TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AR96_LEIMU

TriTrypDb:

LmxM.17.1240

Length:

958

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AR96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR96

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.775
CLV_C14_Caspase3-7	693	697	PF00656	0.652
CLV_C14_Caspase3-7	703	707	PF00656	0.523
CLV_MEL_PAP_1	91	97	PF00089	0.269
CLV_NRD_NRD_1	247	249	PF00675	0.459
CLV_NRD_NRD_1	397	399	PF00675	0.483
CLV_NRD_NRD_1	419	421	PF00675	0.620
CLV_NRD_NRD_1	487	489	PF00675	0.433
CLV_NRD_NRD_1	613	615	PF00675	0.523
CLV_NRD_NRD_1	631	633	PF00675	0.314
CLV_NRD_NRD_1	665	667	PF00675	0.327
CLV_NRD_NRD_1	777	779	PF00675	0.515
CLV_PCSK_KEX2_1	247	249	PF00082	0.466
CLV_PCSK_KEX2_1	397	399	PF00082	0.483
CLV_PCSK_KEX2_1	419	421	PF00082	0.622
CLV_PCSK_KEX2_1	447	449	PF00082	0.505
CLV_PCSK_KEX2_1	485	487	PF00082	0.452
CLV_PCSK_KEX2_1	631	633	PF00082	0.426
CLV_PCSK_KEX2_1	776	778	PF00082	0.520
CLV_PCSK_KEX2_1	937	939	PF00082	0.556
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.492
CLV_PCSK_PC1ET2_1	485	487	PF00082	0.452
CLV_PCSK_PC1ET2_1	937	939	PF00082	0.556
CLV_PCSK_PC7_1	393	399	PF00082	0.440
CLV_PCSK_SKI1_1	149	153	PF00082	0.507
CLV_PCSK_SKI1_1	195	199	PF00082	0.452
CLV_PCSK_SKI1_1	252	256	PF00082	0.259
CLV_PCSK_SKI1_1	341	345	PF00082	0.452
CLV_PCSK_SKI1_1	461	465	PF00082	0.389
CLV_PCSK_SKI1_1	494	498	PF00082	0.428
CLV_PCSK_SKI1_1	540	544	PF00082	0.403
CLV_PCSK_SKI1_1	648	652	PF00082	0.366
CLV_PCSK_SKI1_1	784	788	PF00082	0.441
CLV_PCSK_SKI1_1	954	958	PF00082	0.575
DEG_APCC_DBOX_1	138	146	PF00400	0.529
DEG_COP1_1	152	162	PF00400	0.260
DEG_MDM2_SWIB_1	565	572	PF02201	0.386
DEG_Nend_UBRbox_2	1	3	PF02207	0.574
DOC_CKS1_1	332	337	PF01111	0.559
DOC_CKS1_1	876	881	PF01111	0.609
DOC_CYCLIN_RxL_1	488	500	PF00134	0.406
DOC_CYCLIN_yCln2_LP_2	188	194	PF00134	0.539
DOC_MAPK_gen_1	139	147	PF00069	0.467
DOC_MAPK_HePTP_8	33	45	PF00069	0.538
DOC_MAPK_MEF2A_6	163	171	PF00069	0.381
DOC_MAPK_MEF2A_6	176	185	PF00069	0.510
DOC_MAPK_MEF2A_6	207	215	PF00069	0.435
DOC_MAPK_MEF2A_6	341	349	PF00069	0.386
DOC_MAPK_MEF2A_6	36	45	PF00069	0.538
DOC_MAPK_MEF2A_6	672	679	PF00069	0.517
DOC_MAPK_NFAT4_5	672	680	PF00069	0.519
DOC_PP2B_LxvP_1	223	226	PF13499	0.447
DOC_PP2B_LxvP_1	5	8	PF13499	0.410
DOC_USP7_MATH_1	158	162	PF00917	0.256
DOC_USP7_MATH_1	290	294	PF00917	0.516
DOC_USP7_MATH_1	597	601	PF00917	0.264
DOC_USP7_MATH_1	814	818	PF00917	0.506
DOC_USP7_MATH_1	850	854	PF00917	0.453
DOC_USP7_MATH_1	879	883	PF00917	0.714
DOC_USP7_UBL2_3	481	485	PF12436	0.436
DOC_WW_Pin1_4	121	126	PF00397	0.672
DOC_WW_Pin1_4	187	192	PF00397	0.558
