Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Organic solute transport protein 1, putative

Species:

Leishmania mexicana

UniProt:

E9AR98_LEIMU

TriTrypDb:

LmxM.17.1260

Length:

449

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AR98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR98

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	290	292	PF00675	0.446
CLV_NRD_NRD_1	87	89	PF00675	0.299
CLV_PCSK_SKI1_1	131	135	PF00082	0.359
CLV_PCSK_SKI1_1	191	195	PF00082	0.481
CLV_PCSK_SKI1_1	262	266	PF00082	0.462
CLV_PCSK_SKI1_1	407	411	PF00082	0.414
DEG_APCC_DBOX_1	105	113	PF00400	0.268
DEG_SPOP_SBC_1	372	376	PF00917	0.598
DEG_SPOP_SBC_1	73	77	PF00917	0.233
DOC_CKS1_1	308	313	PF01111	0.609
DOC_CYCLIN_RxL_1	404	414	PF00134	0.496
DOC_CYCLIN_yCln2_LP_2	105	111	PF00134	0.249
DOC_MAPK_gen_1	167	175	PF00069	0.231
DOC_MAPK_MEF2A_6	167	175	PF00069	0.234
DOC_MAPK_MEF2A_6	283	290	PF00069	0.375
DOC_MAPK_RevD_3	276	292	PF00069	0.374
DOC_PP2B_LxvP_1	55	58	PF13499	0.135
DOC_PP4_FxxP_1	187	190	PF00568	0.395
DOC_PP4_FxxP_1	194	197	PF00568	0.368
DOC_PP4_FxxP_1	218	221	PF00568	0.516
DOC_PP4_FxxP_1	416	419	PF00568	0.575
DOC_USP7_MATH_1	132	136	PF00917	0.255
DOC_USP7_MATH_1	232	236	PF00917	0.539
DOC_USP7_MATH_1	257	261	PF00917	0.394
DOC_USP7_MATH_1	357	361	PF00917	0.668
DOC_USP7_MATH_1	368	372	PF00917	0.636
DOC_USP7_MATH_1	380	384	PF00917	0.608
DOC_USP7_MATH_1	73	77	PF00917	0.264
DOC_WW_Pin1_4	193	198	PF00397	0.383
DOC_WW_Pin1_4	307	312	PF00397	0.595
DOC_WW_Pin1_4	415	420	PF00397	0.461
LIG_14-3-3_CanoR_1	131	137	PF00244	0.394
LIG_14-3-3_CanoR_1	143	149	PF00244	0.314
LIG_14-3-3_CanoR_1	157	161	PF00244	0.217
LIG_14-3-3_CanoR_1	170	174	PF00244	0.209
LIG_14-3-3_CanoR_1	244	252	PF00244	0.374
LIG_14-3-3_CanoR_1	262	267	PF00244	0.466
LIG_14-3-3_CanoR_1	283	287	PF00244	0.489
LIG_14-3-3_CanoR_1	34	39	PF00244	0.319
LIG_14-3-3_CanoR_1	396	403	PF00244	0.486
LIG_14-3-3_CanoR_1	81	87	PF00244	0.305
LIG_Actin_WH2_2	129	145	PF00022	0.135
LIG_APCC_ABBA_1	171	176	PF00400	0.361
LIG_APCC_ABBAyCdc20_2	170	176	PF00400	0.361
LIG_BIR_II_1	1	5	PF00653	0.358
LIG_BIR_III_4	426	430	PF00653	0.549
LIG_BRCT_BRCA1_1	183	187	PF00533	0.358
LIG_BRCT_BRCA1_1	246	250	PF00533	0.353
LIG_EVH1_1	225	229	PF00568	0.507
LIG_FHA_1	273	279	PF00498	0.462
LIG_FHA_1	283	289	PF00498	0.405
LIG_FHA_1	47	53	PF00498	0.347
LIG_FHA_2	293	299	PF00498	0.557
LIG_LIR_Apic_2	184	190	PF02991	0.296
LIG_LIR_Apic_2	192	197	PF02991	0.376
LIG_LIR_Apic_2	217	221	PF02991	0.443
LIG_LIR_Apic_2	414	419	PF02991	0.569
LIG_LIR_Gen_1	5	15	PF02991	0.272
LIG_LIR_Gen_1	92	103	PF02991	0.348
LIG_LIR_Nem_3	247	253	PF02991	0.354
LIG_LIR_Nem_3	5	11	PF02991	0.273
LIG_LIR_Nem_3	92	98	PF02991	0.388
LIG_MAD2	124	132	PF02301	0.255
LIG_PDZ_Class_3	444	449	PF00595	0.566
LIG_Pex14_2	47	51	PF04695	0.304
LIG_PTB_Apo_2	50	57	PF02174	0.244
LIG_Rb_pABgroove_1	85	93	PF01858	0.293
LIG_REV1ctd_RIR_1	161	171	PF16727	0.293
LIG_SH2_CRK	91	95	PF00017	0.348
LIG_SH2_NCK_1	253	257	PF00017	0.390
LIG_SH2_NCK_1	62	66	PF00017	0.340
LIG_SH2_NCK_1	91	95	PF00017	0.373
LIG_SH2_STAP1	253	257	PF00017	0.456
LIG_SH2_STAP1	91	95	PF00017	0.379
