Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AR91_LEIMU

TriTrypDb:

LmxM.17.1190

Length:

717

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AR91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR91

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	317	319	PF00675	0.759
CLV_NRD_NRD_1	361	363	PF00675	0.774
CLV_NRD_NRD_1	469	471	PF00675	0.723
CLV_NRD_NRD_1	477	479	PF00675	0.677
CLV_NRD_NRD_1	572	574	PF00675	0.662
CLV_NRD_NRD_1	583	585	PF00675	0.604
CLV_NRD_NRD_1	76	78	PF00675	0.608
CLV_PCSK_FUR_1	580	584	PF00082	0.583
CLV_PCSK_KEX2_1	317	319	PF00082	0.759
CLV_PCSK_KEX2_1	361	363	PF00082	0.779
CLV_PCSK_KEX2_1	469	471	PF00082	0.709
CLV_PCSK_KEX2_1	477	479	PF00082	0.696
CLV_PCSK_KEX2_1	582	584	PF00082	0.714
CLV_PCSK_KEX2_1	588	590	PF00082	0.655
CLV_PCSK_KEX2_1	76	78	PF00082	0.608
CLV_PCSK_PC1ET2_1	588	590	PF00082	0.723
CLV_PCSK_PC7_1	584	590	PF00082	0.657
CLV_PCSK_SKI1_1	25	29	PF00082	0.671
CLV_PCSK_SKI1_1	538	542	PF00082	0.630
CLV_PCSK_SKI1_1	563	567	PF00082	0.729
CLV_PCSK_SKI1_1	659	663	PF00082	0.461
CLV_PCSK_SKI1_1	76	80	PF00082	0.537
DEG_SPOP_SBC_1	300	304	PF00917	0.701
DEG_SPOP_SBC_1	327	331	PF00917	0.552
DEG_SPOP_SBC_1	511	515	PF00917	0.671
DEG_SPOP_SBC_1	618	622	PF00917	0.551
DOC_CKS1_1	321	326	PF01111	0.717
DOC_MAPK_gen_1	76	83	PF00069	0.609
DOC_MAPK_MEF2A_6	201	210	PF00069	0.632
DOC_MAPK_MEF2A_6	555	564	PF00069	0.600
DOC_MAPK_MEF2A_6	76	85	PF00069	0.608
DOC_PP4_MxPP_1	16	19	PF00568	0.584
DOC_SPAK_OSR1_1	149	153	PF12202	0.531
DOC_USP7_MATH_1	12	16	PF00917	0.583
DOC_USP7_MATH_1	182	186	PF00917	0.601
DOC_USP7_MATH_1	278	282	PF00917	0.657
DOC_USP7_MATH_1	301	305	PF00917	0.663
DOC_USP7_MATH_1	327	331	PF00917	0.629
DOC_USP7_MATH_1	337	341	PF00917	0.719
DOC_USP7_MATH_1	346	350	PF00917	0.636
DOC_USP7_MATH_1	401	405	PF00917	0.755
DOC_USP7_MATH_1	424	428	PF00917	0.689
DOC_USP7_MATH_1	491	495	PF00917	0.671
DOC_USP7_MATH_1	507	511	PF00917	0.682
DOC_USP7_MATH_1	512	516	PF00917	0.638
DOC_USP7_MATH_1	533	537	PF00917	0.618
DOC_USP7_MATH_1	619	623	PF00917	0.512
DOC_USP7_MATH_1	652	656	PF00917	0.652
DOC_USP7_MATH_1	670	674	PF00917	0.733
DOC_USP7_MATH_1	684	688	PF00917	0.634
DOC_USP7_MATH_1	704	708	PF00917	0.673
DOC_WW_Pin1_4	127	132	PF00397	0.583
DOC_WW_Pin1_4	136	141	PF00397	0.588
DOC_WW_Pin1_4	18	23	PF00397	0.758
DOC_WW_Pin1_4	196	201	PF00397	0.624
DOC_WW_Pin1_4	320	325	PF00397	0.714
DOC_WW_Pin1_4	344	349	PF00397	0.662
DOC_WW_Pin1_4	393	398	PF00397	0.768
DOC_WW_Pin1_4	447	452	PF00397	0.722
