Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AR89_LEIMU

TriTrypDb:

LmxM.17.1170

Length:

609

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AR89

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR89

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	69	73	PF00656	0.752
CLV_NRD_NRD_1	143	145	PF00675	0.707
CLV_NRD_NRD_1	146	148	PF00675	0.610
CLV_NRD_NRD_1	243	245	PF00675	0.770
CLV_NRD_NRD_1	551	553	PF00675	0.583
CLV_NRD_NRD_1	589	591	PF00675	0.642
CLV_PCSK_FUR_1	144	148	PF00082	0.631
CLV_PCSK_KEX2_1	142	144	PF00082	0.765
CLV_PCSK_KEX2_1	146	148	PF00082	0.624
CLV_PCSK_KEX2_1	210	212	PF00082	0.710
CLV_PCSK_KEX2_1	551	553	PF00082	0.579
CLV_PCSK_KEX2_1	589	591	PF00082	0.642
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.723
CLV_PCSK_PC7_1	142	148	PF00082	0.700
CLV_PCSK_SKI1_1	250	254	PF00082	0.686
CLV_PCSK_SKI1_1	441	445	PF00082	0.721
CLV_PCSK_SKI1_1	450	454	PF00082	0.573
CLV_PCSK_SKI1_1	496	500	PF00082	0.667
CLV_PCSK_SKI1_1	589	593	PF00082	0.552
DEG_Nend_UBRbox_3	1	3	PF02207	0.697
DEG_SCF_FBW7_1	81	88	PF00400	0.535
DEG_SPOP_SBC_1	157	161	PF00917	0.660
DEG_SPOP_SBC_1	359	363	PF00917	0.565
DEG_SPOP_SBC_1	383	387	PF00917	0.696
DEG_SPOP_SBC_1	391	395	PF00917	0.725
DOC_CYCLIN_yCln2_LP_2	353	359	PF00134	0.773
DOC_CYCLIN_yCln2_LP_2	592	598	PF00134	0.539
DOC_MAPK_gen_1	244	251	PF00069	0.609
DOC_MAPK_gen_1	282	292	PF00069	0.757
DOC_MAPK_MEF2A_6	158	166	PF00069	0.464
DOC_PP2B_LxvP_1	122	125	PF13499	0.601
DOC_PP2B_LxvP_1	592	595	PF13499	0.478
DOC_USP7_MATH_1	157	161	PF00917	0.578
DOC_USP7_MATH_1	167	171	PF00917	0.539
DOC_USP7_MATH_1	214	218	PF00917	0.777
DOC_USP7_MATH_1	219	223	PF00917	0.807
DOC_USP7_MATH_1	311	315	PF00917	0.745
DOC_USP7_MATH_1	321	325	PF00917	0.704
DOC_USP7_MATH_1	326	330	PF00917	0.688
DOC_USP7_MATH_1	383	387	PF00917	0.741
DOC_USP7_MATH_1	389	393	PF00917	0.767
DOC_USP7_MATH_1	398	402	PF00917	0.575
DOC_USP7_MATH_1	42	46	PF00917	0.577
DOC_USP7_MATH_1	431	435	PF00917	0.537
DOC_USP7_MATH_1	487	491	PF00917	0.515
DOC_USP7_MATH_1	79	83	PF00917	0.812
DOC_WW_Pin1_4	280	285	PF00397	0.833
DOC_WW_Pin1_4	352	357	PF00397	0.821
DOC_WW_Pin1_4	361	366	PF00397	0.685
DOC_WW_Pin1_4	371	376	PF00397	0.500
DOC_WW_Pin1_4	38	43	PF00397	0.543
DOC_WW_Pin1_4	385	390	PF00397	0.581
DOC_WW_Pin1_4	393	398	PF00397	0.730
DOC_WW_Pin1_4	49	54	PF00397	0.552
DOC_WW_Pin1_4	81	86	PF00397	0.771
LIG_14-3-3_CanoR_1	153	162	PF00244	0.725
LIG_14-3-3_CanoR_1	23	29	PF00244	0.610
