Histone H2B

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Histone H2B

Gene product:

histone H2B

Species:

Leishmania mexicana

UniProt:

E9AR94_LEIMU

TriTrypDb:

LmxM.17.1220

Length:

107

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 45

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0000786	nucleosome	3	23
GO:0005634	nucleus	5	21
GO:0032991	protein-containing complex	1	23
GO:0032993	protein-DNA complex	2	23
GO:0043226	organelle	2	21
GO:0043227	membrane-bounded organelle	3	21
GO:0043229	intracellular organelle	3	21
GO:0043231	intracellular membrane-bounded organelle	4	21
GO:0044815	DNA packaging complex	2	23
GO:0110165	cellular anatomical entity	1	21

Expansion

Sequence features

E9AR94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR94

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	3
GO:0006334	nucleosome assembly	7	3
GO:0006338	chromatin remodeling	5	3
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	3
GO:0022607	cellular component assembly	4	3
GO:0034728	nucleosome organization	6	3
GO:0043933	protein-containing complex organization	4	3
GO:0065003	protein-containing complex assembly	5	3
GO:0065004	protein-DNA complex assembly	6	3
GO:0071824	protein-DNA complex subunit organization	5	3
GO:0071840	cellular component organization or biogenesis	2	3

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	23
GO:0003677	DNA binding	4	23
GO:0005198	structural molecule activity	1	23
GO:0005488	binding	1	23
GO:0005515	protein binding	2	23
GO:0030527	structural constituent of chromatin	2	23
GO:0046982	protein heterodimerization activity	4	23
GO:0046983	protein dimerization activity	3	23
GO:0097159	organic cyclic compound binding	2	23
GO:1901363	heterocyclic compound binding	2	23

