Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AR90_LEIMU

TriTrypDb:

LmxM.17.1180

Length:

911

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AR90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR90

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	302	306	PF00656	0.627
CLV_C14_Caspase3-7	684	688	PF00656	0.704
CLV_C14_Caspase3-7	741	745	PF00656	0.574
CLV_C14_Caspase3-7	877	881	PF00656	0.553
CLV_NRD_NRD_1	107	109	PF00675	0.628
CLV_NRD_NRD_1	118	120	PF00675	0.565
CLV_NRD_NRD_1	389	391	PF00675	0.673
CLV_NRD_NRD_1	453	455	PF00675	0.508
CLV_NRD_NRD_1	496	498	PF00675	0.541
CLV_NRD_NRD_1	620	622	PF00675	0.666
CLV_NRD_NRD_1	730	732	PF00675	0.711
CLV_NRD_NRD_1	883	885	PF00675	0.721
CLV_NRD_NRD_1	894	896	PF00675	0.586
CLV_PCSK_FUR_1	534	538	PF00082	0.653
CLV_PCSK_FUR_1	728	732	PF00082	0.672
CLV_PCSK_KEX2_1	107	109	PF00082	0.628
CLV_PCSK_KEX2_1	117	119	PF00082	0.575
CLV_PCSK_KEX2_1	264	266	PF00082	0.533
CLV_PCSK_KEX2_1	367	369	PF00082	0.465
CLV_PCSK_KEX2_1	389	391	PF00082	0.673
CLV_PCSK_KEX2_1	453	455	PF00082	0.511
CLV_PCSK_KEX2_1	495	497	PF00082	0.547
CLV_PCSK_KEX2_1	536	538	PF00082	0.657
CLV_PCSK_KEX2_1	620	622	PF00082	0.629
CLV_PCSK_KEX2_1	728	730	PF00082	0.722
CLV_PCSK_KEX2_1	883	885	PF00082	0.721
CLV_PCSK_KEX2_1	894	896	PF00082	0.586
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.533
CLV_PCSK_PC1ET2_1	367	369	PF00082	0.418
CLV_PCSK_PC1ET2_1	536	538	PF00082	0.657
CLV_PCSK_PC7_1	491	497	PF00082	0.546
CLV_PCSK_PC7_1	616	622	PF00082	0.574
CLV_PCSK_PC7_1	879	885	PF00082	0.609
CLV_PCSK_SKI1_1	264	268	PF00082	0.576
CLV_PCSK_SKI1_1	453	457	PF00082	0.553
CLV_PCSK_SKI1_1	485	489	PF00082	0.511
CLV_PCSK_SKI1_1	491	495	PF00082	0.539
CLV_PCSK_SKI1_1	509	513	PF00082	0.427
CLV_PCSK_SKI1_1	620	624	PF00082	0.534
CLV_PCSK_SKI1_1	659	663	PF00082	0.647
CLV_PCSK_SKI1_1	671	675	PF00082	0.542
CLV_PCSK_SKI1_1	714	718	PF00082	0.533
CLV_PCSK_SKI1_1	851	855	PF00082	0.574
CLV_PCSK_SKI1_1	860	864	PF00082	0.598
DEG_SPOP_SBC_1	142	146	PF00917	0.633
DEG_SPOP_SBC_1	195	199	PF00917	0.521
DOC_CKS1_1	905	910	PF01111	0.516
DOC_CYCLIN_yCln2_LP_2	220	226	PF00134	0.655
DOC_CYCLIN_yCln2_LP_2	585	591	PF00134	0.544
DOC_MAPK_MEF2A_6	11	19	PF00069	0.521
DOC_PP2B_LxvP_1	220	223	PF13499	0.649
DOC_PP2B_LxvP_1	276	279	PF13499	0.664
DOC_PP2B_LxvP_1	425	428	PF13499	0.509
DOC_PP2B_LxvP_1	580	583	PF13499	0.610
DOC_PP2B_LxvP_1	590	593	PF13499	0.651
DOC_PP4_FxxP_1	661	664	PF00568	0.583
DOC_USP7_MATH_1	127	131	PF00917	0.622
DOC_USP7_MATH_1	142	146	PF00917	0.580
DOC_USP7_MATH_1	180	184	PF00917	0.657
DOC_USP7_MATH_1	195	199	PF00917	0.584
DOC_USP7_MATH_1	228	232	PF00917	0.610
DOC_USP7_MATH_1	240	244	PF00917	0.618
DOC_USP7_MATH_1	299	303	PF00917	0.531
