Methyltranfer_dom domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ARA3_LEIMU

TriTrypDb:

LmxM.17.1310

Length:

1034

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ARA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARA3

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	322	326	PF00656	0.616
CLV_C14_Caspase3-7	57	61	PF00656	0.446
CLV_MEL_PAP_1	343	349	PF00089	0.436
CLV_NRD_NRD_1	1027	1029	PF00675	0.403
CLV_NRD_NRD_1	160	162	PF00675	0.399
CLV_NRD_NRD_1	168	170	PF00675	0.374
CLV_NRD_NRD_1	561	563	PF00675	0.656
CLV_NRD_NRD_1	672	674	PF00675	0.374
CLV_NRD_NRD_1	785	787	PF00675	0.498
CLV_NRD_NRD_1	841	843	PF00675	0.552
CLV_NRD_NRD_1	879	881	PF00675	0.452
CLV_PCSK_FUR_1	166	170	PF00082	0.444
CLV_PCSK_KEX2_1	1027	1029	PF00082	0.403
CLV_PCSK_KEX2_1	160	162	PF00082	0.399
CLV_PCSK_KEX2_1	168	170	PF00082	0.374
CLV_PCSK_KEX2_1	517	519	PF00082	0.590
CLV_PCSK_KEX2_1	560	562	PF00082	0.660
CLV_PCSK_KEX2_1	674	676	PF00082	0.541
CLV_PCSK_KEX2_1	785	787	PF00082	0.498
CLV_PCSK_KEX2_1	841	843	PF00082	0.515
CLV_PCSK_KEX2_1	879	881	PF00082	0.419
CLV_PCSK_PC1ET2_1	517	519	PF00082	0.590
CLV_PCSK_PC1ET2_1	674	676	PF00082	0.541
CLV_PCSK_PC7_1	781	787	PF00082	0.414
CLV_PCSK_SKI1_1	161	165	PF00082	0.478
CLV_PCSK_SKI1_1	582	586	PF00082	0.516
CLV_PCSK_SKI1_1	760	764	PF00082	0.250
CLV_PCSK_SKI1_1	786	790	PF00082	0.441
CLV_PCSK_SKI1_1	818	822	PF00082	0.370
CLV_PCSK_SKI1_1	823	827	PF00082	0.340
CLV_PCSK_SKI1_1	92	96	PF00082	0.449
CLV_PCSK_SKI1_1	933	937	PF00082	0.472
CLV_PCSK_SKI1_1	99	103	PF00082	0.409
DEG_MDM2_SWIB_1	826	833	PF02201	0.442
DEG_SPOP_SBC_1	136	140	PF00917	0.486
DEG_SPOP_SBC_1	603	607	PF00917	0.503
DOC_ANK_TNKS_1	517	524	PF00023	0.664
DOC_CKS1_1	619	624	PF01111	0.642
DOC_CKS1_1	722	727	PF01111	0.533
DOC_CKS1_1	911	916	PF01111	0.524
DOC_CYCLIN_RxL_1	89	96	PF00134	0.453
DOC_CYCLIN_yCln2_LP_2	7	13	PF00134	0.413
DOC_MAPK_gen_1	217	224	PF00069	0.431
DOC_MAPK_gen_1	324	332	PF00069	0.488
DOC_MAPK_gen_1	403	412	PF00069	0.612
DOC_MAPK_gen_1	579	589	PF00069	0.412
DOC_MAPK_gen_1	673	679	PF00069	0.477
DOC_MAPK_gen_1	707	716	PF00069	0.448
DOC_MAPK_gen_1	879	890	PF00069	0.413
DOC_MAPK_MEF2A_6	324	332	PF00069	0.594
DOC_MAPK_MEF2A_6	579	587	PF00069	0.458
DOC_MAPK_MEF2A_6	707	716	PF00069	0.436
DOC_MAPK_MEF2A_6	733	740	PF00069	0.348
DOC_MAPK_NFAT4_5	709	717	PF00069	0.448
DOC_PP1_RVXF_1	816	823	PF00149	0.413
DOC_PP1_RVXF_1	825	831	PF00149	0.360
DOC_PP2B_LxvP_1	333	336	PF13499	0.330
DOC_PP2B_LxvP_1	620	623	PF13499	0.485
DOC_PP2B_LxvP_1	7	10	PF13499	0.333
DOC_USP7_MATH_1	1002	1006	PF00917	0.480
