF00069	0.696
MOD_GSK3_1	45	52	PF00069	0.664
MOD_GSK3_1	456	463	PF00069	0.423
MOD_GSK3_1	478	485	PF00069	0.571
MOD_GSK3_1	535	542	PF00069	0.413
MOD_GSK3_1	58	65	PF00069	0.593
MOD_GSK3_1	87	94	PF00069	0.617
MOD_LATS_1	344	350	PF00433	0.492
MOD_N-GLC_1	134	139	PF02516	0.641
MOD_N-GLC_1	482	487	PF02516	0.511
MOD_N-GLC_1	502	507	PF02516	0.469
MOD_NEK2_1	197	202	PF00069	0.625
MOD_NEK2_1	396	401	PF00069	0.676
MOD_NEK2_1	434	439	PF00069	0.547
MOD_NEK2_1	455	460	PF00069	0.468
MOD_NEK2_1	472	477	PF00069	0.632
MOD_NEK2_1	62	67	PF00069	0.586
MOD_NEK2_1	77	82	PF00069	0.692
MOD_NEK2_1	96	101	PF00069	0.598
MOD_NEK2_2	64	69	PF00069	0.584
MOD_PIKK_1	103	109	PF00454	0.602
MOD_PIKK_1	211	217	PF00454	0.640
MOD_PIKK_1	245	251	PF00454	0.669
MOD_PIKK_1	293	299	PF00454	0.599
MOD_PIKK_1	77	83	PF00454	0.750
MOD_PK_1	16	22	PF00069	0.581
MOD_PKA_2	304	310	PF00069	0.583
MOD_PKA_2	455	461	PF00069	0.420
MOD_PKA_2	87	93	PF00069	0.577
MOD_PKA_2	97	103	PF00069	0.600
MOD_Plk_1	482	488	PF00069	0.508
MOD_Plk_1	502	508	PF00069	0.433
MOD_Plk_1	559	565	PF00069	0.427
MOD_Plk_1	571	577	PF00069	0.669
MOD_Plk_2-3	205	211	PF00069	0.535
MOD_Plk_4	297	303	PF00069	0.528
MOD_Plk_4	309	315	PF00069	0.582
MOD_Plk_4	346	352	PF00069	0.503
MOD_Plk_4	420	426	PF00069	0.624
MOD_Plk_4	535	541	PF00069	0.389
MOD_Plk_4	559	565	PF00069	0.439
MOD_Plk_4	64	70	PF00069	0.491
MOD_ProDKin_1	124	130	PF00069	0.619
MOD_ProDKin_1	143	149	PF00069	0.794
MOD_ProDKin_1	152	158	PF00069	0.583
MOD_ProDKin_1	189	195	PF00069	0.679
MOD_ProDKin_1	213	219	PF00069	0.664
MOD_ProDKin_1	22	28	PF00069	0.577
MOD_ProDKin_1	223	229	PF00069	0.671
MOD_ProDKin_1	243	249	PF00069	0.798
MOD_ProDKin_1	295	301	PF00069	0.727
MOD_ProDKin_1	351	357	PF00069	0.613
MOD_ProDKin_1	36	42	PF00069	0.607
MOD_ProDKin_1	485	491	PF00069	0.549
MOD_ProDKin_1	55	61	PF00069	0.574
MOD_ProDKin_1	91	97	PF00069	0.602
MOD_SUMO_rev_2	378	385	PF00179	0.510
TRG_DiLeu_BaLyEn_6	436	441	PF01217	0.504
TRG_ENDOCYTIC_2	301	304	PF00928	0.517
TRG_ENDOCYTIC_2	506	509	PF00928	0.423
TRG_ER_diArg_1	121	124	PF00400	0.620
TRG_NES_CRM1_1	548	561	PF08389	0.500
TRG_Pf-PMV_PEXEL_1	522	526	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I056	Leptomonas seymouri	50%	90%
A0A3S7WUM9	Leishmania donovani	90%	100%
A4H977	Leishmania braziliensis	69%	100%
E9AGQ1	Leishmania infantum	89%	100%
Q4QE58	Leishmania major	89%	100%