DOC_USP7_MATH_1	308	312	PF00917	0.477
DOC_USP7_MATH_1	333	337	PF00917	0.733
DOC_USP7_MATH_1	596	600	PF00917	0.699
DOC_USP7_MATH_1	633	637	PF00917	0.688
DOC_USP7_MATH_1	648	652	PF00917	0.577
DOC_USP7_MATH_1	673	677	PF00917	0.676
DOC_USP7_MATH_1	681	685	PF00917	0.616
DOC_USP7_MATH_1	764	768	PF00917	0.558
DOC_USP7_MATH_1	80	84	PF00917	0.628
DOC_USP7_MATH_1	808	812	PF00917	0.675
DOC_USP7_MATH_1	837	841	PF00917	0.609
DOC_USP7_MATH_1	842	846	PF00917	0.593
DOC_USP7_MATH_2	342	348	PF00917	0.502
DOC_WW_Pin1_4	110	115	PF00397	0.518
DOC_WW_Pin1_4	162	167	PF00397	0.639
DOC_WW_Pin1_4	226	231	PF00397	0.636
DOC_WW_Pin1_4	26	31	PF00397	0.580
DOC_WW_Pin1_4	329	334	PF00397	0.756
DOC_WW_Pin1_4	423	428	PF00397	0.673
DOC_WW_Pin1_4	511	516	PF00397	0.454
DOC_WW_Pin1_4	578	583	PF00397	0.721
DOC_WW_Pin1_4	646	651	PF00397	0.689
DOC_WW_Pin1_4	660	665	PF00397	0.631
DOC_WW_Pin1_4	736	741	PF00397	0.658
DOC_WW_Pin1_4	780	785	PF00397	0.603
DOC_WW_Pin1_4	790	795	PF00397	0.564
DOC_WW_Pin1_4	888	893	PF00397	0.605
DOC_WW_Pin1_4	899	904	PF00397	0.570
LIG_14-3-3_CanoR_1	107	113	PF00244	0.645
LIG_14-3-3_CanoR_1	348	354	PF00244	0.652
LIG_14-3-3_CanoR_1	453	462	PF00244	0.505
LIG_14-3-3_CanoR_1	550	560	PF00244	0.664
LIG_14-3-3_CanoR_1	621	627	PF00244	0.586
LIG_14-3-3_CanoR_1	730	740	PF00244	0.654
LIG_14-3-3_CanoR_1	779	784	PF00244	0.579
LIG_14-3-3_CterR_2	906	911	PF00244	0.516
LIG_FHA_1	111	117	PF00498	0.564
LIG_FHA_1	195	201	PF00498	0.531
LIG_FHA_1	265	271	PF00498	0.550
LIG_FHA_1	31	37	PF00498	0.602
LIG_FHA_1	519	525	PF00498	0.636
LIG_FHA_1	566	572	PF00498	0.574
LIG_FHA_1	69	75	PF00498	0.601
LIG_FHA_2	354	360	PF00498	0.462
LIG_FHA_2	464	470	PF00498	0.367
LIG_FHA_2	50	56	PF00498	0.548
LIG_FHA_2	623	629	PF00498	0.597
LIG_FHA_2	739	745	PF00498	0.593
LIG_Integrin_RGD_1	865	867	PF01839	0.501
LIG_LIR_Apic_2	636	642	PF02991	0.660
LIG_LIR_Apic_2	658	664	PF02991	0.603
LIG_LIR_Apic_2	824	828	PF02991	0.599
LIG_LIR_Apic_2	902	908	PF02991	0.517
LIG_LIR_Gen_1	168	178	PF02991	0.625
LIG_LIR_Gen_1	751	762	PF02991	0.598
LIG_LIR_Nem_3	168	174	PF02991	0.618
LIG_LIR_Nem_3	751	757	PF02991	0.603
LIG_MYND_1	588	592	PF01753	0.645
LIG_MYND_3	559	563	PF01753	0.610
LIG_SH2_CRK	825	829	PF00017	0.648
LIG_SH2_STAP1	120	124	PF00017	0.624
LIG_SH2_STAP1	445	449	PF00017	0.424
LIG_SH2_STAT5	155	158	PF00017	0.684
LIG_SH2_STAT5	626	629	PF00017	0.524
LIG_SH2_STAT5	900	903	PF00017	0.576
LIG_SH3_3	16	22	PF00018	0.584
LIG_SH3_3	286	292	PF00018	0.763
LIG_SH3_3	293	299	PF00018	0.631
LIG_SH3_3	336	342	PF00018	0.684
LIG_SH3_3	521	527	PF00018	0.691
LIG_SH3_3	580	586	PF00018	0.711
LIG_SH3_3	83	89	PF00018	0.629
LIG_SUMO_SIM_par_1	12	18	PF11976	0.586
LIG_TRAF2_1	342	345	PF00917	0.620