DOC_USP7_MATH_1	144	148	PF00917	0.530
DOC_USP7_MATH_1	3	7	PF00917	0.462
DOC_USP7_MATH_1	365	369	PF00917	0.391
DOC_USP7_MATH_1	382	386	PF00917	0.769
DOC_USP7_MATH_1	398	402	PF00917	0.487
DOC_USP7_MATH_1	445	449	PF00917	0.672
DOC_USP7_MATH_1	592	596	PF00917	0.613
DOC_USP7_MATH_1	603	607	PF00917	0.593
DOC_USP7_MATH_1	72	76	PF00917	0.590
DOC_USP7_MATH_1	720	724	PF00917	0.592
DOC_USP7_MATH_1	847	851	PF00917	0.618
DOC_USP7_MATH_2	564	570	PF00917	0.508
DOC_WW_Pin1_4	1015	1020	PF00397	0.432
DOC_WW_Pin1_4	139	144	PF00397	0.698
DOC_WW_Pin1_4	147	152	PF00397	0.534
DOC_WW_Pin1_4	458	463	PF00397	0.741
DOC_WW_Pin1_4	560	565	PF00397	0.642
DOC_WW_Pin1_4	599	604	PF00397	0.734
DOC_WW_Pin1_4	605	610	PF00397	0.730
DOC_WW_Pin1_4	618	623	PF00397	0.478
DOC_WW_Pin1_4	721	726	PF00397	0.549
DOC_WW_Pin1_4	770	775	PF00397	0.533
DOC_WW_Pin1_4	78	83	PF00397	0.514
DOC_WW_Pin1_4	806	811	PF00397	0.589
DOC_WW_Pin1_4	907	912	PF00397	0.475
LIG_14-3-3_CanoR_1	242	250	PF00244	0.575
LIG_14-3-3_CanoR_1	286	291	PF00244	0.376
LIG_14-3-3_CanoR_1	32	42	PF00244	0.287
LIG_14-3-3_CanoR_1	444	453	PF00244	0.604
LIG_14-3-3_CanoR_1	53	59	PF00244	0.417
LIG_14-3-3_CanoR_1	530	538	PF00244	0.731
LIG_14-3-3_CanoR_1	567	573	PF00244	0.516
LIG_14-3-3_CanoR_1	673	678	PF00244	0.347
LIG_14-3-3_CanoR_1	70	78	PF00244	0.498
LIG_14-3-3_CanoR_1	733	737	PF00244	0.416
LIG_14-3-3_CanoR_1	755	764	PF00244	0.539
LIG_14-3-3_CanoR_1	785	795	PF00244	0.416
LIG_14-3-3_CanoR_1	814	822	PF00244	0.375
LIG_14-3-3_CanoR_1	933	942	PF00244	0.459
LIG_Actin_WH2_2	35	52	PF00022	0.355
LIG_APCC_ABBA_1	981	986	PF00400	0.436
LIG_BIR_III_2	868	872	PF00653	0.300
LIG_BRCT_BRCA1_1	74	78	PF00533	0.479
LIG_Clathr_ClatBox_1	586	590	PF01394	0.427
LIG_Clathr_ClatBox_1	974	978	PF01394	0.325
LIG_deltaCOP1_diTrp_1	69	78	PF00928	0.568
LIG_EH1_1	580	588	PF00400	0.485
LIG_EH1_1	968	976	PF00400	0.334
LIG_eIF4E_1	581	587	PF01652	0.515
LIG_FHA_1	157	163	PF00498	0.366
LIG_FHA_1	33	39	PF00498	0.511
LIG_FHA_1	407	413	PF00498	0.550
LIG_FHA_1	424	430	PF00498	0.390
LIG_FHA_1	646	652	PF00498	0.408
LIG_FHA_1	674	680	PF00498	0.516
LIG_FHA_1	722	728	PF00498	0.571
LIG_FHA_1	733	739	PF00498	0.404
LIG_FHA_1	788	794	PF00498	0.357
LIG_FHA_1	797	803	PF00498	0.391
LIG_FHA_1	89	95	PF00498	0.571
LIG_FHA_2	119	125	PF00498	0.339
LIG_FHA_2	179	185	PF00498	0.426
LIG_FHA_2	34	40	PF00498	0.587
LIG_FHA_2	361	367	PF00498	0.550
LIG_FHA_2	402	408	PF00498	0.770
LIG_FHA_2	496	502	PF00498	0.604
LIG_FHA_2	627	633	PF00498	0.498
LIG_FHA_2	924	930	PF00498	0.463
LIG_Integrin_RGD_1	405	407	PF01839	0.608
LIG_Integrin_RGD_1	683	685	PF01839	0.386
