MSP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MSP (Major sperm protein) domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AR93_LEIMU

TriTrypDb:

LmxM.17.1210

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	7
GO:0016020	membrane	2	7
GO:0031090	organelle membrane	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

E9AR93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR93

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022406	membrane docking	2	1
GO:0051179	localization	1	1
GO:0051640	organelle localization	2	1
GO:0051643	endoplasmic reticulum localization	3	1
GO:0061024	membrane organization	4	1
GO:0061817	endoplasmic reticulum-plasma membrane tethering	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090158	endoplasmic reticulum membrane organization	5	1
GO:0140056	organelle localization by membrane tethering	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	231	233	PF00675	0.538
CLV_NRD_NRD_1	283	285	PF00675	0.560
CLV_NRD_NRD_1	32	34	PF00675	0.458
CLV_PCSK_KEX2_1	171	173	PF00082	0.405
CLV_PCSK_KEX2_1	283	285	PF00082	0.560
CLV_PCSK_KEX2_1	32	34	PF00082	0.506
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.405
CLV_PCSK_SKI1_1	197	201	PF00082	0.376
DEG_Nend_UBRbox_2	1	3	PF02207	0.781
DEG_SPOP_SBC_1	211	215	PF00917	0.768
DEG_SPOP_SBC_1	296	300	PF00917	0.435
DOC_CYCLIN_yCln2_LP_2	133	139	PF00134	0.534
DOC_MAPK_gen_1	126	133	PF00069	0.535
DOC_MAPK_MEF2A_6	262	270	PF00069	0.265
DOC_MAPK_MEF2A_6	86	95	PF00069	0.491
DOC_MAPK_RevD_3	268	284	PF00069	0.216
DOC_PP4_FxxP_1	182	185	PF00568	0.566
DOC_PP4_FxxP_1	52	55	PF00568	0.491
DOC_USP7_MATH_1	101	105	PF00917	0.588
DOC_USP7_MATH_1	211	215	PF00917	0.737
DOC_WW_Pin1_4	141	146	PF00397	0.571
DOC_WW_Pin1_4	171	176	PF00397	0.719
DOC_WW_Pin1_4	216	221	PF00397	0.675
DOC_WW_Pin1_4	26	31	PF00397	0.601
DOC_WW_Pin1_4	362	367	PF00397	0.592
LIG_14-3-3_CanoR_1	103	109	PF00244	0.505
LIG_14-3-3_CanoR_1	126	132	PF00244	0.618
LIG_14-3-3_CanoR_1	24	29	PF00244	0.633
LIG_14-3-3_CanoR_1	245	254	PF00244	0.572
LIG_14-3-3_CanoR_1	295	305	PF00244	0.557
LIG_BIR_III_4	290	294	PF00653	0.417
LIG_Clathr_ClatBox_1	42	46	PF01394	0.407
LIG_EVH1_2	53	57	PF00568	0.491
LIG_FHA_1	111	117	PF00498	0.547
LIG_FHA_1	259	265	PF00498	0.478
LIG_FHA_1	318	324	PF00498	0.497
LIG_FHA_1	339	345	PF00498	0.458
LIG_FHA_1	37	43	PF00498	0.525
LIG_FHA_2	105	111	PF00498	0.491
LIG_FHA_2	168	174	PF00498	0.571
LIG_FHA_2	310	316	PF00498	0.467
LIG_FHA_2	378	384	PF00498	0.428
LIG_FHA_2	401	407	PF00498	0.561
LIG_FHA_2	409	415	PF00498	0.566
LIG_Integrin_RGD_1	155	157	PF01839	0.453
LIG_LIR_Apic_2	181	185	PF02991	0.646
LIG_LIR_Apic_2	373	378	PF02991	0.427
LIG_LIR_Gen_1	102	111	PF02991	0.573
LIG_LIR_Gen_1	147	154	PF02991	0.554
LIG_LIR_Nem_3	102	108	PF02991	0.573
LIG_LIR_Nem_3	147	152	PF02991	0.545
LIG_LIR_Nem_3	186	190	PF02991	0.595
