Hydrolase-like protein (Esterase-like protein)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hydrolase-like protein

Species:

Leishmania mexicana

UniProt:

E9AR78_LEIMU

TriTrypDb:

LmxM.17.1060

Length:

720

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AR78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR78

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016787	hydrolase activity	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	327	331	PF00656	0.683
CLV_C14_Caspase3-7	466	470	PF00656	0.592
CLV_C14_Caspase3-7	612	616	PF00656	0.510
CLV_NRD_NRD_1	173	175	PF00675	0.262
CLV_NRD_NRD_1	193	195	PF00675	0.194
CLV_NRD_NRD_1	209	211	PF00675	0.429
CLV_NRD_NRD_1	232	234	PF00675	0.269
CLV_NRD_NRD_1	309	311	PF00675	0.462
CLV_NRD_NRD_1	450	452	PF00675	0.594
CLV_NRD_NRD_1	471	473	PF00675	0.652
CLV_NRD_NRD_1	696	698	PF00675	0.604
CLV_PCSK_KEX2_1	173	175	PF00082	0.279
CLV_PCSK_KEX2_1	193	195	PF00082	0.206
CLV_PCSK_KEX2_1	208	210	PF00082	0.420
CLV_PCSK_KEX2_1	232	234	PF00082	0.400
CLV_PCSK_KEX2_1	309	311	PF00082	0.531
CLV_PCSK_KEX2_1	437	439	PF00082	0.672
CLV_PCSK_KEX2_1	450	452	PF00082	0.619
CLV_PCSK_KEX2_1	696	698	PF00082	0.604
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.315
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.672
CLV_PCSK_SKI1_1	193	197	PF00082	0.312
CLV_PCSK_SKI1_1	209	213	PF00082	0.312
CLV_PCSK_SKI1_1	237	241	PF00082	0.314
CLV_PCSK_SKI1_1	266	270	PF00082	0.319
CLV_PCSK_SKI1_1	451	455	PF00082	0.611
DEG_APCC_DBOX_1	208	216	PF00400	0.340
DEG_SPOP_SBC_1	151	155	PF00917	0.312
DEG_SPOP_SBC_1	548	552	PF00917	0.616
DEG_SPOP_SBC_1	558	562	PF00917	0.516
DOC_CKS1_1	430	435	PF01111	0.640
DOC_CYCLIN_RxL_1	272	281	PF00134	0.312
DOC_CYCLIN_yCln2_LP_2	244	250	PF00134	0.312
DOC_CYCLIN_yCln2_LP_2	486	492	PF00134	0.481
DOC_MAPK_gen_1	208	215	PF00069	0.312
DOC_MAPK_gen_1	624	632	PF00069	0.505
DOC_MAPK_gen_1	79	87	PF00069	0.321
DOC_MAPK_MEF2A_6	79	87	PF00069	0.388
DOC_PP2B_LxvP_1	117	120	PF13499	0.312
DOC_PP2B_LxvP_1	139	142	PF13499	0.312
DOC_PP2B_LxvP_1	244	247	PF13499	0.326
DOC_PP2B_LxvP_1	486	489	PF13499	0.482
DOC_PP2B_LxvP_1	85	88	PF13499	0.312
DOC_PP4_FxxP_1	22	25	PF00568	0.379
DOC_SPAK_OSR1_1	210	214	PF12202	0.207
DOC_USP7_MATH_1	315	319	PF00917	0.625
DOC_USP7_MATH_1	325	329	PF00917	0.623
