LeishMANIAdb
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3-oxo-5-alpha-steroid 4-dehydrogenase-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
3-oxo-5-alpha-steroid 4-dehydrogenase-like protein
Gene product:
3-oxo-5-alpha-steroid 4-dehydrogenase-like protein
Species:
Leishmania mexicana
UniProt:
E9AR82_LEIMU
TriTrypDb:
LmxM.17.1100
Length:
539

Annotations

LeishMANIAdb annotations

Related to other eukaryotic steroid 5 alpha reductases. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

E9AR82
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR82

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 7
GO:0008152 metabolic process 1 7
GO:0044238 primary metabolic process 2 7
GO:0071704 organic substance metabolic process 2 7
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity 5 6
GO:0016229 steroid dehydrogenase activity 3 6
GO:0016491 oxidoreductase activity 2 7
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3 7
GO:0033765 steroid dehydrogenase activity, acting on the CH-CH group of donors 4 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 400 404 PF00656 0.537
CLV_MEL_PAP_1 135 141 PF00089 0.500
CLV_NRD_NRD_1 356 358 PF00675 0.383
CLV_NRD_NRD_1 373 375 PF00675 0.476
CLV_NRD_NRD_1 530 532 PF00675 0.225
CLV_PCSK_FUR_1 354 358 PF00082 0.384
CLV_PCSK_KEX2_1 356 358 PF00082 0.384
CLV_PCSK_KEX2_1 373 375 PF00082 0.472
CLV_PCSK_SKI1_1 373 377 PF00082 0.352
CLV_PCSK_SKI1_1 481 485 PF00082 0.358
CLV_PCSK_SKI1_1 531 535 PF00082 0.278
CLV_Separin_Metazoa 456 460 PF03568 0.539
DEG_APCC_DBOX_1 225 233 PF00400 0.337
DEG_APCC_DBOX_1 299 307 PF00400 0.411
DEG_Nend_Nbox_1 1 3 PF02207 0.318
DEG_SPOP_SBC_1 385 389 PF00917 0.722
DEG_SPOP_SBC_1 460 464 PF00917 0.615
DOC_ANK_TNKS_1 398 405 PF00023 0.450
DOC_CDC14_PxL_1 157 165 PF14671 0.362
DOC_CYCLIN_yCln2_LP_2 232 238 PF00134 0.390
DOC_MAPK_DCC_7 226 234 PF00069 0.296
DOC_MAPK_MEF2A_6 477 484 PF00069 0.209
DOC_PP1_RVXF_1 136 142 PF00149 0.315
DOC_PP1_RVXF_1 479 485 PF00149 0.358
DOC_PP1_RVXF_1 92 98 PF00149 0.556
DOC_PP2B_LxvP_1 133 136 PF13499 0.381
DOC_PP2B_LxvP_1 232 235 PF13499 0.323
DOC_PP4_FxxP_1 522 525 PF00568 0.460
DOC_PP4_FxxP_1 64 67 PF00568 0.651
DOC_SPAK_OSR1_1 115 119 PF12202 0.398
DOC_USP7_MATH_1 186 190 PF00917 0.575
DOC_USP7_MATH_1 278 282 PF00917 0.454
DOC_USP7_MATH_1 289 293 PF00917 0.461
DOC_USP7_MATH_1 385 389 PF00917 0.649