LIG_SH2_STAT3	331	334	PF00017	0.587
LIG_SH2_STAT5	188	191	PF00017	0.485
LIG_SH2_STAT5	208	211	PF00017	0.261
LIG_SH2_STAT5	331	334	PF00017	0.495
LIG_SH3_3	209	215	PF00018	0.534
LIG_SH3_3	223	229	PF00018	0.366
LIG_SH3_3	274	280	PF00018	0.606
LIG_SH3_3	283	289	PF00018	0.520
LIG_SH3_3	305	311	PF00018	0.736
LIG_SH3_3	364	370	PF00018	0.668
LIG_SH3_3	387	393	PF00018	0.675
LIG_SUMO_SIM_par_1	107	113	PF11976	0.244
LIG_SUMO_SIM_par_1	274	279	PF11976	0.390
LIG_TYR_ITIM	93	98	PF00017	0.396
MOD_CDK_SPK_2	415	420	PF00069	0.461
MOD_CDK_SPxxK_3	195	202	PF00069	0.357
MOD_CK1_1	260	266	PF00069	0.640
MOD_CK1_1	37	43	PF00069	0.347
MOD_CK1_1	371	377	PF00069	0.565
MOD_CK1_1	63	69	PF00069	0.299
MOD_CK1_1	75	81	PF00069	0.113
MOD_CK1_1	83	89	PF00069	0.202
MOD_CK2_1	132	138	PF00069	0.403
MOD_CK2_1	356	362	PF00069	0.639
MOD_GlcNHglycan	183	186	PF01048	0.349
MOD_GlcNHglycan	262	265	PF01048	0.536
MOD_GlcNHglycan	267	270	PF01048	0.559
MOD_GlcNHglycan	322	325	PF01048	0.678
MOD_GlcNHglycan	34	37	PF01048	0.331
MOD_GlcNHglycan	359	362	PF01048	0.704
MOD_GlcNHglycan	363	366	PF01048	0.660
MOD_GlcNHglycan	370	373	PF01048	0.553
MOD_GlcNHglycan	399	402	PF01048	0.479
MOD_GlcNHglycan	423	426	PF01048	0.638
MOD_GlcNHglycan	63	66	PF01048	0.303
MOD_GSK3_1	152	159	PF00069	0.399
MOD_GSK3_1	258	265	PF00069	0.624
MOD_GSK3_1	303	310	PF00069	0.659
MOD_GSK3_1	357	364	PF00069	0.636
MOD_GSK3_1	368	375	PF00069	0.668
MOD_GSK3_1	37	44	PF00069	0.289
MOD_GSK3_1	411	418	PF00069	0.461
MOD_GSK3_1	431	438	PF00069	0.557
MOD_NEK2_1	112	117	PF00069	0.272
MOD_NEK2_1	144	149	PF00069	0.379
MOD_NEK2_1	174	179	PF00069	0.262
MOD_NEK2_1	32	37	PF00069	0.312
MOD_NEK2_1	397	402	PF00069	0.451
MOD_NEK2_1	74	79	PF00069	0.287
MOD_PK_1	34	40	PF00069	0.348
MOD_PKA_1	292	298	PF00069	0.519
MOD_PKA_2	156	162	PF00069	0.328
MOD_PKA_2	169	175	PF00069	0.236
MOD_PKA_2	243	249	PF00069	0.343
MOD_PKA_2	282	288	PF00069	0.516
MOD_PKA_2	395	401	PF00069	0.468
MOD_PKA_2	80	86	PF00069	0.290
MOD_Plk_1	112	118	PF00069	0.234
MOD_Plk_1	361	367	PF00069	0.547
MOD_Plk_1	83	89	PF00069	0.256
MOD_Plk_4	156	162	PF00069	0.244
MOD_Plk_4	169	175	PF00069	0.232
MOD_Plk_4	272	278	PF00069	0.546
MOD_Plk_4	34	40	PF00069	0.278
MOD_Plk_4	63	69	PF00069	0.394
MOD_Plk_4	75	81	PF00069	0.139
MOD_ProDKin_1	193	199	PF00069	0.391
MOD_ProDKin_1	307	313	PF00069	0.595
MOD_ProDKin_1	415	421	PF00069	0.470
MOD_SUMO_rev_2	172	179	PF00179	0.244
TRG_DiLeu_BaEn_1	5	10	PF01217	0.255
TRG_DiLeu_BaLyEn_6	277	282	PF01217	0.461
TRG_ENDOCYTIC_2	100	103	PF00928	0.202
TRG_ENDOCYTIC_2	91	94	PF00928	0.264
TRG_ENDOCYTIC_2	95	98	PF00928	0.237
TRG_NES_CRM1_1	5	16	PF08389	0.297
TRG_NLS_MonoExtN_4	289	295	PF00514	0.445
TRG_Pf-PMV_PEXEL_1	88	92	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1P0	Leptomonas seymouri	50%	98%
A0A0S4JB79	Bodo saltans	33%	100%
A0A1X0NSP8	Trypanosomatidae	33%	100%
A0A3R7MAW0	Trypanosoma rangeli	37%	100%
A0A3S7WUM8	Leishmania donovani	87%	100%
A4H985	Leishmania braziliensis	70%	99%
A4HXK3	Leishmania infantum	86%	100%
C9ZP93	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4QE65	Leishmania major	84%	100%
Q8BHW2	Mus musculus	32%	100%
V5BNX0	Trypanosoma cruzi	35%	100%