LIG_TRAF2_1	466	469	PF00917	0.487
LIG_TRAF2_1	64	67	PF00917	0.551
LIG_WW_2	289	292	PF00397	0.708
LIG_WW_2	583	586	PF00397	0.604
LIG_WW_3	426	430	PF00397	0.555
MOD_CDC14_SPxK_1	229	232	PF00782	0.633
MOD_CDC14_SPxK_1	426	429	PF00782	0.560
MOD_CDC14_SPxK_1	649	652	PF00782	0.554
MOD_CDC14_SPxK_1	891	894	PF00782	0.558
MOD_CDK_SPK_2	790	795	PF00069	0.559
MOD_CDK_SPxK_1	226	232	PF00069	0.638
MOD_CDK_SPxK_1	423	429	PF00069	0.581
MOD_CDK_SPxK_1	646	652	PF00069	0.558
MOD_CDK_SPxK_1	888	894	PF00069	0.606
MOD_CDK_SPxxK_3	110	117	PF00069	0.454
MOD_CDK_SPxxK_3	888	895	PF00069	0.547
MOD_CDK_SPxxK_3	899	906	PF00069	0.514
MOD_CK1_1	130	136	PF00069	0.651
MOD_CK1_1	165	171	PF00069	0.670
MOD_CK1_1	231	237	PF00069	0.627
MOD_CK1_1	254	260	PF00069	0.683
MOD_CK1_1	277	283	PF00069	0.707
MOD_CK1_1	31	37	PF00069	0.643
MOD_CK1_1	545	551	PF00069	0.696
MOD_CK1_1	566	572	PF00069	0.727
MOD_CK1_1	660	666	PF00069	0.614
MOD_CK1_1	683	689	PF00069	0.807
MOD_CK1_1	734	740	PF00069	0.729
MOD_CK1_1	753	759	PF00069	0.679
MOD_CK1_1	790	796	PF00069	0.709
MOD_CK1_1	904	910	PF00069	0.565
MOD_CK2_1	353	359	PF00069	0.469
MOD_CK2_1	463	469	PF00069	0.400
MOD_Cter_Amidation	618	621	PF01082	0.642
MOD_GlcNHglycan	233	236	PF01048	0.628
MOD_GlcNHglycan	259	262	PF01048	0.680
MOD_GlcNHglycan	310	313	PF01048	0.491
MOD_GlcNHglycan	385	388	PF01048	0.645
MOD_GlcNHglycan	400	403	PF01048	0.632
MOD_GlcNHglycan	405	408	PF01048	0.705
MOD_GlcNHglycan	419	422	PF01048	0.576
MOD_GlcNHglycan	528	531	PF01048	0.809
MOD_GlcNHglycan	542	545	PF01048	0.573
MOD_GlcNHglycan	567	571	PF01048	0.675
MOD_GlcNHglycan	598	601	PF01048	0.648
MOD_GlcNHglycan	617	620	PF01048	0.576
MOD_GlcNHglycan	635	638	PF01048	0.555
MOD_GlcNHglycan	652	655	PF01048	0.650
MOD_GlcNHglycan	694	697	PF01048	0.708
MOD_GlcNHglycan	703	706	PF01048	0.614
MOD_GlcNHglycan	766	769	PF01048	0.585
MOD_GlcNHglycan	789	792	PF01048	0.632
MOD_GlcNHglycan	810	813	PF01048	0.678
MOD_GlcNHglycan	82	85	PF01048	0.638
MOD_GlcNHglycan	839	842	PF01048	0.618
MOD_GlcNHglycan	844	847	PF01048	0.581
MOD_GSK3_1	162	169	PF00069	0.653
MOD_GSK3_1	24	31	PF00069	0.658
MOD_GSK3_1	253	260	PF00069	0.601
MOD_GSK3_1	264	271	PF00069	0.573
MOD_GSK3_1	279	286	PF00069	0.653
MOD_GSK3_1	329	336	PF00069	0.748
MOD_GSK3_1	349	356	PF00069	0.547
MOD_GSK3_1	394	401	PF00069	0.649
MOD_GSK3_1	405	412	PF00069	0.642
MOD_GSK3_1	417	424	PF00069	0.639
MOD_GSK3_1	49	56	PF00069	0.442
MOD_GSK3_1	511	518	PF00069	0.561
MOD_GSK3_1	574	581	PF00069	0.697
MOD_GSK3_1	604	611	PF00069	0.540
MOD_GSK3_1	646	653	PF00069	0.720
MOD_GSK3_1	68	75	PF00069	0.508
MOD_GSK3_1	681	688	PF00069	0.757
MOD_GSK3_1	732	739	PF00069	0.740
MOD_GSK3_1	744	751	PF00069	0.564
MOD_GSK3_1	833	840	PF00069	0.611