DOC_WW_Pin1_4	487	492	PF00397	0.529
DOC_WW_Pin1_4	609	614	PF00397	0.567
DOC_WW_Pin1_4	631	636	PF00397	0.530
DOC_WW_Pin1_4	67	72	PF00397	0.657
DOC_WW_Pin1_4	680	685	PF00397	0.784
LIG_14-3-3_CanoR_1	124	131	PF00244	0.566
LIG_14-3-3_CanoR_1	164	170	PF00244	0.634
LIG_14-3-3_CanoR_1	296	301	PF00244	0.682
LIG_14-3-3_CanoR_1	477	482	PF00244	0.764
LIG_14-3-3_CanoR_1	628	633	PF00244	0.701
LIG_14-3-3_CanoR_1	659	668	PF00244	0.546
LIG_14-3-3_CanoR_1	76	85	PF00244	0.546
LIG_Actin_WH2_2	547	565	PF00022	0.589
LIG_BIR_II_1	1	5	PF00653	0.651
LIG_BRCT_BRCA1_1	497	501	PF00533	0.540
LIG_BRCT_BRCA1_1	513	517	PF00533	0.670
LIG_BRCT_BRCA1_1	633	637	PF00533	0.641
LIG_Clathr_ClatBox_1	54	58	PF01394	0.646
LIG_CSL_BTD_1	321	324	PF09270	0.716
LIG_deltaCOP1_diTrp_1	548	558	PF00928	0.573
LIG_eIF4E_1	559	565	PF01652	0.619
LIG_FHA_1	161	167	PF00498	0.624
LIG_FHA_1	239	245	PF00498	0.716
LIG_FHA_1	287	293	PF00498	0.694
LIG_FHA_1	300	306	PF00498	0.571
LIG_FHA_1	327	333	PF00498	0.644
LIG_FHA_1	487	493	PF00498	0.688
LIG_FHA_1	606	612	PF00498	0.651
LIG_FHA_1	619	625	PF00498	0.480
LIG_FHA_1	663	669	PF00498	0.670
LIG_FHA_1	99	105	PF00498	0.556
LIG_FHA_2	124	130	PF00498	0.712
LIG_FHA_2	197	203	PF00498	0.624
LIG_FHA_2	329	335	PF00498	0.633
LIG_FHA_2	435	441	PF00498	0.678
LIG_FHA_2	57	63	PF00498	0.560
LIG_FHA_2	77	83	PF00498	0.650
LIG_FHA_2	8	14	PF00498	0.661
LIG_GBD_Chelix_1	377	385	PF00786	0.524
LIG_HP1_1	424	428	PF01393	0.535
LIG_LIR_Gen_1	263	272	PF02991	0.528
LIG_LIR_Gen_1	50	57	PF02991	0.682
LIG_LIR_Gen_1	548	559	PF02991	0.576
LIG_LIR_Nem_3	167	173	PF02991	0.750
LIG_LIR_Nem_3	263	268	PF02991	0.524
LIG_LIR_Nem_3	50	55	PF02991	0.682
LIG_LIR_Nem_3	548	554	PF02991	0.570
LIG_LYPXL_yS_3	559	562	PF13949	0.607
LIG_MYND_1	190	194	PF01753	0.530
LIG_PDZ_Class_2	712	717	PF00595	0.611
LIG_Pex14_1	322	326	PF04695	0.521
LIG_PTB_Apo_2	553	560	PF02174	0.577
LIG_PTB_Phospho_1	553	559	PF10480	0.575
LIG_Rb_pABgroove_1	113	121	PF01858	0.699
LIG_SH2_CRK	629	633	PF00017	0.499
LIG_SH2_NCK_1	265	269	PF00017	0.683
LIG_SH2_STAT3	549	552	PF00017	0.579
LIG_SH2_STAT5	549	552	PF00017	0.579
LIG_SH3_3	16	22	PF00018	0.610
LIG_SH3_3	188	194	PF00018	0.571
LIG_SH3_3	24	30	PF00018	0.609
LIG_SH3_3	249	255	PF00018	0.719
LIG_SH3_3	318	324	PF00018	0.717
LIG_SH3_3	388	394	PF00018	0.701
LIG_SH3_3	629	635	PF00018	0.621
LIG_SUMO_SIM_par_1	296	304	PF11976	0.701
LIG_SUMO_SIM_par_1	424	430	PF11976	0.536
LIG_SUMO_SIM_par_1	53	60	PF11976	0.647
LIG_TRAF2_1	11	14	PF00917	0.642
LIG_TRAF2_1	437	440	PF00917	0.724