LIG_14-3-3_CanoR_1	368	377	PF00244	0.569
LIG_14-3-3_CanoR_1	441	449	PF00244	0.637
LIG_14-3-3_CanoR_1	450	458	PF00244	0.667
LIG_14-3-3_CanoR_1	468	476	PF00244	0.604
LIG_BIR_III_4	413	417	PF00653	0.702
LIG_deltaCOP1_diTrp_1	106	116	PF00928	0.696
LIG_DLG_GKlike_1	158	166	PF00625	0.464
LIG_FHA_1	132	138	PF00498	0.695
LIG_FHA_1	184	190	PF00498	0.586
LIG_FHA_1	296	302	PF00498	0.616
LIG_FHA_1	314	320	PF00498	0.752
LIG_FHA_1	365	371	PF00498	0.723
LIG_FHA_1	372	378	PF00498	0.699
LIG_FHA_1	4	10	PF00498	0.757
LIG_FHA_1	505	511	PF00498	0.649
LIG_FHA_1	52	58	PF00498	0.752
LIG_FHA_1	86	92	PF00498	0.791
LIG_FHA_2	225	231	PF00498	0.602
LIG_FHA_2	454	460	PF00498	0.729
LIG_FHA_2	5	11	PF00498	0.487
LIG_LIR_Gen_1	104	113	PF02991	0.673
LIG_LIR_Nem_3	104	110	PF02991	0.599
LIG_LIR_Nem_3	512	516	PF02991	0.703
LIG_NRBOX	544	550	PF00104	0.685
LIG_PCNA_yPIPBox_3	563	575	PF02747	0.404
LIG_PTB_Apo_2	265	272	PF02174	0.659
LIG_PTB_Phospho_1	265	271	PF10480	0.713
LIG_RPA_C_Fungi	188	200	PF08784	0.549
LIG_SH2_CRK	271	275	PF00017	0.639
LIG_SH2_NCK_1	271	275	PF00017	0.639
LIG_SH2_STAP1	506	510	PF00017	0.611
LIG_SH2_STAT5	32	35	PF00017	0.800
LIG_SH2_STAT5	506	509	PF00017	0.655
LIG_SH3_3	254	260	PF00018	0.647
LIG_SH3_3	353	359	PF00018	0.773
LIG_SH3_3	531	537	PF00018	0.759
LIG_SH3_3	588	594	PF00018	0.676
LIG_SUMO_SIM_anti_2	544	550	PF11976	0.500
LIG_TRAF2_1	149	152	PF00917	0.702
LIG_TRAF2_1	489	492	PF00917	0.634
LIG_TRAF2_1	8	11	PF00917	0.482
LIG_WW_3	335	339	PF00397	0.658
MOD_CDK_SPK_2	280	285	PF00069	0.771
MOD_CDK_SPxxK_3	361	368	PF00069	0.709
MOD_CDK_SPxxK_3	393	400	PF00069	0.556
MOD_CK1_1	156	162	PF00069	0.718
MOD_CK1_1	170	176	PF00069	0.485
MOD_CK1_1	222	228	PF00069	0.796
MOD_CK1_1	304	310	PF00069	0.812
MOD_CK1_1	313	319	PF00069	0.702
MOD_CK1_1	355	361	PF00069	0.752
MOD_CK1_1	371	377	PF00069	0.667
MOD_CK1_1	385	391	PF00069	0.659
MOD_CK1_1	392	398	PF00069	0.755
MOD_CK1_1	419	425	PF00069	0.738
MOD_CK1_1	49	55	PF00069	0.674
MOD_CK1_1	521	527	PF00069	0.592
MOD_CK2_1	224	230	PF00069	0.751
MOD_CK2_1	4	10	PF00069	0.489
MOD_CK2_1	453	459	PF00069	0.727
MOD_GlcNHglycan	155	158	PF01048	0.732
MOD_GlcNHglycan	181	184	PF01048	0.666
MOD_GlcNHglycan	205	208	PF01048	0.667
MOD_GlcNHglycan	214	217	PF01048	0.655
MOD_GlcNHglycan	221	224	PF01048	0.641
MOD_GlcNHglycan	246	249	PF01048	0.598
MOD_GlcNHglycan	313	316	PF01048	0.782
MOD_GlcNHglycan	328	331	PF01048	0.668
MOD_GlcNHglycan	370	373	PF01048	0.732
MOD_GlcNHglycan	389	392	PF01048	0.635
