Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AR79_LEIMU

TriTrypDb:

LmxM.17.1070

Length:

459

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AR79

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR79

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	135	137	PF00675	0.447
CLV_NRD_NRD_1	225	227	PF00675	0.447
CLV_NRD_NRD_1	271	273	PF00675	0.476
CLV_NRD_NRD_1	279	281	PF00675	0.438
CLV_NRD_NRD_1	57	59	PF00675	0.569
CLV_PCSK_KEX2_1	135	137	PF00082	0.447
CLV_PCSK_KEX2_1	225	227	PF00082	0.447
CLV_PCSK_KEX2_1	271	273	PF00082	0.476
CLV_PCSK_KEX2_1	279	281	PF00082	0.438
CLV_PCSK_KEX2_1	57	59	PF00082	0.569
CLV_PCSK_PC7_1	275	281	PF00082	0.403
CLV_PCSK_SKI1_1	128	132	PF00082	0.438
CLV_PCSK_SKI1_1	138	142	PF00082	0.455
CLV_PCSK_SKI1_1	275	279	PF00082	0.401
CLV_PCSK_SKI1_1	303	307	PF00082	0.421
CLV_PCSK_SKI1_1	351	355	PF00082	0.589
CLV_PCSK_SKI1_1	408	412	PF00082	0.332
CLV_Separin_Metazoa	276	280	PF03568	0.601
DEG_APCC_DBOX_1	274	282	PF00400	0.604
DEG_Nend_UBRbox_1	1	4	PF02207	0.620
DEG_SCF_FBW7_1	445	452	PF00400	0.495
DEG_SPOP_SBC_1	114	118	PF00917	0.665
DOC_CDC14_PxL_1	428	436	PF14671	0.311
DOC_CYCLIN_RxL_1	135	143	PF00134	0.731
DOC_MAPK_gen_1	135	141	PF00069	0.729
DOC_MAPK_gen_1	148	156	PF00069	0.625
DOC_PP2B_LxvP_1	175	178	PF13499	0.642
DOC_PP2B_LxvP_1	217	220	PF13499	0.600
DOC_PP2B_LxvP_1	305	308	PF13499	0.592
DOC_PP2B_LxvP_1	386	389	PF13499	0.440
DOC_PP4_FxxP_1	161	164	PF00568	0.555
DOC_USP7_MATH_1	114	118	PF00917	0.689
DOC_USP7_MATH_1	205	209	PF00917	0.698
DOC_USP7_MATH_1	25	29	PF00917	0.673
DOC_USP7_MATH_1	264	268	PF00917	0.705
DOC_USP7_MATH_1	33	37	PF00917	0.698
DOC_USP7_MATH_1	336	340	PF00917	0.331
DOC_USP7_MATH_1	419	423	PF00917	0.470
DOC_USP7_MATH_1	72	76	PF00917	0.697
DOC_WW_Pin1_4	11	16	PF00397	0.684
DOC_WW_Pin1_4	238	243	PF00397	0.659
DOC_WW_Pin1_4	445	450	PF00397	0.489
DOC_WW_Pin1_4	58	63	PF00397	0.666
LIG_14-3-3_CanoR_1	128	137	PF00244	0.641
LIG_14-3-3_CanoR_1	280	290	PF00244	0.599
LIG_14-3-3_CanoR_1	37	44	PF00244	0.670
LIG_14-3-3_CanoR_1	6	12	PF00244	0.765
LIG_BRCT_BRCA1_1	207	211	PF00533	0.690
LIG_CSL_BTD_1	175	178	PF09270	0.629
LIG_deltaCOP1_diTrp_1	94	103	PF00928	0.615
LIG_eIF4E_1	300	306	PF01652	0.577
LIG_FHA_1	155	161	PF00498	0.665
LIG_FHA_1	172	178	PF00498	0.551
LIG_FHA_1	214	220	PF00498	0.719
LIG_FHA_1	37	43	PF00498	0.650
LIG_FHA_1	370	376	PF00498	0.447
LIG_FHA_1	450	456	PF00498	0.519
LIG_FHA_2	129	135	PF00498	0.636
LIG_FHA_2	419	425	PF00498	0.331
LIG_LIR_Apic_2	183	188	PF02991	0.655
LIG_LIR_Gen_1	47	55	PF02991	0.750
LIG_LIR_Gen_1	94	103	PF02991	0.617
LIG_LIR_Nem_3	104	110	PF02991	0.745
LIG_LIR_Nem_3	94	100	PF02991	0.682
LIG_PCNA_yPIPBox_3	2	11	PF02747	0.625
LIG_PDZ_Class_2	454	459	PF00595	0.534
LIG_Pex14_1	197	201	PF04695	0.709
LIG_Pex14_1	405	409	PF04695	0.603
LIG_Pex14_2	103	107	PF04695	0.569
LIG_PTAP_UEV_1	247	252	PF05743	0.708
LIG_PTB_Apo_2	155	162	PF02174	0.575