DOC_USP7_MATH_1	346	350	PF00917	0.553
DOC_USP7_MATH_1	426	430	PF00917	0.616
DOC_USP7_MATH_1	476	480	PF00917	0.501
DOC_USP7_MATH_1	514	518	PF00917	0.531
DOC_USP7_MATH_1	548	552	PF00917	0.652
DOC_USP7_MATH_1	558	562	PF00917	0.579
DOC_USP7_MATH_1	613	617	PF00917	0.661
DOC_USP7_MATH_1	687	691	PF00917	0.633
DOC_USP7_MATH_1	713	717	PF00917	0.526
DOC_WW_Pin1_4	384	389	PF00397	0.539
DOC_WW_Pin1_4	429	434	PF00397	0.635
DOC_WW_Pin1_4	441	446	PF00397	0.570
DOC_WW_Pin1_4	484	489	PF00397	0.629
DOC_WW_Pin1_4	500	505	PF00397	0.484
DOC_WW_Pin1_4	656	661	PF00397	0.633
DOC_WW_Pin1_4	683	688	PF00397	0.629
LIG_14-3-3_CanoR_1	144	149	PF00244	0.352
LIG_14-3-3_CanoR_1	177	182	PF00244	0.401
LIG_14-3-3_CanoR_1	188	193	PF00244	0.256
LIG_14-3-3_CanoR_1	210	216	PF00244	0.444
LIG_14-3-3_CanoR_1	217	221	PF00244	0.312
LIG_14-3-3_CanoR_1	266	271	PF00244	0.297
LIG_14-3-3_CanoR_1	450	457	PF00244	0.601
LIG_14-3-3_CanoR_1	624	632	PF00244	0.638
LIG_Actin_WH2_2	182	199	PF00022	0.318
LIG_BRCT_BRCA1_1	681	685	PF00533	0.507
LIG_BRCT_BRCA1_1	707	711	PF00533	0.527
LIG_deltaCOP1_diTrp_1	164	170	PF00928	0.340
LIG_DLG_GKlike_1	188	195	PF00625	0.312
LIG_FHA_1	134	140	PF00498	0.320
LIG_FHA_1	143	149	PF00498	0.307
LIG_FHA_1	430	436	PF00498	0.602
LIG_FHA_1	527	533	PF00498	0.592
LIG_FHA_1	637	643	PF00498	0.648
LIG_FHA_2	11	17	PF00498	0.375
LIG_FHA_2	181	187	PF00498	0.361
LIG_FHA_2	325	331	PF00498	0.683
LIG_FHA_2	41	47	PF00498	0.340
LIG_FHA_2	589	595	PF00498	0.573
LIG_FHA_2	610	616	PF00498	0.509
LIG_FHA_2	70	76	PF00498	0.352
LIG_HP1_1	30	34	PF01393	0.207
LIG_LIR_Apic_2	376	380	PF02991	0.657
LIG_LIR_Gen_1	109	119	PF02991	0.347
LIG_LIR_Gen_1	16	25	PF02991	0.342
LIG_LIR_Gen_1	164	172	PF02991	0.340
LIG_LIR_Gen_1	296	303	PF02991	0.265
LIG_LIR_Gen_1	423	433	PF02991	0.649
LIG_LIR_Gen_1	505	514	PF02991	0.588
LIG_LIR_Gen_1	576	585	PF02991	0.491
LIG_LIR_Gen_1	715	720	PF02991	0.654
LIG_LIR_Nem_3	109	114	PF02991	0.311
LIG_LIR_Nem_3	16	22	PF02991	0.335
LIG_LIR_Nem_3	164	169	PF02991	0.340
LIG_LIR_Nem_3	423	428	PF02991	0.622
LIG_LIR_Nem_3	505	510	PF02991	0.565
LIG_LIR_Nem_3	576	580	PF02991	0.493
LIG_LIR_Nem_3	582	586	PF02991	0.458
LIG_LIR_Nem_3	715	720	PF02991	0.606
LIG_MYND_1	488	492	PF01753	0.474
LIG_NRBOX	191	197	PF00104	0.312
LIG_PCNA_yPIPBox_3	173	185	PF02747	0.312