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.347
CLV_NRD_NRD_1	14	16	PF00675	0.315
CLV_NRD_NRD_1	4	6	PF00675	0.709
CLV_PCSK_KEX2_1	18	20	PF00082	0.320
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.316
CLV_PCSK_SKI1_1	27	31	PF00082	0.337
CLV_PCSK_SKI1_1	41	45	PF00082	0.282
CLV_PCSK_SKI1_1	69	73	PF00082	0.307
CLV_PCSK_SKI1_1	83	87	PF00082	0.376
DOC_CYCLIN_RxL_1	66	77	PF00134	0.392
DOC_MAPK_gen_1	15	25	PF00069	0.500
DOC_USP7_MATH_1	31	35	PF00917	0.597
DOC_USP7_UBL2_3	100	104	PF12436	0.390
DOC_USP7_UBL2_3	12	16	PF12436	0.542
LIG_14-3-3_CanoR_1	11	17	PF00244	0.503
LIG_14-3-3_CanoR_1	56	65	PF00244	0.537
LIG_BIR_II_1	1	5	PF00653	0.667
LIG_FHA_1	18	24	PF00498	0.456
LIG_FHA_1	40	46	PF00498	0.497
LIG_FHA_1	97	103	PF00498	0.500
LIG_LIR_Nem_3	20	24	PF02991	0.503
LIG_SH2_GRB2like	49	52	PF00017	0.589
LIG_SH2_STAT5	24	27	PF00017	0.503
LIG_SH2_STAT5	49	52	PF00017	0.602
MOD_CK1_1	34	40	PF00069	0.454
MOD_GSK3_1	1	8	PF00069	0.637
MOD_GSK3_1	56	63	PF00069	0.530
MOD_GSK3_1	96	103	PF00069	0.499
MOD_NEK2_1	1	6	PF00069	0.716
MOD_NEK2_1	36	41	PF00069	0.504
MOD_PIKK_1	31	37	PF00454	0.421
MOD_PKA_1	5	11	PF00069	0.776
MOD_PKA_1	69	75	PF00069	0.503
MOD_PKA_2	10	16	PF00069	0.209
MOD_Plk_4	45	51	PF00069	0.505
MOD_Plk_4	60	66	PF00069	0.511
TRG_NLS_Bipartite_1	5	19	PF00514	0.411
TRG_NLS_MonoCore_2	14	19	PF00514	0.521
TRG_NLS_MonoExtC_3	14	19	PF00514	0.503
TRG_NLS_MonoExtN_4	12	19	PF00514	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD10	Leptomonas seymouri	44%	75%
A0A0N1PDG4	Leptomonas seymouri	91%	97%
A0A0S4IT56	Bodo saltans	45%	73%
A0A1X0NWS2	Trypanosomatidae	39%	75%
A0A2R8Y619	Homo sapiens	47%	88%
A0A381MG06	Leishmania infantum	93%	100%
A0A3R7MD18	Trypanosoma rangeli	69%	100%
A0A3R7NJN4	Trypanosoma rangeli	74%	96%
A0A3S5H748	Leishmania donovani	93%	100%
A0A3S5H7I6	Leishmania donovani	42%	75%
A0A3S7WUK6	Leishmania donovani	85%	96%
A0A422N4F4	Trypanosoma rangeli	39%	82%
A0A422NDW8	Trypanosoma rangeli	74%	96%
A1CJ09	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	51%	76%
A1D8G9	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	51%	76%
A2QY49	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	51%	76%
A2WKP3	Oryza sativa subsp. indica	47%	70%
A2WKP5	Oryza sativa subsp. indica	47%	70%
A2WKS3	Oryza sativa subsp. indica	47%	70%
A2WKS5	Oryza sativa subsp. indica	48%	70%
A2WKS8	Oryza sativa subsp. indica	47%	70%
A2WKT1	Oryza sativa subsp. indica	48%	70%
A2WKT4	Oryza sativa subsp. indica	47%	69%
A2WWU2	Oryza sativa subsp. indica	48%	77%
A2XF66	Oryza sativa subsp. indica	48%	70%
A2Y7R3	Oryza sativa subsp. indica	48%	70%
A2YWI3	Oryza sativa subsp. indica	48%	71%
A3AGM4	Oryza sativa subsp. japonica	48%	70%
A3LXE6	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	51%	82%
A3LZZ1	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	51%	82%
A4H5W2	Leishmania braziliensis	80%	100%
A4H9W2	Leishmania braziliensis	81%	100%
A4HG62	Leishmania braziliensis	43%	100%
A4HU57	Leishmania infantum	90%	96%
A4HXJ9	Leishmania infantum	85%	96%
A4HY42	Leishmania infantum	93%	79%
A4I394	Leishmania infantum	42%	75%
A5DBG5	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	46%	83%
A5DJJ1	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	46%	83%
A5DWF0	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	52%	82%
D0A4I4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	96%
D0A4I7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	80%	96%
D0A4I8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	96%
E9AMY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9ARV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9AZI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	75%
