Hydrolase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hydrolase-like protein

Species:

Leishmania mexicana

UniProt:

E9AR76_LEIMU

TriTrypDb:

LmxM.17.1040

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 37
NetGPI	no	yes: 0, no: 37

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AR76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AR76

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	35
GO:0016787	hydrolase activity	2	35

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.324
CLV_C14_Caspase3-7	319	323	PF00656	0.135
CLV_C14_Caspase3-7	94	98	PF00656	0.336
CLV_NRD_NRD_1	257	259	PF00675	0.192
CLV_NRD_NRD_1	276	278	PF00675	0.210
CLV_NRD_NRD_1	405	407	PF00675	0.461
CLV_PCSK_KEX2_1	276	278	PF00082	0.257
CLV_PCSK_KEX2_1	405	407	PF00082	0.356
CLV_PCSK_SKI1_1	269	273	PF00082	0.327
CLV_PCSK_SKI1_1	286	290	PF00082	0.362
CLV_PCSK_SKI1_1	325	329	PF00082	0.183
DEG_APCC_DBOX_1	285	293	PF00400	0.394
DEG_COP1_1	332	340	PF00400	0.374
DEG_SPOP_SBC_1	207	211	PF00917	0.321
DOC_CYCLIN_RxL_1	172	183	PF00134	0.248
DOC_MAPK_gen_1	273	281	PF00069	0.450
DOC_MAPK_MEF2A_6	49	57	PF00069	0.281
DOC_MIT_MIM_1	146	155	PF04212	0.183
DOC_PP1_RVXF_1	147	153	PF00149	0.183
DOC_PP2B_LxvP_1	292	295	PF13499	0.348
DOC_PP2B_PxIxI_1	337	343	PF00149	0.201
DOC_PP4_FxxP_1	335	338	PF00568	0.183
DOC_USP7_MATH_1	2	6	PF00917	0.723
DOC_USP7_MATH_1	399	403	PF00917	0.415
DOC_USP7_UBL2_3	248	252	PF12436	0.371
DOC_USP7_UBL2_3	423	427	PF12436	0.705
DOC_WW_Pin1_4	185	190	PF00397	0.320
DOC_WW_Pin1_4	330	335	PF00397	0.237
DOC_WW_Pin1_4	5	10	PF00397	0.611
DOC_WW_Pin1_4	58	63	PF00397	0.278
LIG_14-3-3_CanoR_1	175	180	PF00244	0.282
LIG_14-3-3_CanoR_1	276	280	PF00244	0.231
LIG_14-3-3_CanoR_1	30	38	PF00244	0.423
LIG_14-3-3_CanoR_1	304	309	PF00244	0.327
LIG_14-3-3_CanoR_1	325	335	PF00244	0.457
LIG_14-3-3_CanoR_1	356	362	PF00244	0.331
LIG_14-3-3_CanoR_1	69	75	PF00244	0.401
LIG_Actin_WH2_1	366	384	PF00022	0.384
LIG_BIR_III_4	140	144	PF00653	0.397
LIG_FHA_1	123	129	PF00498	0.422
LIG_FHA_1	245	251	PF00498	0.371
LIG_FHA_1	337	343	PF00498	0.240
LIG_FHA_1	35	41	PF00498	0.362
LIG_FHA_2	131	137	PF00498	0.291
LIG_FHA_2	220	226	PF00498	0.183
LIG_FHA_2	45	51	PF00498	0.357
LIG_FHA_2	92	98	PF00498	0.325
LIG_LIR_Apic_2	332	338	PF02991	0.182
LIG_LIR_Gen_1	245	253	PF02991	0.399
LIG_LIR_Gen_1	383	393	PF02991	0.380
LIG_LIR_Gen_1	77	85	PF02991	0.435
LIG_LIR_Nem_3	112	116	PF02991	0.355
LIG_LIR_Nem_3	140	145	PF02991	0.387
LIG_LIR_Nem_3	23	28	PF02991	0.396
LIG_LIR_Nem_3	245	249	PF02991	0.366
LIG_LIR_Nem_3	383	388	PF02991	0.381
LIG_LIR_Nem_3	77	83	PF02991	0.313
LIG_PDZ_Class_1	427	432	PF00595	0.693
LIG_PTAP_UEV_1	3	8	PF05743	0.419
LIG_SH2_CRK	118	122	PF00017	0.287
LIG_SH2_CRK	80	84	PF00017	0.201
LIG_SH2_GRB2like	214	217	PF00017	0.135
LIG_SH2_GRB2like	280	283	PF00017	0.179
LIG_SH2_PTP2	385	388	PF00017	0.456
LIG_SH2_SRC	116	119	PF00017	0.201
LIG_SH2_SRC	214	217	PF00017	0.135
LIG_SH2_SRC	280	283	PF00017	0.239
LIG_SH2_STAP1	116	120	PF00017	0.407
LIG_SH2_STAP1	214	218	PF00017	0.401
LIG_SH2_STAP1	242	246	PF00017	0.401
LIG_SH2_STAT5	113	116	PF00017	0.401
LIG_SH2_STAT5	132	135	PF00017	0.300
LIG_SH2_STAT5	280	283	PF00017	0.279
LIG_SH2_STAT5	336	339	PF00017	0.379
LIG_SH2_STAT5	368	371	PF00017	0.339
LIG_SH2_STAT5	385	388	PF00017	0.412
LIG_SH3_3	1	7	PF00018	0.728
LIG_SH3_3	104	110	PF00018	0.439
LIG_SH3_3	15	21	PF00018	0.604
LIG_SH3_3	345	351	PF00018	0.274
LIG_SUMO_SIM_anti_2	178	184	PF11976	0.224
LIG_SUMO_SIM_anti_2	201	207	PF11976	0.419
LIG_SUMO_SIM_par_1	174	180	PF11976	0.265
LIG_TRAF2_1	223	226	PF00917	0.401
LIG_UBA3_1	199	208	PF00899	0.354
LIG_WRC_WIRS_1	42	47	PF05994	0.317
MOD_CDC14_SPxK_1	12	15	PF00782	0.498
MOD_CDK_SPxK_1	9	15	PF00069	0.443
MOD_CK1_1	183	189	PF00069	0.295
MOD_CK1_1	201	207	PF00069	0.248
MOD_CK1_1	329	335	PF00069	0.316
MOD_CK1_1	5	11	PF00069	0.629
MOD_CK2_1	124	130	PF00069	0.330
MOD_CK2_1	219	225	PF00069	0.355
MOD_Cter_Amidation	403	406	PF01082	0.352
MOD_GlcNHglycan	158	161	PF01048	0.380
MOD_GlcNHglycan	210	213	PF01048	0.396
MOD_GlcNHglycan	222	225	PF01048	0.401
MOD_GlcNHglycan	253	256	PF01048	0.384
MOD_GlcNHglycan	328	331	PF01048	0.418
MOD_GlcNHglycan	4	7	PF01048	0.684
MOD_GlcNHglycan	419	422	PF01048	0.644
MOD_GlcNHglycan	76	79	PF01048	0.463
MOD_GSK3_1	177	184	PF00069	0.269
MOD_GSK3_1	30	37	PF00069	0.501
MOD_GSK3_1	321	328	PF00069	0.432
MOD_GSK3_1	5	12	PF00069	0.528
MOD_GSK3_1	70	77	PF00069	0.429
MOD_NEK2_1	155	160	PF00069	0.340
MOD_NEK2_1	177	182	PF00069	0.282
MOD_NEK2_1	275	280	PF00069	0.280
MOD_NEK2_1	311	316	PF00069	0.213
MOD_NEK2_1	373	378	PF00069	0.353
MOD_NEK2_1	381	386	PF00069	0.401
MOD_NEK2_1	70	75	PF00069	0.408
MOD_NEK2_2	124	129	PF00069	0.201
MOD_PIKK_1	309	315	PF00454	0.445
MOD_PK_1	304	310	PF00069	0.407
MOD_PKA_2	219	225	PF00069	0.193
MOD_PKA_2	275	281	PF00069	0.234
MOD_PKA_2	31	37	PF00069	0.437
MOD_PKA_2	320	326	PF00069	0.416
MOD_PKA_2	381	387	PF00069	0.453
MOD_PKB_1	302	310	PF00069	0.201
MOD_Plk_2-3	130	136	PF00069	0.273
MOD_Plk_4	109	115	PF00069	0.354
MOD_Plk_4	177	183	PF00069	0.237
MOD_Plk_4	198	204	PF00069	0.344
MOD_Plk_4	336	342	PF00069	0.276
MOD_Plk_4	357	363	PF00069	0.283
MOD_Plk_4	373	379	PF00069	0.389
MOD_Plk_4	381	387	PF00069	0.406
MOD_ProDKin_1	185	191	PF00069	0.320
MOD_ProDKin_1	330	336	PF00069	0.237
MOD_ProDKin_1	5	11	PF00069	0.603
MOD_ProDKin_1	58	64	PF00069	0.278
TRG_AP2beta_CARGO_1	140	149	PF09066	0.183
TRG_DiLeu_BaEn_4	225	231	PF01217	0.401
TRG_ENDOCYTIC_2	118	121	PF00928	0.285
TRG_ENDOCYTIC_2	385	388	PF00928	0.474
TRG_ENDOCYTIC_2	42	45	PF00928	0.328
TRG_ENDOCYTIC_2	80	83	PF00928	0.317
TRG_ER_diArg_1	148	151	PF00400	0.408
TRG_ER_diArg_1	227	230	PF00400	0.372
TRG_ER_diArg_1	275	277	PF00400	0.149
TRG_ER_diArg_1	301	304	PF00400	0.366
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.332
TRG_Pf-PMV_PEXEL_1	387	391	PF00026	0.478
TRG_PTS1	429	432	PF00515	0.681

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D3	Leptomonas seymouri	65%	100%
A0A0N0P3S4	Leptomonas seymouri	37%	100%
A0A0N1PA10	Leptomonas seymouri	30%	100%
A0A0N1PCQ2	Leptomonas seymouri	32%	100%
A0A0S4JQB3	Bodo saltans	31%	100%
A0A0S4KKL9	Bodo saltans	29%	82%
A0A1X0NSR3	Trypanosomatidae	30%	97%
A0A1X0NSS6	Trypanosomatidae	33%	100%
A0A1X0NT85	Trypanosomatidae	33%	88%
A0A3Q8IAY1	Leishmania donovani	39%	100%
A0A3R7KKJ0	Trypanosoma rangeli	32%	100%
A0A3S5IRR1	Trypanosoma rangeli	38%	100%
A0A3S7WUJ3	Leishmania donovani	31%	100%
A0A3S7WUK0	Leishmania donovani	91%	100%
A0A3S7X1K2	Leishmania donovani	31%	100%
A0A422NS41	Trypanosoma rangeli	30%	100%
A4H956	Leishmania braziliensis	34%	93%
A4H959	Leishmania braziliensis	82%	100%
A4H960	Leishmania braziliensis	37%	100%
A4HGL0	Leishmania braziliensis	31%	93%
A4HXH8	Leishmania infantum	31%	100%
A4HXI1	Leishmania infantum	91%	100%
A4HXI2	Leishmania infantum	39%	100%
A4I3N6	Leishmania infantum	31%	100%
C9ZP69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
C9ZP70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AR73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	85%
E9AR77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AZX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
Q4Q8A8	Leishmania major	31%	96%
Q4QE86	Leishmania major	38%	100%
Q4QE87	Leishmania major	88%	100%
Q4QE90	Leishmania major	32%	91%
Q54809	Streptomyces peucetius	27%	100%
Q55217	Streptomyces sp. (strain C5)	27%	100%
V5AZB9	Trypanosoma cruzi	31%	100%
V5BER0	Trypanosoma cruzi	33%	100%
V5BNU9	Trypanosoma cruzi	35%	100%