LIG_PTB_Apo_2	42	49	PF02174	0.726
LIG_SH2_CRK	12	16	PF00017	0.696
LIG_SH2_CRK	185	189	PF00017	0.627
LIG_SH2_CRK	254	258	PF00017	0.658
LIG_SH2_CRK	395	399	PF00017	0.331
LIG_SH2_STAP1	269	273	PF00017	0.599
LIG_SH3_3	193	199	PF00018	0.632
LIG_SH3_3	245	251	PF00018	0.742
LIG_SH3_3	56	62	PF00018	0.755
LIG_SUMO_SIM_anti_2	421	427	PF11976	0.328
LIG_SUMO_SIM_par_1	151	157	PF11976	0.591
LIG_SUMO_SIM_par_1	379	385	PF11976	0.327
LIG_TRAF2_1	131	134	PF00917	0.637
MOD_CDC14_SPxK_1	14	17	PF00782	0.545
MOD_CDK_SPxK_1	11	17	PF00069	0.547
MOD_CK1_1	241	247	PF00069	0.529
MOD_CK1_1	309	315	PF00069	0.557
MOD_CK1_1	36	42	PF00069	0.593
MOD_CK1_1	63	69	PF00069	0.675
MOD_CK2_1	114	120	PF00069	0.512
MOD_CK2_1	128	134	PF00069	0.540
MOD_CK2_1	298	304	PF00069	0.667
MOD_CK2_1	367	373	PF00069	0.628
MOD_DYRK1A_RPxSP_1	58	62	PF00069	0.541
MOD_GlcNHglycan	203	206	PF01048	0.705
MOD_GlcNHglycan	227	231	PF01048	0.713
MOD_GlcNHglycan	266	269	PF01048	0.579
MOD_GlcNHglycan	399	402	PF01048	0.440
MOD_GlcNHglycan	47	51	PF01048	0.646
MOD_GlcNHglycan	74	77	PF01048	0.619
MOD_GSK3_1	183	190	PF00069	0.502
MOD_GSK3_1	201	208	PF00069	0.592
MOD_GSK3_1	238	245	PF00069	0.546
MOD_GSK3_1	353	360	PF00069	0.608
MOD_GSK3_1	365	372	PF00069	0.437
MOD_GSK3_1	445	452	PF00069	0.620
MOD_N-GLC_1	321	326	PF02516	0.548
MOD_N-GLC_1	445	450	PF02516	0.612
MOD_NEK2_1	140	145	PF00069	0.681
MOD_NEK2_1	154	159	PF00069	0.523
MOD_NEK2_1	201	206	PF00069	0.624
MOD_NEK2_1	263	268	PF00069	0.705
MOD_NEK2_1	281	286	PF00069	0.479
MOD_NEK2_1	418	423	PF00069	0.331
MOD_NEK2_2	180	185	PF00069	0.397
MOD_NEK2_2	353	358	PF00069	0.516
MOD_PIKK_1	336	342	PF00454	0.331
MOD_PIKK_1	5	11	PF00454	0.659
MOD_PKA_2	180	186	PF00069	0.626
MOD_PKA_2	281	287	PF00069	0.515
MOD_PKA_2	36	42	PF00069	0.587
MOD_PKA_2	5	11	PF00069	0.616
MOD_PKA_2	83	89	PF00069	0.649
MOD_PKB_1	280	288	PF00069	0.490
MOD_Plk_1	321	327	PF00069	0.521
MOD_Plk_1	449	455	PF00069	0.644
MOD_Plk_1	46	52	PF00069	0.654
MOD_Plk_4	102	108	PF00069	0.505
MOD_Plk_4	171	177	PF00069	0.547
MOD_Plk_4	180	186	PF00069	0.501
MOD_Plk_4	188	194	PF00069	0.652
MOD_Plk_4	213	219	PF00069	0.593
MOD_Plk_4	353	359	PF00069	0.519
MOD_ProDKin_1	11	17	PF00069	0.605
MOD_ProDKin_1	238	244	PF00069	0.567
MOD_ProDKin_1	445	451	PF00069	0.616
MOD_ProDKin_1	58	64	PF00069	0.581
TRG_DiLeu_BaLyEn_6	150	155	PF01217	0.531
TRG_ENDOCYTIC_2	328	331	PF00928	0.331
TRG_ENDOCYTIC_2	395	398	PF00928	0.331
TRG_ENDOCYTIC_2	415	418	PF00928	0.183
TRG_ER_diArg_1	135	138	PF00400	0.556
TRG_ER_diArg_1	144	147	PF00400	0.581
TRG_ER_diArg_1	224	226	PF00400	0.551
TRG_ER_diArg_1	278	280	PF00400	0.492
TRG_ER_diArg_1	411	414	PF00400	0.405
TRG_ER_diArg_1	57	59	PF00400	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D5	Leptomonas seymouri	49%	74%
A0A3Q8IAR6	Leishmania donovani	82%	87%
A4H962	Leishmania braziliensis	63%	100%
A4HXI4	Leishmania infantum	82%	87%
Q4QE84	Leishmania major	77%	100%