LIG_LIR_Apic_2	695	700	PF02991	0.486
LIG_LIR_Gen_1	311	321	PF02991	0.476
LIG_LIR_Gen_1	350	361	PF02991	0.463
LIG_LIR_Gen_1	60	69	PF02991	0.403
LIG_LIR_Gen_1	646	655	PF02991	0.488
LIG_LIR_Gen_1	766	777	PF02991	0.450
LIG_LIR_Gen_1	887	898	PF02991	0.380
LIG_LIR_Gen_1	952	962	PF02991	0.390
LIG_LIR_LC3C_4	207	210	PF02991	0.497
LIG_LIR_Nem_3	21	26	PF02991	0.362
LIG_LIR_Nem_3	311	316	PF02991	0.482
LIG_LIR_Nem_3	350	356	PF02991	0.459
LIG_LIR_Nem_3	493	499	PF02991	0.501
LIG_LIR_Nem_3	60	66	PF02991	0.357
LIG_LIR_Nem_3	646	650	PF02991	0.488
LIG_LIR_Nem_3	766	772	PF02991	0.450
LIG_LIR_Nem_3	824	829	PF02991	0.404
LIG_LIR_Nem_3	887	893	PF02991	0.387
LIG_LIR_Nem_3	952	957	PF02991	0.371
LIG_LIR_Nem_3	96	101	PF02991	0.438
LIG_MYND_1	871	875	PF01753	0.410
LIG_NRBOX	824	830	PF00104	0.372
LIG_Pex14_2	822	826	PF04695	0.442
LIG_Rb_pABgroove_1	1007	1015	PF01858	0.392
LIG_REV1ctd_RIR_1	819	827	PF16727	0.405
LIG_RPA_C_Fungi	259	271	PF08784	0.406
LIG_SH2_CRK	1022	1026	PF00017	0.432
LIG_SH2_CRK	581	585	PF00017	0.480
LIG_SH2_CRK	647	651	PF00017	0.538
LIG_SH2_NCK_1	380	384	PF00017	0.471
LIG_SH2_SRC	901	904	PF00017	0.514
LIG_SH2_STAP1	647	651	PF00017	0.416
LIG_SH2_STAT5	283	286	PF00017	0.375
LIG_SH2_STAT5	41	44	PF00017	0.337
LIG_SH2_STAT5	488	491	PF00017	0.530
LIG_SH2_STAT5	540	543	PF00017	0.596
LIG_SH2_STAT5	576	579	PF00017	0.583
LIG_SH2_STAT5	62	65	PF00017	0.464
LIG_SH2_STAT5	647	650	PF00017	0.475
LIG_SH2_STAT5	901	904	PF00017	0.418
LIG_SH2_STAT5	934	937	PF00017	0.523
LIG_SH2_STAT5	982	985	PF00017	0.380
LIG_SH3_1	908	914	PF00018	0.544
LIG_SH3_3	140	146	PF00018	0.632
LIG_SH3_3	247	253	PF00018	0.501
LIG_SH3_3	459	465	PF00018	0.728
LIG_SH3_3	616	622	PF00018	0.726
LIG_SH3_3	713	719	PF00018	0.439
LIG_SH3_3	724	730	PF00018	0.422
LIG_SH3_3	843	849	PF00018	0.632
LIG_SH3_3	864	870	PF00018	0.436
LIG_SH3_3	908	914	PF00018	0.544
LIG_SH3_4	99	106	PF00018	0.384
LIG_SUMO_SIM_anti_2	1005	1011	PF11976	0.382
LIG_SUMO_SIM_anti_2	176	182	PF11976	0.418
LIG_SUMO_SIM_anti_2	204	211	PF11976	0.534
LIG_SUMO_SIM_anti_2	511	517	PF11976	0.472
LIG_SUMO_SIM_anti_2	708	714	PF11976	0.471
LIG_SUMO_SIM_anti_2	792	797	PF11976	0.362
LIG_SUMO_SIM_anti_2	972	978	PF11976	0.328
LIG_SUMO_SIM_par_1	761	766	PF11976	0.288
LIG_SUMO_SIM_par_1	972	978	PF11976	0.328
LIG_TRAF2_1	588	591	PF00917	0.454
LIG_TRAF2_1	926	929	PF00917	0.429
LIG_WRC_WIRS_1	954	959	PF05994	0.439
MOD_CDK_SPK_2	1015	1020	PF00069	0.432
MOD_CDK_SPxxK_3	560	567	PF00069	0.581
MOD_CDK_SPxxK_3	618	625	PF00069	0.646
MOD_CK1_1	137	143	PF00069	0.655
MOD_CK1_1	147	153	PF00069	0.468
MOD_CK1_1	31	37	PF00069	0.521
