Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ARA2_LEIMU

TriTrypDb:

LmxM.17.1300

Length:

188

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9ARA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ARA2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	53	59	PF00089	0.471
CLV_NRD_NRD_1	185	187	PF00675	0.674
CLV_NRD_NRD_1	64	66	PF00675	0.532
CLV_PCSK_SKI1_1	135	139	PF00082	0.594
CLV_Separin_Metazoa	5	9	PF03568	0.657
DEG_APCC_DBOX_1	78	86	PF00400	0.595
DEG_ODPH_VHL_1	53	64	PF01847	0.704
DOC_CKS1_1	113	118	PF01111	0.474
DOC_CKS1_1	43	48	PF01111	0.674
DOC_PP1_RVXF_1	133	139	PF00149	0.463
DOC_PP1_RVXF_1	31	37	PF00149	0.703
DOC_PP1_RVXF_1	64	71	PF00149	0.639
DOC_USP7_MATH_1	129	133	PF00917	0.572
DOC_USP7_MATH_1	159	163	PF00917	0.547
DOC_USP7_UBL2_3	72	76	PF12436	0.649
DOC_WW_Pin1_4	112	117	PF00397	0.450
DOC_WW_Pin1_4	42	47	PF00397	0.676
LIG_14-3-3_CanoR_1	107	111	PF00244	0.407
LIG_14-3-3_CanoR_1	65	71	PF00244	0.719
LIG_14-3-3_CanoR_1	79	83	PF00244	0.324
LIG_BIR_III_4	24	28	PF00653	0.657
LIG_FHA_1	131	137	PF00498	0.478
LIG_FHA_1	17	23	PF00498	0.677
LIG_FHA_1	36	42	PF00498	0.637
LIG_FHA_2	11	17	PF00498	0.678
LIG_LIR_Apic_2	40	46	PF02991	0.675
LIG_LIR_Gen_1	13	22	PF02991	0.723
LIG_LIR_Gen_1	81	92	PF02991	0.423
LIG_LIR_Nem_3	13	17	PF02991	0.696
LIG_LIR_Nem_3	69	73	PF02991	0.611
LIG_LIR_Nem_3	81	87	PF02991	0.368
LIG_LYPXL_yS_3	77	80	PF13949	0.700
LIG_NRP_CendR_1	186	188	PF00754	0.690
LIG_Pex14_1	97	101	PF04695	0.368
LIG_SH2_CRK	43	47	PF00017	0.706
LIG_SH2_CRK	59	63	PF00017	0.660
LIG_SH2_GRB2like	84	87	PF00017	0.423
LIG_SH2_NCK_1	59	63	PF00017	0.699
LIG_SH2_PTP2	84	87	PF00017	0.487
LIG_SH2_SRC	14	17	PF00017	0.720
LIG_SH2_SRC	84	87	PF00017	0.423
LIG_SH2_STAT5	163	166	PF00017	0.467
LIG_SH2_STAT5	29	32	PF00017	0.663
LIG_SH2_STAT5	84	87	PF00017	0.423
LIG_SH3_3	31	37	PF00018	0.685
LIG_TYR_ITIM	82	87	PF00017	0.487
MOD_GlcNHglycan	179	183	PF01048	0.745
MOD_GSK3_1	159	166	PF00069	0.477
MOD_N-GLC_1	130	135	PF02516	0.770
MOD_N-GLC_2	153	155	PF02516	0.542
MOD_PIKK_1	130	136	PF00454	0.481
MOD_PKA_2	106	112	PF00069	0.449
MOD_PKA_2	78	84	PF00069	0.491
MOD_Plk_1	159	165	PF00069	0.524
MOD_Plk_4	159	165	PF00069	0.548
MOD_Plk_4	66	72	PF00069	0.608
MOD_ProDKin_1	112	118	PF00069	0.453
MOD_ProDKin_1	42	48	PF00069	0.673
MOD_SUMO_for_1	25	28	PF00179	0.710
TRG_DiLeu_BaEn_1	142	147	PF01217	0.456
TRG_ENDOCYTIC_2	14	17	PF00928	0.675
TRG_ENDOCYTIC_2	59	62	PF00928	0.635
TRG_ENDOCYTIC_2	77	80	PF00928	0.590
TRG_ENDOCYTIC_2	84	87	PF00928	0.368
TRG_ER_diArg_1	185	188	PF00400	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J6W1	Bodo saltans	61%	72%
A0A3S5H718	Leishmania donovani	96%	100%
A0A422NAT4	Trypanosoma rangeli	67%	67%
A4HXK7	Leishmania infantum	96%	100%
Q4QE61	Leishmania major	96%	100%