LIG_PDZ_Class_1	715	720	PF00595	0.606
LIG_Pex14_1	45	49	PF04695	0.352
LIG_Pex14_2	286	290	PF04695	0.358
LIG_SH2_CRK	198	202	PF00017	0.388
LIG_SH2_CRK	273	277	PF00017	0.388
LIG_SH2_CRK	425	429	PF00017	0.646
LIG_SH2_GRB2like	63	66	PF00017	0.312
LIG_SH2_NCK_1	198	202	PF00017	0.388
LIG_SH2_NCK_1	425	429	PF00017	0.598
LIG_SH2_PTP2	377	380	PF00017	0.608
LIG_SH2_STAP1	273	277	PF00017	0.312
LIG_SH2_STAT5	206	209	PF00017	0.314
LIG_SH2_STAT5	285	288	PF00017	0.381
LIG_SH2_STAT5	311	314	PF00017	0.537
LIG_SH2_STAT5	377	380	PF00017	0.608
LIG_SH2_STAT5	59	62	PF00017	0.338
LIG_SH2_STAT5	595	598	PF00017	0.555
LIG_SH3_3	155	161	PF00018	0.312
LIG_SH3_3	255	261	PF00018	0.315
LIG_SH3_3	396	402	PF00018	0.587
LIG_SH3_3	405	411	PF00018	0.570
LIG_SH3_3	425	431	PF00018	0.451
LIG_SH3_3	433	439	PF00018	0.643
LIG_SH3_3	486	492	PF00018	0.506
LIG_SH3_3	569	575	PF00018	0.659
LIG_SH3_3	657	663	PF00018	0.581
LIG_SUMO_SIM_par_1	275	281	PF11976	0.312
LIG_SUMO_SIM_par_1	637	643	PF11976	0.631
LIG_SUMO_SIM_par_1	83	89	PF11976	0.207
LIG_TRAF2_1	320	323	PF00917	0.565
LIG_TRAF2_1	591	594	PF00917	0.550
LIG_TRAF2_1	692	695	PF00917	0.645
LIG_TRAF2_2	100	105	PF00917	0.388
LIG_TRFH_1	198	202	PF08558	0.388
LIG_TYR_ITIM	271	276	PF00017	0.388
LIG_UBA3_1	276	280	PF00899	0.312
LIG_WRC_WIRS_1	580	585	PF05994	0.468
LIG_WW_3	174	178	PF00397	0.388
MOD_CDK_SPxxK_3	384	391	PF00069	0.612
MOD_CK1_1	147	153	PF00069	0.341
MOD_CK1_1	429	435	PF00069	0.723
MOD_CK1_1	444	450	PF00069	0.574
MOD_CK1_1	550	556	PF00069	0.621
MOD_CK1_1	561	567	PF00069	0.551
MOD_CK1_1	656	662	PF00069	0.693
MOD_CK1_1	686	692	PF00069	0.618
MOD_CK2_1	180	186	PF00069	0.361
MOD_CK2_1	317	323	PF00069	0.559
MOD_CK2_1	370	376	PF00069	0.672
MOD_CK2_1	440	446	PF00069	0.538
MOD_CK2_1	45	51	PF00069	0.340
MOD_CK2_1	588	594	PF00069	0.575
MOD_CK2_1	69	75	PF00069	0.312
MOD_CK2_1	8	14	PF00069	0.406
MOD_GlcNHglycan	295	298	PF01048	0.283
MOD_GlcNHglycan	313	316	PF01048	0.566
MOD_GlcNHglycan	317	320	PF01048	0.630
MOD_GlcNHglycan	327	330	PF01048	0.635
MOD_GlcNHglycan	340	343	PF01048	0.670
MOD_GlcNHglycan	348	351	PF01048	0.633
MOD_GlcNHglycan	353	359	PF01048	0.616
MOD_GlcNHglycan	516	519	PF01048	0.575
MOD_GlcNHglycan	563	566	PF01048	0.537
MOD_GlcNHglycan	655	658	PF01048	0.596
MOD_GlcNHglycan	681	684	PF01048	0.583