DOC_USP7_MATH_1 460 464 PF00917 0.605
DOC_USP7_MATH_1 90 94 PF00917 0.566
DOC_WW_Pin1_4 143 148 PF00397 0.308
DOC_WW_Pin1_4 164 169 PF00397 0.444
DOC_WW_Pin1_4 179 184 PF00397 0.477
DOC_WW_Pin1_4 281 286 PF00397 0.474
DOC_WW_Pin1_4 59 64 PF00397 0.653
LIG_14-3-3_CanoR_1 115 121 PF00244 0.398
LIG_14-3-3_CanoR_1 124 130 PF00244 0.314
LIG_14-3-3_CanoR_1 138 142 PF00244 0.334
LIG_14-3-3_CanoR_1 206 216 PF00244 0.359
LIG_14-3-3_CanoR_1 459 469 PF00244 0.597
LIG_14-3-3_CanoR_1 51 57 PF00244 0.588
LIG_14-3-3_CanoR_1 510 518 PF00244 0.402
LIG_14-3-3_CanoR_1 81 89 PF00244 0.662
LIG_14-3-3_CanoR_1 98 102 PF00244 0.423
LIG_Actin_WH2_2 8 25 PF00022 0.358
LIG_Actin_WH2_2 99 117 PF00022 0.398
LIG_APCC_ABBA_1 32 37 PF00400 0.581
LIG_BIR_III_4 381 385 PF00653 0.559
LIG_BRCT_BRCA1_1 127 131 PF00533 0.386
LIG_BRCT_BRCA1_1 289 293 PF00533 0.351
LIG_BRCT_BRCA1_1 334 338 PF00533 0.398
LIG_BRCT_BRCA1_1 98 102 PF00533 0.478
LIG_deltaCOP1_diTrp_1 59 64 PF00928 0.667
LIG_EH1_1 102 110 PF00400 0.209
LIG_FHA_1 108 114 PF00498 0.321
LIG_FHA_1 16 22 PF00498 0.398
LIG_FHA_1 246 252 PF00498 0.253
LIG_FHA_1 427 433 PF00498 0.537
LIG_FHA_2 235 241 PF00498 0.366
LIG_FHA_2 449 455 PF00498 0.601
LIG_FHA_2 519 525 PF00498 0.537
LIG_GBD_Chelix_1 449 457 PF00786 0.292
LIG_Integrin_isoDGR_2 256 258 PF01839 0.485
LIG_Integrin_RGD_1 357 359 PF01839 0.417
LIG_LIR_Apic_2 227 231 PF02991 0.306
LIG_LIR_Apic_2 403 408 PF02991 0.508
LIG_LIR_Apic_2 521 525 PF02991 0.460
LIG_LIR_Apic_2 62 67 PF02991 0.600
LIG_LIR_Gen_1 110 118 PF02991 0.440
LIG_LIR_Gen_1 148 158 PF02991 0.337
LIG_LIR_Gen_1 18 26 PF02991 0.385
LIG_LIR_Gen_1 250 259 PF02991 0.292
LIG_LIR_Gen_1 429 437 PF02991 0.509
LIG_LIR_Gen_1 464 474 PF02991 0.537
LIG_LIR_Gen_1 524 534 PF02991 0.537
LIG_LIR_Gen_1 99 109 PF02991 0.237
LIG_LIR_LC3C_4 240 245 PF02991 0.347
LIG_LIR_Nem_3 110 114 PF02991 0.440
LIG_LIR_Nem_3 148 153 PF02991 0.334
LIG_LIR_Nem_3 159 163 PF02991 0.381
LIG_LIR_Nem_3 18 22 PF02991 0.385
LIG_LIR_Nem_3 200 205 PF02991 0.342
LIG_LIR_Nem_3 250 255 PF02991 0.296
LIG_LIR_Nem_3 349 353 PF02991 0.514
LIG_LIR_Nem_3 427 431 PF02991 0.493
LIG_LIR_Nem_3 463 469 PF02991 0.637
LIG_LIR_Nem_3 498 502 PF02991 0.346
LIG_LIR_Nem_3 524 529 PF02991 0.489
LIG_LIR_Nem_3 59 64 PF02991 0.652
LIG_LIR_Nem_3 99 105 PF02991 0.237
LIG_LYPXL_yS_3 160 163 PF13949 0.385
LIG_MYND_1 171 175 PF01753 0.484
LIG_MYND_1 63 67 PF01753 0.652
LIG_NRBOX 213 219 PF00104 0.369