LIG_UBA3_1	417	423	PF00899	0.649
MOD_CDK_SPK_2	196	201	PF00069	0.624
MOD_CDK_SPxxK_3	136	143	PF00069	0.564
MOD_CDK_SPxxK_3	18	25	PF00069	0.699
MOD_CK1_1	123	129	PF00069	0.734
MOD_CK1_1	165	171	PF00069	0.725
MOD_CK1_1	174	180	PF00069	0.641
MOD_CK1_1	246	252	PF00069	0.709
MOD_CK1_1	261	267	PF00069	0.550
MOD_CK1_1	273	279	PF00069	0.717
MOD_CK1_1	299	305	PF00069	0.703
MOD_CK1_1	330	336	PF00069	0.628
MOD_CK1_1	340	346	PF00069	0.694
MOD_CK1_1	356	362	PF00069	0.503
MOD_CK1_1	460	466	PF00069	0.673
MOD_CK1_1	480	486	PF00069	0.674
MOD_CK1_1	510	516	PF00069	0.649
MOD_CK1_1	631	637	PF00069	0.756
MOD_CK1_1	67	73	PF00069	0.698
MOD_CK1_1	673	679	PF00069	0.736
MOD_CK1_1	687	693	PF00069	0.613
MOD_CK1_1	98	104	PF00069	0.667
MOD_CK2_1	127	133	PF00069	0.673
MOD_CK2_1	18	24	PF00069	0.540
MOD_CK2_1	260	266	PF00069	0.640
MOD_CK2_1	276	282	PF00069	0.579
MOD_CK2_1	304	310	PF00069	0.719
MOD_CK2_1	434	440	PF00069	0.779
MOD_CK2_1	47	53	PF00069	0.677
MOD_CK2_1	619	625	PF00069	0.507
MOD_CK2_1	686	692	PF00069	0.607
MOD_CK2_1	7	13	PF00069	0.657
MOD_CK2_1	76	82	PF00069	0.659
MOD_Cter_Amidation	74	77	PF01082	0.603
MOD_GlcNHglycan	1	4	PF01048	0.731
MOD_GlcNHglycan	107	110	PF01048	0.624
MOD_GlcNHglycan	136	139	PF01048	0.677
MOD_GlcNHglycan	235	238	PF01048	0.679
MOD_GlcNHglycan	403	406	PF01048	0.823
MOD_GlcNHglycan	444	447	PF01048	0.671
MOD_GlcNHglycan	457	460	PF01048	0.662
MOD_GlcNHglycan	493	496	PF01048	0.689
MOD_GlcNHglycan	502	505	PF01048	0.634
MOD_GlcNHglycan	509	512	PF01048	0.581
MOD_GlcNHglycan	570	573	PF01048	0.653
MOD_GlcNHglycan	595	598	PF01048	0.740
MOD_GlcNHglycan	647	650	PF01048	0.596
MOD_GlcNHglycan	66	69	PF01048	0.714
MOD_GlcNHglycan	678	681	PF01048	0.734
MOD_GlcNHglycan	706	709	PF01048	0.673
MOD_GlcNHglycan	97	100	PF01048	0.746
MOD_GSK3_1	123	130	PF00069	0.698
MOD_GSK3_1	158	165	PF00069	0.711
MOD_GSK3_1	168	175	PF00069	0.643
MOD_GSK3_1	208	215	PF00069	0.694
MOD_GSK3_1	228	235	PF00069	0.788
MOD_GSK3_1	243	250	PF00069	0.573
MOD_GSK3_1	254	261	PF00069	0.587
MOD_GSK3_1	266	273	PF00069	0.724
MOD_GSK3_1	296	303	PF00069	0.739
MOD_GSK3_1	326	333	PF00069	0.698
MOD_GSK3_1	336	343	PF00069	0.606
MOD_GSK3_1	389	396	PF00069	0.753
MOD_GSK3_1	473	480	PF00069	0.668
MOD_GSK3_1	482	489	PF00069	0.588
MOD_GSK3_1	491	498	PF00069	0.533
MOD_GSK3_1	506	513	PF00069	0.665
MOD_GSK3_1	515	522	PF00069	0.513
MOD_GSK3_1	593	600	PF00069	0.825
MOD_GSK3_1	605	612	PF00069	0.600
MOD_GSK3_1	668	675	PF00069	0.770
MOD_GSK3_1	676	683	PF00069	0.686