DOC_WW_Pin1_4	322	327	PF00397	0.496
DOC_WW_Pin1_4	331	336	PF00397	0.477
DOC_WW_Pin1_4	376	381	PF00397	0.510
DOC_WW_Pin1_4	6	11	PF00397	0.507
DOC_WW_Pin1_4	741	746	PF00397	0.543
DOC_WW_Pin1_4	78	83	PF00397	0.480
DOC_WW_Pin1_4	875	880	PF00397	0.706
DOC_WW_Pin1_4	894	899	PF00397	0.669
LIG_14-3-3_CanoR_1	149	159	PF00244	0.388
LIG_14-3-3_CanoR_1	207	212	PF00244	0.504
LIG_14-3-3_CanoR_1	22	28	PF00244	0.464
LIG_14-3-3_CanoR_1	260	266	PF00244	0.287
LIG_14-3-3_CanoR_1	384	389	PF00244	0.467
LIG_14-3-3_CanoR_1	429	438	PF00244	0.474
LIG_14-3-3_CanoR_1	46	53	PF00244	0.585
LIG_Actin_WH2_2	602	619	PF00022	0.428
LIG_APCC_ABBA_1	675	680	PF00400	0.538
LIG_BRCT_BRCA1_1	431	435	PF00533	0.425
LIG_BRCT_BRCA1_1	436	440	PF00533	0.383
LIG_BRCT_BRCA1_1	597	601	PF00533	0.522
LIG_BRCT_BRCA1_1	852	856	PF00533	0.533
LIG_deltaCOP1_diTrp_1	633	641	PF00928	0.362
LIG_FHA_1	121	127	PF00498	0.672
LIG_FHA_1	208	214	PF00498	0.480
LIG_FHA_1	408	414	PF00498	0.404
LIG_FHA_1	421	427	PF00498	0.472
LIG_FHA_1	497	503	PF00498	0.553
LIG_FHA_1	652	658	PF00498	0.419
LIG_FHA_1	672	678	PF00498	0.225
LIG_FHA_2	151	157	PF00498	0.504
LIG_FHA_2	175	181	PF00498	0.370
LIG_FHA_2	24	30	PF00498	0.565
LIG_FHA_2	365	371	PF00498	0.398
LIG_FHA_2	428	434	PF00498	0.410
LIG_FHA_2	460	466	PF00498	0.389
LIG_FHA_2	512	518	PF00498	0.501
LIG_FHA_2	730	736	PF00498	0.734
LIG_FHA_2	762	768	PF00498	0.601
LIG_FHA_2	79	85	PF00498	0.457
LIG_GBD_Chelix_1	60	68	PF00786	0.525
LIG_LIR_Gen_1	210	219	PF02991	0.384
LIG_LIR_Gen_1	403	413	PF02991	0.406
LIG_LIR_Gen_1	465	471	PF02991	0.430
LIG_LIR_Gen_1	472	477	PF02991	0.381
LIG_LIR_Gen_1	546	555	PF02991	0.397
LIG_LIR_Gen_1	587	597	PF02991	0.413
LIG_LIR_Gen_1	600	611	PF02991	0.388
LIG_LIR_Gen_1	619	627	PF02991	0.444
LIG_LIR_Gen_1	853	862	PF02991	0.529
LIG_LIR_Nem_3	210	215	PF02991	0.388
LIG_LIR_Nem_3	403	409	PF02991	0.428
LIG_LIR_Nem_3	432	438	PF02991	0.378
LIG_LIR_Nem_3	449	453	PF02991	0.364
LIG_LIR_Nem_3	465	470	PF02991	0.402
LIG_LIR_Nem_3	472	476	PF02991	0.381
LIG_LIR_Nem_3	546	551	PF02991	0.407
LIG_LIR_Nem_3	568	572	PF02991	0.366
LIG_LIR_Nem_3	587	592	PF02991	0.401
LIG_LIR_Nem_3	600	606	PF02991	0.351
LIG_LIR_Nem_3	853	859	PF02991	0.517
LIG_LIR_Nem_3	86	91	PF02991	0.343
LIG_LIR_Nem_3	910	915	PF02991	0.531
LIG_LIR_Nem_3	93	98	PF02991	0.308
LIG_MLH1_MIPbox_1	431	435	PF16413	0.443
LIG_NRBOX	146	152	PF00104	0.476
LIG_Pex14_1	637	641	PF04695	0.378
LIG_Pex14_2	440	444	PF04695	0.476
LIG_Pex14_2	565	569	PF04695	0.401
LIG_Pex14_2	787	791	PF04695	0.247
LIG_PTB_Apo_2	559	566	PF02174	0.405
LIG_REV1ctd_RIR_1	195	203	PF16727	0.476
LIG_RPA_C_Fungi	393	405	PF08784	0.450