LIG_Pex14_1 127 131 PF04695 0.424
LIG_Pex14_1 174 178 PF04695 0.384
LIG_Pex14_1 320 324 PF04695 0.248
LIG_Pex14_2 293 297 PF04695 0.345
LIG_SH2_CRK 111 115 PF00017 0.358
LIG_SH2_CRK 405 409 PF00017 0.478
LIG_SH2_CRK 526 530 PF00017 0.537
LIG_SH2_PTP2 431 434 PF00017 0.478
LIG_SH2_SRC 431 434 PF00017 0.537
LIG_SH2_STAP1 287 291 PF00017 0.396
LIG_SH2_STAP1 518 522 PF00017 0.537
LIG_SH2_STAP1 72 76 PF00017 0.568
LIG_SH2_STAT3 72 75 PF00017 0.647
LIG_SH2_STAT5 223 226 PF00017 0.294
LIG_SH2_STAT5 24 27 PF00017 0.542
LIG_SH2_STAT5 252 255 PF00017 0.291
LIG_SH2_STAT5 287 290 PF00017 0.492
LIG_SH2_STAT5 327 330 PF00017 0.239
LIG_SH2_STAT5 33 36 PF00017 0.552
LIG_SH2_STAT5 351 354 PF00017 0.524
LIG_SH2_STAT5 431 434 PF00017 0.503
LIG_SH2_STAT5 502 505 PF00017 0.333
LIG_SH2_STAT5 526 529 PF00017 0.537
LIG_SH3_3 115 121 PF00018 0.316
LIG_SH3_3 165 171 PF00018 0.433
LIG_SH3_3 315 321 PF00018 0.202
LIG_SUMO_SIM_anti_2 8 14 PF11976 0.209
LIG_SUMO_SIM_par_1 104 110 PF11976 0.398
LIG_SUMO_SIM_par_1 240 246 PF11976 0.312
LIG_SUMO_SIM_par_1 432 439 PF11976 0.429
LIG_TRAF2_1 67 70 PF00917 0.661
LIG_TYR_ITIM 109 114 PF00017 0.250
LIG_TYR_ITIM 158 163 PF00017 0.420
LIG_TYR_ITSM 427 434 PF00017 0.398
MOD_CDC14_SPxK_1 167 170 PF00782 0.376
MOD_CDK_SPxK_1 164 170 PF00069 0.359
MOD_CK1_1 137 143 PF00069 0.394
MOD_CK1_1 169 175 PF00069 0.581
MOD_CK1_1 176 182 PF00069 0.581
MOD_CK1_1 190 196 PF00069 0.531
MOD_CK1_1 281 287 PF00069 0.533
MOD_CK1_1 305 311 PF00069 0.522
MOD_CK1_1 386 392 PF00069 0.587
MOD_CK1_1 393 399 PF00069 0.519
MOD_CK1_1 439 445 PF00069 0.501
MOD_CK1_1 448 454 PF00069 0.375
MOD_CK1_1 462 468 PF00069 0.480
MOD_CK1_1 49 55 PF00069 0.534
MOD_CK2_1 482 488 PF00069 0.453
MOD_CK2_1 81 87 PF00069 0.347
MOD_Cter_Amidation 371 374 PF01082 0.658
MOD_Cter_Amidation 529 532 PF01082 0.250
MOD_GlcNHglycan 178 181 PF01048 0.625
MOD_GlcNHglycan 193 196 PF01048 0.397
MOD_GlcNHglycan 263 266 PF01048 0.377
MOD_GlcNHglycan 27 30 PF01048 0.478
MOD_GlcNHglycan 280 283 PF01048 0.528
MOD_GlcNHglycan 309 312 PF01048 0.555
MOD_GlcNHglycan 334 337 PF01048 0.398
MOD_GlcNHglycan 389 392 PF01048 0.578
MOD_GlcNHglycan 40 43 PF01048 0.530
MOD_GlcNHglycan 438 441 PF01048 0.467
MOD_GlcNHglycan 484 487 PF01048 0.472
MOD_GlcNHglycan 83 86 PF01048 0.535
MOD_GSK3_1 169 176 PF00069 0.632
MOD_GSK3_1 186 193 PF00069 0.538
MOD_GSK3_1 230 237 PF00069 0.394