MOD_N-GLC_1	47	52	PF02516	0.677
MOD_N-GLC_1	645	650	PF02516	0.490
MOD_N-GLC_1	673	678	PF02516	0.686
MOD_NEK2_1	162	167	PF00069	0.621
MOD_NEK2_1	172	177	PF00069	0.593
MOD_NEK2_1	232	237	PF00069	0.740
MOD_NEK2_1	238	243	PF00069	0.715
MOD_NEK2_1	313	318	PF00069	0.692
MOD_NEK2_1	326	331	PF00069	0.591
MOD_NEK2_1	455	460	PF00069	0.667
MOD_NEK2_1	481	486	PF00069	0.674
MOD_NEK2_1	519	524	PF00069	0.666
MOD_NEK2_1	66	71	PF00069	0.682
MOD_NEK2_1	668	673	PF00069	0.715
MOD_NEK2_1	95	100	PF00069	0.668
MOD_NEK2_2	512	517	PF00069	0.687
MOD_PIKK_1	174	180	PF00454	0.661
MOD_PIKK_1	346	352	PF00454	0.567
MOD_PIKK_1	369	375	PF00454	0.514
MOD_PIKK_1	523	529	PF00454	0.649
MOD_PIKK_1	533	539	PF00454	0.509
MOD_PIKK_1	684	690	PF00454	0.536
MOD_PK_1	296	302	PF00069	0.658
MOD_PK_1	628	634	PF00069	0.651
MOD_PKA_1	477	483	PF00069	0.752
MOD_PKA_1	588	594	PF00069	0.646
MOD_PKA_1	76	82	PF00069	0.609
MOD_PKA_2	123	129	PF00069	0.710
MOD_PKA_2	369	375	PF00069	0.473
MOD_PKA_2	477	483	PF00069	0.756
MOD_PKA_2	588	594	PF00069	0.619
MOD_PKA_2	642	648	PF00069	0.707
MOD_PKA_2	76	82	PF00069	0.662
MOD_PKB_1	628	636	PF00069	0.661
MOD_PKB_1	657	665	PF00069	0.466
MOD_Plk_1	12	18	PF00069	0.562
MOD_Plk_1	327	333	PF00069	0.507
MOD_Plk_1	356	362	PF00069	0.640
MOD_Plk_1	47	53	PF00069	0.677
MOD_Plk_1	519	525	PF00069	0.737
MOD_Plk_2-3	328	334	PF00069	0.594
MOD_Plk_2-3	56	62	PF00069	0.535
MOD_Plk_4	165	171	PF00069	0.658
MOD_Plk_4	477	483	PF00069	0.668
MOD_Plk_4	512	518	PF00069	0.666
MOD_Plk_4	519	525	PF00069	0.576
MOD_ProDKin_1	127	133	PF00069	0.585
MOD_ProDKin_1	136	142	PF00069	0.588
MOD_ProDKin_1	18	24	PF00069	0.761
MOD_ProDKin_1	196	202	PF00069	0.625
MOD_ProDKin_1	320	326	PF00069	0.716
MOD_ProDKin_1	344	350	PF00069	0.663
MOD_ProDKin_1	393	399	PF00069	0.765
MOD_ProDKin_1	447	453	PF00069	0.724
MOD_ProDKin_1	487	493	PF00069	0.530
MOD_ProDKin_1	609	615	PF00069	0.566
MOD_ProDKin_1	631	637	PF00069	0.532
MOD_ProDKin_1	67	73	PF00069	0.656
MOD_ProDKin_1	680	686	PF00069	0.782
TRG_ENDOCYTIC_2	265	268	PF00928	0.528
TRG_ENDOCYTIC_2	559	562	PF00928	0.607
TRG_ENDOCYTIC_2	629	632	PF00928	0.499
TRG_ENDOCYTIC_2	697	700	PF00928	0.677
TRG_ER_diArg_1	360	362	PF00400	0.777
TRG_ER_diArg_1	477	479	PF00400	0.769
TRG_ER_diArg_1	580	583	PF00400	0.694
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.673

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WUL3	Leishmania donovani	85%	100%
A4HXJ6	Leishmania infantum	87%	100%
E9AI56	Leishmania braziliensis	61%	100%
Q4QE72	Leishmania major	85%	100%