LIG_SH2_CRK	548	552	PF00017	0.461
LIG_SH2_CRK	574	578	PF00017	0.458
LIG_SH2_CRK	710	714	PF00017	0.680
LIG_SH2_CRK	88	92	PF00017	0.517
LIG_SH2_CRK	936	940	PF00017	0.459
LIG_SH2_NCK_1	436	440	PF00017	0.390
LIG_SH2_NCK_1	801	805	PF00017	0.447
LIG_SH2_STAP1	436	440	PF00017	0.389
LIG_SH2_STAP1	467	471	PF00017	0.450
LIG_SH2_STAP1	548	552	PF00017	0.407
LIG_SH2_STAP1	801	805	PF00017	0.447
LIG_SH2_STAT5	17	20	PF00017	0.489
LIG_SH2_STAT5	368	371	PF00017	0.393
LIG_SH2_STAT5	434	437	PF00017	0.382
LIG_SH2_STAT5	554	557	PF00017	0.458
LIG_SH2_STAT5	640	643	PF00017	0.379
LIG_SH2_STAT5	685	688	PF00017	0.538
LIG_SH3_3	122	128	PF00018	0.664
LIG_SH3_3	178	184	PF00018	0.568
LIG_SH3_3	292	298	PF00018	0.523
LIG_SH3_3	329	335	PF00018	0.536
LIG_SH3_3	435	441	PF00018	0.369
LIG_SH3_3	498	504	PF00018	0.386
LIG_SH3_3	747	753	PF00018	0.595
LIG_SH3_3	792	798	PF00018	0.419
LIG_SUMO_SIM_par_1	2	9	PF11976	0.441
LIG_TRAF2_1	26	29	PF00917	0.578
LIG_TRAF2_1	734	737	PF00917	0.707
LIG_TRAF2_1	764	767	PF00917	0.588
LIG_TRAF2_1	925	928	PF00917	0.525
LIG_TYR_ITIM	572	577	PF00017	0.441
LIG_TYR_ITIM	708	713	PF00017	0.704
LIG_TYR_ITSM	84	91	PF00017	0.377
LIG_UBA3_1	167	176	PF00899	0.483
LIG_WRC_WIRS_1	815	820	PF05994	0.519
MOD_CDC14_SPxK_1	190	193	PF00782	0.529
MOD_CDK_SPxK_1	187	193	PF00069	0.552
MOD_CDK_SPxxK_3	78	85	PF00069	0.380
MOD_CK1_1	129	135	PF00069	0.692
MOD_CK1_1	205	211	PF00069	0.476
MOD_CK1_1	31	37	PF00069	0.286
MOD_CK2_1	108	114	PF00069	0.746
MOD_CK2_1	150	156	PF00069	0.379
MOD_CK2_1	174	180	PF00069	0.261
MOD_CK2_1	23	29	PF00069	0.564
MOD_CK2_1	297	303	PF00069	0.594
MOD_CK2_1	364	370	PF00069	0.421
MOD_CK2_1	6	12	PF00069	0.454
MOD_CK2_1	729	735	PF00069	0.716
MOD_CK2_1	761	767	PF00069	0.600
MOD_CK2_1	78	84	PF00069	0.475
MOD_CMANNOS	521	524	PF00535	0.432
MOD_CMANNOS	634	637	PF00535	0.400
MOD_GlcNHglycan	416	419	PF01048	0.514
MOD_GlcNHglycan	583	587	PF01048	0.393
MOD_GlcNHglycan	61	64	PF01048	0.494
MOD_GlcNHglycan	76	79	PF01048	0.289
MOD_GSK3_1	170	177	PF00069	0.306
MOD_GSK3_1	224	231	PF00069	0.509
MOD_GSK3_1	28	35	PF00069	0.439
MOD_GSK3_1	455	462	PF00069	0.438
MOD_GSK3_1	74	81	PF00069	0.509
MOD_GSK3_1	875	882	PF00069	0.719
MOD_N-GLC_1	288	293	PF02516	0.548
MOD_N-GLC_1	74	79	PF02516	0.396
MOD_NEK2_1	202	207	PF00069	0.439
MOD_NEK2_1	23	28	PF00069	0.300
MOD_NEK2_1	288	293	PF00069	0.565
MOD_NEK2_1	3	8	PF00069	0.470
MOD_NEK2_1	427	432	PF00069	0.464
MOD_NEK2_1	455	460	PF00069	0.414
MOD_NEK2_2	573	578	PF00069	0.488
MOD_NEK2_2	814	819	PF00069	0.513
MOD_PIKK_1	621	627	PF00454	0.439
MOD_PIKK_1	883	889	PF00454	0.720
MOD_PKA_2	259	265	PF00069	0.452
MOD_PKA_2	45	51	PF00069	0.567
MOD_PKA_2	616	622	PF00069	0.485