LIG_LIR_Nem_3	369	375	PF02991	0.419
LIG_MYND_1	141	145	PF01753	0.643
LIG_NRBOX	147	153	PF00104	0.584
LIG_SH2_CRK	134	138	PF00017	0.471
LIG_SH2_NCK_1	134	138	PF00017	0.471
LIG_SH2_NCK_1	375	379	PF00017	0.413
LIG_SH2_PTP2	187	190	PF00017	0.596
LIG_SH2_SRC	134	137	PF00017	0.468
LIG_SH2_SRC	187	190	PF00017	0.579
LIG_SH2_STAT5	168	171	PF00017	0.555
LIG_SH2_STAT5	187	190	PF00017	0.596
LIG_SH2_STAT5	87	90	PF00017	0.491
LIG_SH3_3	186	192	PF00018	0.606
LIG_SH3_3	319	325	PF00018	0.604
LIG_SH3_3	364	370	PF00018	0.529
LIG_SH3_3	393	399	PF00018	0.544
LIG_SH3_3	401	407	PF00018	0.549
LIG_SH3_3	48	54	PF00018	0.491
LIG_SH3_3	85	91	PF00018	0.491
LIG_SUMO_SIM_anti_2	277	282	PF11976	0.449
LIG_SUMO_SIM_par_1	135	140	PF11976	0.516
LIG_SUMO_SIM_par_1	272	277	PF11976	0.310
LIG_TRAF2_1	379	382	PF00917	0.550
LIG_TRFH_1	26	30	PF08558	0.600
LIG_WRC_WIRS_1	179	184	PF05994	0.645
LIG_WW_1	184	187	PF00397	0.582
MOD_CDC14_SPxK_1	29	32	PF00782	0.599
MOD_CDK_SPK_2	141	146	PF00069	0.563
MOD_CDK_SPxK_1	26	32	PF00069	0.598
MOD_CDK_SPxxK_3	26	33	PF00069	0.600
MOD_CK1_1	104	110	PF00069	0.604
MOD_CK1_1	193	199	PF00069	0.653
MOD_CK1_1	210	216	PF00069	0.740
MOD_CK1_1	3	9	PF00069	0.663
MOD_CK2_1	356	362	PF00069	0.506
MOD_CK2_1	377	383	PF00069	0.425
MOD_CK2_1	400	406	PF00069	0.533
MOD_CK2_1	408	414	PF00069	0.518
MOD_CK2_1	8	14	PF00069	0.760
MOD_GlcNHglycan	20	23	PF01048	0.506
MOD_GlcNHglycan	203	206	PF01048	0.606
MOD_GlcNHglycan	209	212	PF01048	0.558
MOD_GlcNHglycan	301	304	PF01048	0.810
MOD_GlcNHglycan	99	102	PF01048	0.294
MOD_GSK3_1	167	174	PF00069	0.649
MOD_GSK3_1	203	210	PF00069	0.725
MOD_GSK3_1	212	219	PF00069	0.688
MOD_GSK3_1	253	260	PF00069	0.573
MOD_GSK3_1	295	302	PF00069	0.476
MOD_GSK3_1	97	104	PF00069	0.578
MOD_N-GLC_1	68	73	PF02516	0.302
MOD_NEK2_1	127	132	PF00069	0.538
MOD_NEK2_2	178	183	PF00069	0.642
MOD_PIKK_1	120	126	PF00454	0.600
MOD_PIKK_1	309	315	PF00454	0.532
MOD_PIKK_1	356	362	PF00454	0.519
MOD_PIKK_1	377	383	PF00454	0.425
MOD_PIKK_1	408	414	PF00454	0.573
MOD_PIKK_1	78	84	PF00454	0.573
MOD_PKA_2	127	133	PF00069	0.531
MOD_PKB_1	243	251	PF00069	0.573
MOD_Plk_2-3	135	141	PF00069	0.542
MOD_Plk_4	178	184	PF00069	0.634
MOD_Plk_4	190	196	PF00069	0.612
MOD_ProDKin_1	141	147	PF00069	0.571
MOD_ProDKin_1	171	177	PF00069	0.721
MOD_ProDKin_1	216	222	PF00069	0.672
MOD_ProDKin_1	26	32	PF00069	0.598
MOD_ProDKin_1	362	368	PF00069	0.591
MOD_SUMO_for_1	43	46	PF00179	0.491
TRG_DiLeu_BaEn_1	46	51	PF01217	0.491
TRG_DiLeu_BaLyEn_6	138	143	PF01217	0.473
TRG_ENDOCYTIC_2	134	137	PF00928	0.541
TRG_ENDOCYTIC_2	187	190	PF00928	0.596
TRG_ER_diArg_1	283	285	PF00400	0.360
TRG_ER_diArg_1	32	34	PF00400	0.637
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILZ1	Leptomonas seymouri	49%	100%
A0A3S5H717	Leishmania donovani	76%	95%
A4H978	Leishmania braziliensis	61%	96%
A4HXJ8	Leishmania infantum	76%	95%
Q4QE70	Leishmania major	75%	100%