MOD_GSK3_1	142	149	PF00069	0.345
MOD_GSK3_1	211	218	PF00069	0.312
MOD_GSK3_1	289	296	PF00069	0.259
MOD_GSK3_1	311	318	PF00069	0.545
MOD_GSK3_1	440	447	PF00069	0.654
MOD_GSK3_1	45	52	PF00069	0.340
MOD_GSK3_1	451	458	PF00069	0.612
MOD_GSK3_1	484	491	PF00069	0.601
MOD_GSK3_1	526	533	PF00069	0.622
MOD_GSK3_1	557	564	PF00069	0.597
MOD_GSK3_1	609	616	PF00069	0.665
MOD_GSK3_1	636	643	PF00069	0.633
MOD_GSK3_1	679	686	PF00069	0.636
MOD_GSK3_1	712	719	PF00069	0.565
MOD_LATS_1	449	455	PF00433	0.541
MOD_N-GLC_1	177	182	PF02516	0.312
MOD_NEK2_1	125	130	PF00069	0.350
MOD_NEK2_1	146	151	PF00069	0.338
MOD_NEK2_1	152	157	PF00069	0.299
MOD_NEK2_1	211	216	PF00069	0.444
MOD_NEK2_1	290	295	PF00069	0.381
MOD_NEK2_1	370	375	PF00069	0.598
MOD_NEK2_1	40	45	PF00069	0.399
MOD_NEK2_1	463	468	PF00069	0.667
MOD_NEK2_1	49	54	PF00069	0.296
MOD_NEK2_1	640	645	PF00069	0.586
MOD_PIKK_1	705	711	PF00454	0.530
MOD_PKA_2	216	222	PF00069	0.317
MOD_PKA_2	449	455	PF00069	0.622
MOD_PKA_2	623	629	PF00069	0.639
MOD_Plk_1	142	148	PF00069	0.312
MOD_Plk_1	177	183	PF00069	0.312
MOD_Plk_1	45	51	PF00069	0.340
MOD_Plk_1	614	620	PF00069	0.513
MOD_Plk_1	636	642	PF00069	0.633
MOD_Plk_4	147	153	PF00069	0.317
MOD_Plk_4	180	186	PF00069	0.207
MOD_Plk_4	266	272	PF00069	0.297
MOD_Plk_4	290	296	PF00069	0.361
MOD_Plk_4	49	55	PF00069	0.332
MOD_ProDKin_1	384	390	PF00069	0.533
MOD_ProDKin_1	429	435	PF00069	0.638
MOD_ProDKin_1	441	447	PF00069	0.572
MOD_ProDKin_1	484	490	PF00069	0.630
MOD_ProDKin_1	500	506	PF00069	0.485
MOD_ProDKin_1	656	662	PF00069	0.632
MOD_ProDKin_1	683	689	PF00069	0.632
MOD_SUMO_rev_2	359	368	PF00179	0.635
TRG_DiLeu_BaLyEn_6	191	196	PF01217	0.205
TRG_DiLeu_BaLyEn_6	272	277	PF01217	0.388
TRG_ENDOCYTIC_2	19	22	PF00928	0.391
TRG_ENDOCYTIC_2	273	276	PF00928	0.317
TRG_ENDOCYTIC_2	425	428	PF00928	0.639
TRG_ER_diArg_1	172	174	PF00400	0.279
TRG_ER_diArg_1	192	194	PF00400	0.192
TRG_ER_diArg_1	209	211	PF00400	0.449
TRG_ER_diArg_1	231	233	PF00400	0.269
TRG_ER_diArg_1	309	311	PF00400	0.426
TRG_NLS_Bipartite_1	193	212	PF00514	0.205

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBI2	Leptomonas seymouri	55%	89%
A0A3Q8IAT8	Leishmania donovani	83%	99%
A4H961	Leishmania braziliensis	67%	97%
A4HXI3	Leishmania infantum	84%	91%
Q4QE85	Leishmania major	81%	99%