MOD_CK1_1	320	326	PF00069	0.550
MOD_CK1_1	401	407	PF00069	0.477
MOD_CK1_1	602	608	PF00069	0.584
MOD_CK1_1	806	812	PF00069	0.475
MOD_CK1_1	860	866	PF00069	0.360
MOD_CK1_1	904	910	PF00069	0.649
MOD_CK2_1	118	124	PF00069	0.326
MOD_CK2_1	178	184	PF00069	0.429
MOD_CK2_1	312	318	PF00069	0.598
MOD_CK2_1	382	388	PF00069	0.688
MOD_CK2_1	497	503	PF00069	0.564
MOD_CK2_1	505	511	PF00069	0.675
MOD_CK2_1	560	566	PF00069	0.733
MOD_CK2_1	78	84	PF00069	0.475
MOD_CK2_1	923	929	PF00069	0.464
MOD_Cter_Amidation	839	842	PF01082	0.481
MOD_GlcNHglycan	1003	1007	PF01048	0.570
MOD_GlcNHglycan	1030	1033	PF01048	0.552
MOD_GlcNHglycan	11	14	PF01048	0.403
MOD_GlcNHglycan	193	196	PF01048	0.625
MOD_GlcNHglycan	243	246	PF01048	0.638
MOD_GlcNHglycan	268	271	PF01048	0.422
MOD_GlcNHglycan	380	383	PF01048	0.746
MOD_GlcNHglycan	50	53	PF01048	0.494
MOD_GlcNHglycan	507	510	PF01048	0.485
MOD_GlcNHglycan	554	558	PF01048	0.814
MOD_GlcNHglycan	635	638	PF01048	0.622
MOD_GlcNHglycan	757	760	PF01048	0.314
MOD_GlcNHglycan	815	818	PF01048	0.384
MOD_GlcNHglycan	849	852	PF01048	0.580
MOD_GlcNHglycan	95	98	PF01048	0.513
MOD_GSK3_1	135	142	PF00069	0.608
MOD_GSK3_1	208	215	PF00069	0.371
MOD_GSK3_1	21	28	PF00069	0.465
MOD_GSK3_1	266	273	PF00069	0.347
MOD_GSK3_1	282	289	PF00069	0.357
MOD_GSK3_1	365	372	PF00069	0.430
MOD_GSK3_1	378	385	PF00069	0.778
MOD_GSK3_1	454	461	PF00069	0.731
MOD_GSK3_1	599	606	PF00069	0.651
MOD_GSK3_1	669	676	PF00069	0.578
MOD_GSK3_1	728	735	PF00069	0.451
MOD_GSK3_1	787	794	PF00069	0.373
MOD_GSK3_1	903	910	PF00069	0.365
MOD_GSK3_1	985	992	PF00069	0.534
MOD_N-GLC_1	479	484	PF02516	0.581
MOD_N-GLC_1	755	760	PF02516	0.303
MOD_N-GLC_1	854	859	PF02516	0.483
MOD_N-GLC_2	749	751	PF02516	0.313
MOD_NEK2_1	208	213	PF00069	0.578
MOD_NEK2_1	225	230	PF00069	0.239
MOD_NEK2_1	25	30	PF00069	0.501
MOD_NEK2_1	371	376	PF00069	0.542
MOD_NEK2_1	48	53	PF00069	0.356
MOD_NEK2_1	529	534	PF00069	0.792
MOD_NEK2_1	54	59	PF00069	0.324
MOD_NEK2_1	633	638	PF00069	0.642
MOD_NEK2_1	754	759	PF00069	0.297
MOD_NEK2_1	763	768	PF00069	0.305
MOD_NEK2_1	796	801	PF00069	0.394
MOD_NEK2_1	821	826	PF00069	0.417
MOD_NEK2_1	88	93	PF00069	0.461
MOD_NEK2_1	958	963	PF00069	0.339
MOD_NEK2_1	970	975	PF00069	0.330
MOD_NEK2_2	406	411	PF00069	0.617
MOD_NEK2_2	72	77	PF00069	0.426
MOD_OFUCOSY	364	369	PF10250	0.426
MOD_PIKK_1	208	214	PF00454	0.425
MOD_PIKK_1	612	618	PF00454	0.653
MOD_PIKK_1	645	651	PF00454	0.492
MOD_PIKK_1	796	802	PF00454	0.378
MOD_PIKK_1	934	940	PF00454	0.385
MOD_PK_1	842	848	PF00069	0.494
MOD_PKA_1	673	679	PF00069	0.498
MOD_PKA_1	879	885	PF00069	0.510
