Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AR80_LEIMU

TriTrypDb:

LmxM.17.1080

Length:

732

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AR80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR80

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.618
CLV_C14_Caspase3-7	190	194	PF00656	0.772
CLV_C14_Caspase3-7	227	231	PF00656	0.421
CLV_C14_Caspase3-7	390	394	PF00656	0.603
CLV_C14_Caspase3-7	472	476	PF00656	0.674
CLV_C14_Caspase3-7	493	497	PF00656	0.541
CLV_C14_Caspase3-7	567	571	PF00656	0.469
CLV_C14_Caspase3-7	639	643	PF00656	0.539
CLV_C14_Caspase3-7	668	672	PF00656	0.476
CLV_NRD_NRD_1	268	270	PF00675	0.512
CLV_PCSK_KEX2_1	116	118	PF00082	0.534
CLV_PCSK_KEX2_1	268	270	PF00082	0.457
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.534
CLV_PCSK_SKI1_1	214	218	PF00082	0.494
CLV_PCSK_SKI1_1	402	406	PF00082	0.664
CLV_PCSK_SKI1_1	460	464	PF00082	0.697
CLV_PCSK_SKI1_1	48	52	PF00082	0.539
CLV_PCSK_SKI1_1	503	507	PF00082	0.561
CLV_PCSK_SKI1_1	592	596	PF00082	0.502
CLV_PCSK_SKI1_1	653	657	PF00082	0.621
DEG_APCC_DBOX_1	502	510	PF00400	0.506
DEG_Nend_Nbox_1	1	3	PF02207	0.545
DEG_SCF_FBW7_2	131	138	PF00400	0.653
DEG_SPOP_SBC_1	109	113	PF00917	0.697
DEG_SPOP_SBC_1	250	254	PF00917	0.603
DEG_SPOP_SBC_1	407	411	PF00917	0.544
DEG_SPOP_SBC_1	466	470	PF00917	0.579
DOC_CKS1_1	132	137	PF01111	0.791
DOC_CYCLIN_RxL_1	276	287	PF00134	0.538
DOC_CYCLIN_RxL_1	500	510	PF00134	0.512
DOC_CYCLIN_RxL_1	589	600	PF00134	0.443
DOC_CYCLIN_yCln2_LP_2	618	624	PF00134	0.552
DOC_MAPK_gen_1	500	508	PF00069	0.518
DOC_MAPK_gen_1	98	107	PF00069	0.625
DOC_MAPK_MEF2A_6	347	355	PF00069	0.727
DOC_PP2B_LxvP_1	106	109	PF13499	0.610
DOC_PP2B_LxvP_1	340	343	PF13499	0.629
DOC_USP7_MATH_1	110	114	PF00917	0.709
DOC_USP7_MATH_1	182	186	PF00917	0.539
DOC_USP7_MATH_1	251	255	PF00917	0.674
DOC_USP7_MATH_1	288	292	PF00917	0.571
DOC_USP7_MATH_1	357	361	PF00917	0.751
DOC_USP7_MATH_1	367	371	PF00917	0.642
DOC_USP7_MATH_1	407	411	PF00917	0.544
DOC_USP7_MATH_1	419	423	PF00917	0.608
DOC_USP7_MATH_1	431	435	PF00917	0.626
DOC_USP7_MATH_1	481	485	PF00917	0.463
DOC_USP7_MATH_1	612	616	PF00917	0.471
DOC_USP7_MATH_1	715	719	PF00917	0.668
DOC_WW_Pin1_4	131	136	PF00397	0.764
DOC_WW_Pin1_4	462	467	PF00397	0.576
DOC_WW_Pin1_4	539	544	PF00397	0.638
DOC_WW_Pin1_4	586	591	PF00397	0.639
DOC_WW_Pin1_4	625	630	PF00397	0.423
DOC_WW_Pin1_4	687	692	PF00397	0.779
DOC_WW_Pin1_4	718	723	PF00397	0.659
LIG_14-3-3_CanoR_1	148	157	PF00244	0.471
LIG_14-3-3_CanoR_1	268	276	PF00244	0.534
LIG_14-3-3_CanoR_1	294	299	PF00244	0.394
LIG_14-3-3_CanoR_1	321	328	PF00244	0.612
LIG_14-3-3_CanoR_1	330	340	PF00244	0.554
LIG_14-3-3_CanoR_1	507	516	PF00244	0.519
LIG_14-3-3_CanoR_1	632	641	PF00244	0.597
LIG_14-3-3_CanoR_1	73	79	PF00244	0.470