MOD_PKA_2	671	677	PF00069	0.435
MOD_PKB_1	391	399	PF00069	0.491
MOD_PKB_1	486	494	PF00069	0.429
MOD_PKB_1	938	946	PF00069	0.591
MOD_Plk_1	266	272	PF00069	0.526
MOD_Plk_1	455	461	PF00069	0.454
MOD_Plk_1	679	685	PF00069	0.535
MOD_Plk_1	83	89	PF00069	0.385
MOD_Plk_2-3	228	234	PF00069	0.500
MOD_Plk_2-3	671	677	PF00069	0.530
MOD_Plk_4	207	213	PF00069	0.398
MOD_Plk_4	240	246	PF00069	0.285
MOD_Plk_4	267	273	PF00069	0.514
MOD_Plk_4	297	303	PF00069	0.624
MOD_Plk_4	364	370	PF00069	0.421
MOD_Plk_4	384	390	PF00069	0.192
MOD_Plk_4	455	461	PF00069	0.491
MOD_Plk_4	605	611	PF00069	0.388
MOD_ProDKin_1	121	127	PF00069	0.672
MOD_ProDKin_1	187	193	PF00069	0.552
MOD_ProDKin_1	322	328	PF00069	0.495
MOD_ProDKin_1	331	337	PF00069	0.465
MOD_ProDKin_1	376	382	PF00069	0.508
MOD_ProDKin_1	6	12	PF00069	0.517
MOD_ProDKin_1	741	747	PF00069	0.545
MOD_ProDKin_1	78	84	PF00069	0.475
MOD_ProDKin_1	875	881	PF00069	0.706
MOD_ProDKin_1	894	900	PF00069	0.661
MOD_SUMO_for_1	175	178	PF00179	0.534
MOD_SUMO_for_1	446	449	PF00179	0.404
MOD_SUMO_for_1	686	689	PF00179	0.592
MOD_SUMO_rev_2	608	616	PF00179	0.568
TRG_DiLeu_BaEn_3	766	772	PF01217	0.357
TRG_DiLeu_BaEn_4	738	744	PF01217	0.681
TRG_DiLeu_BaLyEn_6	146	151	PF01217	0.380
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.490
TRG_DiLeu_BaLyEn_6	368	373	PF01217	0.393
TRG_ENDOCYTIC_2	450	453	PF00928	0.439
TRG_ENDOCYTIC_2	467	470	PF00928	0.318
TRG_ENDOCYTIC_2	548	551	PF00928	0.414
TRG_ENDOCYTIC_2	574	577	PF00928	0.358
TRG_ENDOCYTIC_2	640	643	PF00928	0.379
TRG_ENDOCYTIC_2	710	713	PF00928	0.677
TRG_ENDOCYTIC_2	88	91	PF00928	0.495
TRG_ENDOCYTIC_2	936	939	PF00928	0.470
TRG_ER_diArg_1	192	195	PF00400	0.371
TRG_ER_diArg_1	274	277	PF00400	0.432
TRG_ER_diArg_1	390	393	PF00400	0.383
TRG_ER_diArg_1	397	400	PF00400	0.461
TRG_ER_diArg_1	486	488	PF00400	0.489
TRG_ER_diArg_1	775	778	PF00400	0.536
TRG_ER_diArg_1	85	88	PF00400	0.489
TRG_NES_CRM1_1	500	512	PF08389	0.529
TRG_NES_CRM1_1	58	74	PF08389	0.433
TRG_NES_CRM1_1	742	754	PF08389	0.557
TRG_Pf-PMV_PEXEL_1	149	154	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	371	375	PF00026	0.396
TRG_Pf-PMV_PEXEL_1	494	498	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	937	941	PF00026	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA34	Leptomonas seymouri	70%	96%
A0A1X0NSN3	Trypanosomatidae	47%	99%
A0A3R7K6J2	Trypanosoma rangeli	52%	100%
A0A3S7WUL1	Leishmania donovani	92%	100%
A4H983	Leishmania braziliensis	82%	100%
A4HXK1	Leishmania infantum	92%	100%
C9ZP90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
Q4QE67	Leishmania major	91%	99%
V5AZD3	Trypanosoma cruzi	56%	100%