MOD_PKA_2	184	190	PF00069	0.554
MOD_PKA_2	225	231	PF00069	0.357
MOD_PKA_2	241	247	PF00069	0.534
MOD_PKA_2	31	37	PF00069	0.368
MOD_PKA_2	529	535	PF00069	0.747
MOD_PKA_2	566	572	PF00069	0.572
MOD_PKA_2	626	632	PF00069	0.521
MOD_PKA_2	732	738	PF00069	0.419
MOD_PKA_2	754	760	PF00069	0.404
MOD_PKA_2	813	819	PF00069	0.364
MOD_PKA_2	847	853	PF00069	0.608
MOD_PKA_2	879	885	PF00069	0.510
MOD_Plk_1	1002	1008	PF00069	0.491
MOD_Plk_1	3	9	PF00069	0.264
MOD_Plk_1	317	323	PF00069	0.555
MOD_Plk_1	376	382	PF00069	0.459
MOD_Plk_1	406	412	PF00069	0.663
MOD_Plk_1	479	485	PF00069	0.521
MOD_Plk_1	511	517	PF00069	0.597
MOD_Plk_1	854	860	PF00069	0.646
MOD_Plk_2-3	184	190	PF00069	0.402
MOD_Plk_2-3	626	632	PF00069	0.494
MOD_Plk_4	175	181	PF00069	0.404
MOD_Plk_4	312	318	PF00069	0.518
MOD_Plk_4	352	358	PF00069	0.595
MOD_Plk_4	416	422	PF00069	0.393
MOD_Plk_4	511	517	PF00069	0.738
MOD_Plk_4	650	656	PF00069	0.411
MOD_Plk_4	732	738	PF00069	0.404
MOD_Plk_4	90	96	PF00069	0.350
MOD_Plk_4	953	959	PF00069	0.365
MOD_Plk_4	970	976	PF00069	0.270
MOD_ProDKin_1	1015	1021	PF00069	0.427
MOD_ProDKin_1	139	145	PF00069	0.690
MOD_ProDKin_1	147	153	PF00069	0.531
MOD_ProDKin_1	458	464	PF00069	0.740
MOD_ProDKin_1	560	566	PF00069	0.642
MOD_ProDKin_1	599	605	PF00069	0.733
MOD_ProDKin_1	618	624	PF00069	0.480
MOD_ProDKin_1	721	727	PF00069	0.533
MOD_ProDKin_1	770	776	PF00069	0.404
MOD_ProDKin_1	78	84	PF00069	0.515
MOD_ProDKin_1	806	812	PF00069	0.583
MOD_ProDKin_1	907	913	PF00069	0.465
TRG_DiLeu_BaEn_1	511	516	PF01217	0.512
TRG_DiLeu_BaEn_1	972	977	PF01217	0.329
TRG_DiLeu_BaEn_4	985	991	PF01217	0.334
TRG_DiLeu_BaLyEn_6	50	55	PF01217	0.311
TRG_DiLeu_BaLyEn_6	97	102	PF01217	0.484
TRG_ENDOCYTIC_2	1022	1025	PF00928	0.432
TRG_ENDOCYTIC_2	434	437	PF00928	0.564
TRG_ENDOCYTIC_2	540	543	PF00928	0.596
TRG_ENDOCYTIC_2	581	584	PF00928	0.474
TRG_ENDOCYTIC_2	62	65	PF00928	0.464
TRG_ENDOCYTIC_2	647	650	PF00928	0.480
TRG_ER_diArg_1	160	162	PF00400	0.397
TRG_ER_diArg_1	166	169	PF00400	0.379
TRG_ER_diArg_1	327	330	PF00400	0.585
TRG_ER_diArg_1	560	562	PF00400	0.660
TRG_ER_diArg_1	680	683	PF00400	0.476
TRG_ER_diArg_1	878	880	PF00400	0.463
TRG_NES_CRM1_1	204	219	PF08389	0.448
TRG_NES_CRM1_1	972	986	PF08389	0.334
TRG_Pf-PMV_PEXEL_1	112	117	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7R1	Leptomonas seymouri	55%	100%
A0A1X0NSN0	Trypanosomatidae	34%	100%
A0A3Q8IE30	Leishmania donovani	86%	99%
A0A3R7LJI9	Trypanosoma rangeli	37%	100%
A4H976	Leishmania braziliensis	72%	100%
A4HXK8	Leishmania infantum	87%	99%
Q4QE60	Leishmania major	88%	100%
V5BET6	Trypanosoma cruzi	35%	100%