LIG_14-3-3_CanoR_1	98	107	PF00244	0.625
LIG_Actin_WH2_2	428	445	PF00022	0.557
LIG_BIR_III_4	496	500	PF00653	0.568
LIG_BRCT_BRCA1_1	671	675	PF00533	0.579
LIG_Clathr_ClatBox_1	489	493	PF01394	0.540
LIG_deltaCOP1_diTrp_1	642	648	PF00928	0.548
LIG_eIF4E_1	220	226	PF01652	0.332
LIG_EVH1_1	688	692	PF00568	0.602
LIG_FHA_1	17	23	PF00498	0.410
LIG_FHA_1	204	210	PF00498	0.593
LIG_FHA_1	240	246	PF00498	0.705
LIG_FHA_1	251	257	PF00498	0.589
LIG_FHA_1	336	342	PF00498	0.701
LIG_FHA_1	4	10	PF00498	0.553
LIG_FHA_1	451	457	PF00498	0.668
LIG_FHA_1	469	475	PF00498	0.581
LIG_FHA_1	496	502	PF00498	0.525
LIG_FHA_1	543	549	PF00498	0.497
LIG_FHA_1	696	702	PF00498	0.578
LIG_FHA_1	74	80	PF00498	0.403
LIG_FHA_2	225	231	PF00498	0.405
LIG_FHA_2	467	473	PF00498	0.643
LIG_FHA_2	510	516	PF00498	0.462
LIG_FHA_2	666	672	PF00498	0.484
LIG_FHA_2	73	79	PF00498	0.538
LIG_FXI_DFP_1	62	66	PF00024	0.504
LIG_LIR_Gen_1	127	135	PF02991	0.701
LIG_LIR_Gen_1	334	345	PF02991	0.547
LIG_LIR_Gen_1	646	656	PF02991	0.544
LIG_LIR_Nem_3	127	132	PF02991	0.704
LIG_LIR_Nem_3	334	340	PF02991	0.574
LIG_LIR_Nem_3	544	549	PF02991	0.488
LIG_LIR_Nem_3	646	651	PF02991	0.543
LIG_NRBOX	279	285	PF00104	0.536
LIG_PDZ_Class_2	727	732	PF00595	0.621
LIG_SH2_CRK	129	133	PF00017	0.701
LIG_SH2_CRK	222	226	PF00017	0.474
LIG_SH2_GRB2like	238	241	PF00017	0.497
LIG_SH2_NCK_1	142	146	PF00017	0.625
LIG_SH2_NCK_1	37	41	PF00017	0.544
LIG_SH2_STAP1	222	226	PF00017	0.320
LIG_SH2_STAT5	222	225	PF00017	0.514
LIG_SH2_STAT5	518	521	PF00017	0.479
LIG_SH3_3	197	203	PF00018	0.768
LIG_SH3_3	366	372	PF00018	0.579
LIG_SH3_3	532	538	PF00018	0.586
LIG_SH3_3	686	692	PF00018	0.701
LIG_SUMO_SIM_anti_2	102	108	PF11976	0.624
LIG_SUMO_SIM_anti_2	484	490	PF11976	0.549
LIG_SUMO_SIM_par_1	143	149	PF11976	0.634
LIG_TRAF2_1	359	362	PF00917	0.816
LIG_WW_3	119	123	PF00397	0.661
MOD_CDC14_SPxK_1	589	592	PF00782	0.462
MOD_CDK_SPxK_1	586	592	PF00069	0.482
MOD_CDK_SPxxK_3	625	632	PF00069	0.433
MOD_CK1_1	112	118	PF00069	0.718
MOD_CK1_1	149	155	PF00069	0.615
MOD_CK1_1	201	207	PF00069	0.624
MOD_CK1_1	316	322	PF00069	0.631
MOD_CK1_1	370	376	PF00069	0.716
MOD_CK1_1	382	388	PF00069	0.589
MOD_CK1_1	408	414	PF00069	0.669
MOD_CK1_1	454	460	PF00069	0.621
MOD_CK1_1	465	471	PF00069	0.686
MOD_CK1_1	542	548	PF00069	0.557
MOD_CK1_1	636	642	PF00069	0.555
MOD_CK1_1	678	684	PF00069	0.597
MOD_CK1_1	718	724	PF00069	0.653
MOD_CK1_1	88	94	PF00069	0.628
MOD_CK2_1	166	172	PF00069	0.803
MOD_CK2_1	321	327	PF00069	0.562
MOD_CK2_1	430	436	PF00069	0.442
MOD_CK2_1	466	472	PF00069	0.628
MOD_CMANNOS	645	648	PF00535	0.538
MOD_GlcNHglycan	101	104	PF01048	0.625
MOD_GlcNHglycan	117	120	PF01048	0.544
MOD_GlcNHglycan	151	154	PF01048	0.612
MOD_GlcNHglycan	290	293	PF01048	0.602
MOD_GlcNHglycan	3	6	PF01048	0.546