MOD_GSK3_1	904	911	PF00069	0.565
MOD_N-GLC_1	333	338	PF02516	0.715
MOD_N-GLC_1	394	399	PF02516	0.568
MOD_N-GLC_1	50	55	PF02516	0.442
MOD_N-GLC_1	690	695	PF02516	0.664
MOD_N-GLC_1	833	838	PF02516	0.530
MOD_N-GLC_1	99	104	PF02516	0.590
MOD_NEK2_1	143	148	PF00069	0.661
MOD_NEK2_1	349	354	PF00069	0.701
MOD_NEK2_1	565	570	PF00069	0.568
MOD_NEK2_1	657	662	PF00069	0.599
MOD_NEK2_1	68	73	PF00069	0.575
MOD_NEK2_1	750	755	PF00069	0.616
MOD_NEK2_1	807	812	PF00069	0.513
MOD_NEK2_1	835	840	PF00069	0.570
MOD_NEK2_1	873	878	PF00069	0.599
MOD_NEK2_2	299	304	PF00069	0.592
MOD_PIKK_1	251	257	PF00454	0.708
MOD_PIKK_1	268	274	PF00454	0.522
MOD_PIKK_1	515	521	PF00454	0.654
MOD_PIKK_1	591	597	PF00454	0.613
MOD_PK_1	108	114	PF00069	0.462
MOD_PKA_1	264	270	PF00069	0.527
MOD_PKA_1	453	459	PF00069	0.508
MOD_PKA_2	231	237	PF00069	0.607
MOD_PKA_2	264	270	PF00069	0.552
MOD_PKA_2	453	459	PF00069	0.473
MOD_PKA_2	462	468	PF00069	0.624
MOD_PKA_2	539	545	PF00069	0.640
MOD_PKA_2	615	621	PF00069	0.643
MOD_PKA_2	732	738	PF00069	0.752
MOD_PKB_1	729	737	PF00069	0.606
MOD_Plk_1	344	350	PF00069	0.512
MOD_Plk_1	566	572	PF00069	0.514
MOD_Plk_1	608	614	PF00069	0.587
MOD_Plk_1	657	663	PF00069	0.662
MOD_Plk_1	866	872	PF00069	0.545
MOD_Plk_1	873	879	PF00069	0.592
MOD_Plk_2-3	874	880	PF00069	0.601
MOD_Plk_4	143	149	PF00069	0.678
MOD_Plk_4	166	172	PF00069	0.538
MOD_Plk_4	234	240	PF00069	0.717
MOD_Plk_4	53	59	PF00069	0.417
MOD_Plk_4	750	756	PF00069	0.614
MOD_Plk_4	88	94	PF00069	0.477
MOD_ProDKin_1	110	116	PF00069	0.514
MOD_ProDKin_1	162	168	PF00069	0.639
MOD_ProDKin_1	226	232	PF00069	0.638
MOD_ProDKin_1	26	32	PF00069	0.580
MOD_ProDKin_1	329	335	PF00069	0.757
MOD_ProDKin_1	423	429	PF00069	0.669
MOD_ProDKin_1	511	517	PF00069	0.456
MOD_ProDKin_1	578	584	PF00069	0.722
MOD_ProDKin_1	646	652	PF00069	0.692
MOD_ProDKin_1	660	666	PF00069	0.626
MOD_ProDKin_1	736	742	PF00069	0.654
MOD_ProDKin_1	780	786	PF00069	0.601
MOD_ProDKin_1	790	796	PF00069	0.554
MOD_ProDKin_1	888	894	PF00069	0.606
MOD_ProDKin_1	899	905	PF00069	0.571
MOD_SUMO_rev_2	3	13	PF00179	0.465
MOD_SUMO_rev_2	359	369	PF00179	0.438
TRG_DiLeu_BaEn_4	344	350	PF01217	0.615
TRG_DiLeu_BaEn_4	472	478	PF01217	0.550
TRG_ER_diArg_1	116	119	PF00400	0.551
TRG_ER_diArg_1	346	349	PF00400	0.592
TRG_ER_diArg_1	428	431	PF00400	0.541
TRG_ER_diArg_1	452	454	PF00400	0.507
TRG_ER_diArg_1	494	497	PF00400	0.548
TRG_ER_diArg_1	620	622	PF00400	0.656
TRG_ER_diArg_1	728	731	PF00400	0.723
TRG_ER_diArg_1	894	896	PF00400	0.627
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WUT3	Leishmania donovani	81%	100%
A4H973	Leishmania braziliensis	58%	100%
A4HXJ5	Leishmania infantum	81%	100%
Q4QE73	Leishmania major	81%	100%