RNA cytidine acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA cytidine acetyltransferase

Species:

Leishmania mexicana

UniProt:

E9AR97_LEIMU

TriTrypDb:

LmxM.17.1250

Length:

1062

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

E9AR97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR97

Function

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Biological processes
Term	Name	Level	Count
GO:0000154	rRNA modification	6	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006399	tRNA metabolic process	7	12
GO:0006400	tRNA modification	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008033	tRNA processing	8	12
GO:0008152	metabolic process	1	12

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Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	1
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008080	N-acetyltransferase activity	6	12
GO:0016407	acetyltransferase activity	5	12
GO:0016410	N-acyltransferase activity	5	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	681	685	PF00656	0.487
CLV_C14_Caspase3-7	894	898	PF00656	0.410
CLV_C14_Caspase3-7	978	982	PF00656	0.658
CLV_NRD_NRD_1	1012	1014	PF00675	0.594
CLV_NRD_NRD_1	220	222	PF00675	0.555
CLV_NRD_NRD_1	3	5	PF00675	0.479
CLV_NRD_NRD_1	439	441	PF00675	0.240
CLV_PCSK_KEX2_1	1060	1062	PF00082	0.661
CLV_PCSK_KEX2_1	281	283	PF00082	0.535
CLV_PCSK_KEX2_1	3	5	PF00082	0.479

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8D1	Leptomonas seymouri	81%	98%
A0A0S4J7H9	Bodo saltans	59%	100%
A0A1X0NTC6	Trypanosomatidae	63%	100%
A0A3Q8IAZ3	Leishmania donovani	94%	100%
A0A422NAR4	Trypanosoma rangeli	64%	100%
A4H984	Leishmania braziliensis	89%	100%
A4HXK2	Leishmania infantum	94%	100%
C9ZP92	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
O01757	Caenorhabditis elegans	39%	100%
P53914	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	100%

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