MOD_GSK3_1 243 250 PF00069 0.341
MOD_GSK3_1 267 274 PF00069 0.460
MOD_GSK3_1 277 284 PF00069 0.716
MOD_GSK3_1 285 292 PF00069 0.458
MOD_GSK3_1 302 309 PF00069 0.488
MOD_GSK3_1 383 390 PF00069 0.579
MOD_GSK3_1 393 400 PF00069 0.513
MOD_GSK3_1 435 442 PF00069 0.420
MOD_GSK3_1 46 53 PF00069 0.502
MOD_GSK3_1 461 468 PF00069 0.557
MOD_GSK3_1 482 489 PF00069 0.629
MOD_N-GLC_1 442 447 PF02516 0.447
MOD_NEK2_1 116 121 PF00069 0.319
MOD_NEK2_1 131 136 PF00069 0.522
MOD_NEK2_1 15 20 PF00069 0.432
MOD_NEK2_1 178 183 PF00069 0.495
MOD_NEK2_1 188 193 PF00069 0.521
MOD_NEK2_1 243 248 PF00069 0.370
MOD_NEK2_1 306 311 PF00069 0.615
MOD_NEK2_1 332 337 PF00069 0.413
MOD_NEK2_1 461 466 PF00069 0.425
MOD_NEK2_2 247 252 PF00069 0.362
MOD_NEK2_2 97 102 PF00069 0.209
MOD_PIKK_1 207 213 PF00454 0.390
MOD_PIKK_1 393 399 PF00454 0.464
MOD_PIKK_1 65 71 PF00454 0.525
MOD_PKA_1 373 379 PF00069 0.414
MOD_PKA_2 123 129 PF00069 0.476
MOD_PKA_2 137 143 PF00069 0.390
MOD_PKA_2 169 175 PF00069 0.502
MOD_PKA_2 373 379 PF00069 0.466
MOD_PKA_2 5 11 PF00069 0.228
MOD_PKA_2 50 56 PF00069 0.453
MOD_PKA_2 80 86 PF00069 0.572
MOD_PKA_2 97 103 PF00069 0.254
MOD_Plk_4 137 143 PF00069 0.362
MOD_Plk_4 145 151 PF00069 0.339
MOD_Plk_4 15 21 PF00069 0.398
MOD_Plk_4 169 175 PF00069 0.573
MOD_Plk_4 197 203 PF00069 0.455
MOD_Plk_4 247 253 PF00069 0.348
MOD_Plk_4 289 295 PF00069 0.340
MOD_Plk_4 462 468 PF00069 0.524
MOD_Plk_4 97 103 PF00069 0.258
MOD_ProDKin_1 143 149 PF00069 0.359
MOD_ProDKin_1 164 170 PF00069 0.555
MOD_ProDKin_1 179 185 PF00069 0.597
MOD_ProDKin_1 281 287 PF00069 0.587
MOD_ProDKin_1 59 65 PF00069 0.564
TRG_DiLeu_BaEn_1 159 164 PF01217 0.422
TRG_DiLeu_BaLyEn_6 318 323 PF01217 0.290
TRG_ENDOCYTIC_2 111 114 PF00928 0.398
TRG_ENDOCYTIC_2 154 157 PF00928 0.439
TRG_ENDOCYTIC_2 160 163 PF00928 0.250
TRG_ENDOCYTIC_2 252 255 PF00928 0.334
TRG_ENDOCYTIC_2 350 353 PF00928 0.372
TRG_ENDOCYTIC_2 431 434 PF00928 0.316
TRG_ENDOCYTIC_2 526 529 PF00928 0.316
TRG_ER_diArg_1 353 356 PF00400 0.441
TRG_ER_diArg_1 373 375 PF00400 0.550
TRG_ER_diArg_1 399 402 PF00400 0.209
TRG_Pf-PMV_PEXEL_1 23 27 PF00026 0.423

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P837 Leptomonas seymouri 46% 100%
A0A3S7WUK3 Leishmania donovani 86% 100%
A4H965 Leishmania braziliensis 72% 100%
A4HXI7 Leishmania infantum 87% 100%
Q4QE81 Leishmania major 85% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS