Hydrolase-like protein (Esterase-like protein)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hydrolase-like protein

Species:

Leishmania mexicana

UniProt:

E9AR77_LEIMU

TriTrypDb:

LmxM.17.1050

Length:

390

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 35
NetGPI	no	yes: 0, no: 35

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AR77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR77

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	34
GO:0016787	hydrolase activity	2	34

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	272	274	PF00675	0.295
CLV_PCSK_KEX2_1	26	28	PF00082	0.519
CLV_PCSK_KEX2_1	272	274	PF00082	0.321
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.503
CLV_PCSK_SKI1_1	136	140	PF00082	0.240
CLV_PCSK_SKI1_1	166	170	PF00082	0.322
CLV_PCSK_SKI1_1	238	242	PF00082	0.293
CLV_PCSK_SKI1_1	45	49	PF00082	0.512
CLV_PCSK_SKI1_1	67	71	PF00082	0.443
DEG_APCC_DBOX_1	271	279	PF00400	0.397
DOC_MAPK_gen_1	252	260	PF00069	0.366
DOC_MAPK_gen_1	26	36	PF00069	0.383
DOC_MAPK_MEF2A_6	319	326	PF00069	0.414
DOC_PP1_RVXF_1	234	240	PF00149	0.401
DOC_PP1_RVXF_1	348	355	PF00149	0.366
DOC_PP4_FxxP_1	48	51	PF00568	0.303
DOC_PP4_FxxP_1	76	79	PF00568	0.350
DOC_USP7_MATH_1	141	145	PF00917	0.346
DOC_USP7_MATH_1	211	215	PF00917	0.359
DOC_USP7_MATH_1	298	302	PF00917	0.304
DOC_WW_Pin1_4	128	133	PF00397	0.356
DOC_WW_Pin1_4	202	207	PF00397	0.323
DOC_WW_Pin1_4	305	310	PF00397	0.471
LIG_14-3-3_CanoR_1	212	216	PF00244	0.190
LIG_14-3-3_CanoR_1	61	69	PF00244	0.428
LIG_BIR_III_4	160	164	PF00653	0.401
LIG_BRCT_BRCA1_1	129	133	PF00533	0.343
LIG_CtBP_PxDLS_1	31	35	PF00389	0.323
LIG_EVH1_1	48	52	PF00568	0.297
LIG_FHA_1	224	230	PF00498	0.223
LIG_FHA_2	122	128	PF00498	0.338
LIG_FHA_2	151	157	PF00498	0.311
LIG_FHA_2	27	33	PF00498	0.412
LIG_FHA_2	63	69	PF00498	0.404
LIG_FHA_2	73	79	PF00498	0.381
LIG_HP1_1	322	326	PF01393	0.401
LIG_HP1_1	332	336	PF01393	0.401
LIG_IRF3_LxIS_1	164	171	PF10401	0.293
LIG_LIR_Apic_2	127	132	PF02991	0.401
LIG_LIR_Apic_2	74	79	PF02991	0.381
LIG_LIR_Gen_1	53	63	PF02991	0.447
LIG_LIR_Gen_1	70	79	PF02991	0.262
LIG_LIR_LC3C_4	331	335	PF02991	0.190
LIG_LIR_Nem_3	53	59	PF02991	0.427
LIG_LIR_Nem_3	70	76	PF02991	0.288
LIG_LIR_Nem_3	98	104	PF02991	0.331
LIG_Pex14_1	97	101	PF04695	0.254
LIG_REV1ctd_RIR_1	237	245	PF16727	0.211
LIG_SH2_CRK	129	133	PF00017	0.339
LIG_SH2_GRB2like	115	118	PF00017	0.312
LIG_SH2_NCK_1	129	133	PF00017	0.160
LIG_SH2_STAT5	104	107	PF00017	0.298
LIG_SH2_STAT5	111	114	PF00017	0.267
LIG_SH2_STAT5	152	155	PF00017	0.293
LIG_SH2_STAT5	360	363	PF00017	0.405
LIG_SH3_3	25	31	PF00018	0.615
LIG_SH3_3	349	355	PF00018	0.329
LIG_SH3_3	46	52	PF00018	0.522
LIG_SH3_3	76	82	PF00018	0.419
LIG_SUMO_SIM_anti_2	331	337	PF11976	0.473
LIG_SUMO_SIM_par_1	331	337	PF11976	0.190
LIG_UBA3_1	164	169	PF00899	0.240
LIG_WRC_WIRS_1	73	78	PF05994	0.336
MOD_CK1_1	13	19	PF00069	0.674
MOD_CK1_1	205	211	PF00069	0.297
MOD_CK2_1	141	147	PF00069	0.343
MOD_CK2_1	26	32	PF00069	0.430
MOD_CK2_1	298	304	PF00069	0.406
MOD_Cter_Amidation	270	273	PF01082	0.211
MOD_GlcNHglycan	207	210	PF01048	0.377
MOD_GlcNHglycan	283	287	PF01048	0.321
MOD_GlcNHglycan	296	299	PF01048	0.282
MOD_GlcNHglycan	300	303	PF01048	0.356
MOD_GlcNHglycan	312	315	PF01048	0.409
MOD_GSK3_1	10	17	PF00069	0.744
MOD_GSK3_1	146	153	PF00069	0.308
MOD_GSK3_1	201	208	PF00069	0.280
MOD_GSK3_1	22	29	PF00069	0.697
MOD_GSK3_1	278	285	PF00069	0.413
MOD_GSK3_1	294	301	PF00069	0.294
MOD_GSK3_1	305	312	PF00069	0.419
MOD_GSK3_1	67	74	PF00069	0.468
MOD_N-GLC_1	90	95	PF02516	0.211
MOD_NEK2_1	168	173	PF00069	0.309
MOD_NEK2_1	195	200	PF00069	0.291
MOD_NEK2_1	201	206	PF00069	0.278
MOD_NEK2_1	71	76	PF00069	0.512
MOD_NEK2_1	90	95	PF00069	0.379
MOD_NEK2_1	96	101	PF00069	0.381
MOD_NEK2_2	15	20	PF00069	0.453
MOD_PIKK_1	168	174	PF00454	0.211
MOD_PKA_1	26	32	PF00069	0.359
MOD_PKA_2	211	217	PF00069	0.389
MOD_PKA_2	26	32	PF00069	0.400
MOD_PKA_2	293	299	PF00069	0.413
MOD_PKA_2	304	310	PF00069	0.377
MOD_Plk_1	67	73	PF00069	0.364
MOD_Plk_1	90	96	PF00069	0.425
MOD_Plk_2-3	228	234	PF00069	0.401
MOD_Plk_4	211	217	PF00069	0.362
MOD_Plk_4	228	234	PF00069	0.376
MOD_Plk_4	91	97	PF00069	0.411
MOD_ProDKin_1	128	134	PF00069	0.356
MOD_ProDKin_1	202	208	PF00069	0.323
MOD_ProDKin_1	305	311	PF00069	0.471
TRG_ENDOCYTIC_2	73	76	PF00928	0.351
TRG_ER_diArg_1	235	238	PF00400	0.415
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D3	Leptomonas seymouri	36%	90%
A0A0N0P3S4	Leptomonas seymouri	58%	100%
A0A0N1PA10	Leptomonas seymouri	40%	100%
A0A0N1PCQ2	Leptomonas seymouri	41%	100%
A0A0S4JQB3	Bodo saltans	35%	100%
A0A1X0NSR3	Trypanosomatidae	35%	87%
A0A1X0NSS6	Trypanosomatidae	41%	100%
A0A3Q8IAY1	Leishmania donovani	91%	100%
A0A3R7KKJ0	Trypanosoma rangeli	37%	100%
A0A3S5IRR1	Trypanosoma rangeli	34%	96%
A0A3S7WUJ3	Leishmania donovani	38%	100%
A0A3S7WUK0	Leishmania donovani	37%	90%
A0A3S7X1K2	Leishmania donovani	37%	100%
A0A422NS41	Trypanosoma rangeli	36%	91%
A4H956	Leishmania braziliensis	40%	100%
A4H959	Leishmania braziliensis	36%	100%
A4H960	Leishmania braziliensis	78%	100%
A4HGL0	Leishmania braziliensis	40%	96%
A4HXH8	Leishmania infantum	38%	100%
A4HXI1	Leishmania infantum	38%	90%
A4HXI2	Leishmania infantum	91%	100%
A4I3N6	Leishmania infantum	37%	100%
C9ZP69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	97%
C9ZP70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AR73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	98%
E9AR76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AZX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
Q4Q8A8	Leishmania major	37%	99%
Q4QE86	Leishmania major	90%	100%
Q4QE87	Leishmania major	37%	100%
Q4QE90	Leishmania major	37%	100%
Q54528	Streptomyces purpurascens	27%	100%
Q54809	Streptomyces peucetius	28%	100%
Q55217	Streptomyces sp. (strain C5)	28%	100%
V5AZB9	Trypanosoma cruzi	34%	91%
V5BER0	Trypanosoma cruzi	39%	100%
V5BNU9	Trypanosoma cruzi	31%	96%