L7I1W3	Magnaporthe oryzae (strain Y34)	50%	78%
O22582	Gossypium hirsutum	48%	73%
O23629	Arabidopsis thaliana	47%	71%
O49118	Capsicum annuum	47%	74%
O60814	Homo sapiens	48%	85%
O65818	Solanum lycopersicum	47%	76%
O65819	Solanum lycopersicum	48%	78%
O65821	Solanum lycopersicum	47%	75%
O97484	Euplotes crassus	51%	95%
P02281	Xenopus laevis	49%	85%
P02283	Drosophila melanogaster	48%	87%
P02284	Patella granatina	48%	88%
P02285	Marthasterias glacialis	49%	88%
P02286	Asterias rubens	49%	88%
P02287	Psammechinus miliaris	50%	87%
P02288	Psammechinus miliaris	47%	87%
P02289	Strongylocentrotus purpuratus	45%	86%
P02290	Parechinus angulosus	48%	74%
P02291	Parechinus angulosus	49%	74%
P02292	Parechinus angulosus	49%	72%
P02293	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	52%	82%
P02294	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	52%	82%
P04255	Caenorhabditis elegans	51%	88%
P04913	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	51%	85%
P05621	Triticum aestivum	47%	71%
P06145	Strongylocentrotus purpuratus	47%	76%
P06146	Lytechinus pictus	49%	75%
P06899	Homo sapiens	47%	85%
P06900	Xenopus laevis	47%	85%
P07794	Psammechinus miliaris	48%	86%
P07795	Psammechinus miliaris	50%	86%
P08993	Tetrahymena thermophila (strain SB210)	47%	88%
P08994	Tetrahymena thermophila (strain SB210)	47%	88%
P0C1H3	Gallus gallus	48%	85%
P0C1H4	Gallus gallus	48%	85%
P0C1H5	Gallus gallus	47%	85%
P0C1H6	Homo sapiens	33%	69%
P0CO02	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	43%	77%
P0CO03	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	43%	77%
P0CT13	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	50%	78%
P10853	Mus musculus	48%	85%
P10854	Mus musculus	48%	85%
P14001	Cairina moschata	48%	85%
P16867	Volvox carteri	49%	68%
P16868	Volvox carteri	49%	69%
P16887	Strongylocentrotus purpuratus	47%	74%
P16888	Strongylocentrotus purpuratus	51%	87%
P16889	Strongylocentrotus purpuratus	51%	87%
P16890	Strongylocentrotus purpuratus	52%	100%
P17271	Drosophila hydei	47%	87%
P19374	Platynereis dumerilii	48%	87%
P21897	Chironomus thummi thummi	48%	86%
P23527	Homo sapiens	47%	85%
P23754	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	51%	76%
P27326	Urechis caupo	45%	87%
P27795	Trypanosoma cruzi	78%	96%
P27807	Triticum aestivum	48%	70%
P27893	Leishmania enriettii	87%	96%
P30755	Zea mays	47%	71%
P30756	Zea mays	48%	71%
P30757	Sipunculus nudus	46%	87%
P33778	Homo sapiens	47%	85%
P35067	Acropora formosa	43%	86%
P35068	Tigriopus californicus	47%	87%
P35069	Tigriopus californicus	47%	87%
P37210	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	51%	78%
P40283	Arabidopsis thaliana	48%	71%
P40284	Entamoeba invadens	34%	80%
P48557	Holothuria tubulosa	46%	87%
P48989	Candida albicans (strain SC5314 / ATCC MYA-2876)	52%	82%
P49120	Zea mays	48%	78%
P50565	Chlamydomonas reinhardtii	49%	70%
P54345	Chlamydomonas reinhardtii	49%	69%
P54346	Chlamydomonas reinhardtii	49%	70%
P54347	Chlamydomonas reinhardtii	49%	70%
P54348	Zea mays	48%	69%
P57053	Homo sapiens	49%	85%
P58876	Homo sapiens	48%	85%
P59781	Drosophila erecta	48%	87%
P59782	Drosophila simulans	48%	87%
P62807	Homo sapiens	48%	85%
P62808	Bos taurus	48%	85%
P69069	Oncorhynchus mykiss	46%	86%
P69070	Salmo trutta	46%	86%
P70696	Mus musculus	46%	84%
P78567	Agaricus bisporus	48%	75%
P82887	Olisthodiscus luteus	49%	94%
P83863	Penaeus vannamei	48%	92%
P93354	Nicotiana tabacum	47%	73%
Q00715	Rattus norvegicus	48%	86%
Q00729	Rattus norvegicus	46%	84%
Q0CBD1	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	51%	76%
Q0U1A0	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	47%	76%
Q16778	Homo sapiens	47%	85%
Q1E5N0	Coccidioides immitis (strain RS)	51%	77%