MOD_GlcNHglycan	44	47	PF01048	0.754
MOD_GlcNHglycan	58	62	PF01048	0.763
MOD_GlcNHglycan	601	604	PF01048	0.761
MOD_GlcNHglycan	66	69	PF01048	0.661
MOD_GSK3_1	1	8	PF00069	0.688
MOD_GSK3_1	152	159	PF00069	0.706
MOD_GSK3_1	167	174	PF00069	0.425
MOD_GSK3_1	175	182	PF00069	0.614
MOD_GSK3_1	183	190	PF00069	0.690
MOD_GSK3_1	301	308	PF00069	0.726
MOD_GSK3_1	337	344	PF00069	0.658
MOD_GSK3_1	348	355	PF00069	0.722
MOD_GSK3_1	360	367	PF00069	0.803
MOD_GSK3_1	38	45	PF00069	0.718
MOD_GSK3_1	381	388	PF00069	0.707
MOD_GSK3_1	389	396	PF00069	0.768
MOD_GSK3_1	419	426	PF00069	0.733
MOD_GSK3_1	450	457	PF00069	0.658
MOD_GSK3_1	517	524	PF00069	0.669
MOD_GSK3_1	77	84	PF00069	0.707
MOD_N-GLC_1	187	192	PF02516	0.763
MOD_N-GLC_1	599	604	PF02516	0.663
MOD_NEK2_1	1	6	PF00069	0.781
MOD_NEK2_1	162	167	PF00069	0.646
MOD_NEK2_1	24	29	PF00069	0.607
MOD_NEK2_1	301	306	PF00069	0.815
MOD_NEK2_1	348	353	PF00069	0.713
MOD_NEK2_1	404	409	PF00069	0.779
MOD_NEK2_1	476	481	PF00069	0.475
MOD_NEK2_1	57	62	PF00069	0.786
MOD_NEK2_2	518	523	PF00069	0.451
MOD_PKA_1	244	250	PF00069	0.609
MOD_PKA_2	152	158	PF00069	0.621
MOD_PKA_2	24	30	PF00069	0.488
MOD_PKA_2	337	343	PF00069	0.735
MOD_PKA_2	459	465	PF00069	0.830
MOD_PKA_2	467	473	PF00069	0.749
MOD_PKA_2	476	482	PF00069	0.737
MOD_Plk_1	301	307	PF00069	0.648
MOD_Plk_4	171	177	PF00069	0.674
MOD_Plk_4	419	425	PF00069	0.786
MOD_Plk_4	52	58	PF00069	0.685
MOD_Plk_4	570	576	PF00069	0.573
MOD_Plk_4	66	72	PF00069	0.734
MOD_ProDKin_1	280	286	PF00069	0.832
MOD_ProDKin_1	352	358	PF00069	0.820
MOD_ProDKin_1	361	367	PF00069	0.685
MOD_ProDKin_1	371	377	PF00069	0.502
MOD_ProDKin_1	38	44	PF00069	0.548
MOD_ProDKin_1	385	391	PF00069	0.582
MOD_ProDKin_1	393	399	PF00069	0.731
MOD_ProDKin_1	49	55	PF00069	0.551
MOD_ProDKin_1	81	87	PF00069	0.768
TRG_DiLeu_BaEn_1	544	549	PF01217	0.585
TRG_DiLeu_BaEn_4	140	146	PF01217	0.522
TRG_DiLeu_BaEn_4	587	593	PF01217	0.452
TRG_ENDOCYTIC_2	107	110	PF00928	0.667
TRG_ENDOCYTIC_2	271	274	PF00928	0.758
TRG_ENDOCYTIC_2	287	290	PF00928	0.680
TRG_ENDOCYTIC_2	513	516	PF00928	0.640
TRG_ER_diArg_1	142	144	PF00400	0.719
TRG_ER_diArg_1	145	147	PF00400	0.647
TRG_ER_diArg_1	551	553	PF00400	0.662
TRG_ER_diArg_1	589	591	PF00400	0.718
TRG_Pf-PMV_PEXEL_1	143	148	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEN2	Leptomonas seymouri	30%	70%
A0A3S7WUL8	Leishmania donovani	77%	100%
A4H972	Leishmania braziliensis	54%	100%
A4HXJ4	Leishmania infantum	78%	100%
Q4QE74	Leishmania major	80%	99%