MOD_GlcNHglycan	315	318	PF01048	0.681
MOD_GlcNHglycan	323	326	PF01048	0.711
MOD_GlcNHglycan	381	384	PF01048	0.682
MOD_GlcNHglycan	410	413	PF01048	0.721
MOD_GlcNHglycan	527	530	PF01048	0.635
MOD_GlcNHglycan	677	680	PF01048	0.616
MOD_GSK3_1	108	115	PF00069	0.695
MOD_GSK3_1	127	134	PF00069	0.493
MOD_GSK3_1	162	169	PF00069	0.576
MOD_GSK3_1	203	210	PF00069	0.557
MOD_GSK3_1	220	227	PF00069	0.547
MOD_GSK3_1	246	253	PF00069	0.702
MOD_GSK3_1	331	338	PF00069	0.595
MOD_GSK3_1	363	370	PF00069	0.715
MOD_GSK3_1	374	381	PF00069	0.618
MOD_GSK3_1	406	413	PF00069	0.554
MOD_GSK3_1	419	426	PF00069	0.827
MOD_GSK3_1	446	453	PF00069	0.647
MOD_GSK3_1	462	469	PF00069	0.560
MOD_GSK3_1	477	484	PF00069	0.512
MOD_GSK3_1	491	498	PF00069	0.407
MOD_GSK3_1	582	589	PF00069	0.713
MOD_GSK3_1	665	672	PF00069	0.421
MOD_GSK3_1	73	80	PF00069	0.571
MOD_GSK3_1	81	88	PF00069	0.520
MOD_N-GLC_1	239	244	PF02516	0.653
MOD_N-GLC_1	454	459	PF02516	0.520
MOD_N-GLC_1	73	78	PF02516	0.455
MOD_N-GLC_2	244	246	PF02516	0.600
MOD_N-GLC_2	275	277	PF02516	0.398
MOD_NEK2_1	1	6	PF00069	0.563
MOD_NEK2_1	224	229	PF00069	0.582
MOD_NEK2_1	296	301	PF00069	0.544
MOD_NEK2_1	378	383	PF00069	0.696
MOD_NEK2_1	501	506	PF00069	0.643
MOD_NEK2_1	525	530	PF00069	0.665
MOD_NEK2_1	548	553	PF00069	0.525
MOD_NEK2_1	665	670	PF00069	0.644
MOD_NEK2_1	675	680	PF00069	0.531
MOD_NEK2_1	72	77	PF00069	0.538
MOD_NEK2_1	79	84	PF00069	0.481
MOD_PIKK_1	491	497	PF00454	0.496
MOD_PIKK_1	573	579	PF00454	0.620
MOD_PIKK_1	636	642	PF00454	0.555
MOD_PIKK_1	79	85	PF00454	0.462
MOD_PK_1	294	300	PF00069	0.510
MOD_PKA_2	201	207	PF00069	0.489
MOD_PKA_2	267	273	PF00069	0.566
MOD_PKA_2	378	384	PF00069	0.660
MOD_PKA_2	72	78	PF00069	0.471
MOD_Plk_1	363	369	PF00069	0.715
MOD_Plk_1	481	487	PF00069	0.419
MOD_Plk_2-3	166	172	PF00069	0.629
MOD_Plk_4	127	133	PF00069	0.704
MOD_Plk_4	204	210	PF00069	0.593
MOD_Plk_4	220	226	PF00069	0.349
MOD_Plk_4	387	393	PF00069	0.771
MOD_Plk_4	481	487	PF00069	0.573
MOD_ProDKin_1	131	137	PF00069	0.762
MOD_ProDKin_1	462	468	PF00069	0.579
MOD_ProDKin_1	539	545	PF00069	0.624
MOD_ProDKin_1	586	592	PF00069	0.636
MOD_ProDKin_1	625	631	PF00069	0.425
MOD_ProDKin_1	687	693	PF00069	0.769
MOD_ProDKin_1	718	724	PF00069	0.653
MOD_SUMO_rev_2	64	72	PF00179	0.360
TRG_DiLeu_BaLyEn_6	276	281	PF01217	0.535
TRG_DiLeu_BaLyEn_6	521	526	PF01217	0.654
TRG_ENDOCYTIC_2	129	132	PF00928	0.701
TRG_ENDOCYTIC_2	142	145	PF00928	0.480
TRG_ENDOCYTIC_2	222	225	PF00928	0.612
TRG_ENDOCYTIC_2	238	241	PF00928	0.533
TRG_ER_diArg_1	728	731	PF00400	0.503
TRG_Pf-PMV_PEXEL_1	592	597	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H715	Leishmania donovani	82%	99%
A4H963	Leishmania braziliensis	65%	100%
A4HXI5	Leishmania infantum	82%	99%
Q4QE83	Leishmania major	81%	100%