Q1S9I9	Medicago truncatula	47%	72%
Q1SU99	Medicago truncatula	47%	78%
Q1SWQ1	Medicago truncatula	45%	72%
Q27442	Anopheles gambiae	47%	86%
Q27484	Caenorhabditis elegans	51%	87%
Q27749	Psammechinus miliaris	48%	78%
Q27750	Psammechinus miliaris	48%	75%
Q27876	Caenorhabditis elegans	51%	87%
Q27894	Caenorhabditis elegans	51%	87%
Q2HH38	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	51%	78%
Q2M2T1	Bos taurus	48%	85%
Q2PFX4	Macaca fascicularis	48%	85%
Q2U5A9	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	51%	76%
Q32L48	Bos taurus	47%	85%
Q41575	Triticum aestivum	46%	88%
Q43215	Triticum aestivum	47%	79%
Q43216	Triticum aestivum	48%	79%
Q43217	Triticum aestivum	47%	78%
Q43261	Zea mays	47%	70%
Q4HTT2	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	49%	78%
Q4JHM7	Leishmania donovani	90%	96%
Q4PEF8	Ustilago maydis (strain 521 / FGSC 9021)	47%	75%
Q4Q8P9	Leishmania major	43%	100%
Q4QDL6	Leishmania major	92%	100%
Q4QHP1	Leishmania major	90%	100%
Q4WWC5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	51%	76%
Q54LP8	Dictyostelium discoideum	36%	69%
Q59VP1	Candida albicans (strain SC5314 / ATCC MYA-2876)	51%	82%
Q5BJA5	Danio rerio	47%	86%
Q5QNW6	Homo sapiens	48%	85%
Q5R893	Pongo abelii	48%	85%
Q5RCP8	Pongo abelii	47%	85%
Q64475	Mus musculus	48%	85%
Q64478	Mus musculus	48%	85%
Q64524	Mus musculus	46%	85%
Q64525	Mus musculus	48%	85%
Q6BKW7	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	47%	83%
Q6BRG2	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	47%	82%
Q6C4I7	Yarrowia lipolytica (strain CLIB 122 / E 150)	48%	77%
Q6CK60	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	51%	81%
Q6CMV8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	51%	81%
Q6F362	Oryza sativa subsp. japonica	48%	70%
Q6FM30	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	51%	82%
Q6FWM8	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	51%	83%
Q6PC60	Danio rerio	48%	85%
Q6ZBP3	Oryza sativa subsp. japonica	48%	71%
Q6ZWY9	Mus musculus	48%	85%
Q74ZL5	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	51%	81%
Q75VN4	Zhangixalus schlegelii	48%	85%
Q76FD7	Drosophila sechellia	47%	87%
Q76FE5	Drosophila mauritiana	48%	87%
Q76FE9	Drosophila orena	48%	87%
Q76FF3	Drosophila teissieri	48%	87%
Q7GBK0	Oryza sativa subsp. japonica	47%	70%
Q7M400	Tetrahymena pyriformis	47%	88%
Q7M4G7	Patiria pectinifera	48%	88%
Q7Z9J4	Ajellomyces capsulatus	51%	78%
Q875B7	Podospora anserina	51%	78%
Q8CGP0	Mus musculus	49%	85%
Q8CGP1	Mus musculus	48%	85%
Q8CGP2	Mus musculus	48%	85%
Q8I1N0	Drosophila yakuba	48%	87%
Q8J1F8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	51%	84%
Q8J1K2	Rosellinia necatrix	49%	79%
Q8N257	Homo sapiens	49%	85%
Q8WNR4	Bos taurus	40%	88%
Q93079	Homo sapiens	48%	85%
Q943L2	Oryza sativa subsp. japonica	48%	77%
Q94JE1	Oryza sativa subsp. japonica	47%	69%
Q94JJ4	Oryza sativa subsp. japonica	47%	70%
Q94JJ7	Oryza sativa subsp. japonica	47%	70%
Q96A08	Homo sapiens	45%	84%
Q99285	Pisum sativum	44%	89%
Q99877	Homo sapiens	48%	85%
Q99879	Homo sapiens	48%	85%
Q99880	Homo sapiens	48%	85%
Q9D2U9	Mus musculus	49%	85%
Q9D9Z7	Mus musculus	33%	87%
Q9FFC0	Arabidopsis thaliana	47%	74%
Q9LFF6	Arabidopsis thaliana	45%	78%
Q9LGH4	Oryza sativa subsp. japonica	49%	70%
Q9LGH8	Oryza sativa subsp. japonica	48%	70%
Q9LGI2	Oryza sativa subsp. japonica	47%	70%
Q9LQQ4	Arabidopsis thaliana	47%	72%
Q9LZ45	Arabidopsis thaliana	48%	81%
Q9LZT0	Arabidopsis thaliana	47%	74%
Q9MBF7	Lilium longiflorum	32%	68%
Q9PSW9	Gallus gallus	48%	85%
Q9SF55	Arabidopsis thaliana	49%	85%
Q9SI96	Arabidopsis thaliana	48%	71%
Q9U8C0	Leishmania major	87%	100%
Q9ZUS0	Arabidopsis thaliana	47%	78%
V5D812	Trypanosoma cruzi	41%	75%